A difficult airway as defined by the ASA Task Force on Management of the Difficult Airway is ‘the clinical situation in which a conventionally trained anaesthesiologist experiences difficulty with facemask ventilation of the upper airway, difficulty with tracheal intubation, or both’. In a retrospective review of 11 219 paediatric procedures, the risk of difficult laryngoscopy was estimated as 1.35%. The risk was found to be higher in neonates and infants, children who are underweight, ASA physical status III and IV, or have Mallampati score III and IV. 1 However, the reliability of the Mallampati score in predicting difficult airway management in the paediatric population has been questioned and some clinicians prefer the Colorado Pediatric Airway Score (COPUR), since it uses a detailed scoring system and is therefore possibly more reliable. 2 Cooperation for airway assessment in children is not always easy and the availability of a score which accounts for a number of different aspects of the airway is more thorough. (See Table 1 for details.) Data pertaining to the real incidence of difficult airway management in children are sparse, but they are thought to be lower than in the adult population. Certain features predicting potential difficulties with airway management are often present in a number of syndromic children seen in paediatric anaesthesia practice. Predictors of difficult intubation include the presence of dysmorphic features, limited neck extension due to fusion of cervical vertebrae as found in Klippel‐ Feil syndrome, limited mouth opening, and restricted mobility of temporo-mandibular joints, a large tongue (macroglossia) such as found in Beckwith‐Wiedemann syndrome, limited submandibular space (retrognathia, micrognathia, mandibular hypoplasia or dysplasia) as found in Pierre Robin syndrome and Treacher Collins syndrome, and the presence of structural abnormalities in the laryngo-tracheal passage. Other predictors include soft tissue tumours, storage diseases such as mucopolysaccharidoses, and arteriovenous or lymphatic malformations involving the airway. In neonates and infants, the lateral profile may be more useful in eliciting the subtle signs of mandibular hypoplasia which are easily missed. (Refer to Table 2 for the anatomical site predominantly causing the airway problem in these syndromes.) This review focuses on some common syndromes predominantly seen in paediatric anaesthesia practice that are associated with potentially difficult airway management and highlights the related relevant features. A broader discussion of difficult intubation in the paediatric population has been published elsewhere and is beyond the scope of this review. 34