The accuracy of traditional measuring machines is affected by the measuring range and sensitive geometric errors, and it is not possible to combine large caliber and high-precision measurements. This study proposes a differential geometric error-weighting method for designing a high-precision, large-diameter measuring machine. The machine utilized a zero-Abbe arm structure and applied the rigid body theory and small-angle hypothesis to model geometric errors. Weights were calculated for 23 geometric errors, identifying eight sensitive ones. A picometer-precision laser interferometer (quDIS) with a theoretical positioning accuracy of 0.2 nm/mm and standard flat rulers are used to ensure highly accurate positioning of the Y-axis/Z-axis of the measuring platform and reduce the straightness of both axes by approximately 75%, with radial and axial runout of the rotary table under 100 nm. The development and design method of the high-precision measuring machine proposed in this study is applicable to large-diameter high-precision flexible measurement, and the accurate control of measuring machine movement accuracy is realized by calculating the geometric error weights.