Differential Diagnosis Of Rheumatoid Arthritis Research Articles

Does Eta Protein Differentiate Rheumatoid Arthritis from Psoriatic Arthritis?

The clinical symptoms and laboratory markers of Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) can be very similar, so making a differential diagnosis between these two diseases is often difficult. Serological parameters to be used in differential diagnosis can guide the clinician. This study aimed to investigate the usability of 14-3-3η (eta) protein as a biomarker in the differential diagnosis of PsA and RA, and the relationships between eta protein and disease activity scores and joint erosions in PsA and RA. 54 PsA patients, 53 RA patients, and 56 healthy individuals were included in this study. The ELISA (Enzyme-Linked ImunoSorbent Assay) kit was used as a quantitative sandwich enzyme immunoassay technique to detect human eta protein levels. Receiver- operating Characteristic (ROC) curves analysis was used to determine the sensitivity and specificity of the eta protein. Eta protein levels were found to be significantly higher in the RA group than in the PsA [B: -0.341, OR (95% CI): 0.711 (0.556-0.909), p: 0.007] and control [B: -0.225, OR (95% CI): 0.798 (0.641-0.995), p: 0.045] groups. Eta protein median values were significantly higher in patients with joint erosion than in those without [β= 0.151, OR (95% CI): 1.163 (1.003-1.349), p: 0.046]. Eta protein levels are higher in the serum of RA patients than PsA and are associated with joint erosion. Eta protein may be a potential biomarker in the differential diagnosis of RA and PsA. It may represent a possible therapeutic step in the pathophysiological pathways in the development of joint erosion.

The role of albumin-to-globulin ratio in undifferentiated arthritis: Rheumatoid arthritis versus primary Sjögren syndrome.

Objectives This study aims to compare initial albumin-to-globulin ratio (AGR) in patients with rheumatoid arthritis (RA) and primary Sjögren syndrome (pSS) presenting with undifferentiated arthritis (UA) and to investigate whether there was a difference in terms of AGR between the two patient groups and healthy controls.Patients and methods Between January 2019 and December 2019, a total of 177 patients including 96 RA (10 males, 86 females; mean age: 53.6±10.8 years; range, 21 to 74 years) and 81 pSS (5 males, 76 females; mean age: 53.2±14.1 years; range, 23 to 79 years) and 82 healthy controls (20 males, 62 females; mean age: 50.5±13.6 years; range, 20 to 79 years) were included in this case-control study. Demographic characteristics, albumin, and globulin levels of all participants were recorded. The AGR, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-nuclear antibody (ANA), and anti-citrullinated protein antibodies (ACPA) were assessed.Results The mean AGR was 1.50±0.16 in the control group, 1.48±0.24 in the RA group, and 1.30±0.23 in the pSS group, indicating a significant difference between the pSS and the other two groups (p<0.001). The receiver operating characteristic analysis revealed that the cut-off value for AGR was 1.39 (area under the curve=0.736) with a sensitivity of 0.642 and a specificity of 0.646 (p<0.001). The ESR and CRP values were higher (p<0.001), and ANA (p<0.001) and RF (p=0.003) positivity were lower in the RA group, compared to the pSS group.Conclusion This study findings indicate that AGR is a helpful tool in the differential diagnosis of RA and pSS presenting with UA at the time of admission, and Sjögren syndrome should be considered in case of AGR ≤1.39.

Polymyalgia rheumatica in 18-fluorodeoxyglucose-positron-emission-tomography/computed tomography : Improvement in diagnostic accuracy and differentiation from rheumatoid arthritis

The diagnosis of patients with polymyalgia rheumatica (PMR) has relied upon the clinical examination of symptoms and laboratory parameters of inflammation until now. Currently, the use of different imaging modalities is being explored, including ultrasound, MRI and PET. The aim was to evaluate the diagnostic value of 18-fluorodeoxyglucose-positron-emission-tomography/computed tomography (18F-FDG-PET/CT) for PMR, in order to improve the sensitivity and specificity of diagnosing PMR and to improve the differential diagnosis of rheumatoid arthritis (RA). Examinations using 18F-FDG-PET/CT of 284 rheumatological patients, including 97 patients with PMR, were retrospectively evaluated over a44-month period. Furthermore, 13regions changed by inflammation were analysed via athree-dimensional region of interest (ROI) measurement with determination of maximum standardized uptake values (SUVmax), followed by statistical analyses. Patients with PMR presented significantly elevated uptake in all regions examined (p < 0.001), compared with acontrol group treated for rheumatological diseases. The method with the highest diagnostic relevance was represented by the combination of four SUVmax values of both anterolateral hip capsules and both ischial tuberosities, reaching asensitivity of 91.3% and aspecificity of 97.6% with acut-off of 11.0 SUV at the initial diagnosis of PMR patients who had not yet received any immunosuppressive therapy. Patients with RA could be significantly distinguished from those with PMR at initial diagnosis in the same anatomical regions (p < 0.001).

Expert consensus on clinical detection of rheumatoid arthritis related autoantibodies

Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. Early diagnosis and standard treatment are the keys to control the disease and improve the prognosis. A variety of autoantibodies such as rheumatoid factor and anti-citrullinated peptide/protein antibodies can be detected in serum of patients with rheumatoid arthritis, which are important for early diagnosis and differential diagnosis of RA, judgment of disease severity and prognosis evaluation. The standardization of autoantibody detection related to rheumatoid arthritis is very important for its clinical application. Under the organization of the Committee of the Autoantibodies Detection of Rheumatology and Immunology Physicians Committee of Chinese Medical Doctor Association, expert consensus on clinical application of rheumatoid arthritis related autoantibodies detection were established by a joint group of Chinese multi-disciplinary experts. The consensus aims to standardize the detection of RA associated autoantibodies, and to provide a reference for clinicians and laboratory technicians to use and interpret rheumatoid arthritis-related autoantibodies in daily practice.

Detection of rheumatoid arthritis from hand radiographs using a convolutional neural network

Plain hand radiographs are the first-line and most commonly used imaging methods for diagnosis or differential diagnosis of rheumatoid arthritis (RA) and for monitoring disease activity. In this study, we used plain hand radiographs and tried to develop an automated diagnostic method using the convolutional neural networks to help physicians while diagnosing rheumatoid arthritis. A convolutional neural network (CNN) is a deep learning method based on a multilayer neural network structure. The network was trained on a dataset containing 135 radiographs of the right hands, of which 61 were normal and 74 RA, and tested it on 45 radiographs, of which 20 were normal and 25 RA. The accuracy of the network was 73.33% and the error rate 0.0167. The sensitivity of the network was 0.6818; the specificity was 0.7826 and the precision 0.7500. Using only pixel information on hand radiographs, a multi-layer CNN architecture with online data augmentation was designed. The performance metrics such as accuracy, error rate, sensitivity, specificity, and precision state shows that the network is promising in diagnosing rheumatoid arthritis.

Efficacy of Integrating a Novel 16-Gene Biomarker Panel and Intelligence Classifiers for Differential Diagnosis of Rheumatoid Arthritis and Osteoarthritis.

Introducing novel biomarkers for accurately detecting and differentiating rheumatoid arthritis (RA) and osteoarthritis (OA) using clinical samples is essential. In the current study, we searched for a novel data-driven gene signature of synovial tissues to differentiate RA from OA patients. Fifty-three RA, 41 OA, and 25 normal microarray-based transcriptome samples were utilized. The area under the curve random forests (RF) variable importance measurement was applied to seek the most influential differential genes between RA and OA. Five algorithms including RF, k-nearest neighbors (kNN), support vector machines (SVM), naïve-Bayes, and a tree-based method were employed for the classification. We found a 16-gene signature that could effectively differentiate RA from OA, including TMOD1, POP7, SGCA, KLRD1, ALOX5, RAB22A, ANK3, PTPN3, GZMK, CLU, GZMB, FBXL7, TNFRSF4, IL32, MXRA7, and CD8A. The externally validated accuracy of the RF model was 0.96 (sensitivity = 1.00, specificity = 0.90). Likewise, the accuracy of kNN, SVM, naïve-Bayes, and decision tree was 0.96, 0.96, 0.96, and 0.91, respectively. Functional meta-analysis exhibited the differential pathological processes of RA and OA; suggested promising targets for further mechanistic and therapeutic studies. In conclusion, the proposed genetic signature combined with sophisticated classification methods may improve the diagnosis and management of RA patients.

Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case-control study.

ObjectiveTo analyse the role of serum cartilage oligomeric matrix protein (COMP) levels in the differential diagnosis of rheumatoid arthritis (RA).MethodsThis case–control study analysed the clinical and laboratory characteristics of patients with RA and healthy control subjects. The diagnostic ability of COMP for RA was evaluated by comparing it with anti-cyclic citrullinated peptide antibody levels. The sensitivity, specificity, positive and negative predictive values were calculated.ResultsThe study enrolled 82 patients with RA and 34 healthy control subjects. The serum COMP level was significantly higher in patients with RA compared with control subjects (mean ± SD 29.51 ± 9.21 ng/ml versus 17.85 ± 5.55 ng/ml, respectively). The serum COMP level was significantly higher in patients with active RA compared with patients with RA in remission (mean ± SD 33.08 ± 8.80 ng/ml versus 24.94 ± 7.65 ng/ml, respectively). The cut-off value for COMP to discriminate patients with RA from healthy individuals was 21.51 ng/ml (sensitivity 0.817, specificity 0.882, positive predictive value 0.944, negative predictive value 0.667, and accuracy 0.836).ConclusionThe serum COMP level has the potential to be used as a biological marker for differentiating between patients with RA and healthy individuals.

Lyme disease in the differential diagnosis of rheumatoid arthritis

Romatoid artrit (RA) ile Lyme hastaligi klinik olarak farkliliklar gostermektedir. Lyme artriti RA'dan belirgin farkliliklar gostermesine ragmen, benzer bir sekilde kronik proliferatif sinovitise bagli olarak eklem yerlerinde erozyona neden olabilmektedir. Literaturde her iki hastaligin birlikte goruldugu olguda bildirilmistir. Biz bu makalede el kucuk eklemlerinde simetrik artriti ve el bileklerinde artraljisi olup RA’yi taklit eden ancak oyku, klinik ve laboratuvar olarak Lyme Hastaligi tanisi koydugumuz ve tedavisi tamamlanan bir vakayi sunmayi amacladik

Lupus erythematosus cells in vivo (pleural fluid): An unusual presentation of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease in which organs and cells undergo damage mediated by tissue-binding autoantibodies and immune complexes. In earlier times, the diagnosis of SLE included the lupus erythematosus (LE) cell assay. Though the LE cell test has now been declared obsolete, its presence carries importance especially when one finds LE cells in vivo. We report an unusual case of SLE in a 27-year-old female who presented with acute shortness of breath, fever, and cough. On initial outpatient basis investigations, the patient was detected with anemia, bilateral pleural effusion, synovitis, and juxta-articular swelling of the soft tissues. Her chest radiograph effusion was tapped and sent to the cytopathology laboratory. The cytological examination of the pleural fluid revealed numerous LE cells that prompted the diagnosis of SLE. Autoimmune serology techniques such as antinuclear antibody staining have replaced the LE cell assay. However, as presented in this report and found in a review of the literature, the in vivo finding of LE cells by cytopathology can provide an important clue to the diagnosis of SLE. This case is interesting because although pleural effusion is common, very rarely LE Cells are encountered in vivo. There are very few case reports of SLE diagnosed in a cytopathology laboratory. Moreover, our finding of LE cells in the pleural fluid of the patient led to swift diagnosis, helped rule out the differential diagnosis of rheumatoid arthritis and prompted the immediate initiation of treatment. Furthermore, our case highlights the fact that no matter the advances in diagnostic testing methods, practitioners must always keep an eye open for the basic pathognomonic findings of diseases.

Pixel-based approach to assess contrast-enhanced ultrasound kinetics parameters for differential diagnosis of rheumatoid arthritis.

Inflammatory rheumatic diseases are the leading causes of disability and constitute a frequent medical disorder, leading to inability to work, high comorbidity, and increased mortality. The standard for diagnosing and differentiating arthritis is based on clinical examination, laboratory exams, and imaging findings, such as synovitis, bone edema, or joint erosions. Contrast-enhanced ultrasound (CEUS) examination of the small joints is emerging as a sensitive tool for assessing vascularization and disease activity. Quantitative assessment is mostly performed at the region of interest level, where the mean intensity curve is fitted with an exponential function. We showed that using a more physiologically motivated perfusion curve, and by estimating the kinetic parameters separately pixel by pixel, the quantitative information gathered is able to more effectively characterize the different perfusion patterns. In particular, we demonstrated that a random forest classifier based on pixelwise quantification of the kinetic contrast agent perfusion features can discriminate rheumatoid arthritis from different arthritis forms (psoriatic arthritis, spondyloarthritis, and arthritis in connective tissue disease) with an average accuracy of 97%. On the contrary, clinical evaluation (DAS28), semiquantitative CEUS assessment, serological markers, or region-based parameters do not allow such a high diagnostic accuracy.

Molecular pathological diagnostics of infections in orthopedic pathology

The diagnosis of infections in patients with arthritis and/or in joint prostheses requires interdisciplinary cooperation and the application of up-to-date methods. The histological investigation of the synovial membrane allows the differentiation of acute, chronic and granulomatous synovialitis. Detection of conserved regions of the microbial genome by PCR, especially 16S rRNA for bacteria and 18S rRNA for fungi, is a broad approach for the classification of pathogens which cannot be cultured. Acute infectious arthritis and periprosthetic infections share the spectrum of pathogens with sepsis, therefore multiplex PCR-based methods for the detection of sepsis can be employed. Molecular diagnostics can detect minimal infections in periprosthetic tissues even after antibiotic therapy. The anamnesis (enteral or urogenital infection), clinical picture (oligoarthritis) and further parameters (e.g. HLA B27 status) are important for the diagnosis of reactive arthritis. In many cases of reactive arthritis, molecular methods allow the detection of bacterial DNA or RNA in synovial fluid or tissue samples. The low sensitivity of histopathological methods may be compensated by application of PCR techniques, especially in the differential diagnosis of granulomatous synovitis including mycobacterial infections. Molecular methods can be used to support the differential diagnosis of septic and reactive arthritis. MicroRNA techniques combined with PCR for detection of pathogens support the differential diagnosis of rheumatoid arthritis with severe inflammatory activity compared to infectious arthritis. Proteomic methods could expand the methodological spectrum for the diagnosis of infections.

Analyses of Human and Rat Clinical Parameters in Rheumatoid Arthritis Raise the Possibility of Use of Crude Aloe vera Gel in Disease Amelioration

Rheumatoid Arthritis (RA) is a chronic inflammatory condition affecting the joints causing swelling, stiffness and pain which finally leads to substantial loss of functioning and mobility in its advanced stages. In the present study we have monitored important serological parameters of fifty RA patients and also have discussed the justification of using rat as a model for human RA researches by comparing their respective serological parameters. We have also evaluated the anti-arthritic roles of raw Aloe vera gel and its effects in rat model where arthritis was induced by using Freund’s Complete Adjuvant (FCA). Three essential conclusive statements were derived from the study. Firstly, the six clinical parameters that we have selected for the study namely, RA factor, CRP, ASO, ESR, ceruloplasmin and serum creatinine were all essential for the differential diagnosis of Rheumatoid Arthritis during its early and later stages, RA factor being the most sensitive of all parameters (92% sensitivity). Secondly, this study has supported the use of the rat as a model for designing therapeutic strategies against RA. Lastly, as evident from our study, Aloe vera extracts can be beneficial for the reduction of inflammatory edema and also for the reduction of ceruloplasmin in RA condition in rat model. However, further investigations are necessary for more refined therapeutic usage of Aloe vera for the treatment of RA in human.

Serum and erythrocyte membrane sialic acid levels in patients with rheumatoid arthritis and ankylosing spondylitis and a methodological evaluation

Objectives: Aim of this study was to investigate serum and erythrocyte membrane total sialic acid levels in patients with rheumatoid arthritis and ankylosing spondylitis and demonstrate any correlation between total sialic acid and disease activity score and other inflammation variables. Material and methods: Serum total sialic acid and erythrocyte membrane sialic acid levels were measured in 24 rheumatoid arthritis, 19 ankylosing spondylitis patients and 24 healthy controls as well as serum C-reactive protein, anticyclic citrullinated peptide, rheumatoid factor, alkaline phophatase and erythrocyte sedimentation rate and compared with activity of the diseases. Results: Serum total sialic acid levels of patient groups were statistically higher than control group (p<0.05). Serum total sialic acid levels in rheumatoid arthritis were significantly higher than the ankylosing spondylitis patients (p<0.05). There was no significant difference between the groups for erythrocyte membrane sialic acid. Significant correlation was found between serum total sialic acid and serum C-reactive protein in both groups (r=0.411, r=0.825); correlation between serum total sialic acid and erythrocyte sedimentation rate was found only in ankylosing spondylitis group (r=0.515). There was a significantly negative correlation between erythrocyte membrane sialic acid and serum C-reactive protein in ankylosing spondylitis group (r =-0.570). Conclusion: Serum total sialic acid is a useful diagnostic tool as an inflammatory parameter and can be used in the differential diagnosis of rheumatoid arthritis and ankylosing spondylitis.

English

In Behcet&rsquo;s disease (BD) and Brucellosis, joint involvement is very common and it may share similarities with rheumatoid arthritis (RA). Anti-cyclic citrullinated peptides (CCP) are evaluated as more specific autoantibodies than rheumatoid factor (RF) in RA. The aim of this study is to determine whether anti-CCP antibodies are useful in the differential diagnosis of RA from other arthritis or not.&nbsp;153 serum samples were used in the study;&nbsp;34 from RA patients, 26 from brucellar arthritis, 20 from BD with arthritis, 41 from BD without arthritis and 32 from&nbsp;healthy&nbsp;controls.&nbsp;In vitro&nbsp;quantitative, anti-CCP levels were measured by using fluoroenzyme-immunoassay (FEIA) method.&nbsp;Among RA patients, 73.5% were anti-CCP-positive and 70.5% were RF-positive. While there was a statistical difference in the anti-CCP and RF positivity rates between RA and brucellar arthritis patients,&nbsp;BD patients and healthy controls&nbsp;(p = 0.0001), there was no statistical difference between BD patients with arthritis and BD patients without arthritis. Also none of the&nbsp;Brucellar arthritispatients was positive for anti-CCP antibodies, one of them were positive for RF. Our results indicate that anti-CCP antibodies are not associated with brucellar arthritis or&nbsp;BD with&nbsp;joint involvement and since they show high specificity and good sensitivity for RA, they can be evaluated as a better marker than RF especially for the differentiation of RA from other types of arthritis such as BD and brucellar arthritis. &nbsp; Key words:&nbsp;Rheumatoid arthritis, Behcet&#39;s disease,&nbsp;brucellar arthritis, anti-cyclic citrullinated peptide antibody, rheumatoid factor.

Detection of rheumatoid arthritis-specific anti-filaggrin antibodies by line immunoassay shows complementarity to RF and corresponds to the AFA-blot using natural antigen

Anti-filaggrin autoantibodies (AFA) are highly specific markers for rheumatoid arthritis (RA) and can be detected by immunoblotting using human epidermal protein extracts. Furthermore, it was demonstrated that citrullination of the filaggrin epitopes is crucial for epitope recognition and that citrullinated peptides are also recognized by these specific autoantibodies. Based on these data, a line immunoassay (LIA) was developed containing as individual markers in vitro citrullinated recombinant filaggrin and two citrullinated synthetic peptides. Firstly, a comparison was made between this prototype LIA and the AFA blot using natural filaggrin. A blind serum panel consisting of 25 early RA, 25 longstanding RA, and 25 disease controls was selected. Results showed a similar performance of both tests at a specificity level of 95%, while the LIA proved significantly better (P = 0.035) than the AFA blot at 99% specificity. At the latter specificity level, 2 out of 17 RF negative samples were retrieved on LIA but not on Western blot. The LIA was further evaluated on sera obtained from 335 RA patients and 254 patients with non-RA rheumatological disorders in a retrospective study. The overall sensitivity of the LIA including three markers (LIA3) was 65.1% versus 61.8% if only the reactivity towards the citrullinated peptides was considered (LIA2). The specificity of LIA3 was 97.6% versus 98.4% for LIA2, which correlates with an estimated positive predictive value (PPV) of 87.3% for LIA3 and 90.7% for LIA2. Thirty-seven percent (30/81) of the RF-negative RA samples proved LIA2-positive, while 52 out of 55 RF positive control samples were negative for anti-filaggrin. Higher specificity and sensitivity was obtained for LIA2 in comparison with anti-RA33 immunoblot, whereas good agreement could be observed with anti-keratin antibody (AKA) testing. In conclusion, anti-filaggrin autoantibodies can be readily detected by a LIA test based on citrullinated peptides, resulting in a high specificity and hence high PPV for RA. The assay can serve as a user-friendly alternative for AKA immunofluorescent and immunoblot techniques. Together with the RF complementarity, this test provides a valuable tool in the differential diagnosis of RA.

Immunoglobulin G galactosylation deficiency determined by isoelectric focusing and lectin affinoblotting in differential diagnosis of rheumatoid arthritis.

IgG galactosylation deficiency in patients with rheumatoid arthritis (RA) can be detected by isoelectric focusing (IEF)/lectin affinoblotting. We analyzed IgG glycosylation in patients with early arthritis (n = 50) and healthy controls in order to determine the clinical value of this parameter in differential diagnosis of RA. A significant correlation between the IgG galactosylation defect at disease onset and the diagnosis of RA during the follow-up was observed. Involvement of other clinical parameters (erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor) did not improve the predictive value of IgG galactosylation changes.

Management of Rheumatoid Arthritis and Its Complications

The dual purposes of the author are provide a framework that may help the physician manage the rheumatoid and to update his highly regarded monographLocal and Systemic Complications of Rheumatoid Arthritis, published in 1968. To achieve these goals within a rather small space, Hollingsworth has sacrificed the presentation of many practical details in favor of ample references to the literature. This approach diminishes the usefulness of this book guide residents, fellows and general physicians. Proper management requires accurate diagnosis. For example, while the differential diagnosis of rheumatoid arthritis from other systemic diseases is presented succinctly but clearly, the differentiation of a bursitis from symptoms of an adjacent arthritis is lacking. Instead of finding directions for the simple procedure of injecting the temporomandibular joints, the physician is advised to refer his patient to a dentist. Although corticosteroid preparations for intra-articular administration are available in at least three

Synovial membrane histopathology in the differential diagnosis of rheumatoid arthritis, gout, pseudogout, systemic lupus erythematosus, infectious arthritis and degenerative joint disease.

The synovial membrane histologic sections from patients with six common rheumatic diseases were reviewed without knowledge of the clinical diagnosis. After histopathologic evaluation, the synovial membrane characteristics were grouped according to the patient's clinical diagnosis, and included 29 patients with rheumatoid arthritis, 13 with systemic lupus erythematosus, 17 with degenerative joint disease, 10 with acute bacterial arthritis, 8 with gout, and 13 with pseudogout. The only specific characteristics identified were bacteria (infectious arthritis), crystals (gout, pseudogout), and lymphoid follicles (rheumatoid arthritis). Nevertheless, other characteristic features of differential diagnostic utility were recognized, including the intensity and nature of synovial lining cell hyperplasia and of leukocyte infiltration. Light microscopic histopathologic changes in the common rheumatic diseases are not specific, but are of diagnostic utility. Complete and exhaustive review of each pathologic synovial membrane characteristic provides more justification for the routine use of synovial membrane biopsy as an adjunct to arthrocentesis in the evaluation of common rheumatic diseases.

Differential Diagnosis of Rheumatoid Arthritis by Biopsy of Muscle

Journal Article Differential Diagnosis of Rheumatoid Arthritis by Biopsy of Muscle Get access Gabriel Steiner, M.D., Gabriel Steiner, M.D. From the Departments of Pathology, Wayne University College of Medicine, Detroit, and Wayne County General Hospital and Infirmary, Eloise, Michigan Search for other works by this author on: Oxford Academic Google Scholar J. L. Chason, M.D. J. L. Chason, M.D. From the Departments of Pathology, Wayne University College of Medicine, Detroit, and Wayne County General Hospital and Infirmary, Eloise, Michigan Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 18, Issue 12, 1 December 1948, Pages 931–939, https://doi.org/10.1093/ajcp/18.12.931 Published: 01 December 1948 Article history Received: 14 July 1948 Published: 01 December 1948

GASTRIC ACIDITY IN CHRONIC ARTHRITIS

Article1 September 1935GASTRIC ACIDITY IN CHRONIC ARTHRITISEDWARD F. HARTUNG, M. D., OTTO STEINBROCKER, M.D.EDWARD F. HARTUNG, M. D.Search for more papers by this author, OTTO STEINBROCKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-3-252 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAchlorhydria and hypochlorhydria are frequently mentioned as accompaniments of chronic arthritis, but a search of the literature does not reveal any recent investigations of their occurrence in which the present technic including fractional analysis or the present standards of interpretation have been employed. There has, moreover, not been found any attempt to differentiate the gastric secretions in rheumatoid arthritis from those in osteoarthritis, although the present day division of arthritis into these two great groups would seem to make such a distinction of importance.The object of this study was three-fold: to determine the gastric acidity in chronic arthritis by...Bibliography1. COATESGORDON VRG: Differential diagnosis of rheumatoid arthritis as clinical entity, Brit. Med. Jr., 1923, ii, 561-563. CrossrefGoogle Scholar2. DOUTHWAITE AH: Clinical study of rheumatoid arthritis, Brit. Med. Jr., 1925, i, 1170-1172. CrossrefGoogle Scholar3. VANZANT FR: Normal range of gastric acidity from youth to old age; analysis of 3746 records, Arch. Int. Med., 1932, xlix, 345-359. CrossrefGoogle Scholar4. WOODWARKWALLIS ASRL: The relation of the gastric secretion to rheumatoid arthritis, Lancet, 1912, ii, 942-944. CrossrefGoogle Scholar5. FABER K: Anaemiske Tilstande ved den kroniske Achylia gastrica, Berl. klin. Wchnschr., 1913, l, 958-962. Google Scholar6. LOTTRUP MC: Über chronische Arthritiden, Achylie und Anämie, Ztschr. f. d. ges. phys. Therap., 1929, xxxviii, 10-16. Google Scholar7. BELL JR: Notes on consecutive series of 425 gastric analyses by fractional method, Guy's Hosp. Rep., 1922, lxxii, 302-314. Google Scholar8. VENABLESKNOTT JFFA: Investigation of duodenal contents and bile in man, Guy's Hosp. Rep., 1924, lxxiv, 245-255. Google Scholar9. ASHCROFT LS: Arthritis deformans; observations on its etiology and treatment, Brit. Med. Jr., 1925, ii, 13. CrossrefGoogle Scholar10. MILLERSMITH SFB: Investigation of gastric function in chronic arthritis and fibrositis, Quart. Jr. Med., 1927, xx, 271-283. CrossrefGoogle Scholar11. HURST AF: Discussion on the etiology and treatment of osteoarthritis and rheumatoid arthritis, Proc. Roy. Soc. Med., 1923-1924, xvii, 10. Google Scholar12. REHFUSSBERGEIMHAWK MEOPB: Gastrointestinal studies. II. The fractional study of gastric digestion with a description of normal and pathologic curves, Jr. Am. Med. Assoc., 1914, lxiii, 909-915. CrossrefGoogle Scholar13. SAGALMARKSKANTOR ZJAJL: Clinical significance of gastric acidity, ANN. INT. MED., 1933, vii, 76-88. LinkGoogle Scholar14. CANNON WB: Bodily changes in pain, hunger, fear and rage, 1920, D. Appleton and Co., New York, p. 19. Google Scholar15. HEATHCASTLESTRAUSS CWWBMB: Quantitative aspects of iron deficiency in hypochromic anemia; parenteral administration of iron, Jr. Clin. Invest., 1932, xi, 1293-1312. CrossrefGoogle Scholar16. FURBYARNOLD SFL: Influence of gastric acid secretion upon the bactericidal power of gastrointestinal tract, Proc. Soc. Exper. Biol. and Med., 1931, xxviii, 372-374. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication April 22, 1935.From the Arthritis Clinic, Department of Medicine, New York Post-Graduate Medical School and Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAntagonism of GPR4 with NE 52-QQ57 and the Suppression of AGE-Induced Degradation of Type II Collagen in Human ChondrocytesAchlorhydria 1 September 1935Volume 9, Issue 3Page: 252-257KeywordsAchlorhydriaArthritisHospital medicineOsteoarthritisRheumatoid arthritis Issue Published: 1 September 1935 PDF DownloadLoading ...