Different Stages Of Recovery Research Articles

VR-Aided Ankle Rehabilitation Decision-Making Based on Convolutional Gated Recurrent Neural Network.

Traditional rehabilitation training for stroke patients with ankle joint issues typically relies on the expertise of physicians. However, when confronted with complex challenges, such as online decision-making or assessing rehabilitation progress, even seasoned experts may not anticipate all potential hurdles. A novel approach is necessary-one that effectively addresses these complexities without solely leaning on expert experience. Previous studies have introduced a rehabilitation assessment method based on fuzzy neural networks. This paper proposes a novel approach, which is a VR-aided ankle rehabilitation decision-making model based on a convolutional gated recurrent neural network. This model takes various inputs, including ankle dorsiflexion range of motion, angular velocity, jerk, and motion performance scores, gathered from wearable motion inertial sensors during virtual reality rehabilitation. To overcome the challenge of limited data, data augmentation techniques are employed. This allows for the simulation of five stages of rehabilitation based on the Brunnstrom staging scale, providing tailored control parameters for virtual training scenarios suited to patients at different stages of recovery. Experiments comparing the classification performance of convolutional neural networks and long short-term memory networks were conducted. The results were compelling: the optimized convolutional gated recurrent neural network outperformed both alternatives, boasting an average accuracy of 99.16% and a Macro-F1 score of 0.9786. Importantly, it demonstrated a strong correlation (correlation coefficient r > 0.9) with the assessments made by clinical rehabilitation experts, showing its effectiveness in real-world applications.

Ascorbic Acid Mediated Amelioration of Bridelia micrantha Induced Alterations in Haematological, Histological and Proximate Composition of the Carcass of African Catfish, Clarias gariepinus (Burchell, 1822)

Acute and sub-acute exposure of piscicidal plant Bridelia micrantha (BM) during fishing of Sharptooth Catfish Clarias gariepinus juvenile causes alterations in haematological, histological and the carcass analysis. The result of water quality shows the normal value for fish culture in the tropics, the DO2 level of the water varies slightly such that the T1 , T2 , T3, T5and T0 were in the normal range, conductivity followed by T2 whereas T1 had the least value for conductivity, which the mean differences were statistically not significant (p>0.05) among the individual treatments. There was severe alterations in haematology, of Clarias gariepinus exposed to Brandelia micrantha, at 0.00, 0.042, 0.084, 0.126, 0.168 and 0.21mg/l during 60days of exposure periods, blood analysis show a reduction in white blood cell (mg/l)), Haemoglobin, Red blood cell (mg/l) Haemoglobin (g/dl), Lymphocytes (mg/l), Mean cell volume (fl), Mean cell concentration, tissue analysis indicated an alterations in the gill, liver and kidney while tissue analysis reveals severe degeneration of the renal tissue with severe intra renal necrosis (TN) and inflammatory cell aggregate (IC) with tubular atrophy (TA) in some areas and carcass analysis show severe reduction in Moisture (M), Crude Protein (CP) (Mg/l), Crude Lipid (CL), Ash, Nitrogen Free Extract (NFE), and Energy (kcal/100g). The recovery of C. gariepinus from Bridelia micrantha (BM) was evaluated by exposing C. gariepinus to a 60-days depuration, on ascorbic acid (AA) supplemented diet at concentrations of 0.00, 25, 50, 75, 100, 125ml/l. After 60-days depuration some of the lesions in histological, haematological and proximate composition of the carcass attained different stages of recovery as compared to the control.

Application of sensing techniques for quantifying CO2 flux and dynamics in environments affected by the fundão dam collapse, mariana, Brazil

The District of Mariana in Minas Gerais, Brazil, witnessed one of the largest natural disasters in history. It involved the deposition of thousands of cubic meters of mining waste on soils near tributaries of the Doce River, resulting in degraded areas and a new environmental landscape. Numerous studies have focused on changes in soil microbiota and physical-chemical attributes. However, studies quantifying and analyzing carbon flux (FCO2) dynamics in the field using proximal sensors under varying temperatures, humidity conditions, and vegetation cover are scarce and nearly nonexistent. These studies could aid in monitoring the recovery of degraded areas and in understanding FCO2 dynamics in such environments. The aim of this study was to quantify and assess FCO2 dynamics using combined sensing techniques in diverse mining-affected areas, comparing different stages of recovery and their vegetation impact, and linking the results to pedoenvironmental factors. To achieve this, four areas were carefully selected and evaluated: affected pasture (AP), pasture (P) (non-affected), mix (MIX), and native trees (NT). In each area, readings were taken using an Infrared gas analyzer (IRGA) sensor, and temperature and soil moisture were measured. Additionally, soil samples were collected for chemical, physical, and biological characterization. Normalized Difference Vegetation Index (NDVI) assessments were conducted using satellites to evaluate vegetation cover. Non-parametric tests (Kruskal Wallis and Principal Component Analyses - PCA) were employed to evaluate differences between the areas and to assess the correlation among the environmental variables. The P area had the highest FCO2 and total organic carbon (TOC), differing significantly from the other site areas. Conversely, AP had the lowest FCO2 and was distinct from other sites. The MIX and NT areas had intermediate FCO2 and TOC values, which were statistically similar to each other. PCA identified distinct patterns in FCO2, soil temperature, and moisture. FCO2 was positively correlated with soil temperature and negatively correlated with moisture. There was a relationship between the biological variables microbial quotient (qMic), metabolic quotient (qCO2), COT, and FCO2. qMic reached the highest values in the MIX area, decreasing linearly from NT to P. Conversely, AP had the lowest qMic. qCO2 had the highest value in AP and NT. The proximal IRGA sensor effectively quantified FCO2 and differentiated mining tailing-affected areas. This assessment incorporated soil temperature, moisture sensors, vegetation index, and soil attribute data. The FCO2 levels were higher in P areas and lower in AP areas. Elevated FCO2 levels were correlated with a high soil temperature and low humidity. In AP, qMic was low, and qCO2 was high, indicating lower FCO2 levels. Conversely, P exhibited a higher FCO2. Higher NDVI values were correlated with elevated FCO2 in areas with specific vegetation cover during environmental recovery, while lower NDVI areas had lower FCO2 levels.

Changes in soil bacterial community characteristics in patches of different vegetation types under different stages of restoration in the desert of northern China.

In desert areas, the process of mobile sandy land changing to semi-fixed sandy land and eventually to fixed sandy land after undergoing vegetation restoration is inevitable. The presence of shrub patches and herb patches is common in this restoration process. No relevant studies have reported the soil bacterial community characteristics of different vegetation-type patches (shrub patches and herb patches) under different stages of restoration. Therefore, we utilized long-established experimental plots to collect soil from 0-20 cm soil layer under shrub patches (dominated by Salix psammophila) and herb patches under different stages of restoration (i.e., mobile sand land, semi-fixed sand land, and fixed sand land), by determining soil physicochemical properties, enzyme activities, and soil bacterial communities. Our results found that soil bacterial α-diversity under different restoration stages showed higher shrub patches than herb patches. The dominant bacterial communities (phyla) in shrub patches and herb patches at different recovery stages were Actinobacteria, Proteobacteria, and Bacteroidota. When the mobile sandy land returned to fixed sandy land, the relative abundance of Actinobacteria and Bacteroidota gradually decreased under shrub patches and herb patches, while the relative abundance of Proteobacteria increased significantly. In addition, herb patches significantly increased the relative abundance of bacteria (genus) relative to shrub patches at different stages of recovery. Soil nutrients, soil fine particles, and soil enzyme activities were significantly higher under shrub patches than under herb patches when fixed sandy land due to differences in life form and architecture between shrub patches and herb patches. Based on this, soil bacterial community composition and diversity under shrub patches were driven by more soil properties during the restoration of sandy land. This study complements the dynamic recovery processes and driving mechanisms of soil bacterial community structure under different vegetation patches in sandy areas, especially in the context of global climate change.

Climatic and disturbance impacts on temperate rainforest development since ∼18 ka in central-west Isla Grande de Chiloé (42.7°S)

Understanding the role of disturbance regimes on terrestrial ecosystems is often compounded by the paucity of time series sufficiently long and detailed to capture triggering events and the sequence of changes in species composition, community structure and dynamics along a time continuum until the present. Adding complexity to this problem, disturbance regimes and the distribution/competitive interactions of participating species may vary in time with shifts in mean climatic conditions and variability. Here we present results from sediment cores we collected from small closed-basin lakes near the Pacific coast of central Isla Grande de Chiloé, a sector with the lowest seasonality and recurrence of explosive volcanic events in Northwestern Patagonia (NWP). Our aim is examining vegetation development since the last glaciation and exploring potential climatic and disturbance impacts. We found rapid establishment of closed-canopy rainforests, which have persisted with little variation in terms of physiognomy until the present. Significant changes in species composition, structure, dynamics, and rates of change are evident over the last ∼18,000 years, along with fire maxima at ∼16.7 ka, ∼12.7 ka, between ∼11.7-9 ka, from ∼2 ka to the present, and minima in the interim. Fires precede major increases in disturbance favored taxa, which correspond in timing with fire activity maxima at NWP scale. The most recent ∼2000 years coincide with the highest number and ubiquity of human occupations at central-west and NWP scale, raising the possibility that fires were driven by human activities near our study sites. We detect a conspicuous increase in disturbance-favored trees ∼150 years after deposition of the Puma Verde Tephra (∼8.3 ka) and interpret their subsequent maintenance by frequent blowdown events after ∼7.5 ka in exposed sectors of the Coastal Range. We posit that enhanced storminess driven by stronger Southern Westerly Winds since ∼7.5 ka has favored early successional opportunistic trees in detriment of old-growth forests dominated by shade-tolerant species, generating a spatial mosaic of forest patches or gaps in different stages of recovery.

Recovery from gaming addiction: A thematic synthesis

In recent years the field of gaming addiction has experienced an upsurge in empirical studies on various treatment approaches. Despite the advances in our understanding of how gaming addiction can be treated, the wider concept of recovery continues to be under-researched. The purpose of this review was to explore how individuals addicted to video games experience the process of recovery. Seven databases were systematically searched for qualitative studies. Eight studies representing the views of 225 participants were included in the review. Study findings were exported into NVivo software and analysed using Thematic Synthesis. Six themes were constructed: “developing awareness”, “deciding to change”, “the process of quitting”, “the challenges of quitting”, “recovery never stops” and “treatment for gaming addiction”. Except for the last, themes represent processes that most participants had gone through during recovery, though significant variation was found in how each process was experienced. In addition to overcoming addiction symptoms, recovery involved management of concomitant problems and various negative consequences of excessive gaming. Regarding practice implications, current findings suggest that treatment programs should adopt a multidimensional approach, providing evidence-based treatments, help for co-occurring problems, as well as pre- and post-treatment support to accommodate individuals at different stages of recovery. Further research is needed to expand our understanding of recovery, for instance, the impact of gender differences or how recovery experiences change based on different recovery goals (i.e., abstinence or reduced play time).

A266 TISSUE-SPECIFIC FUNCTION OF THE CIRCADIAN GENE, BMAL1, DURING COLITIS RECOVERY

Abstract Background The circadian clock is a self-sustained molecular oscillator which drives 24-hour physiological rhythms in nearly every cell of the body. It consists of the genes Bmal1 and Clock that positively regulate Cry and Per, their negative regulators, resulting in a 24-hour transcription/translation feedback cycle. Shift work, which causes disruptions to 24-hour physiological rhythms, has been linked with an increased incidence of inflammatory bowel disease (IBD). Aims We have previously established that mice lacking the non-redundant circadian regulator, Bmal1, exhibit more severe colitis compared to controls. The loss of Bmal1 also negatively impacts post-colitis regeneration and recovery. However, the role of Bmal1 in specific cell types remains unknown in regard to regenerative capacity following colitis. The intestinal stem cell niche includes stromal cells that provide signaling factors to regulate the proliferation of epithelial cells in the colonic crypt. Methods To test the role of the circadian clock in these cell types, we conditionally disrupted Bmal1 in intestinal epithelial versus stromal cells using VilCre/+;Bmal1flox/flox and PdgfraCre/+;Bmal1flox/flox mice, respectively. Dextran Sulfate Sodium (DSS) was applied to induce acute colitis, disease progression was evaluated, and regeneration at different stages of recovery was analyzed. We hypothesize that the cell-specific disruption of Bmal1 in both intestinal epithelial and stromal cells negatively impacts the regenerative capacity following colitis, leading to delayed recovery and increased inflammation. Results No differences in survival and colitis disease activity were observed between Vil+/+;Bmal1flox/flox control and VilCre/+;Bmal1flox/flox but increases in lesion number, inflammation, and disrupted recovery are evident in VilCre/+;Bmal1flox/flox colons histologically. Whereas control animals are able to recover two weeks following DSS treatment, regenerative proliferation is still present in conditional knockouts. Thus, Bmal1 is required in intestinal epithelial cells for efficient repair. Preliminary results in the PdgfraCre/+;Bmal1flox/flox conditional stromal mutanats do not show differences in survival or disease severity, and we are currently evaluating effects on regeneration. Conclusions Our results support a critical role for Bmal1 in intestinal epithelial cells during post-colitis regeneration and recovery. Funding Agencies CCC, CIHR

Resilience dynamics and their determinants: the transition to coronavirus pandemic recovery

ObjetivoEste artículo presenta una perspectiva dinámica sobre la resiliencia del turismo mediante el análisis de la demanda turística en España durante los veranos de 2020 y 2021 en el contexto de la pandemia de COVID-19.Diseño/metodología/aproximaciónUtilizamos métodos de regresión y tipo Lasso para demostrar la capacidad de los determinantes pasados para explicar la demanda turística en las provincias españolas.ResultadosNuestros resultados muestran cómo la especialización previa del mercado interno, la densidad y el tipo de producto ofrecido relacionado con la ubicación están detrás del grueso de las diferencias territoriales en la resiliencia de la demanda, aunque en 2021 hubo un proceso de adaptación al nuevo contexto.OriginalidadEstos hallazgos representan un cambio de paradigma en la concepción estática de la resiliencia en el turismo.Implicaciones de la investigaciónEste estudio contribuye a la comprensión teórica de los comportamientos turísticos y la gestión de los destinos turísticos al introducir el concepto de dinámica de resiliencia específica del destino.Implicaciones prácticas y para la sociedadPor un lado, los resultados son útiles para que los destinos turísticos comprendan las diferentes etapas de recuperación de un shock y, por otro lado, para explorar el comportamiento del consumidor después de un shock.Graphical abstract: The evaluation of the vulnerability of tourism.

The Healing Elements of an Eclectic Life Skills Programme: Clients' Perspectives.

Introduction: The article reports the healing elements of an eclectic life skills programme (ELSP) from the perspective of group members. An ELSP utilising open groups was developed to manage clients with mixed diagnostic profiles and different stages of recovery simultaneously. The aim was to explore the healing elements of an ELSP. Methods: Maximum variation purposive sampling was used to select six participants for the phenomenological inquiry. Data collection is comprised of observations, semistructured interviews, and reflective journals. Data analysis comprised an inductive thematic analysis. Consumer Involvement: Participants all attended groups offered within the ELSP. They participated in two semistructured interviews: the first interview in the week following admission and the second just before discharge. In addition, they documented their experiences in reflective journals for the duration of their participation. Findings: The analogy of a kaleidoscope portrayed the four themes; three pertained to structural dynamics, namely, programme mirror, facilitator mirror, and mirror of other group members. The fourth theme, namely, the magical pattern, pertained to personal sense-making by individual group members. Conclusions: The dynamic interplay of healing factors, captured in the themes, facilitated healing. Self-reflection was integral to the creation of a bespoke, facilitated self-learning process with direct application in group members' own lives.

Plant functional groups and soil properties vary with the restoration periods in Zoige desertification land

Desertification has a significant impact on the Zoige meadow. Research efforts are directed towards the rehabilitation of the Zoige desertified alpine meadow, specifically in understanding the soil’s physical and chemical characteristics and the functional groupings of plants. However, the relationships between plant functional groups and soil properties remains uncertain. The primary objective of this study is to investigate the correlation between plant functional groups and soil nutrients across various stages of restoration. This study examined important value of plant functional groups, as well as variations in several soil characteristics, such as soil total nitrogen, total carbon, total phosphorus, available nitrogen, available potassium, available phosphorus, and soil pH during the stages of recovery. The results showed that the relative significance of importance values differed across distinct functional groups during different stages of recovery. The important value of legumes was found to have a strong negative correlation with the levels of soil available nitrogen and potassium. In contrast, there was a substantial positive correlation between the important value of grass and both soil total carbon and available potassium. Conversely, there was a strong negative relationship between the importance value of sedges and both total soil carbon and phosphorus. These findings indicate that the linkages between soil properties and plant functional groups varied across different recovery periods. This study would shed new light on the restoration in the Zoige desertified alpine meadows.

Using Clinician-Patient WeChat Group Communication Data to Identify Symptom Burdens in Patients With Uterine Fibroids Under Focused Ultrasound Ablation Surgery Treatment: Qualitative Study.

Unlike research project-based health data collection (questionnaires and interviews), social media platforms allow patients to freely discuss their health status and obtain peer support. Previous literature has pointed out that both public and private social platforms can serve as data sources for analysis. This study aimed to use natural language processing (NLP) techniques to identify concerns regarding the postoperative quality of life and symptom burdens in patients with uterine fibroids after focused ultrasound ablation surgery. Screenshots taken from clinician-patient WeChat groups were converted into free texts using image text recognition technology and used as the research object of this study. From 408 patients diagnosed with uterine fibroids in Chongqing Haifu Hospital between 2010 and 2020, we searched for symptom burdens in over 900,000 words of WeChat group chats. We first built a corpus of symptoms by manually coding 30% of the WeChat texts and then used regular expressions in Python to crawl symptom information from the remaining texts based on this corpus. We compared the results with a manual review (gold standard) of the same records. Finally, we analyzed the relationship between the population baseline data and conceptual symptoms; quantitative and qualitative results were examined. A total of 408 patients with uterine fibroids were included in the study; 190,000 words of free text were obtained after data cleaning. The mean age of the patients was 39.94 (SD 6.81) years, and their mean BMI was 22.18 (SD 2.78) kg/m2. The median reporting times of the 7 major symptoms were 21, 26, 57, 2, 18, 30, and 49 days. Logistic regression models identified preoperative menstrual duration (odds ratio [OR] 1.14, 95% CI 5.86-6.37; P=.009), age of menophania (OR -1.02 , 95% CI 11.96-13.47; P=.03), and the number (OR 2.34, 95% CI 1.45-1.83; P=.04) and size of fibroids (OR 0.12, 95% CI 2.43-3.51; P=.04) as significant risk factors for postoperative symptoms. Unstructured free texts from social media platforms extracted by NLP technology can be used for analysis. By extracting the conceptual information about patients' health-related quality of life, we can adopt personalized treatment for patients at different stages of recovery to improve their quality of life. Python-based text mining of free-text data can accurately extract symptom burden and save considerable time compared to manual review, maximizing the utility of the extant information in population-based electronic health records for comparative effectiveness research.

Long-term forecasting of a motor outcome following rehabilitation in chronic stroke via a hierarchical bayesian dynamic model

BackgroundGiven the heterogeneity of stroke, it is important to determine the best course of motor therapy for each patient, i.e., to personalize rehabilitation based on predictions of long-term outcomes. Here, we propose a hierarchical Bayesian dynamic (i.e., state-space) model (HBDM) to forecast long-term changes in a motor outcome due to rehabilitation in the chronic phase post-stroke.MethodsThe model incorporates the effects of clinician-supervised training, self-training, and forgetting. In addition, to improve forecasting early in rehabilitation, when data are sparse or unavailable, we use the Bayesian hierarchical modeling technique to incorporate prior information from similar patients. We use HBDM to re-analyze the Motor Activity Log (MAL) data of participants with chronic stroke included in two clinical trials: (1) the DOSE trial, in which participants were assigned to a 0, 15, 30, or 60-h dose condition (data of 40 participants analyzed), and (2) the EXCITE trial, in which participants were assigned a 60-h dose, in either an immediate or a delayed condition (95 participants analyzed).ResultsFor both datasets, HBDM accounts well for individual dynamics in the MAL during and outside of training: mean RMSE = 0.28 for all 40 DOSE participants (participant-level RMSE 0.26 ± 0.19—95% CI) and mean RMSE = 0.325 for all 95 EXCITE participants (participant-level RMSE 0.32 ± 0.31), which are small compared to the 0-5 range of the MAL. Bayesian leave-one-out cross-validation shows that the model has better predictive accuracy than static regression models and simpler dynamic models that do not account for the effect of supervised training, self-training, or forgetting. We then showcase model’s ability to forecast the MAL of “new” participants up to 8 months ahead. The mean RMSE at 6 months post-training was 1.36 using only the baseline MAL and then decreased to 0.91, 0.79, and 0.69 (respectively) with the MAL following the 1st, 2nd, and 3rd bouts of training. In addition, hierarchical modeling improves prediction for a patient early in training. Finally, we verify that this model, despite its simplicity, can reproduce previous findings of the DOSE trial on the efficiency, efficacy, and retention of motor therapy.ConclusionsIn future work, such forecasting models can be used to simulate different stages of recovery, dosages, and training schedules to optimize rehabilitation for each person.Trial registration This study contains a re-analysis of data from the DOSE clinical trial ID NCT01749358 and the EXCITE clinical trial ID NCT00057018

Social Determinants of Health and Traumatic Brain Injury: Implications for Rehabilitation Service Delivery and Outcomes.

Social Determinants of Health and Traumatic Brain Injury: Implications for Rehabilitation Service Delivery and Outcomes.

Information, involvement, self-care and support-The needs of caregivers of people with stroke: A grounded theory approach.

Globally, stroke is a leading cause of death and disability, with most care undertaken by caregivers who are generally family and friends without prior experience of care. The lack of experience or unpreparedness results in feelings of uncertainty, burnout, anxiety, burden, etc. Hence, it is necessary to identify the needs of caregivers to better support them in their caregiving journey and improve the quality of care delivered. The study employed a grounded theory methodology that utilizes information gathered from literature reviews and social media to represent the needs and create a storyline visually. The storyline is further refined and evaluated using an online survey of 72 participants recruited through online stroke caregiving communities. The study identified four core categories of needs: (i) Information: sufficient information delivered in layman's terms based on the individual situation of the caregiver and survivor through oral and hands-on demonstrations, (ii) Involvement: inclusion in the decision-making processes at different stages of recovery through face-to-face communication at the hospital, (iii) Self-care: ability to engage in work and leisure activities, (iv) Support: receive support in the form of resources, services and finances from different other stakeholders. There is a need to create a caregiver-centered approach in stroke recovery to ensure limited obstruction to care and reduced uncertainty in stroke recovery. Moreover, through the inclusion of caregivers in stroke recovery, it may be possible to reduce the burden of care to the caregiver and ensure the satisfaction of the healthcare system throughout stroke recovery.

Measuring Recovery: The Addiction Recovery Questionnaire (ARQ)

ABSTRACT The Addiction Recovery Questionnaire (ARQ) is derived from the views of service users, their families and friends. Data were collected from 305 participants in the UK general population and addiction services, asked to self-identify as being in one of three groups: treatment, recovery or well-functioning, and complete the ARQ. Regression and latent class analyses were used to determine that the ARQ could distinguish the three groups. Clinically significant change values were established. Although there are some discrepancies in the way individuals define their recovery, self-identification was found to be broadly valid. The ARQ is able to assign people to different stages of recovery from addiction, and provides an instrument for monitoring change and measuring outcomes in the key components of lifestyle, involvement with substance use and self-confidence.

School performance in youth after a concussion.

This study aimed to identify school problems and levels of cognitive activity in youths aged 5-18 years with a concussion during the recovery stages of return to school (RTS). In a prospective cohort, participants completed in-person assessments at three time points: First Visit Post-injury, Symptom Resolution Visit, and Follow-Up Visit. These time points varied based on the participants' recovery progress. The post-concussion symptom scale (PCSS) and a cognitive activity scale were completed every 2 days until symptom resolution was achieved. Participants and their parents completed a school questionnaire detailing how their concussion had impacted their school learning/performance and their level of concern about their injury as well as the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). Sixty-three percent (N = 44/70) of participants returned to school by the First Visit Post-injury (average 7.7 days following injury), and of these, 50% (N = 22) were experiencing school problems. Sixty-five participants (out of 70) returned to school at the Follow-Up Visit, and of these, 18% reported school problems. There was a significant difference in the school problems reported by parents and youth. At the First Visit Post-injury, the youth reported more problems (p = 0.02), and the In-Person Symptom Resolution Visit with parents reported more problems (p = 0.01). The cognitive activity score increased, while the PCSS score decreased from RTS Stage 1 to Stage 5. This study identified that 50% of youth experienced school problems at the First Visit Post-injury, whereas only 18% reported school problems at the Follow-Up Visit. There is a significant difference in the perception of school problems reported by youth and their parents at different stages of recovery. The amount and complexity of cognitive activity increased with decreasing symptoms and increasing RTS stage. Findings can guide youth with a concussion and their parents in supporting a cautious return to school with accommodations. Healthcare providers and researchers can use this knowledge to better support youth in their return to school and understand the importance of gathering information from youth and their parents to gain the best insight into recovery.

Hydroxysafflor yellow A attenuates heat stroke-induced acute lung injury in mice by inhibiting necroptosis

To investigate the protective effect of hydroxysafflor yellow A (HSYA) against heat stroke (HS)-induced acute lung injury and its possible mechanism. The optimal dose of HSYA pretreatment via intraperitoneal injection prior to HS was determined in a mice by observing heat tolerance of the mice. C57BL/6J mice were pretreated with HSYA at the optimal dose or with Nec-1 (a RIP1 activation inhibitor) before HS, and the changes in core body temperature and survival of the mice were observed during the 72-h recovery period. At different stages of recovery, lung tissues, bronchoalveolar lavage fluid and blood samples were collected from the mice for assessing lung tissue pathology, wet-to-dry weight ratio and water content of the lungs; leukocyte and neutrophil counts, total protein levels and HMGB1 level in the bronchoalveolar lavage fluid (BLF) were also detected. Serum levels of TNF-α, IL-6 and HMGB1 were detected with ELISA, and the expression levels of RIP1, RIP3, MLKL-s358, MLKL and MLKL-s358 proteins in the lung tissues were detected using Western blotting. HSYA pretreatment at the moderate and high doses significantly improved heat tolerance of the mice with comparable effects. At the optimal dose of 2.25 mg/kg, HSYA pretreatment significantly increased heat tolerance of the mice (P<0.05), showing a similar effect with Nec-1 pretreatment. Pretreatment with HSYA and Nec-1 both significantly increased survival rate of the mice (P<0.05), lowered histopathological score and water content of the lungs, and reduced the levels of TNF-α, IL-6 and HMGB1 (P<0.05), leukocyte and neutrophil counts, and total protein and HMGB1 levels in the BLF (P<0.05). The mice during recovery from HS showed significantly increased RIP1 expression and MLKL-s358 phosphorylation level in the lung tissue (P<0.05), which were obviously lowered by HSYA pretreatment of the mice. Severe HS results in necroptosis in the lung tissue of mice, which can be alleviated by HSYA pretreatment.

Особенности восстановления нарушенных фитоценозов на севере Республики Коми

The paper presents the studied conducted in 17 plant communities with different stages of recovery in northern taiga ecosystems in Usinsk district of the Komi Republic. Habitats of rare and protected orchid species — Dactylorhiza maculata (L.) Soó were marked. Stages of phytocoenoses recovery and level of human disturbance were defined. To estimate the communities’ resilience towards human impact, hemeroby index was determined and hemeroby spectra for each studied community compiled.

Effect of Different Recovery Methods on Oxidative Stress and Hematological Indicators in Female Runners

Background and Objectives Exercise can increase oxidative and metabolic stress. The aim of this research was to investigate the effect of different recovery methods after an acute training session on aspartate aminotransferase activity, oxidative stress, and some hematological indices of female runners. Subjects and Methods In the present quasi-experimental study, 30 semi-professional female runners were selected as the research sample and randomly divided into three groups (n=10): active running recovery, passive recovery, and sports massage. After two weeks, the same training protocol was performed for athletes and also after a week of rest, fasting blood sampling was performed. Blood sampling was performed in three stages: 1- fasting, 2- after 1500 meters competition, and 3- immediately after different stages of recovery. The one-way analysis of variance was used for statistical analysis. Results The results showed that in the massage group, the change in hematocrit, white blood cells, and hemoglobin was more than in the active and inactive recovery group (P&lt;0.05), while in the active recovery group, the level of malondialdehyde decreased more than the massage and inactive recovery groups (P&lt;0.05). There was no significant difference between the three recovery methods on changes in iron, red blood cells, aspartate aminotransferase, and total antioxidant capacity (P&lt;0.05). Conclusion According to the results, it can be said that active recovery can prevent damage caused by oxidative stress by increasing blood flow.

The role of therapeutic physical culture in rehabilitation after a stroke

Relevance. This article discusses the processes and changes that affect the human body during a stroke, and the impact of the use of therapeutic physical culture to restore functions and tissues disturbed by pathological processes. The article also describes the tasks and principles of physical rehabilitation by means of therapeutic physical culture at different stages of recovery, presents the statistics of morbidity and disability of the population due to acute violation of cerebral circulation. The purpose of the study: to study the role of therapeutic physical culture in rehabilitation after a stroke.