Different Grades Of Obesity Research Articles

Prevalence and Factors Associated with Grade of Obesity in Selected Health Areas in Yaoundé: A Cross-Sectional Study

Background: According to the WHO, obesity is an abnormal or excessive accumulation of body fat that poses a health risk. It is a major public health problem with growing numbers (1,400,000,000 overweight adults and more than 500,000,000 obese). Every year, there are at least 2,800,000 associated deaths. The prevalence of obesity in Africa is above 61% in the adult population. Despite control strategies, obesity is still a real problem in Cameroon. Methodology: This study aimed to determine the relationship between various risk factors and the prevalence of different grades of obesity in selected health areas in Yaounde. This work consisted of a descriptive cross-sectional study carried out in Yaoundé, in Central Cameroon. Data were collected via a questionnaire administered face-to-face to obese patients in the target hospitals and the anthropometric parameters of these were determined. These data were analyzed using CSPRO 7.1 and SPSS 21.0 software. Results: The total number of participants in this study was 267 patients, most of whom were women (82.4%). The predominant type of obesity was moderate obesity; its frequency was 53%, followed by severe obesity, 37%. The factors associated with all grades of obesity were female gender (73% moderate obesity, 89% severe obesity, 100% morbid obesity), and genetic factors (54.6% moderate obesity, 73.5% severe obesity, 54.6% morbid obesity). Age was associated with moderate obesity: the age group most affected by moderate obesity was 55–65 years (37.5%). Conclusion: These results show that it is of paramount importance to reeducate the population on diet and lifestyle to prevent obesity, including among genetically predisposed people and even women, whatever their conditions (Menopause, multipara).

Assessment of BMI in obese patients after semiconductor laser acupuncture therapy

Background/aim There is an urgent need to diminish BMI due to the increased prevalence of chronic critical diseases accompanied by overweight and obesity. Laser acupuncture (LA) is a complementary modality that might lower the BMI by diminishing the abdominal and visceral adipose tissue content and influencing the regulation of the lipid metabolism process. It is a painless tool which is almost free from side effects. The aim of the present study is to assess the BMI in obese patients after semiconductor LA therapy. Patients and methods This is a randomized clinical trial study that enrolled 111 obese patients who visited the Acupuncture and Laser Clinic, Excellence Medical Centre, National Research Centre, Cairo, Egypt. They received 19 successive LA sessions for 2 months without any intervention concerning their routine lifestyle. Low-level laser irradiation was applied at certain acupuncture points according to the principles of Traditional Chinese Medicine. Laser parameters were wavelength 850 nm, and power density 200 mW. Calculated energy 6 J/cm2 for 24 s per acupoints. The anthropometric measurements were done on all participants before and after the end of LA sessions. Results The present result indicated that there is a significant decrease in weight (P<0.05), with a percent of changes –5.8%. Additionally, the BMI showed a significant decrease (P<0.05), with a percent of changes –6.1% after 2 months of stimulated LA sessions compared to before laser therapy. Also, more than 15 sessions gave 95% sensitivity, 100% specificity for successful significant response, and the number of LA sessions had a significant good utility in predicting successful responses in weight reduction and BMI management. Conclusion The upgrading of the conducted LA sessions had a promising value in different grades of obesity and was safely applicable for BMI management.

Serum adiponectin profile in obese Bangladeshi children attending an obesity clinic

Background and objective: Childhood obesity plays major role in the pathogenesis of various cardiovascular and metabolic diseases. Serum adiponectin has been found to be associated with several cardiometabolic risk factors. The study investigated the serum adiponectin levels and its relationship with obesity and cardiometabolic risk factors in Bangladeshi obese children. Material and methods: Overweight or obese children, between 6-18 years of age, attending the obesity clinic of the Department of Endocrinology, BSMMU were enrolled. Waist circumference (WC) and blood pressure (BP) were measured and blood samples were taken for estimation of glucose, insulin, lipid profile and adiponectin. Fasting plasma glucose (FPG), serum insulin and lipid profile were estimated by automated analyzer. Insulin resistance (HOMA-IR) was calculated from fasting insulin and fasting plasma glucose values. Serum adiponectin (total) was measured by ELISA method using DRG ELISA kit, Germany. Results:A total of 78 overweight or obese children of 6-18-year of age were enrolled. The mean (±SD) age of the study population was 12.22 ± 2.56 years and the mean BMI was 28.79 ± 4.54 kg/m2. Mean (±SD) serum adiponectin was 36.93 ± 17.85 µg/ml in 78 overweight/obese children. One way ANOVA showed no significant (P= 0.582) difference of adiponectin levels among children with overweight and different grades of obesity. There was no significant correlation between adiponectin and measures of generalized (r=0.035, p=0.763) or central (r=0.098, p=0.392) obesity. Also, no significant correlation was found between serum adiponectin level and any of cardiovascular risk factors of obesity or metabolic health. Conclusion: The study showed high serum adiponectin level in obese Bangladeshi children. Also, no association was found between serum adiponectin levels with grades of obesity and cardiometabolic risk factors among obese children of Bangladesh. IMC J Med Sci. 2023; 17(2):009. DOI: https://doi.org/10.55010/imcjms.17.019 *Correspondence: Palash Chandra Sutradhar, Department of Medicine, Sir Salimullah Medical College Mitford Hospital, Kotwali, Dhaka-1000, Bangladesh. Email: palashdmc@gmail.com

Body Mass Index (BMI) is a Popular Anthropometric Tool to Measure Obesity Among Adults

This paper tries to discuss aspects of Body Mass Index (BMI) that represents an index of body fat content in human, and is extensively used worldwide to measure different grades of obesity. BMI is simple, inexpensive and non-intrusive method of screening for weight categories. It is directly related to various morbidity and premature mortality in many nations irrespective of age, sex, social status, and ethnicity. This study also tries to show some drawbacks of body mass index that arise due to gender, age, social status, and ethnic differences; and also for confidence on self-reported values of weight and height for BMI measurement. At present underweight, overweight, obesity, physical inactivity, and unhealthy eating habits are all responsible for the various non-communicable diseases. The aim of the study is to discuss aspects of BMI in brief.

Les recommandations de prise de poids gestationnelle pour les femmes obèses sont-elles encore adaptées ?

Guidelines for adequate gestational weight gain were proposed in 2009 by the Institute of Medicine. In case of a BMI>30kg/m2, the recommended gestational weight gain should be between 5 and 9kg. However, these recommendations do not distinguish between different grades of obesity. Recent data suggest that the IOM recommendations are not restrictive enough for obese pregnant women and should be adapted to the grade of obesity.

Fetuin A Levels Among Different Grades Of Obesity With Its Potential Link To Its Complication With Elaboration Of Physical Training Effects In Rats

Fetuin A Levels Among Different Grades Of Obesity With Its Potential Link To Its Complication With Elaboration Of Physical Training Effects In Rats

Pregnancy and post-partum outcomes of obese women after bariatric surgery: A case-control study

IntroductionBariatric surgery (BS) is known to reduce several obesity-related complications during pregnancy, but there is concern that it may increase the risk of maternal-fetal morbidity because of the malabsorption. This study aimed to investigate the impact of restrictive BS on several pregnancy outcomes in comparison with different grades of obesity. Materials and methodsA single-center retrospective case-control study. All primiparous singleton pregnant women who underwent BS between the previous 1–5 years or with body mass index (BMI) ≥ 30 kg/m2 delivering in our center were included. Obstetric and perinatal outcomes were analyzed and compared between the two groups. ResultsOverall, 90 women were included: 30 underwent BS and 60 were obese. The mean pre-pregnancy BMI was 31.0 ± 4.2 kg/m2 in the BS group and 38.1 ± 4.3 kg/m2 in the control group (p < 0.001). The obese group experienced higher rate of fetal macrosomia (25% vs 6.7%; p = 0.049), gestational hypertension (23.3% vs 3.3%; p = 0.04), preeclampsia (23.3% vs 0%; p = 0.04), gestational diabetes (33.3% vs 6.7%; p = 0.01), and cesarean section (68.3% vs 20%; p < 0.0001). The BS group showed higher frequency of small for gestational age (SGA) (46.7% vs 18.3%; p = 0.006), late preterm delivery (PTD) (33.3% vs 10%; p = 0.009), cholestasis (13.3% vs 1.7%; p = 0.049). Breastfeeding ≥ 6 months was higher among BS mothers (36.7% vs 11.7%; p = 0.007). ConclusionsOur findings support the positive impact of BS on several obstetric outcomes, at the expense of a higher frequency of SGA and PTD. BS mothers more frequently achieved the recommended goal of breastfeeding for 6 months compared to obese women.

Circulating IL-6, clusterin and irisin in obese subjects with different grades of obesity: association with insulin resistance and sexual dimorphism.

There are discrepancies about the relationship of IL-6, clusterin and irisin with obesity and obesity associated insulin resistance and also about their sexual dimorphism. This study aimed at evaluating the circulating levels of IL-6, clusterin and irisin in obese subjects of both sexes who had different grades of obesity and examining their sexual dimorphism and their association with insulin resistance. This study included 176 non-diabetic subjects of both sexes who were classified according to their sex into two groups; the male and the female groups. The male group (88 men) was classified according to BMI into; group 1 (22 lean men), group 2 (22 class I obese men), group 3 (22 class II obese men) and group 4 (22 class III obese men). The female group (88 women) was classified according to BMI exactly as the male group. Metabolic parameters, IL-6, clusterin, and irisin levels were measured. Data were analyzed by ANOVA test, post hoc Tukey's test and independent t-test. Pearson correlation was used to assess the association between variables. In obese subjects of both sexes, circulating IL-6, clusterin and irisin levels were significantly elevated and positively correlated with HOMA-IR. Obese males showed significantly higher HOMA-IR, IL-6, clusterin and irisin levels than obese females. Obesity in both sexes, especially in males was associated with high levels of IL-6, clusterin and irisin and worsened the metabolic pattern. Circulating IL-6, clusterin and irisin may represent possible therapeutic targets for insulin resistance in obese subjects.

Combined effect of Kinesio taping and exercises on pain and function in individuals having patellofemoral pain syndrome with different grades of obesity

BACKGROUND: Obesity causes an excess amount of weight on the knee joint and promotes abnormal functioning of the joint. Correction with Kinesio taping allows forces to act in the correct direction. This study was conducted to see the combined effectiveness of Kinesio taping and exercises among different grades of obese population with anterior knee pain. METHODOLOGY: This study was conducted on obese individuals with anterior knee pain. Thirty-six participants were divided into three groups as per three grades of obesity. All the groups received the same treatment, Kinesio taping, and exercises. Participants received treatment three times a week for 4 weeks. The Visual Analog Scale and Kujala Scale were taken as outcome measures. RESULTS: Data were analyzed using Primer statistical software. A paired t-test was applied for within-group analysis, and one-way ANOVA was applied to compare data between the groups. All the groups showed a significant reduction in the pain score and improvement in function (P &lt; 0.005). However, no statistically significant difference was seen for both outcome measures when comparing the three groups. CONCLUSION: The findings suggest that exercising and Kinesio taping are together effective in the treatment of anterior knee pain. This combined protocol was effective in restoring the knee function and reducing knee pain in all the three groups.

Circulating level of interleukin-6 in relation to body mass indices and lipid profile in Egyptian adults with overweight and obesity

BackgroundObesity is an important feature of metabolic syndrome, and the link between them has been attributed to the state of chronic inflammatory process.The purpose of the study is to investigate the relation of circulating level of IL-6 as an inflammatory cytokine to body mass index and lipid profile in adults with overweight and obesity.MethodsThis cross-sectional study included 15 adults with overweight, 45 with obesity (15 grade I, 15 grade II, and 15 grade III), and 25 average weight controls. Circulating IL-6 level and lipid profile were measured.ResultsHighly significant differences were found between study groups in different grades of obesity as regards weight, body mass index, serum triglycerides, and serum LDL-C. Circulating levels of IL6 were significantly higher in subjects with overweight and obesity. There were significantly positive correlations between circulating levels of IL6 and BMI in subjects with grade III obesity and negative correlation with serum HDL-C in subjects with grade II obesity.ConclusionHigh circulating level of IL-6 could reflect the intensity of the chronic and systemic inflammation that develops with high degrees of obesity, which might contribute to the development of atherosclerosis and coronary heart diseases, both directly and by reducing HDL-C levels.

Prevalence of impaired fasting glucose in different grades of obesity

Background: Impaired fasting glucose (IFG) is a pre-stage to type 2 diabetes mellitus (T2DM) in adults and generally in obese population. In different studies this occurrence varied significantly, but the true prevalence is unknown due to lack of larger representative cohort studies. Authors objectives was to study the prevalence of IFG in different grades of obesity.Methods: One hundred obese subjects of obesity Grade1 (BMI &gt;25 kg/m2 but &lt;30) and Grade 2 (BMI &gt;30 kg/m2) were studied at Gandhi Medical College, Bhopal from April 2019 to June 2019. Physical examination, blood investigations including fasting blood glucose and oral glucose tolerance test (OGTT) was carried out for all the patients.Results: Out of 100 subjects, 18(9%) males and 18(9%) females had IFG. Among male subjects highest IFG was recorded in the age group of 60+ years and in the weight rage of 71 to 80 kg. In female subjects, highest prevalence was in the age group 51 to 60 years and in weight range of 51-60 kg. Out of 24 males and 34 female of with Grade 1 obesity, 7% and 10.4% had IFG similarly, out of 25 males and 17 females with grade 2 obesity, 11% and 7.6% had IFG.Conclusions: IFG is highly prevalent in different grades of obesity. Obesity is the risk factor for the development of diabetes.

Prevalence of impaired glucose tolerance in different grades of obesity

Background: Surgical Background: Impaired glucose tolerance is known precursor of type-2 diabetes mellitus and more prevalent in obese people, different studies have varied results and true prevalence is still debatable. Aims of this study to investigate the prevalence of IGT in different grades of obesity.Methods: Authors have studied100 patients with obesity Grade1 (BMI &gt;25 kg/m2 but &lt;30) and Grade2 (BMI &gt;30 kg/m2) at Gandhi Medical College, Bhopal during April to June 2019. Complete physical examination and blood tests including fasting blood glucose and oral glucose tolerance test (OGTT) were done.Results: Results shows that 16% male and 14% female subjects had IGT. Male of age more than 60yrs and female aged between 51 to 60 were more pre-diabetic. Males having weight 71 to 80 kg and female of 51-60 kg were more pre-diabetic. Subjects with grade 1 obesity, 6.12% male and 5.88% female had IGT. Similarly, in grade 2-obese subjects 10.20% males and 7.84% females had IGT.Conclusion: IGT is more prevalent in grade-1 and grade-2 obese population and a strong indicator of diabetes.

Obesity impairs leukocyte-endothelium cell interactions and oxidative stress in humans.

To evaluate the relationship between leukocyte-endothelial cell interactions and oxidative stress parameters in non-diabetic patients with different grades of obesity. For this cross-sectional study, 225 subjects were recruited from January 1, 2014 to December 31, 2016 and divided into groups according to BMI (<30kg/m2 , 30-40kg/m2 and >40kg/m²). We determined clinical parameters, systemic inflammatory markers, soluble cellular adhesion molecules, leukocyte-endothelium cell interactions-rolling flux, velocity and adhesion-, oxidative stress parameters-total ROS, total superoxide, glutathione-and mitochondrial membrane potential in leukocytes. We verified that HOMA-IR and hsCRP increased progressively as obesity developed, whereas A1c, IL6 and TNFα were augmented in the BMI>40kg/m² group. The cellular adhesion molecule sP-selectin was increased in patients with obesity, while sICAM, total ROS, total superoxide and mitochondrial membrane potential were selectively higher in the BMI>40kg/m² group. Obesity induced a progressive decrease in rolling velocity and an enhancement of rolling flux and leukocyte adhesion. Our findings reveal that endothelial dysfunction markers are altered in human obesity and are associated with proinflammatory cytokines and increased oxidative stress parameters.

The Association between Degenerative Spine Disease and Obesity in Cancer Patients: An Evaluation by Bone Scintigraphy

Introduction: Degenerative changes of the spine are common in obese cancer patients and are frequently confusing duringthe interpretation of bone scan of those patients. Aim: To investigate the influence of body weight on the frequency of degenerative spine disease in a cohort of cancer patients using technetium-99m methylene diphosphonate (Tc-99m MDP) bone scan. Methods: A prospective study of 100 cancer patients with or without back pain referred for bone scanning. Their mean age was 58.5±10.2 years and 46% were males. Tc-99m MDP bone scan was done followed by spinal magneticresonance imaging (MRI) examination. Patients were divided into two groups according to the body mass index (BMI) intogroup 1 including 60 overweight and obese (BMI ≥ 25) patients and group 2 including 40 non-obese (BMI < 25) patientsserving as a control group. Any spot of enhanced radiotracer uptake at any part of the vertebrae was considered abnormaland correlated with MRI findings. Results: A total of 168 vertebral lesions were detected by bone scan (150 in group 1 and 18 in group 2) with significant difference between both groups and between different grades of obesity in group 1. All lesions were accurately localized and proved to be of degenerative nature by MRI. The percentage of patients with back pain in group 1 was significantly higher than in group 2 (65% vs. 35%, respectively). Conclusion: Bone scintigraphy is a good technique to detect degenerative spinal disease in obese cancer patients.

Relationship Between the Respiratory Polygraphy Indicators in Patients With Sleep Apneas. Comparison Between Normal-Weight Subjects and Patients With Different Grades of Obesity

Relationship Between the Respiratory Polygraphy Indicators in Patients With Sleep Apneas. Comparison Between Normal-Weight Subjects and Patients With Different Grades of Obesity

Adipokines and biochemical changes in Egyptian obese subjects: possible variation with sex and degree of obesity.

The purpose of this study was firstly to evaluate the adipokines and biochemical changes in obese subjects in relation to different grades of obesity and in relation to gender difference (males versus females) and secondly to evaluate the role of TNF-α in obesity. From January 2013 to February 2014, a total number of 120 non-diabetic subjects of both sexes were recruited and randomly selected from Dr. Abd-Elhamid Elsheikh center for physiotherapy and weight control, El-menofia-Egypt. Those subjects were classified according to their sex into two main groups; the female group and the male group. The female group (60 women) was distributed according to BMI into group 1 (15 lean women), group 2 (15 class I obese women), group 3 (15 class II obese women), and group 4 (15 class III obese women). The male group (60 men) was also distributed according to the BMI into group 1 (15 lean men), group 2 (15 class I obese men), group 3 (15 class II obese men), and group 4 (15 class III obese men). All individuals enrolled in the study were submitted to weight and height measurements with subsequent calculation of body mass index. Fasting blood samples were collected from all participants for quantitative determination of blood glucose, serum lipid, TNF-α, leptin, and adiponectin levels. One-way analysis of variance followed by LSD post hoc test was used for comparison of variables. In obese subjects of both sexes, it was found that circulating leptin and TNF-α levels were significantly high (P<0.05) and positively correlated to BMI. In contrast to leptin, adiponectin concentrations were significantly low (P<0.05) and inversely correlated to BMI. Regarding gender difference, although serum leptin and adiponectin levels were higher in women than men, men showed higher atherogenic parameters. We conclude that leptin, TNF-α, and adiponectin were related to both BMI and grades of obesity. Furthermore, TNF-α may play a role in obesity.

Role of SN1 Lipases on Plasma Lipids in Metabolic Syndrome and Obesity

To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride (TG)-hydrolyses to complete the analyses of SN1 lipolytic enzymes in the same patient. Plasma EL, HL, and LPL activities were evaluated in 59 patients with MS and 36 controls. A trend toward higher EL activity was observed in MS. EL activity was increased in obese compared with normal weight group (P=0.009) and was negatively associated with high-density lipoprotein-cholesterol (P=0.014 and P=0.005) and apolipoprotein A-I (P=0.045 and P=0.001) in control and MS group, respectively. HL activity, as TG-hydrolase, was increased in MS (P=0.025) as well as in obese group (P=0.017); directly correlated with low-density lipoprotein-cholesterol (P=0.005) and apolipoprotein B (P=0.003) and negatively with high-density lipoprotein-cholesterol (P=0.021) in control group. LPL was decreased in MS (P<0.001) as well as in overweight and obese compared with normal weight group (P=0.015 and P=0.004, respectively); inversely correlated %TG-very low-density lipoproteins (P=0.04) and TG/apolipoprotein B index (P=0.013) in control group. These associations were not found in MS. We describe for the first time EL and HL activity as phospholipases in MS/obesity, being both responsible for high-density lipoprotein catabolism. Our results elucidate part of the remaining controversies about SN1 lipases activity in MS and different grades of obesity. The impact of insulin resistance on the activity of the 3 enzymes determines the lipoprotein alterations observed in these states.

Obesity is associated with activated and insulin resistant immune cells

Obesity and type 2 diabetes mellitus are characterized by insulin resistance and 'low-grade inflammation'; however, the pathophysiological link is poorly understood. To determine the relative contribution of obesity and insulin resistance to systemic 'inflammation', this study comprehensively characterized circulating immune cells in different grades of obesity. Immune cell phenotypes and activation status were analysed by flow cytometry cross-sectionally in morbidly obese (n = 16, body mass index (BMI) 42.2 ± 5.4 kg/m2), overweight (n = 13, BMI 27.4 ± 1.6 kg/m2) and normal weight (n = 12, BMI 22.5 ± 1.9 kg/m2) subjects. Obese, but not overweight subjects, had increased activation marker expression on neutrophils, monocytes, T-lymphocytes and polarization of T helper cells towards a pro-inflammatory type 1-phenotype (Th1). Th1 numbers correlated positively with the degree of insulin resistance (homeostasis model assessment, p < 0.05). Lymphocytes from obese subjects showed reduced insulin-stimulated AKT-phosphorylation in vitro. Supra-physiological insulin concentrations did not affect T-cell differentiation, which under normal circumstances would promote an anti-inflammatory T helper type 2-phenotype. These results show that morbid obesity is characterized by circulating immune cells that are activated and insulin resistant, with the T-cell balance polarized towards a pro-inflammatory Th1 phenotype. The loss of insulin-induced suppression of inflammatory phenotypes in circulating immune cells could contribute to the systemic and adipose tissue inflammation found in morbid obesity.

Adiponectin Can Affect ER Signaling in Obese Breast Cancer Patients

Background: While the various antitumororal activities of adiponectin as an adipocyte-derived hormone well studied, it is speculated that there is a crosstalk between adiponectin and esterogen receptor (ER) signaling. To test this hypothesis we evaluate the possible correlation between serum level of adiponectin with two estrogen receptors (ERα and ERβ) gene expression in breast cancer patients. Methods: In this case-control study, 70 women with breast cancer participated with different grades of obesity (36 none obese, BMI 2 and 34 obese, BMI ≥ 25 kg/m2).The mean age of Participants was 44.53 yr ± 1.79 yr (21 yr - 70 yr) .Serum level of adiponectin determined by ELISA. Following quantitative expression of estrogen receptors mRNA in tumor tissues was evaluated by Real-time PCR. Results: We find a significant reverse correlation between serum level of Adiponectin and ERα mRNA (r = –0.229, n = 64, p = 0.035) but no correlation was between adiponectin and ERβ in samples (p = 0.228). The lower adiponectin multiplied the odds of having higher ERα mRNA level by a factor of OR = 4.33, 1.28 - 14.6, 95% confidence interval (CI) as compared with those that displayed a moderate or higher serum level of adiponectin (>7.02 ng/ml). The same odds for next estrogen receptor, ERβ, was not greater than unity (OR = 0.31, 0.06 - 1.56, 95% CI). Conclusion: According to the obtained results, it is speculated that as adiponectin can affect ERs gene expression, so affecting the steroid receptor signaling can be proposed as a new underling mechanism of action for this adipokine in breast cancer pathogenesis especially in obese ones.

Relationship between DHEA and DHEA-S with anthropometric indices in healthy obese women with different grades of obesity

Relationship between DHEA and DHEA-S with anthropometric indices in healthy obese women with different grades of obesity