Different Degrees Of Oxidation Research Articles

Oxidative Evolution of Different Model Rosé Wines Affected by Distinct Anthocyanin and Tannin Contents

The quality of rosé wines significantly depends on their phenolic composition, particularly tannins, anthocyanins, and their derivatives, which determine the perceived color of these products and their color evolution throughout the storage and shelf-life periods. This study investigated the impact of phenolic content on the oxidation and color evolution of five different model rosé wines obtained by blending a fixed amount of grape tannins with varying concentrations of oenocyanin to modulate their respective ratio and color intensity. The solutions were monitored for color and pigment changes promoted by oxidation in a Fenton-like environment. The findings revealed a potential correlation between the initial phenolic concentration and the different degrees of oxidation within each solution, resulting in significant variations in CIELAB data. Overall, all solutions exhibited a substantial decrease in redness, with losses ranging from 23% in the darkest solution to 43% in the lightest one compared to their initial levels. Additionally, their color profiles shifted toward yellow hues, up to triple the original value, indicating the degradation of the pigments responsible for the characteristic rosé color. Greater amounts of anthocyanins preserved higher Fe(II) concentrations over time, suggesting the antioxidant role of these compounds. The whole dataset also permitted the evaluation of the different oxidation susceptibilities of individual anthocyanins, among which derived pigments, such as vitisins, proved to be notably more stable than native pigments, particularly delphinidin and petunidin.

Impact of TEMPO-Oxidation Pretreatment of Red Ginseng Residual on Nanofibrillation

Red ginseng extract is one of the most widely used herbal medicines to prevent and cure various diseases. Among the processed products derived from red ginseng, the water-insoluble part as red ginseng residual (RGR) becomes waste, even though it contains important ingredients. TEMPO-oxidation (TO) can be used as a pre-treatment with different degrees of oxidation (DO) (0 to 0.4) in red ginseng residual (RGR-TO) by introducing chemical oxidation and high-pressure homogenizer (HPH) as a nanofibrillation process. 1H NMR was used to determine the carbohydrate composition and calculate DO, size was examined using a nanoparticle analyzer, and the zeta potential was used to determine surface charge density. RGR-TO with different concentrations had different compositions; glucose and uronic acid were the main ingredients. All treated RGR-TO showed higher oxidant levels than the untreated counterpart (RGR-TO 0). As the oxidant levels increased, the zeta potential and uronic acid increased, but the size of the nanofibril from RGR-TO decreased. The results of this study showed that TEMPO-oxidation pretreatment was effective in producing RGR cellulose nanofibril (CNF) with a variety of properties by adjusting the level of oxidation pretreatment and the number of HPH passes.

Use of ozone oxidation in combination with deacetylation for improving the structure and gelation properties of konjac glucomannan

In this study, oxidized deacetylated konjac glucomannans with different degrees of oxidation were prepared by a combination of deacetylation and ozone oxidation. Carboxyl groups were found to be introduced into the modified konjac glucomannan while acetyl groups were removed. The backbone, branched chains, and crystal structure of modified konjac glucomannan were not significantly affected. The whiteness was enhanced to 97–99 % and the thermal degradation temperature was up to 250 °C after modification. The solubility of the modified konjac glucomannan (oxidized for 60 min) was significantly increased to 84.56 % (p < 0.05), while its viscosity and swelling power were notably decreased owing to the changes in molecular weight (from 106 to 104) and functional groups. Rheological analysis showed that oxidized deacetylated konjac glucomannan has the ability to form soft-textured gels and the potential to develop dysphagia foods. Future studies should focus on the gelation mechanisms of oxidized deacetylated konjac glucomannan.

MnO@Mn2O3 nanocrystals embedded in biochar networks for sustainable anode of lithium-ion batteries

MnO is an alternative for commercial graphite as anode material for lithium-ion batteries (LIBs), if the issue of unstable performance caused by volume changes, poor conductivity, and changes in valence state of Mn is addressed. In this study, a series of nano MnO/biochar-containing composite materials were prepared with Mn(NO3)2, urea and pomelo peel as raw materials, via simple hydrothermal treatment and calcination, as anode materials for LIBs, where the biochar was used as inexpensive conductive medium and volume buffer. The electrochemical performance of the composite materials shows complicated correlation with the biochar contents, which associate with different carbonization temperatures. Elaborate characterizations with XRD, SEM, TEM, and Mn 2p, Mn 3s XPS spectra were conducted and jointly analyzed, which revealed that the surface of MnO nanocrystals undergoes different degrees of oxidation. The thickness of the surface amorphous Mn2O3 layer on the MnO nanocrystals influences the long-term electrochemical stability more significantly than the circumstances of biochar encapsulation, which was proved through cyclic voltammetry (CV) measurements. A composite material with moderate biochar content and thin layer of Mn2O3 coating on MnO nanocrystals will show more stable electrochemical performance. Based on this principle, one regulated composite material (MnOx/BC-650) gives an ultra-stable capacity of 446.9 mAh∙g−1 at 500 mA∙g−1 after 200 cycles. This study provides new insight for both revealing the true structure of manganese oxides and developing long-term stable MnO-containing anode materials for LIBs.

TEMPO-Oxidized Nanocellulose Films Modified by Tea Saponin Derived from Camellia oleifera: Physicochemical, Mechanical, and Antibacterial Properties.

Nanocellulose materials have been widely used in biomedicine, food packaging, aerospace, composite material, and other fields. In this work, cellulose obtained from Camellia shells through alkali boiling and subbleaching was micro-dissolved and regenerated using the DMAc (N,N-Dimethylacetamide)/LiCl system, and TOCNs (TEMPO-oxidized cellulose nanofibers) with different degrees of oxidation. The membrane was prepared by filtration of polytetrafluoroethylene (pore size 0.1 μm), and the oxidized nanocellulose film was obtained after drying, Then, the crystallinity, mechanical properties and oxygen barrier properties of the TOCN film were investigated. Furthermore, based on TS (tea saponin) from Camellia oleifera seed cake and TOCNs, TS-TOCN film was prepared by the heterogeneous reaction. The TS-TOCN film not only shows excellent oxygen barrier properties (the oxygen permeability is 2.88 cc·m-2·d-1) but also has good antibacterial effects on both Gram-negative and Gram-positive bacteria. The antibacterial property is comparable to ZnO-TOCN with the same antibacterial content prepared by the in-situ deposition method. Antioxidant activity tests in vitro showed that TS-TOCN had a significant scavenging effect on DPPH (2,2-Diphenyl-1-picrylhydrazyl) radicals. This design strategy makes it possible for inexpensive and abundant Camellia oleifera remainders to be widely used in the field of biobased materials.

Characterization of HIPEs stabilized by soy protein isolate with excellent rheological properties for 3D printing: Bridging the correlation among structure, function and application

Currently, the correlation between how protein structural changes affected the function of high internal phase emulsions (HIPEs) and the regulation of 3D printing performance was still unclear. Herein, this study was aimed to research the relationship between interface properties and stability of soy protein isolate (SPI) at different degrees of oxidation and prepare HIPEs with desirable rheological properties and a solid-like structure to use for 3D printing. The findings of this study suggested that moderate oxidation led to the disruption of the protein's main chain skeleton, resulting in enhancing protein flexibility and surface hydrophobicity. The HIPEs stabilized by this condition owned higher apparent viscosity, over 70% of thixotropic recovery rate, sufficient yield stress (160.8 Pa) and higher G′ and G″. This HIPEs with excellent properties could be the food-grade 3D printing inks to produce samples with high resolution. In addition, this HIPEs exhibited a slow-release effect on free fatty acids (FFA) in the gastrointestinal digestion. Finally, the findings of the correlation analysis indicated that the flexibility and surface hydrophobicity of SPI was a key factor to affect the quality of HIPEs and 3D printing. In conclusion, moderate oxidation could change the structure and interfacial characteristics of SPI, thus endowing HIPEs stabilized by modified SPI with better properties and expanding the field of SPI in the food industry. These findings not only were of great significance for guiding protein production and providing new protein-based 3D printable materials, but also this provided new possibilities for preparing fat substitutes with good appearance.

Contribution of Mine-Derived Airborne Particulate Matter to Ca, Fe, Mn and S Content and Distribution in the Lichen Punctelia hypoleucites Transplanted to Bajo de la Alumbrera Mine, Catamarca (Argentina).

The aim of this work was to relate the contribution of mine-derived airborne particulate matter to Ca, Fe, Mn and S content and distribution in Punctelia hypoleucites transplanted to Bajo de la Alumbrera, an important open-pit mine in Catamarca, Argentina. Lichen samples were transplanted to four monitoring sites: two sites inside the mine perimeter and two sites outside the mine. After three months, elemental distribution in samples was analyzed by microparticle-induced X-ray emission (microPIXE), and elemental concentration was determined by specific techniques: Ca and Fe by instrumental neutron activation analysis, Mn by inductively coupled plasma atomic emission spectrometry and S by a turbidimetric method. A differential distribution of S and Ca in thalli transplanted in-mine sites was detected compared to that of samples transplanted outside-mine sites. An overlap of Fe and S in the upper cortex of the apothecium section was observed, leading to infer a mineral association of both elements. Similar association was observed for Ca and S. In addition to these results, the significantly higher concentration detected for S and Mn in in-mine site samples suggests a contribution of Fe, S, Ca and Mn of mining origin to the content and distribution of these elements in P. hypoleucites. MicroPIXE complemented with Mössbauer spectroscopy analysis determined the presence of pyrite particles together with other iron-bearing minerals displaying different degrees of oxidation. These results point to a mining origin of the airborne particulate matter trapped by the lichen thalli transplanted to Bajo de la Alumbrera. These findings indicate that P. Hypoleucites acts as an excellent air quality biomonitor in the Bajo de la Alumbrera mine area.

Spatial-Arrangement-Assisted Emission Energy Fine Tuning of CdSe Quantum Dots (QDs) in QD–Block Copolymer Complexes

Quantum dots (QDs) exhibit size-dependent optical properties, where both the absorption and fluorescence energy levels vary with QD size. However, this dependence results in a discontinuity of intrinsically accessible energy levels for the bandgap, posing challenges in achieving precise energy tuning within a specific range. Herein, we demonstrate emission energy control of QDs with identical absorption energy levels by manipulating the spatial arrangement of QDs within QD–polymer complexes through hydrophobic interactions. The phase behavior of the QD–polymer complexes was modulated by adjusting the mass fraction of hydrophilic and hydrophobic blocks in the block copolymer, utilizing two types of amphiphilic block copolymers and varying temperatures. The QDs were spontaneously trapped within the hydrophobic region of the polymer template in water, resulting in spherical, cylindrical, and vesicle structures of QD–polymer complexes, corresponding to spherical, cylindrical, and layered assemblies of QDs, respectively. Depending on the QDs’ location within the QD–polymer complex, the surface area in contact with water varied, leading to different degrees of oxidation and, consequently, a change in the fluorescence energy level of QDs. This study introduces a novel method to fine tune the emission energy (&lt;15 eV) of QDs by adjusting the polymer form factor without complicated procedures.

Chemical characterization of sunflower oil oxidized by UV and ozone with different degrees of oxidation and study of their antimicrobial action

Oxidation by the action of ozone takes place at high rates and involves the reaction of ozone molecules with fatty acid double bonds followed by the formation of stable oxidation products with biological activity. In the present work, a comparative study on sunflower oil oxidized by ultraviolet (UV) light and ozone was carried out. This study involved the chemical characterization of sunflower oil oxidized by UV irradiation and ozonation, in addition to assessing the germicidal activity of oxidized oils obtained under various conditions. The results indicated that under the conditions studied, the increase in the dose of UV irradiation did not produce significant changes in the level of oxidation of the oil. Ozonation promoted the formation of oxygenated compounds at higher rates, increasing in concentration as the applied dosage of ozone increased. The germicidal activity of the oils behaved similarly, with considerably higher activity found in the ozonized oils.

Optical analysis of aligned Ni nanowire arrays with different degree of oxidation for terahertz polarizer application

The optical properties of aligned nickel nanowire arrays (NiNWAs) with different degrees of oxidation for terahertz (THz) polarizer applications have been investigated by using THz time-domain spectroscopy. In frequency-domain spectra, the full width at half maxima of transmitted peaks was broadened and the peak positions have a blue shift with increasing oxidation levels, besides the enhancement in peak intensity. It is indicated that the oxidation of Ni nanowires (NWs) has a significant influence on the interaction between Ni NWs and THz wave. The transmittance of the aligned NiNWAs increases with annealing temperature increasing. Conversely, the degree of polarization and extinction ratio (ER) decreases. A corresponding relationship between the change of ER and degree of oxidation is summarized by means of thermogravimetric analysis. The change of ER for the annealing sample with the degree of oxidation of 0.507% is 27.32%, which induced the polarization properties of aligned NiNWAs to be sensitive to the oxidation of Ni NWs. These findings can provide new positive features in the development of future polarization-based device applications for THz electronics and photonics.

Systematic screening strategy for fungal laccase activity of endophytes from Otoba gracilipes with bioremediation potential

Fungal laccases are promising for biotechnological applications, including bioremediation and dye biotransformation, due to their high redox potential and broad substrate specificity. However, current bioprospecting methods for identifying laccase-producing fungi can be challenging and time-consuming. For early detection, it was developed a three-step, multi-criteria weighting system that evaluates fungal strains based on: First, the biotransformation capacity of three dyes (i.e., Congo red, brilliant blue G-250, and malachite green), at three different pH values, and with a relative weighting supported for the redox potential of each colorant. The relative decolorization coefficient (RDC), used as th2e first classification criterion, expressed their potential performance. Second, under the same conditions, laccase activity was estimated by observing the different degrees of oxidation of a given substrate. The selection criterion was the relative oxidation coefficient (ROC). Finally, laccase activity was quantified in submerged fermentations using three inducers (i.e., loofah sponge, Tween 80, and veratyl alcohol). This multicriteria screening strategy evaluated sixteen isolated endophytic fungal strains from Otoba gracilipes. The system identified Beltraniopsis sp. ET-17 (at pH values of 5.00 and 5.50) as a promising strain for dye biotransformation, and Phlebia floridensis as the best laccase producer, achieving a high activity of 116 μmol min−1 L−1 with loofah sponge as an inducer. In-vitro testing confirmed the efficacy of P. floridensis, with 53.61 % decolorization of a dye mixture (brilliant blue-Congo red. ratio 1:1) after 15 days of incubation. Thus, with the proposed screening strategy it was possible to highlight two species of interest at an early bioprospecting stage on a Colombian native tree poorly explored.

Curing performance and print accuracy of oxidized SiC ceramic via vat photopolymerization

To improve the print quality of SiC ceramic, an amorphous SiO2 layer is prepared on the surface of SiC by oxidation (SiC@SiO2). The changes in curing depth and width direction of SiC@SiO2 curing sheets with different degrees of oxidation were investigated. The results showed that curing depth increased while curing width decreased with an increasing degree of oxidation. The edge morphologies of SiC@SiO2 curing sheets changed from serration to flat shape with increasing degree of oxidation, and uneven overcuring regions appear in the width direction. Additionally, 12% SiC@SiO2 ceramic was fabricated via vat photopolymerization combined with reaction sintering. The dimensional deviation ratio of printed green bodies increased with decreasing printed line width and pore diameter. The minimum printed line width of 329 μm and pore diameter of 483 μm with good print quality were obtained. Furthermore, the flexural strength of 225.4 MPa and bulk density of 2.77 g cm−3 for sintered 12% SiC@SiO2 parts were obtained.

Promoted electrocatalytic water splitting by regulating the concentration of oxygen vacancies

Among the many methods of hydrogen production, the electrolysis of water has a broad prospect. In this experiment, NiCo2O4 nanosheets with different degrees of oxidation were synthesized on nickel foam by the hydrothermal method, air calcination and reduction steps. The experimental results show that reduction treatment significantly improved the catalytic activity of NiCo2O4 materials under alkaline medium conditions of 1.0 mol/L KOH. V–NiCo2O4-4 shows better catalytic activity with an overpotential of 285 mV and 340 mV for the oxygen evolution reaction (OER) at 10 mA cm−2 and 50 mA cm−2, respectively. The better catalytic activity of V–NiCo2O4-4 is mainly assigned to the flower-like structure of the catalyst surface and the moderate reduction of NaBH4, resulting in more oxygen vacancies and active sites. Density functional theory calculation also indicates that the V–NiCo2O4-4 material has a stronger water absorption energy (0.75 eV) compared to the V–NiCo2O4-2 and V–NiCo2O4-6 materials, which provides a new foundation for the construction of binder-free high-performance electrodes for water splitting.

Chemical Influence of Carbon Interface Layers in Metal/Oxide Resistive Switches.

Thin layers introduced between a metal electrode and a solid electrolyte can significantly alter the transport of mass and charge at the interfaces and influence the rate of electrode reactions. C films embedded in functional materials can change the chemical properties of the host, thereby altering the functionality of the whole device. Using X-ray spectroscopies, here we demonstrate that the chemical and electronic structures in a representative redox-based resistive switching (RS) system, Ta2O5/Ta, can be tuned by inserting a graphene or ultrathin amorphous C layer. The results of the orbitalwise analyses of synchrotron Ta L3-edge, C K-edge, and O K-edge X-ray absorption spectroscopy showed that the C layers between Ta2O5 and Ta are significantly oxidized to form COx and, at the same time, oxidize the Ta layers with different degrees of oxidation depending on the distance: full oxidation at the nearest 5 nm Ta and partial oxidation in the next 15 nm Ta. The depth-resolved information on the electronic structure for each layer further revealed a significant modification of the band alignments due to C insertion. Full oxidation of the Ta metal near the C interlayer suggests that the oxygen-vacancy-related valence change memory mechanism for the RS can be suppressed, thereby changing the RS functionalities fundamentally. The knowledge on the origin of C-enhanced surfaces can be applied to other metal/oxide interfaces and used for the advanced design of memristive devices.

Quantum mechanical analysis of adsorption for CH4 and CO2 onto graphene oxides

Graphene oxide (GO) surfaces with rich and diverse oxygen-containing functional groups might endow GOs with unique chemical adsorption activity. Exploring the adsorption behavior of gas molecules on GOs with different degrees of oxidation can help design highly efficient adsorbents and catalysts. Herein, the interaction energies between two kinds of gas molecules, CH4 and CO2, and the GO surfaces with varied oxidization degrees were simulated by density functional theory. It is numerically demonstrated that CO2 has a stronger interaction strength than CH4. More specifically, the interaction energies for the gases on GO surfaces do not show monotonous variation with the degree of oxidization. The results suggest that there exists an appropriate range of oxidized degrees on GOs, which can impose higher adsorption interaction. The AIM (atom in molecule) and NOCV (natural orbital for chemical valence) analyses were applied to reveal the interaction mechanisms between the gas molecules and GO surfaces. The adsorption free energy and adsorption coverage of CH4 and CO2 on GO surfaces were calculated. Generally, the gas adsorption on GO is thermodynamically unfavorable under standard conditions. The computational results provide an improved understanding of the adsorption mechanism, which might be valuable for the application of high-performance GO-based adsorbents and catalysts.

Effect of air frying and baking on physicochemical properties and digestive properties of scallop (Patinopecten yessoensis) adductor muscle

In this study, the effects of dry heat treatments including air frying and baking on the physicochemical and digestive properties of proteins in scallop adductor muscle (SAM) were evaluated. After heat treatments, the proteins in SAM exhibited different degrees of oxidation, aggregation and degradation. For both heat treatments, the increase of carbonyl and dityrosine contents and the decrease of free sulfhydryl groups and surface hydrophobicity of proteins in SAM were observed along with increasing heat temperature. Meanwhile, with increasing heat temperature, there was a progressive transition from α-helix to β-sheet in protein secondary structure. However, the protein solubility first increased and then decreased with increasing temperature. Among which, the solubility of 160°C-treated samples was the highest, which were 21.02% and 20.32% for air frying and baking. The protein digestive properties which reflected by the degree of hydrolysis (DH), soluble amino groups and soluble peptides showed a trend of increasing first and then decreasing with increasing temperature. After gastrointestinal digestion, the DH, soluble amino groups and soluble peptides of 160°C-treated SAMs cooking by air frying were 69.96%, 61.14% and 39.33%, respectively, which were significantly higher than all other samples including the fresh ones. Correlation analysis showed that the protein digestive indexes were positively correlated with solubility, free sulfhydryl content and surface hydrophobicity, and negatively correlated with protein carbonyl content, dityrosine content and protein aggregation degree. These results provide evidence for knowing more about the effects of dry heat treatments on physicochemical and digestive properties of aquatic muscle food.

Nanostructured Silicon Matrix for Materials Engineering.

Tin-containing layers with different degrees of oxidation are uniformly distributed along the length of silicon nanowires formed by a top-down method by applying metalorganic chemical vapor deposition. The electronic and atomic structure of the obtained layers is investigated by applying nondestructive surface-sensitive X-ray absorption near edge spectroscopy using synchrotron radiation. The results demonstrated, for the first time, a distribution effect of the tin-containing phases in the nanostructured silicon matrix compared to the results obtained for planar structures at the same deposition temperatures. The amount and distribution of tin-containing phases can be effectively varied and controlled by adjusting the geometric parameters (pore diameter and length) of the initial matrix of nanostructured silicon. Due to the occurrence of intense interactions between precursor molecules and decomposition by-products in the nanocapillary, as a consequence of random thermal motion of molecules in the nanocapillary, which leads to additional kinetic energy and formation of reducing agents, resulting in effective reduction of tin-based compounds to a metallic tin state for molecules with the highest penetration depth in the nanostructured silicon matrix. This effect will enable clear control of the phase distributions of functional materials in 3D matrices for a wide range of applications.

Study of the interaction mechanism between human serum albumin and Ti3C2Tx with different degrees of oxidation by multi-spectroscopic method and molecular docking

Currently, despite the wide application of Ti3C2Tx in various fields, little information is available regarding its toxicity to humans, thus, it is necessary to study its interactions with human proteins as well as its biotoxicity. In the study, spectroscopic analysis and molecular simulation were used to investigated the interaction mechanism between human serum albumin (HSA) and Ti3C2Tx with different oxidation degrees. The three prepared Ti3C2Tx materials with different oxidation degrees were analyzed by X-ray diffractometer, X-ray photoelectron spectroscopy, scanning electron microscope and transmission electron microscope, and the results demonstrated that TiO2 nanoparticles were formed during the oxidation process. In conclusion, the results of the ultra violet spectrum, fluorescence spectra and zeta potential measurements showed that fully oxidized Ti3C2Tx (F-Ti3C2Tx) had a greater binding ability to HSA than unoxidized Ti3C2Tx (U-Ti3C2Tx), followed by partially oxidized Ti3C2Tx (P-Ti3C2Tx). Based on synchronous fluorescence, circular dichroism and infrared characterization, it has been determined that with a gradual increase of Ti3C2Tx oxidation degree, its effect on the conformation of HSA increases, followed by F-Ti3C2Tx > P-Ti3C2Tx > U-Ti3C2Tx. Further analysis of the fluorescence binding ability revealed that hydrogen bonds played a major role in the interaction between HSA and Ti3C2Tx.

Malondialdehyde treatment reduced immunoreactivity of amandin and delayed its digestion

AbstractObjectivesThe secondary products of lipid oxidation are one of the main factors inducing protein oxidation. The effects of oxidation treatment with malondialdehyde (MDA) on the immunoreactivity of amandin and its digestion were studied.Materials and MethodsThe rabbit IgG binding ability of amandin was analyzed by western blotting, and the changes in amandin oxidation and immunoreactivity during digestion of amandin with different degrees of oxidation were investigated in combination with an almond allergen enzyme-linked immunosorbent assay kit. Alteration of linear epitopes of amandin by oxidation was investigated by liquid chromatography–tandem mass spectrometry (LC-MS/MS).ResultsThe results showed that the immunoreactivity of amandin was significantly reduced after 1 mmol/L MDA and 100 mmol/L MDA treatment. However, the 1 mmol/L MDA treatment was owing to cleavage of linear epitope peptide in amandin and oxidation of the active amino acid. The 100 mmol/L MDA treatment was due to aggregation of amandin and significant decrease in its solubility. Oxidation also reduced digestibility of amandin and significantly affected immunoreactivity during digestion. LC-MS/MS also identified four oxidation-prone methionine sites (aa 264–274, 298–308, 220–240, and 275–297) in gamma conglutinin 1.ConclusionsMDA treatment reduced the immunoreactivity of amandin. MDA treatment also led to protein aggregation, which slowed down the digestion of amandin and altered the immunoreactivity of amandin during digestion.

Application of metabolomics to explore the automatic oxidation process of hazelnut oil

The oxidation metabolites of hazelnut oil are complex and vary with different degrees of oxidation. At present, few studies have investigated the change law of metabolites during the oxidation process of hazelnut oil. In this study, ultrahigh-performance liquid chromatography tandem Q-Exactive high-resolution mass spectrometry (UPLC-QE/MS) was used to analyze the differential metabolites resulting from the oxidation of cold-pressed hazelnut oil during storage for 40 days with accelerated oxidation. The oxidation level of cold-pressed hazelnut oil was evaluated by monitoring the free radical relative strength during accelerated oxidation. A total of 1010 metabolites in 12 super classes were detected in fresh hazelnut oil. Based on multivariate statistical analysis of all metabolites and the change law of free radicals in hazelnut oil, it was found that hazelnut oil enters the deep oxidation stage after accelerated oxidation for 30 days. A statistical analysis of differential metabolites and metabolic pathways was also carried out. The metabolite map obtained in this study can further distinguish hazelnut oil with different degrees of oxidation. Bioinformatics analysis indicated that linoleic acid metabolism and sphingolipid (SP) metabolism are the most important metabolic pathways in the entire oxidation process. These results provide a basis for better understanding the composition of hazelnut oil metabolites with different oxidation levels, identifying markers for oxidation level evaluation and analyzing the oxidative metabolism mechanism of hazelnut oil. This study provides new resources and new ideas for studying methods to prolong the shelf life of edible oils.