Differences In Geographic Patterns Research Articles

Differences in Geographic Patterns of Absolute and Relative Black-White Disparities in Stroke Mortality in the United States.

Preventing Chronic Disease (PCD) is a peer-reviewed electronic journal established by the National Center for Chronic Disease Prevention and Health Promotion. PCD provides an open exchange of information and knowledge among researchers, practitioners, policy makers, and others who strive to improve the health of the public through chronic disease prevention.

HPV and lung cancer: A systematic review and meta-analysis.

BackgroundLung cancer has emerged as a global public health problem and is the most common cause of cancer deaths by absolute cases globally. Besides tobacco, smoke infectious diseases such as human papillomavirus (HPV) might be involved in the pathogenesis of lung cancer. However, data are inconsistent due to differences in study design and HPV detection methods.AimA systematic meta‐analysis was performed to examine the presence of HPV‐infection with lung cancer.Methods and ResultsAll studies in all languages were considered for the search concepts “lung cancer” and “HPV” if data specific to HPV prevalence in lung cancer tissue were given. This included Journal articles as well as abstracts and conference reports. As detection method, only HPV PCR results from fresh frozen and paraffin‐embedded tissue were included. Five bibliographic databases and three registers of clinical trials including MEDLINE, Embase, Cochrane Library, and ClinicalTrials.gov were searched through February 2020. A total 4298 publications were identified, and 78 publications were selected, resulting in 9385 included lung cancer patients. A meta‐analysis of 15 case‐control studies with n = 2504 patients showed a weighted overall prevalence difference of 22% (95% CI: 12%‐33%; P < .001) and a weighted overall 4.7‐fold (95% CI: 2.7‐8.4; P < .001) increase of HPV prevalence in lung cancer patients compared to controls. Overall, HPV prevalence amounted to 13.5% being highest in Asia (16.6%), followed by America (12.8%), and Europe (7.0%). A higher HPV prevalence was found in squamous cell carcinoma (17.9%) compared to adenocarcinoma (P < .01) with significant differences in geographic patterns. HPV genotypes 16 and 18 were the most prevalent high‐risk genotypes identified.ConclusionIn conclusion, our review provides convincing evidence that HPV infection increases the risk of developing lung cancer.

The Impact of Homelessness in Social Vulnerability Assessment: A Case Study of Austin, Texas

Among existing research on social vulnerability, virtually no studies have considered homelessness as a variable in their vulnerability assessments. This study identified the relevance of homelessness as a key index in social vulnerability assessment to inform the public, policymakers and the broader body of literature of its impacts on shaping vulnerability patterns in cities. In this study, the 2018 Homeless data for Austin was disaggregated from the council district level to block group level using dasymetric mapping in Geographic Information System (GIS). Principal Component Analysis (PCA) was used to group highly correlated demographic and socioeconomic variables into factors, which were normalized and summed to model social vulnerability with homeless index (SOVI_H) and without homeless index (SOVI) for each Austin Blockgroup. The result revealed significant differences in geographic patterns between SOVI_H and SOVI. SOVI_H showed hotspots of vulnerabilities in Downtown and East-Austin neighborhoods, depicting a slight shift of social vulnerability westwards of the city. This finding differs from past results of social vulnerabilities in Austin where it used to be predominant in the East. This study showed that incorporating homelessness in identifying social vulnerability can help researchers and other associated organizations identify the most vulnerable groups when conducting social vulnerability assessments.

An International Survey of Commonly Used Interventions for Management of Pelvic Pain.

Pelvic pain (PP) is a debilitating condition that is challenging to manage. Despite differences in suspected etiologies of different PP conditions, common clinical signs and symptoms make it appropriate to group these diagnoses. The presence of neuro-musculoskeletal impairments in PP suggests that physical therapists are ideally situated to be included as part of the health care team managing this condition; however, little information is available to guide physical therapist management of PP. As a first step to developing management guidelines, we sought to determine common interventions currently used by physical therapists to manage PP. Descriptive survey. A modified Delphi approach was used to identify broad categories of interventions that were then used to build a survey. Purposeful selection with snowball recruiting methods was used to collect responses from practitioners. Frequency data were collected for survey responses. Chi-square analysis determined associations among responses based on practitioner training. A total of 984 responses from 17 different countries were analyzed. The primary responses were from physical therapists in the USA and Canada. The majority of respondents were board-certified clinical specialists. More than 80% of physical therapist respondents indicated that they "frequently used" education, exercise, and manual therapy for patients with PP. The most common interventions considered effective but not frequently used were cognitive-behavioral therapy, dry needling, acupuncture, topical medications, and internal pelvic manual therapy techniques. Geographical differences in patterns of usespecific manual therapy and exercise interventions were noted. Differences were also noted on the basis of the levels of advanced postprofessional training. Physical therapists routinely use education, manual therapy, and exercise to manage pelvic pain conditions.

Temporal and geographic distribution of weather conditions favorable to airborne spread of foot-and-mouth disease in the coterminous United States

Foot-and-mouth disease (FMD) is a highly infectious viral disease of cloven-hoofed animals. FMD outbreaks have the potential to cause significant economic consequences, and effective control strategies are needed to minimize the damage to livestock systems and the economy. Although not the predominant route of infection, airborne transmission has been implicated in previous outbreaks. Under favorable weather conditions, airborne spread of FMD can make the rapid containment of an outbreak more difficult. Our objective was to identify seasonal and geographic differences in patterns of conditions favorable to airborne FMD spread in the United States. Data from a national network of surface weather stations were examined for three study years (December 2011–November 2012, December 2012–November 2013, December 2014–November 2015). Weather conditions were found to be most frequently favorable to airborne spread during the winter (December, January, February). Geographically, conditions were most frequently favorable to airborne FMD spread in the upper Midwestern United States, a region where swine and cattle populations are common. Across study years, conditions for airborne FMD spread were more frequently favorable when weather conditions were generally mild with few extremes with respect to temperature and precipitation (e.g., 2014–2015). However, national patterns in risk areas for airborne FMD spread were similar across study years even though the degree of risk differed based on variations in weather patterns among study years. Our findings suggest that airborne transmission could contribute to FMD spread between livestock premises in the event of an outbreak in the coterminous United States, and that some geographic areas are at an increased risk particularly in seasons with conducive weather conditions. To our knowledge, this is the first study to characterize the risk of airborne FMD spread on a national scale in the United States. The findings presented here can be used to enhance preparedness and surveillance activities by identifying specific geographic areas in the United States where airborne spread is most likely to be a risk factor for transmission during an outbreak.

Maternal mortality in Ifakara Health and Demographic Surveillance System: Spatial patterns, trends and risk factors, 2006 - 2010.

IntroductionMaternal mortality was the subject of the United Nations’ fifth Millennium Development Goal which was to reduce the maternal mortality ratio by three quarters from 1990 to 2015. The Sustainable Development Goals (SDGs), target 3.1 requires participating countries to reduce their maternal mortality ratio to less than 70 deaths per 100,000 live births by 2030. Although much research has been conducted, knowing the spatial patterns and risk factors associated with maternal mortality in developing countries helps target scarce resources and intervention programmes to high risk areas for the greatest impact.MethodsData were analysed from a longitudinal open cohort of women aged 15 to 49 years, enrolled from 2006 to 2010. An inverse distance weighted method of interpolation was used to assess spatial patterns of maternal mortality. Cox proportional hazards regression analysis was used to identify risk factors associated with maternal mortality.ResultsThe overall maternal mortality rate for the 36 792 study participants for the five years was 0.79 per 1000 person years. The trend declined from 90.42 in 2006 to 57.42 in 2010. Marked geographical differences were observed in maternal mortality patterns. The main causes of maternal death were eclampsia (23%), haemorrhage (22%) and abortion-related complications (10%). There was a reduced risk of 82% (HR = 0.18, 95% CI:0.05–0.74) and 78% (HR = 0.22, 95% CI:0.05–0.92) for women aged 20–29 and 30–39 years, respectively, compared with those younger than 20 years. While being married had a protective effect of 94% (HR = 0.06, 95% CI: 0.01–0.51) compared with being single, women who were widowed had an increased risk of maternal death of 913% (HR = 9.13, 95% CI: 1.02–81.94). Women who belong to poorer, poor and least poor socioeconomic quintile had 84%, 71% and 72% reduction in risk of maternal mortality respectively compared to those in the poorest category (HR = 0.16, 95% CI: 0.06–0.42; HR = 0.29, 95% CI: 0.12–0.69; HR = 0.28, 95% CI: 0.10–0.80).ConclusionMaternal mortality has declined in rural southern Tanzania since 2006, with geographical differences in patterns of death. Eclampsia, haemorrhage and abortion-related complications are the three leading causes of maternal death in the region, with risk factors being younger than 20 years, being single or widowed, and having a low socioeconomic status.

Interoceptive Anxiety and Body Representation in Anorexia Nervosa.

Individuals with anorexia nervosa (AN) typically display anxious traits prior to the onset of food avoidance and weight loss that characterize the disorder. Meal associated anxiety is an especially common clinical feature in these patients, and heightened sensitivity to sympathetically mediated interoceptive sensations has also been observed. However, it remains unclear how heightened interoceptive sensitivity relates to experiences of anxiety before and after meals. To investigate this relationship, we experimentally induced anxiety and panic symptoms with isoproterenol, a peripheral sympathetic agonist similar to adrenaline, across several different conditions: during panic provocation, during anticipation of a 1,000 Calorie meal, and after meal consumption. Fifteen AN and 15 age- and sex-matched healthy comparisons received bolus infusions of isoproterenol and saline in a double-blinded, randomized design. Participants rated anxiety symptoms after each infusion, completed panic rating scales, and traced the location of perceived palpitations on a manikin to index interoceptive “body map” representation. The AN group reported significantly elevated anxiety relative to healthy comparisons during infusions before and after the meal, but surprisingly, not during panic provocation. These symptoms were accompanied by geographical differences in patterns of perceived heartbeat sensations across each condition. In particular, the AN group localized heartbeat sensations disproportionately to the chest during meal related saline infusions, when no cardiorespiratory modulation actually occurred. The AN group also showed a trend toward higher panic attack rates during the meal anticipation period. Correcting for anxiety levels reported during saline infusions abolished group differences in anxiety change across all conditions, suggesting a significant contribution of anxious traits in AN. The observation of meal related “visceral illusions” provides further evidence that AN is associated with abnormal interoceptive representation of the heartbeat and suggests that meal consumption, particularly when anticipated, preferentially alters the processing of interoception related signals in AN.

Uncertainty in geographical estimates of performance and fitness

Abstract Thermal performance curves (TPCs) have become key tools for predicting geographical distributions of performance by ectotherms. Such TPC‐based predictions, however, may be sensitive to errors arising from diverse sources. We analysed potential errors that arise from common choices faced by biologists integrating TPCs with climate data by constructing case studies focusing on experimental sets of TPCs and simulating geographical patterns of mean performance. We first analysed differences in geographical patterns of performance derived from two pairs of commonly used TPCs. Mean performance differed most (up to 30%) in regions with relatively constant mean temperatures similar to those at which the TPCs diverged the most. We also analysed the effects of thermal history by comparing geographical estimates derived from (a) a broad TPC based on short‐term measurements of insect larvae (Manduca sexta) with a history of exposure to thermal variation versus (b) a narrow TPC based on long‐term measurements of larvae held at constant temperatures. Estimated mean performance diverged by up to 40%, and differences were magnified in simulated future climates. Finally, to quantify geographical error arising from statistical error in fitted TPCs, we propose and illustrate a bootstrapping technique for establishing 95% prediction intervals on mean performance at each location (pixel). Collectively, our analyses indicate that error arising from several underappreciated sources can significantly affect the mean performance values derived from TPCs, and we suggest that the magnitudes of these errors should be estimated routinely in future studies.

Canine and human infection with Borrelia burgdorferi in the New York City metropolitan area

BackgroundAutochthonous transmission of Borrelia burgdorferi, the primary agent of Lyme disease in dogs and people in North America, commonly occurs in the northeastern United States, including the New York City metropolitan area, a region with a large human and pet population and broadly diverse demographics and habitats.MethodsWe evaluated results from a specific, C6-based serologic assay performed on 234,633 canine samples to compare evidence of past or current infection with B. burgdorferi (sensu stricto) in dogs to county-wide social and environmental factors, as well as to reported cases of Lyme disease in people.ResultsThe data revealed a wide range of county level percent positive canine test results (1.2–27.3%) and human case reports (0.5–438.7 case reports/100,000 people). Dogs from highly (> 50%) forested areas and counties with lower population density had the highest percent positive test results, at 21.1% and 17.9%, respectively. Canine percent positive tests correlated with population-adjusted human case reports (R2 = 0.48, P < 0.0001), as well as population density, development intensity, temperature, normalized difference vegetation index, and habitat type. Subsequent multiple regression allowed an accurate prediction of infection risk in dogs (R2 = 0.90) but was less accurate at predicting human case reports (R2 = 0.74).ConclusionIn areas where Lyme disease is endemic, canine serology continues to provide insight into risk factors for transmission to both dogs and people although some differences in geographic patterns of canine infection and human disease reports are evident.

A geography of child and elderly pedestrian injury in the City of Toronto, Canada

Walking is one of the most accessible forms of physical activity for people of all ages. Promoting increased walking for transport may contribute to reduced air pollution, noise and traffic congestion. Understanding the geography of pedestrian motor vehicle collisions (PMVCs) can provide evidence to inform policy and planning that targets increased walking while reducing pedestrian injury risk, however age-related differences in the geography of injury are expected given differences in activity patterns and physical and cognitive abilities. The purpose of this paper is to explore spatial patterns of pedestrian motor vehicle collisions (PMVCs) by age, injury severity, and location in Canada's largest city, the City of Toronto. Geographical variation in PMVCs and injuries by age (namely seniors and children) and severity were explored using indirect standardized rates. Moran's I statistics were estimated to study the spatial clustering of PMVCs across urban and inner suburban neighbourhoods. Distinct spatial patterns of PMVCs and injuries were evident among children and seniors. While evidence of spatial clustering was indicated for both age groups, children's injuries revealed the strongest clustering, while PMVCs involving seniors were more dispersed. Furthermore, fatal and major injury events appeared to be concentrated toward and within Toronto's inner suburbs for both age groups. Findings from this study demonstrate the importance of planning pedestrian safety interventions that acknowledge spatial differences in geographic patterns of PMVCs by age.

American exceptionalism: population trends and flight initiation distances in birds from three continents.

BackgroundAll organisms may be affected by humans' increasing impact on Earth, but there are many potential drivers of population trends and the relative importance of each remains largely unknown. The causes of spatial patterns in population trends and their relationship with animal responses to human proximity are even less known.Methodology/Principal FindingWe investigated the relationship between population trends of 193 species of bird in North America, Australia and Europe and flight initiation distance (FID); the distance at which birds take flight when approached by a human. While there is an expected negative relationship between population trend and FID in Australia and Europe, we found the inverse relationship for North American birds; thus FID cannot be used as a universal predictor of vulnerability of birds. However, the analysis of the joint explanatory ability of multiple drivers (farmland breeding habitat, pole-most breeding latitude, migratory habit, FID) effects on population status replicated previously reported strong effects of farmland breeding habitat (an effect apparently driven mostly by European birds), as well as strong effects of FID, body size, migratory habit and continent. Farmland birds are generally declining.Conclusions/SignificanceFlight initiation distance is related to population trends in a way that differs among continents opening new research possibilities concerning the causes of geographic differences in patterns of anti-predator behavior.

Long-Term Climate Sensitivity of Grazer Performance: A Cross-Site Study

Climate change will affect grasslands in a number of ways, but the consequences of a warmer, drier world for grazers is uncertain. Predicting future grazer performance is complex since climate change affects both the quantity and quality of forage through a combination of processes that occur over a range of time scales. To better predict the consequences of climate change for grazer performance, a dataset was compiled of over a quarter million bison weights distributed across 22 US herds that span a large range of climates. Patterns of bison body mass among sites, age classes, and sexes were analyzed with respect to differences in geographic patterns of climate and interannual variation in climate. While short-term effects of climate variability are likely to depend on the magnitude and timing of precipitation during the year, grazers will be negatively affected by sustained hotter, drier conditions most likely associated with reductions in forage quality. Short-term, little effect of high temperatures on bison performance is observed, which suggests that the long-term effects of higher temperatures are likely to accrue over time as nitrogen availability in grasslands is reduced and forage quality declines. If relationships observed for bison are general for cattle, the economic consequences of higher temperatures due to decreased weight gain in US cattle could be on the order of US$1B per 1°C increase in temperature. Long-term monitoring of forage quality as well as native and domesticated grazer performance is recommended to better understand climate change effects on grazers.

Crop-raiding macaques: predictions, patterns and perceptions from Langtang National Park, Nepal

Crop-raiding by wild animals is increasingly known to cause conflict between these animals and humans; subsequent losses incurred by farmers may make communities antagonistic and intolerant towards wildlife protection. There is an increasing need to understand interspecific and geographic differences in patterns of crop-raiding. Here, focussing on macaques, a group of primates that feature high on the list of crop-raiders throughout Asia, we calculate incidence rates (IRs; the proportion of farms where a particular crop is raided by macaques in relation to the total number of farms where this crop is grown and available to macaques) for different crops and relate this to physical and temporal features. Based on interview data from 120 farmers in 3 Vil- lage Development Committees in Lantang National Park in Nepal, IRs were highest for potato (0.783) and maize (0.697) and lower for cereals (0.353 and 0.357 for buckwheat and millet, respec- tively), and IRs of 4 crops were negatively related to the distance to the forest edge. IRs for potato and maize were close to 1 near the forest edge but dropped significantly when the distance between the forest edge and fields exceeded 150 and 400 m, respectively. Farmers mostly employed benign crop-deterrent tactics, but macaques disproportionally raided farms in the early hours of the day, presumably to avoid conflict with farmers. Comparisons with IRs from other macaque species from Sri Lanka and Indonesia show that IRs are not related to caloric or nutri- tional content of crops or to the quantities in which crops are grown. With respect to the manage- ment of macaques and mitigating conflict due to crop-raiding, we advocate an integrative approach taking into account both the IRs and the interactions among macaques, crops and farmers but also the relations among the farmers themselves and the local authorities.

Risk factors and geographical heterogeneity in unintentional home injuries incidence rate: new evidence based on Multiscopo Survey in Italy

Home injuries together, with road traffic accidents, are estimated to be the third cause of death in Italy (Arokiasamy and Krishnan 1994). However, as in most other countries, in Italy there is a lack of information on home injuries and on how differences in geographical patterns may influence the scope and magnitude of this phenomenon. By analysing a multipurpose large survey (Multiscopo) carried out annually, geographical heterogeneity in home injuries incidence rate can be investigated. The aim of this study is the assessment of possible differences in geographical patterns among the Italian regions making use of a re-analysis of Multiscopo home injury data. The study results show that Italian regions differ greatly in the number of home injuries. The geographical heterogeneity may be due to the unemployment rate and the incidence of poverty that is greater in the Southern and Insular regions than in other zones. Other socio-economic variables such as alcohol consumption can increase the risk of injury in the home. To prevent them it could be useful to organize campaigns aimed at increasing the awareness among people about this problem.

World-wide control of hepatitis B.

It has been 30 years since the Third World Health Assembly convened a WHO Expert Committee to consider investigation, control, and prevention of viral hepatitis. During that time, significant advances have been made in understanding the etiology and epidemiology of viral hepatitis. Technological advances of the 1970s enabled widespread rapid diagnosis and the development of vaccines of high efficacy. These advances have allowed the implementation of control programs on a global scale. Because liver cancer (PHC) is among the 10 most common cancers in the world, the link between PHC and viral hepatitis is important. Up to 80% of these cancers are attributable to the hepatitis B virus. Although the development of PHC is not associated with acute hepatitis B virus itself, the chronic HBV carrier state may be classified as a precancerous lesion. Task forces have been convened consider implementation of hepatitis control programs, especially in countries where the infection is hyperendemic. The most important prevention method is active immunization, but vaccination strategies must consider differences in geographical patterns of prevalence. In areas of low endemicity, such as North America, Western Europe, and Australia, immunization of selected high risk groups is suggested. In areas of high endemicity, such as sub-Saharan Africa, southeast Asia, and China, large-scale vaccination of infants is recommended, similar to DPT and polio vaccination programs. Current hepatitis B vaccines are favorable to mass infant immunization because of their high tolerability, excellent immunogenicity, and their ability to induce primary humeral antibody response. However, these vaccines are available in insufficient quantities and the costs are too high for use on a large scale. Newer vaccines, based on recombinant DNA techniques (rather than plasma-derived vaccines) show promise in increasing the quantity and reducing the cost of hepatitis B vaccines.