Difference In Transit Time Research Articles

Study on On-Line Monitoring Technique and Case Study of Pump-Storage Turbine Headcover Bolt Axial Load

Abstract This work is based on the principle of acoustoelasticity of metallic materials, systematically studied the headcover bolt axial load on-line monitoring, the method of calibration technique based on ultrasound transit time difference and temperature, and case study. By analytical calculation, test, and finite element analysis (FEA), derived the coefficients of acoustoelasticity and temperature, and investigated the bolt thermal stress and the temperature correction method. A scheme for the on-line monitoring of pump-storage turbine headcover bolt axial load is given, providing a reference for important bolt axial load monitoring of hydropower units.

A deflected ray model of the transit time difference in ultrasonic flow meters applied to non-ideal flow profiles

Transit time difference (TTD) ultrasonic meters have widespread applications due to their high dynamic range, lack of moving parts and low maintenance requirements. In earlier work, the TTD is considered to arise due to the fluid flow changing the effective speed of sound along a fixed ray path, but recent publications have introduced a new way of viewing how the TTD arises. The flow velocity in the axial direction does not affect the speed of sound in the direction normal to the pipe wall. Therefore, in a clamp-on meter with the fluid at constant temperature and pressure, the transit time in the liquid must be constant with changing flow rate. The TTD then arises due to the ray path in the water being deflected, and the received wavefront travelling some extra distance along the pipe axis, which results in a different transit through the transducer wedge than for zero flow conditions. In a meter with wetted transducers, the mechanism causing the TTD is slightly different. The deflected ray travels a different distance in the fluid along the direction normal to the pipe walls due to the transducer surface being at an angle to the flow direction, and this is responsible for the TTD that is measured.Previous work has focused on calculating the magnitude of the ray deflection effect in clamp-on meters for ideal flow conditions, where the flow velocity does not depend on the position in the pipe. In this article, the ray deflection is calculated for a series of analytic profiles, and it is shown that the two models result in the same calculated TTD for both clamp-on meters and meters with wetted transducers at low flow speeds. The hydraulic correction factors calculated using the model which considers a change in the effective speed of sound are recovered using the ray deflection models. The resulting equations for beam deflection are the same as those for the conventional fixed ray path model, but the beam deflection model is more physically realistic and presents new opportunities for calibration methods utilising carefully controlled movement of the transducers. The conventional model typically has a correction factor which is allowed to vary in cases where the flows are expected to approach the speed of sound to account for the effect of ray deflection. However, the ray deflection model automatically takes this into account, so is expected to be useful in these circumstances.

Photocell-Based Optofluidic Device for Clogging-Free Cell Transit Time Measurements.

Measuring the transit time of a cell forced through a bottleneck is one of the most widely used techniques for the study of cell deformability in flow. It in turn provides an accessible and rapid way of obtaining crucial information regarding cell physiology. Many techniques are currently being investigated to reliably retrieve this time, but their translation to diagnostic-oriented devices is often hampered by their complexity, lack of robustness, and the bulky external equipment required. Herein, we demonstrate the benefits of coupling microfluidics with an optical method, like photocells, to measure the transit time. We exploit the femtosecond laser irradiation followed by chemical etching (FLICE) fabrication technique to build a monolithic 3D device capable of detecting cells flowing through a 3D non-deformable constriction which is fully buried in a fused silica substrate. We validated our chip by measuring the transit times of pristine breast cancer cells (MCF-7) and MCF-7 cells treated with Latrunculin A, a drug typically used to increase their deformability. A difference in transit times can be assessed without the need for complex external instrumentation and/or demanding computational efforts. The high throughput (4000-10,000 cells/min), ease of use, and clogging-free operation of our device bring this approach much closer to real scenarios.

Effect of volume and methylene blue on fluorescence intensity and transit of indocyanine green for sentinel lymph node mapping in a simulated feline tumor model.

To compare the effect of volume and solution on transit time and fluorescence intensity (FI) using near-infrared fluorescence imaging (NIRF) in a simulated tumor model in cats. Secondarily, to describe SLN mapping with indocyanine green (ICG) NIRF and report any adverse effects of intradermally injected ICG in cats. 7 healthy purpose-bred domestic shorthaired male cats. Cats were randomly divided into 2 groups (ICG or ICG + methylene blue [MB]). Transit time and FI were determined for 1 or 2 mL solutions injected intradermally in 4 quadrants around a simulated tumor. Following massage, fluorescence intensity was quantified by calculating the corrected total ROI fluorescence using ImageJ software. Cats were monitored for adverse effects up to 4 weeks post-injection. A larger solution volume had decreased transit times to the SLN (P = .001). There was no significant difference in transit times between ICG and ICG-MB. ICG demonstrated a greater FI (P = .001) in the SLN compared to ICG-MB. Methylene blue did not percutaneously fluoresce under NIRF. The volume of the solution did not significantly affect FI. No adverse reactions were reported. Increased volume of ICG may aid in rapid percutaneous lymphatic tracking from tumor to SLN. Indocyanine green alone may be preferred over ICG-MB for greater visualization of the SLN. Intradermal injections of ICG and ICG-MB were well-tolerated in healthy cats with no significant complications. Clinical evaluation of this technique in an impaired lymphatic system, as seen in cancer patients, should be assessed in future research.

Effect of rapid maxillary expansion on masticatory and swallowing functions in children with posterior crossbite

ObjectiveInvestigate the influence of posterior crossbite on masticatory and swallowing functions by videofluoroscopy examination and to analyze the effects of Rapid Maxillary Expansion (RME) on the same functions. MethodsA prospective longitudinal study was conducted on 32 children, 21 of them with posterior crossbite (10 girls and 11 boys, mean age 9.2 years, study group) and 11 children with no occlusal changes (6 girls and 5 boys, mean age 9.3 years, control group). The children were evaluated by an orthodontist for diagnosis, group characterization and occlusal treatment, by the otorhinolaryngology team for the assessment of respiratory symptoms, and by a speech therapist for videofluoroscopic evaluation of masticatory and swallowing parameters. The children with posterior crossbite were treated orthodontic ally using the Haas disjunctor for approximately six months and re-evaluated 5-months after removal of the appliance. Data were analyzed statistically by the Studentt-test for independent samples for comparison of the crossbite and control groups before and after treatment. ResultsThere was no significant difference in oral preparatory and oral transit times, nor in cycles and masticatory frequency, between the pre and post orthodontic treatment groups and the control group. ConclusionRapid maxillary expansion did not influence the masticatory and swallowing variables studied by videofluoroscopy. However, the data require caution in interpretation.

Findings of a videofluoroscopic swallowing study in patients with dysphagia.

Swallowing examination is crucial in patients with dysphagia. We aimed to compare qualitative and quantitative videofluoroscopic swallowing study (VFSS) results to provide reference for standardizing quantitative parameters. In total, 117 patients with dysphagia were included, 38 with Parkinson's disease and 39 and 40 in convalescence following cerebral hemorrhage and infarction. VFSS was both qualitatively and quantitatively analyzed. A significant difference of Oral transit time was found between the oral motor function grades (p < 0.001), also was swallowing reaction times found between swallowing reaction duration grades (p < 0.001), and soft palate lift duration between the soft palate lift grades (p < 0.001). Superior hyoid bone movement (p < 0.001), anterior hyoid bone movement (p < 0.001), hyoid pause time (p < 0.001), and hyoid movement duration (p = 0.032) had significant differences between the hyoid laryngeal complex movement grades, as did the pharyngeal cavity transit time among the cricopharyngeal muscle opening duration grades (p < 0.001). The laryngeal vestibule closure duration differed among the glottic closure grades (p < 0.001). No statistically significant difference in upper esophageal sphincter opening diameter (p = 0.682) or duration (p = 0.682) among the cyclopharyngeal muscle opening duration grades. The pharyngeal area at rest did not significantly differ among the different vallecular residue (p = 0.202) and pyriform sinus residue (p = 0.116) grades. Several quantitative parameters can reflect the swallowing assessment process well. Further optimization of quantitative parameters is recommended.

Simultaneous data acquisition for improved performance in transit time difference ultrasonic flowmeters

Clamp-on ultrasonic transit time difference meters have many benefits for use in industry such as their non-intrusive nature, portability and ability to work with corrosive fluids. However, all transit time difference meters suffer from a sensitivity to changes in the speed of sound or flow profile in the fluid during the ultrasonic measurement. Trigger time jitter in the data acquisition electronics can also contribute to fluctuations in the output of the meter, since the upstream and downstream signals jitter back and forth in time independently of one another. Both of these mechanisms are a product of the method of data acquisition used, where one transducer is used as a generator and the signal is received on the other, then the other transducer is driven to send ultrasound the other way. A new method of performing the measurement is proposed in which the transducers are both driven simultaneously and the signal is received on both transducers at the same time, with the ultrasonic waves having passed through the same volume of fluid with the same flow profile. It is shown that fluctuations in the output of a flowmeter at constant flow rate can be reduced by over an order of magnitude compared to acquisition modes where the generation pulse and the start of data acquisition are not actively synchronised.

Parabolic equation simulation of diffraction effects in a sound beam propagating through a flowing fluid

Ultrasonic transit time difference flow meters are today industrially accepted for custody transfer measurements of oil and for natural gas. Such meters are currently planned to be used also subsea and in remote operations, where the calibration possibilities are few. In such applications the speed of sound measured by these meters will be a powerful input for estimation of density and calorific value of the flowing oil or gas. The ultrasonic transit time measurements in such meters are carried out in a flowing oil or gas, over a range typically between 6 and 40 in. For precise transit time measurements over such ranges, diffraction corrections may be of high importance. Diffraction effects for an acoustic beam generated by a uniform piston source and propagating through a flowing fluid are therefore studied numerically. The flow direction will be perpendicular to the propagation direction of the acoustic beam. The investigation is based on a narrow-angle three-dimensional parabolic equation. Effects both on amplitude and on phase will be presented.

Early Gastrointestinal Neuropathy Assessed by Wireless Motility Capsules in Adolescents with Type 1 Diabetes

To assess the prevalence of objective signs of gastrointestinal (GI) autonomic neuropathy (AN) in adolescents with type 1 diabetes (T1D). In addition, to investigate associations between objective GI findings and self-reported symptoms or other findings of AN. Fifty adolescents with T1D and 20 healthy adolescents were examined with a wireless motility capsule to assess the total and regional GI transit times and motility index. GI symptoms were evaluated with the GI Symptom Rating Scale questionnaire. AN was evaluated with cardiovascular and quantitative sudomotor axon reflex tests. There was no difference in GI transit times in adolescents with T1D and healthy controls. Adolescents with T1D had a higher colonic motility index and peak pressure than the controls, and GI symptoms were associated with low gastric and colonic motility index (all p < 0.05). Abnormal gastric motility was associated with the duration of T1D, while a low colonic motility index was inversely associated with "time in target range" for blood glucose (all p < 0.01). No associations were found between signs of GI neuropathy and other measures of AN. Objective signs of GI neuropathy are common in adolescents with T1D and it seems to require early interventions in patients at high risk of developing GI neuropathy.

Magnetic-Assisted Capsule Endoscopy in Children With Crohn Disease: Feasibility and Impact on Gastric Transit Time.

Standard capsule endoscopy (CE) is ineffective for upper gastrointestinal (GI) tract examination because it does not allow operator-controlled navigation of the capsule. Magnetically assisted capsule endoscopy (MACE) may offer a solution to these problems. This pilot study is aimed to evaluate the feasibility of MACE system in pediatric Crohn disease (CD) and if magnetic steering could enhance capsule gastric emptying when compared with standard CE. Pediatric CD patients already studied by standard small bowel CE were enrolled. All participants swallowed a magnetically assisted CE and an external magnetic field navigator was used to guide the capsule through the upper GI tract. Maneuverability, completeness of the MACE examination, differences in the esophageal transit time (ETT), gastric transit time (GTT), and pyloric transit time (PTT) between standard CE and MACE were assessed. Ten patients [mean age 11.4 years (range 6-15); 60% male] were enrolled. Maneuverability was defined as good and fair in 60% and 40% of participants, respectively. Completeness of MACE examination was 95%, 65%, and 92.5% in the esophagus, proximal, and distal stomach, respectively. Transpyloric passage of the capsule under magnetic control was successfully performed in 80% of patients. Magnetic intervention significantly increased ETT ( P < 0.001) and reduced GTT and PTT ( P = 0.002). No significant adverse events occurred. MACE is a safe and feasible technique in children. Magnetic steering enhances capsule gastric emptying and facilitates capsule transpyloric passage when compared with standard CE.

Mass derivation of planets K2-21b and K2-21c from transit timing variations

ABSTRACT While various indirect methods are used to detect exoplanets, one of the most effective and accurate methods is the transit method, which measures the brightness of a given star for periodic dips when an exoplanet is passing in front of the parent star. For systems with multiple transiting planets, the gravitational perturbations between planets affect their transit times. The difference in transit times allows a measurement of the planet masses and orbital eccentricities. These parameters help speculating on the formation, evolution, and stability of the system. Using transit timing variations (TTVs), we measure the masses and eccentricities of two planets orbiting K2-21, a relatively bright K7 dwarf star. These two planets exhibit measurable TTVs, have orbital periods of about 9.32 and 15.50 d, respectively, and a period ratio of about 1.66, which is relatively near to the 5:3 mean motion resonance. We report that the inner and outer planets in the K2-21 system have properties consistent with the presence of a hydrogen- and helium-dominated atmosphere, as we estimate their masses to be $1.59^{+0.52}_{-0.44}$ and $3.88^{+1.22}_{-1.07}\, \mathrm{ M}_\oplus$ and densities of $0.22^{+0.05}_{-0.04}$ and $0.34^{+0.08}_{-0.06}\, \rho _\oplus$, respectively (M⊕ and ρ⊕ are the mass and density of the Earth, respectively). Our results show that the inner planet is less dense than the outer planet; one more counterintuitive exoplanetary system such as Kepler-105, LTT 1445, TOI-175, and Kepler-279 systems.

Blood oxygenation-level dependent cerebrovascular reactivity imaging as strategy to monitor CSF-hemoglobin toxicity

ObjectivesCell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) may be one of the main drivers of secondary brain injury after aneurysmal subarachnoid hemorrhage (aSAH). Haptoglobin scavenging of CSF-Hb has been shown to mitigate cerebrovascular disruption. Using digital subtraction angiography (DSA) and blood oxygenation-level dependent cerebrovascular reactivity imaging (BOLD-CVR) the aim was to assess the acute toxic effect of CSF-Hb on cerebral blood flow and autoregulation, as well as to test the protective effects of haptoglobin. MethodsDSA imaging was performed in eight anesthetized and ventilated sheep (mean weight: 80.4 kg) at baseline, 15, 30, 45 and 60 minutes after infusion of hemoglobin (Hb) or co-infusion with haptoglobin (Hb:Haptoglobin) into the left lateral ventricle. Additionally, 10 ventilated sheep (mean weight: 79.8 kg) underwent BOLD-CVR imaging to assess the cerebrovascular reserve capacity. ResultsDSA imaging did not show a difference in mean transit time or cerebral blood flow. Whole-brain BOLD-CVR compared to baseline decreased more in the Hb group after 15 minutes (Hb vs Hb:Haptoglobin: -0.03 ± 0.01 vs -0.01 ± 0.02) and remained diminished compared to Hb:Haptoglobin group after 30 minutes (Hb vs Hb:Haptoglobin: -0.03 ± 0.01 vs 0.0 ± 0.01), 45 minutes (Hb vs Hb:Haptoglobin: -0.03 ± 0.01 vs 0.01 ± 0.02) and 60 minutes (Hb vs Hb:Haptoglobin: -0.03 ± 0.02 vs 0.01 ± 0.01). ConclusionIt is demonstrated that CSF-Hb toxicity leads to rapid cerebrovascular reactivity impairment, which is blunted by haptoglobin co-infusion. BOLD-CVR may therefore be further evaluated as a monitoring strategy for CSF-Hb toxicity after aSAH.

Algorithm to Correct Measurement Offsets Introduced by Inactive Elements of Transducer Arrays in Ultrasonic Flow Metering

Ultrasonic flow meters (UFMs) based on transducer arrays offer several advantages. With electronic beam steering, it is possible to tune the steering angle of the beam for optimal signal-tonoise ratio (SNR) upon reception. Moreover, multiple beams can be generated to propagate through different travel paths, covering a wider section of the flow profile. Furthermore, in a clamp-on configuration, UFMs based on transducer arrays can perform self-calibration. In this manner, userinput is minimized and measurement repeatability is increased. In practice, transducer array elements may break down. This could happen due to aging, exposure to rough environments, and/or rough mechanical contact. As a consequence of inactive array elements, the measured transit time difference contains two offsets. One offset originates from non-uniform spatial sampling of the generated wavefield. Another offset originates from the ill-defined beam propagating through a travel path different from the intended one. In this paper, an algorithm is proposed that corrects for both of these offsets. The algorithm also performs a filtering operation in the frequency-wavenumber domain of all spurious (i.e., flow-insensitive) wave modes. The advantage of implementing the proposed algorithm is demonstrated on simulations and measurements, showing improved accuracy and precision of the transit time differences compared to the values obtained when the algorithm is not applied. The proposed algorithm can be implemented in both in-line and clamp-on configuration of UFMs based on transducer arrays.

Transit Time index (TTi) as an adaptation of the humification index to illustrate transit time differences in karst hydrosystems: application to the karst springs of the Fontaine de Vaucluse system (southeastern France)

Abstract. Transit time can be estimated thanks to natural tracers, but few of them are usable in the 0–6-month range. The main purpose of this work is to analyze the potential of the ratio of heavy- to light-weight organic compounds (the humification index (HIX); Ohno, 2002; Zsolnay et al., 1999) as a natural tracer of short transit time (Blondel et al., 2012). Critical analysis of former studies shows that although the link between HIX and transit time seems consistent, the whole methodological approach needs to be consolidated. Natural organic matter fluorescence from 289 groundwater samples from four springs and 10 flow points located in the unsaturated zone of the Vaucluse karst system is characterized by parallel factor analysis (PARAFAC) thanks to the excitation–emission matrix (EEM), thus (i) allowing for the identification of main fluorescent compounds of sampled groundwater and (ii) evidencing the inadequacy of HIX 2D emission windows to characterize groundwater organic matter. We then propose a new humification index called the Transit Time index (TTi) based on the Ohno (2002) formula but using PARAFAC components of heavy and light organic matter from our samples instead of 2D windows. Finally, we evaluate TTi relevance as a transit time tracer by (i) performing a detailed analysis of its dynamics on a selected spring (Millet) and (ii) comparing its mean value over karst springs of the Vaucluse karst system. Principal component analysis (PCA) of TTi and other hydrochemical parameters monitored at Millet spring put in relief the different ranges of transit time associated with the different organic matter compounds. PCA results also provide evidence that TTi can detect a small proportion of fast infiltration water within a mix, while other natural tracers of transit time provide no or less sensitive information. TTi distributions at monitored karst springs are consistent with relative transit times expected for the small-scale, short average transit time systems. TTi thus appears as a relevant qualitative tracer of transit time in the 0–6-month range where existing tracers fail and may remain applicable, even in the case of anthropic contamination thanks to PARAFAC modeling. Transforming it into quantitative information is a challenging task which may be possible thanks to intensive studies of organic matter degradation kinetics in natural waters with the help of radiogenic isotope usage or an artificial tracer test.

Oral or intranasal immunization with recombinant Lactobacillus plantarum displaying head domain of Swine Influenza A virus hemagglutinin protects mice from H1N1 virus

BackgroundSwine influenza A virus (swIAV) is a major concern for the swine industry owing to its highly contagious nature and acute viral disease. Currently, most commercial swIAV vaccines are traditional inactivated virus vaccines. The Lactobacillus plantarum-based vaccine platform is a promising approach for mucosal vaccine development. Oral and intranasal immunisations have the potential to induce a mucosal immune response, which confers protective immunity. The aim of this study was to evaluate the probiotic potential and adhesion ability of three L. plantarum strains. Furthermore, a recombinant L. plantarum strain expressing the head domain of swIAV antigen HA1 was constructed and evaluated for its ability to prevent swIAV infection.ResultsThe three L. plantarum strains isolated from healthy pig faecal samples maintained the highest survival rate when incubated at pH 3 and at bile salt concentration of 0.3%. They also showed high adherence to intestinal cells. All three L. plantarum strains were monitored in live mice, and no major differences in transit time were observed. Recombinant L. plantarum expressed swIAV HA1 protein (pSIP401-HA1-ZN-3) and conferred effective mucosal, cellular and systemic immune responses in the intestine as well as in the upper respiratory airways of mice. In conclusion, the oral and intranasal administration of L. plantarum strain pSIP401-HA1-ZN-3 in mice induced mucosal immunity and most importantly, provided protection against lethal influenza virus challenge.ConclusionIn summary, these findings suggest that the engineered L. plantarum strain pSIP401-HA1-ZN-3 can be considered as an alternative approach for developing a novel vaccine during an swine influenza A pandemic.

Comparison of gastrointestinal landmarks using the gas-sensing capsule and wireless motility capsule.

Accurate definition of the gastroduodenal and ileocaecal junctions (GDJ, ICJ) is essential for the measurement of regional transit times. To compare the assessment of these landmarks using the novel gas-sensing capsule and validated wireless motility capsule (WMC), and to evaluate intra-subject variance in transit times METHODS: Healthy subjects ingested the gas-sensing capsule and WMC tandemly in random order. Inter-observer agreement was evaluated by intra-class correlation coefficient (ICC). Agreement between the paired devices' transit times was assessed using Bland-Altman analysis; coefficient of variation was performed to express intra-individual variance in transit times. Similar analyses were completed with tandemly ingested gas-sensing capsules. The inter-observer agreement for landmarks for both capsules was excellent (mean ICC ≥0.97) in 50 studies. The GDJ was identifiable in 92% of the gas-sensing capsule studies versus 82% of the WMC studies (p= 0.27); the ICJ in 96% versus 84%, respectively (p= 0.11). In the primary cohort (n= 26), median regional transit times differed by less than 6min between paired capsules. Bland-Altman revealed a bias of -0.12 (95% limits of agreement, -0.94 to 0.70) hours for GDJ and -0.446 (-2.86 to 2.0) hours for ICJ. Similar results were found in a demographically distinct validation cohort (n= 24). For tandemly ingested gas-sensing capsules, coefficients of variation of transit times were 11%-35%, which were similar to variance between the paired gas-sensing capsule and WMC, as were the biases. The capsules were well tolerated. Key anatomical landmarks are accurately identified with the gas-sensing capsule in healthy individuals. Intra-individual differences in transit times between capsules are probablydue to physiological factors. Studies in populations with gastrointestinal diseases are now required.

Measuring glomerular blood transfer rate in kidney using diffusion-weighted arterial spin labeling.

To propose a two-compartment renal perfusion model for calculating glomerular blood transfer rate ( ) as a new measure of renal function. The renal perfusion signal was divided into preglomerular and postglomerular flows according to flow velocity. By analyzing perfusion signals acquired with and without diffusion gradients, we estimated , the blood transfer rate from the afferent arterioles into the glomerulus. A multislice multidelay diffusion-weighted arterial spin labeling sequence was applied to subjects with no history of renal dysfunctions. In the multiple b-value experiment, images were acquired with seven b-values to validate the bi-exponential decays of the renal perfusion signal and to determine the appropriate b-value for suppressing preglomerular flow. In the caffeine challenge, six subjects were scanned twice on the caffeine day and the control day. The values of the two dates were compared. The perfusion signal showed a bi-exponential decay with b-values. There was no significant difference in renal blood flow and arterial transit time between caffeine and control days. In contrast, cortical was significantly higher on the caffeine day (caffeine day: min control day: min ). These results were consistent with those from the literature. We showed that the perfusion signal consists of two compartments of preglomerular flow and postglomerular flow. The proposed diffusion-weighted arterial spin labeling could measure the glomerular blood transfer rate ( ), which was sensitive enough to noninvasively monitor the caffeine-induced vasodilation of afferent arterioles.

Singlemode-Multimode-Singlemode Optical Fiber Sensor for Accurate Blood Pressure Monitoring

A dual-channel single-mode-multi-mode-single-mode (SMS) fiber optic sensor encapsulated by polydimethylsiloxane (PDMS) was proposed for the first time, for the simultaneous monitoring of the brachial and radial arteries for accurate blood pressure prediction. With the help of the machine learning algorithm Support Vector Regression (SVR), the SMS fiber sensor can continuously and accurately monitor the systolic and diastolic blood pressure. Commercial sphygmomanometers are used to calibrate the accuracy of blood pressure measurement. Compared with the single-channel system, this system can extract more pulse wave features for blood pressure prediction, such as radial artery transit time (RPTT), brachial artery transit time (BPTT), and the transit time difference between the radial artery and the brachial artery (DBRPTT). The results show that the performance of dual-channel blood pressure monitoring is more accurate than that of single-channel blood pressure monitoring in terms of the absolute value of the correlation coefficient (R) and the average value of the difference between SBP and DBP. In addition, both the single-channel and dual-channel blood pressure monitoring are in line with the Association for the Advancement of Medical Devices (AAMI), but the average deviation (DM, 0.06 mmHg) and standard deviation (SD, 1.54 mmHg) of dual-channel blood pressure monitoring are more accurate. The blood pressure monitoring system has the characteristics of low cost, high sensitivity, non-invasive and capability for remote real time monitoring, which can provide effective solution for intelligent health monitoring in the era of artificial intelligence in the future.

Correlation of CT perfusion with MRI brain in symptomatic carotid artery stenosis

BackgroundCerebral white matter disease and large vessel cerebral steno-occlusive are both associated with high incidence of strokes and mortality. There is a lack of literature correlating the cerebral perfusion downstream of a stenotic lesion with white matter changes in the cerebral hemispheres. The aim of this study was to correlate the white matter changes in magnetic resonance imaging (MRI) with computed tomography (CT) perfusion parameters in patients with symptomatic carotid stenosis. MethodsA total of 50 patients with symptomatic carotid stenosis underwent MRI brain and CT Perfusion. Percentage differences in cerebral blood flow (CBF) and mean transit time (MTT) were correlated with symmetric and asymmetric small vessel ischemic disease (SVID) on MRI. Receiver operating characteristic (ROC) curve analysis was performed to determine sensitivity and specificity for different values of percentage CBF and MTT difference. ResultsA total of 17 patients with symmetrical SVID had a mean CBF difference of 6.58 (SD of 3.17) and mean MTT difference of 11.61 (SD of 4.32). 33 patients with asymmetrical SVID had a mean CBF difference of 34.73 (SD of 6.87) and mean MTT difference of 44.63 (SD of 9.12). ROC curve analysis showed percentage CBF and MTT differences of 12.5% and 26.5% respectively to be associated with 100% specificity and sensitivity. ConclusionIn patients with symptomatic carotid stenosis, CT perfusion parameters correlate with MRI features of SVID.

Transducer Design for Clamp-on Guided Wave Flow Measurement in Thin-Walled Pipes

Clamp-on ultrasonic transit time difference flow meters provide opportunities for metering where it is impractical or undesirable to cut into an existing pipeline to install an alternative flow meter. Up until now, it has been difficult to perform this type of measurement on thin-walled metal pipes, due to the difficulty of interpreting the guided wave modes in the combined pipe wall and internal fluid system, but a new method has been reported recently that utilises these guided wave modes for flow measurement. Through computational modelling, and construction and testing of different transducers, the design considerations for clamp-on transducers are highlighted and their impact on guided wave flow rate measurement is evaluated. The design features considered include a curved contact face to provide focusing of the ultrasound within the pipe and a scattering surface to reduce internal reflections. It is found that additional unwanted ultrasonic modes can be minimised by ultrasonic transducer wedge design features such as profiling the curvature of the transducer to conform to the pipe wall or creating a scattering edge to minimise internal wedge reflections. It is also observed that minimising these unwanted modes does not offer any advantage for the transit time difference measurement used in calculating flow.