Dietary Intake Of Pb Research Articles

Exposure sources, intake pathways and accumulation of lead in human blood

Lead (Pb) is a toxic heavy metal and its long-term accumulation in human bodies can lead to serious diseases. Investigation on Pb exposure provides an effective intervention opportunity to reduce the blood lead levels (BLLs) of the populations. Although the phase-out of the gasoline has been conducted in many developing countries (e.g., China), the BLLs of these populations are still higher than the alert BLL (5.0 μg/dL) set by World Health Organization (WHO) and Centers for Disease Control and Prevention of USA (CDC). Here, we reviewed the BLLs of the populations in different countries and summarized the sources and intake pathways of blood Pb which were associated with dietary Pb intake and non-dietary Pb intake. Extensive progress has been made in the studies of soil biogeochemistry and the plant biological processes, including the effects of soil pH, redox potential, Fe/Mn oxides, and organic matter on the availability of soil Pb, as well as the mechanisms regulating the Pb absorption by plant root and transport from root to shoot. The oral-nasal respiration and skin infiltration pathways have been specifically identified as the main causes of the increased BLLs of the populations exposed to different Pb sources. In the developing countries, complex dietary and non-dietary Pb intakes increase the BLLs, making intervention strategies to reduce BLLs difficult. This review provides a systematic understanding in the processes and mechanisms of Pb intake from environment to human blood and helps to guide safe strategies to reduce the BLLs and enhance human health.

Assessment of the Long-Term Exposure to Lead in Four European Countries Using PBPK Modeling

Lead (Pb) is a naturally occurring heavy metal that received, in the last decades, much attention in the human health risk assessment community. In the European Human Biomonitoring Initiative (HBM4EU), Pb was identified as a priority substance as various scientific and policy questions were open and still to be answered. They included the further investigation of the internal exposure to Pb, the factors determining it, and its variations within European populations. The aim of this work was to develop an integrative modeling framework for the assessment of the aggregated long-term exposure to Pb in Belgium, Czech Republic, Germany, and Norway. This framework enabled predicting the concentrations of Pb in human blood (PbB) from estimates of the external exposure. The effect of past and current exposure events was accounted for, as multiple country-specific Pb concentration data in environmental compartments and diet, and estimates of the dietary intake of Pb covering a period from the 1970s until the present times were compiled. This modeling approach allowed, using a two-dimensional Monte Carlo (MC2D) approach, running a population-based simulation and characterizing the inter-individual variability within the simulated populations and the uncertainty on the external exposure estimates. The predicted PbB levels were compared with the results drawn from HBM data. To the best of our knowledge, this holistic modeling approach combines for the first time temporal and country-specific trends in environmental lead concentrations to derive internal exposure, in order to get better insights into the relationship between environmental and human lead exposure, and to characterize individual exposure at different ages.Graphical

Bioaccumulation of selected trace elements in some aquatic organisms from the proximity of Qeshm Island ecosystems: Human health perspective

In this study selected marine species from north Persian Gulf ecosystems were collected to investigate the concentration of 15 trace elements (Al, As, Co, Cr, Cu, Fe, Li, Mo, Ni, Pb, Se, Sr, V, Zn and Hg) in muscle and liver tissues for the purpose of evaluating potential health risks for human consumers. The results indicated that Fe, Zn, Sr, Cu and As are the most abundant TEs in the tissues of the species. The concentration of Cu in P. semisulcatus and As in most investigated species pose the highest risk of exposure. The carcinogenic risk values indicate that As and Ni concentrations in the species are above the acceptable lifetime risk for adults and children in most of the species. The margin of exposure risk approach indicated that the risk of detrimental effects due to dietary Pb intake for age groups is low, except for consumers of T. tonggol.

Dietary Intake of Toxic Heavy Metals with Major Groups of Food Products-Results of Analytical Determinations.

Food contains a complex matrix of various substances, including essential nutrients, non-nutritive substances, and toxins, including metals. The main purpose of the study was to evaluate the contribution of major groups of food products to an overall intake of toxic heavy metals (Cd, Pb, Hg, and Ni) using a combination of the 24-dietary recall technique, the ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometry) method, and chemometric tools. The obtained results reveal that there is a high potential risk of developing nephrotoxicity through the dietary intake of Pb in the case of both genders. The dietary intake determined for other elements (Cd, Hg, and Ni) was far below the limits established by European Food Safety Authority (EFSA). Principal Component Analysis (PCA) supported analytical determinations and revealed that cereals and vegetables were major contributors to a total intake of Cd (39.6 and 17.4% of the total exposure, respectively), Ni (40.4 and 19.3%), and Hg (16.8 and 19.6%), while water and beverages were major dietary sources of Pb (31% of the total daily intake). In contrast, eggs, fats and oils, and milk and dairy products provided the smallest amounts of Cd, Pb, and Ni. Despite containing high amounts of Hg, considering very low consumption, fish were not found to be an important source of this element.

Risk assessment of potentially toxic trace elements via consumption of dairy products sold in the city of Yerevan, Armenia

The study aimed to investigate the potentially toxic trace elements (PTEs) Pb, Cd, Hg, Mo, and Cu in dairy products sold in Yerevan's markets and to assess the related exposure and possible health risks among the adult population residing in the capital city of Armenia, Yerevan.The PTEs contents were determined in widely consumed dairy products (pasteurized milk, sour cream, matsoun and cheese from cow milk) using graphite furnace atomic absorption spectrometry. PTE contents were in the range of 7.90E-04 (Pb in pasteurized milk) to 6.75E-01 (Cu in cheese) mg/kg. Food consumption was assessed by the 24-h dietary recall method. The PTE daily intakes and margin of exposure (MOE) were calculated by the deterministic approach.The results indicated potential health concerns for the contribution of dairy products to the overall dietary intake of Pb and Cd. MOEs of Pb and Cd (8.71 and 8.80, respectively) estimated for high consumers of cheese (90 g/day and more) were lower than 10. The pilot data set provides the first comprehensive appraisal on the dairy products contamination by PTEs in the Caucasus region. The results point out further attention to sources of Pb and Cd in Armenian dairy products, including environment and farm characteristics.

Exposure to Lead and Cadmium in the Sixth Total Diet Study - China, 2016-2019.

What is already known about this topicLead (Pb) and cadmium (Cd) are widespread toxic heavy metal pollutants in the environment. Dietary intakes of Pb and Cd have been a major concern in the world.What is added by this report?The average dietary exposure to Pb and Cd among Chinese adult males from the Sixth China Total Diet Study (TDS) was within acceptable levels, except for a potential health risk of Cd exposure among adult men in Hunan Province.What are the implications for public health practice?It is necessary to continuously monitor the levels of Pb and Cd in foods. More attention should be paid to dietary Cd exposure in Hunan Province.

Derivation of human health risk-based thresholds for lead in soils promote the production of safer wheat and rice

A reliable and accurate soil threshold helps prevent excessive dietary Pb intake risks to consumers of locally grown wheat and rice crops. Based on a three-year investigation of 206 wheat fields and 358 rice fields throughout China, this study aimed to improve the soil protection guidelines by investigating Pb accumulation in soil-wheat and soil-rice systems and by assessing Pb exposure risks through the soil-grain-human pathway. A site-specific bioconcentration factor (BCF, ratio of Pb concentration in plant to that in soil) was calculated and used to assess grain Pb intake risks instead of a generic BCF value to reduce data uncertainty. In addition to soil pH, cation-exchange capacity exerted a major influence on the Pb BCF variations in wheat, whereas the organic carbon dynamics affected the BCF variations in rice. Once normalized BCF against those soil variables, the distributions of BCF were log-normal in nature. Optimizing the pH and cation-exchange capacity of wheat soils would help protect 49.8% of local adults from excessive Pb dietary intake. The scenario soil thresholds linked to soil variables and grain Pb intake risks were then derived and validated by independent data from field surveys and published articles. Poor production practices in the wheat fields under study included using soils with low fertility.

Assessment of the risks from dietary lead exposure in China

The dietary lead (Pb) risk across China was assessed based on the margin of exposure (MOE) approach by comparing the level (1.5 μg/kg/d) based on the Pb concentrations in foodstuffs from1386 published articles. The Pb averages of the 18 foods were lower than their corresponding limits enacted by the Chinese government, ranging from 0.09 to 0.30 mg/kg. Food from plants had a much higher contribution to dietary Pb intake than that from animals (86% vs. 14%), and cereals and vegetables contributed 79% of the Pb intake from plant-based food. Although each category of food contained a relatively low Pb concentration, the accumulated Pb from the total diet posed a high risk to human health. The MOE risk from dietary Pb averaged 1.57 and ranged from 0.13 to 6.18, with high risks in southern, southwestern, eastern, central, and northern China. The MOE risk from Pb could be decreased by adjusting the dietary structure, and the ratio of people categorized as high risk (MOE < 1) would decrease from 56% to 37%, 41%, or 24% if the category of cereal or vegetable or both cereals and vegetables with the lowest Pb concentration in their local areas were selected, respectively.

Variation in the Estimated Value of Dietary Pb Intake among the General Korean Population: Domestic Research from 2008 to 2018

Variation in the Estimated Value of Dietary Pb Intake among the General Korean Population: Domestic Research from 2008 to 2018

Lead Toxicity in Cereals: Mechanistic Insight Into Toxicity, Mode of Action, and Management.

Cereals are the major contributors to global food supply, accounting for more than half of the total human calorie requirements. Sustainable availability of quality cereal grains is an important step to address the high-priority issue of food security. High concentrations of heavy metals specifically lead (Pb) in the soil negatively affect biochemical and physiological processes regulating grain quality in cereals. The dietary intake of Pb more than desirable quantity via food chain is a major concern for humans, as it can predispose individuals to chronic health issues. In plant systems, high Pb concentrations can disrupt several key metabolic processes such as electron transport chain, cellular organelles integrity, membrane stability index, PSII connectivity, mineral metabolism, oxygen-evolving complex, and enzymatic activity. Plant growth-promoting rhizobacteria (PGPR) has been recommended as an inexpensive strategy for remediating Pb-contaminated soils. A diverse group of Ascomycetes fungi, i.e., dark septate endophytes is successfully used for this purpose. A symbiotic relationship between endophytes and host cereal induces Pb tolerance by immobilizing Pb ions. Molecular and cellular modifications in plants under Pb-stressed environments are explained by transcription factor families such as bZIP, ERF, and GARP as a regulator. The role of metal tolerance protein (MTP), natural resistance-associated macrophage protein (NRAMP), and heavy metal ATPase in decreasing Pb toxicity is well known. In the present review, we provided the contemporary synthesis of existing data regarding the effects of Pb toxicity on morpho-physiological and biochemical responses of major cereal crops. We also highlighted the mechanism/s of Pb uptake and translocation in plants, critically discussed the possible management strategies and way forward to overcome the menace of Pb toxicity in cereals.

Assessment of lead food contamination and dietary intake in a Northern Italian population

Abstract Background Lead is a heavy metal naturally occurring in the environment and also released by some anthropogenic activities. Food is one the major sources of human exposure for non-occupationally exposed individuals. In this study, we aimed at characterizing lead (Pb) content in foods consumed in Northern Italy population, in order to estimate its dietary intake. Methods We measured lead content in 908 food and beverage samples bought at small shops and supermarkets of the Northern Italy provinces of Modena and Reggio Emilia, through inductively coupled plasma mass spectrometry. We used a validated semi-quantitative food frequency questionnaire to assess the dietary habits of a representative sample of 719 individuals (319 males and 400 females) aged 18-87 years residing in Northern Italy (Emilia Romagna). We estimated weekly dietary intakes of Pb, and we compared them with safety standards set by the European Food Safety Authority (EFSA). Results In this population, vegetables and vegetables products were the main contributors to Pb intake. The highest levels of Pb were in edible offal, and then in crustaceans, dry fruits, chocolate free sweet confectionery, and coffee and tea as beverages. In general, Pb levels in our samples were comparable and did not exceed the average contamination levels reported by EFSA in various European countries. We found a comparable average Pb intake in both sexes. Average weekly intake of Pb was below EFSA recommended provisional tolerable weekly intake. Conclusions Our study provides an updated assessment of lead exposure through diet in a Northern Italian community. Although environmental lead contamination and exposure have markedly decreased in the last decades, recent evidence pointed out that a safety threshold value cannot yet be established for prevention of adverse effects due to lead exposure, since even low levels of lead intake may still increase the risk of chronic renal disease and hypertension. Key messages Food is one the major lead sources of human exposure for non-occupationally exposed individuals. Lead levels in Northern Italian population studied are comparable and do not exceed the average contamination levels reported by European Food Safety Authority in various European countries.

Lead (Pb) Accumulation in Plants Grown on Contaminated Soil

The effects of Pb treatments on Pb uptake by three food crops were investigated in a growth chamber experiment. Pb was added as Pb-acetate at the rates of 0, 200, 1000 and 2000 mg/kg soil. Lead concentrations in some plant parts were influenced more dramatically by soil Pb treatments than levels in other plant sections. Lettuce and carrot roots accumulated markedly higher Pb concentrations than the other plant parts. Since excessive dietary intake of Pb is undesirable, growth of Pb-responsive crops in contaminated soils should be avoided.

Monitoring and Risk Assessment of Lead and Cadmium in Various Agricultural Products Collected from the Korean Market

This study was carried out to determine the levels of lead and cadmium as found in nine agricultural products (n = 578) sold in Korea, and to estimate the risk to human health that is summarily associated with their intake. The concentrations of Pb and Cd were measured using an ICP-MS after microwave digestion in this study. The average contents of Pb and Cd were measured as 0.014 and 0.017 mg/kg for barley, 0.006 and 0.005 mg/kg for mung bean, 0.008 and 0.007 mg/kg for kidney bean, 0.010 and 0.004 mg/kg for green bean, 0.008 and 0.001 mg/kg for pineapple, 0.016 and 0.002 mg/kg for apricot, 0.015 and 0.002 mg/kg for Japanese apricot, 0.021 and 0.002 mg/kg for plum and 0.019 and 0.003 mg/kg for jujube, respectively. The levels of Pb and Cd in the study samples were less than the maximum residual levels established by the European Union (EU), CODEX, and the Korea Food Code. As we have seen, the daily dietary exposures of Pb and Cd from these agricultural products for the general population were noted as 0.067% of PTWI (25μg/kgb.w./week) and 0.28% of PTMI (25 μg/kg b.w./month), respectively. In line with the study conclusions, these results suggest that the current dietary intakes of Pb and Cd from these agricultural products in Korea have no appreciable risk effects on health for humans as noted in this experiment.

Effects of graded concentrations of supplemental lead on lead concentrations in tissues of pigs and prediction equations for estimating dietary lead intake.

The objectives of this experiment were to determine the effects of graded dietary lead (Pb) concentrations on body weight and Pb concentrations in blood, hair, soft tissues, and urine from pigs and to generate equations for estimating daily Pb intake. Sixteen barrows with initial body weight 36.3 kg (standard deviation = 2.3) were allotted to four dietary treatments that consisted of graded supplemental Pb concentrations (0, 10, 25, and 250 mg/kg of diet). Daily feed allowances for each pig were 1 kg for first two weeks and 2 kg for last two weeks. The hair and blood of pigs were collected on d 14 and 28. At the end of experiment, the pigs were euthanized, and the liver, kidneys, muscle, and urine samples were collected. The prediction equations for estimating daily Pb intake of pigs were generated using Pb concentration of blood, hair, tissues, or urine as an independent variable. The Pb concentrations in the blood, hair, liver, kidneys, muscle, and urine linearly increased (P < 0.01) with increasing dietary Pb concentrations. There were quadratic effects (P < 0.05) of increasing dietary Pb concentration on Pb concentrations in the blood, hair, and muscle. There were highly positive correlations between dietary Pb concentration and Pb concentrations in the blood, hair, liver, kidneys, muscle, and urine (r > 0.83; P < 0.01). The equations were significant (P < 0.01) and showed high r2 (>0.83), except the equation using Pb concentration in the muscle as an independent variable. In conclusion, the dietary Pb concentration was highly correlated with Pb concentrations in the blood, hair, soft tissues, and urine of pigs. The total dietary Pb intake can be estimated from the Pb concentrations in the blood, hair, soft tissues, or urine for pigs.

Risk assessment of dietary lead exposure among First Nations people living on-reserve in Ontario, Canada using a total diet study and a probabilistic approach

Indigenous peoples have elevated risk of lead (Pb) exposure as hunted traditional food can be contaminated with lead-containing ammunition. Recent scientific consensus states that there is no threshold level for Pb exposure. The objective of this study was to estimate dietary exposure to Pb among First Nations living on-reserve in the province of Ontario, Canada. A total diet study was constructed based on a 24-h recall and Pb concentrations for traditional foods from the First Nations Food, Nutrition, and Environment Study (FNFNES) and Pb concentrations in market foods from Health Canada. A probabilistic assessment of annual and seasonal traditional food consumption was conducted. Results indicate that traditional foods, particularly moose and deer meat. are the primary source of dietary Pb intake (73%), despite providing only 1.8% of the average caloric intake. The average dietary Pb exposure (0.21μg/kg/d) in the First Nations population in Ontario was 1.7 times higher than the dietary Pb exposure in the general Canadian population. Pb intake was associated with an estimated average increase in systolic blood pressure of 1.2mmHg. These results indicate that consumption of foods hunted with Pb containing ammunition and shot puts the population at elevated risk of Pb toxicity.

Health risk assessment of Chinese consumers to lead via diet

ABSTRACTThis paper investigated the concentrations of Pb in foods and the potential health risk from Pb exposure via surveys and a literature review. It was shown that the mean Pb concentration in different food groups was in the following decreasing order: marine products > meat > egg > vegetable > cereal > bean> dairy > fruit. More precisely, on average the weekly Pb intake (mg kg−1 bw week−1) for men, women, 2–3-year-old children, and 4–17-year-old children was 0.0055, 0.0059, 0.0145, and 0.0091, respectively. We used both deterministic and probabilistic methods to estimate the target hazard quotients (THQs) by comparing the dietary Pb intake estimation with respect to the provisional tolerable weekly intake (PTWI). The result showed that THQ values were lower than 1 in most cases, except the 97.5th percentile THQ values for 2–3-year-old children, and the probability of greater dietary Pb exposure than the tolerant weekly intake (THQ > 1) were 0.2%, 0.6%, 3.7%, and 1.2% for adult men, women, 2–3-year-old children, and 4–17-year-old children, respectively, indicating a low health risk for Chinese consumers. Among all groups, children, especially 2–3-year-old children were the most sensitive sub-population with regard to Pb exposure. Finally, it still appeared necessary to continue undertaking efforts to reduce exposure to Pb.

Daily dietary intakes of zinc, copper, lead, and cadmium as determined by duplicate portion sampling combined with either instrumental analysis or the use of food composition tables, Shiraz, Iran.

Estimation of essential and toxic element intakes is crucial to evaluate the risks of deficiency or toxicity. The purpose of this study was to investigate and also to compare the dietary intakes of zinc (Zn) and copper (Cu) by adults living in Shiraz, Iran, determined by two procedures: duplicate portion sampling of 21 hospital meals combined with either instrumental analysis (voltammetric measurement) or the use of food composition tables (FCTs). The level of exposure to lead (Pb) and cadmium (Cd) was evaluated as well. The daily Zn intakes of both methods were not significantly different and were higher than the RDA values except the value measured by the instrumental analysis which was lower than the RDA established for a male adult. Daily intake of Cu determined by instrumental analysis was significantly lower and closer to RDA for adults compared with the value estimated by FCTs. The dietary intakes of Pb and Cd were 313 and 61% of the respective provisional tolerable weekly intakes (PTWIs), respectively. The accuracy of two methods used for estimation of Zn intake was similar. In the case of Cu, the use of FCTs, in which the influence of environmental conditions and dietary habits of meal preparation is not taken into account, overestimated dietary intake. The risk of zinc deficiency was found in adult males. Moreover, the estimated intake of Pb, but not Cd, could be a cause of concern for Shiraz population. Thus, conducting regular periodic studies to assess the dietary intake of mentioned elements are recommended.

Health Risks Evaluation of Heavy Metals in Seafood

ABSTRACT Fish is an excellent, low-fat source of protein and provides many benefits, such as contributing to low blood cholesterol. Heavy metals are increasingly being released into natural waters from geological and anthropogenic sources. Due to the rapid development of agriculture and industry, and a historical lack of enforcement of regulations, the study areas have become contaminated by metals, especially cadmium (Cd) and lead (Pb) which has been emitted into the environment through atmospheric deposition, solid-waste emissions, sludge applications, and irrigations with wastewater. The health risks posed to the local inhabitants by exposure to Pb and Cd in two coastal regions of Iran through the consumption of contaminated fish were investigated, based on estimated target hazard quotients (THQs). The results showed that THQ values are less than 1 for both adults and children by either group consuming fish alone. The distribution of several heavy metals (Cd and Pb) was investigated in muscle and liver in six different fish species seasonally collected in the Persian Gulf (autumn 2008 - summer 2009). The concentrations of all metals were lower in flesh than those recorded in liver due to their physiological roles. The THQ index for fish was calculated. Estimation of target hazard quotients calculations for the contaminated fish consumption was calculated to evaluate the effect of pollution on human health. Total metal THQs values (Pb and Cd) for adults were 0.05 and 0.04 in Bushehr and Bandar-Genaveh, respectively, and for children was 0.08 and 0.05 in Bushehr and Bandar-Genaveh, respectively. The dietary intake of Pb estimated for the inhabitants in this area is far below the limit considered tolerable. The Cd intake through the consumption of fish is also less than the limit of daily dietary intake considered tolerable by FAO/WHO.

Pb in medicinal plants from Jordan

This is the first report on Pb in medicinal herbs from Jordan. Medicinal herbs may present a health risk due to the presence of toxic metals. Seventy-nine dry medicinal plant samples were collected from herbalist shops in Jordan. The plants were digested with acids and analyzed for total Pb concentration using atomic absorption spectrometry. Mean Pb concentration was 15.9 μg/g on a dry weight basis. Our results show that Pb concentrations in Jordan medicinal plants are higher than published data in other countries. The highest level of 33.4 μg Pb/g was determined in Inula viscosa, and the lowest level of 3.0 μg Pb/g was found in Nigella sativa. Calculated daily intakes of Pb of most analyzed herbs were high; most of them are higher than recommended values by the world health organization (WHO). Fortunately, the herbs that contain the highest Pb levels are the less commonly used medicinal herbs in Jordan. The mean Pb levels in the most commonly, commonly and less commonly used herbs in Jordan are 13.9, 13.1 and 16.9 μg Pb/g, respectively. The average dietary intake of Pb through a mixture of these medicinal herbs consumption, assuming 5.0 g herbs is consumed daily, is 79.5 μg Pb/day, which is higher than the maximum daily limit allowed by WHO. We conclude that most of the medicinal plants consumed in Jordan contain significant amount of Pb, and therefore, people of Jordan should not consume large amounts of these herbs.

식품군별 섭취중량 변화에 따른 납의 경구섭취 추정량의 경년변화

Objectives: The aim of this study is to examine the possible changes over the past ten years in the estimated daily dietary lead intake (Pb-D) stemming from the variation of daily intake amounts for each food group. The following factors were considered; 1. time trends in Pb-D as the estimated values, 2. the time trend in Pb-D by food groups 3. the most influential food groups for dietary Pb intake. Methods: Estimated Pb-D was drawn from food consumption according to food groups reported in the Korean National Health and Nutrition Survey and the lead contents of each food group as reported in 23 prior publications. Results: The estimated Pb-D in a 2009 survey was 40.8 <TEX>${\mu}g/day$</TEX>, of which 22.5 <TEX>${\mu}g/day$</TEX> (55.1%) was of plant origin and 18.3 <TEX>${\mu}g/day$</TEX> (44.9%) was of animal origin. Meats and poultry, fish and shellfish among foods of animal origin and beverages of plant origin had the largest contribution in Pb-D among the food groups. Conclusion: Over past ten years, daily lead intakes have slightly increased among men. Otherwise, no clear variation is apparent among women.