Diet Of Albino Rats Research Articles

The Effect of Zizyphus spina-christi Extracts on hyperglycemia induced by hyperlipidemic diet in Albino rats

The study was carried out to evaluate the protective effects of Ziziphus Spina Christi (ZSC) leaves, fruits and seed extracts to ameliorate the adverse effects of hyperglycemia induced in Albino rats. Ziziphus Spina Christi seeds, fruit and leaves extracts revealed positive results for carbohydrates, phenols, saponins, alkaloids, tannins, steroids, and flavonoids. High-fat diet intake has been associated with many pathological alterations in all studied parameters; one of these pathological alterations was hyperglycemia. Treatment of hyperglycemic rats with ZSC leaves, fruits and seeds extracts reduced these pathological alterations. Hyperglycemic rats were treated with ZSC seeds, fruit and leaves ethanolic extracts separately and in combination for 7 weeks. Results showed that the extracts succeeded in reducing the elevated glucose, insulin and HbA1C levels. On the other hand, the extracts improved histological alterations induced by a hyperlipidemic diet.

Moringa oleifera attenuates testicular damage induced by high fructose diet in Albino rats: Histological study

Moringa oleifera attenuates testicular damage induced by high fructose diet in Albino rats: Histological study

RETRACTED: Cinnamomum zeylanicum alleviate testicular damage induced by high fat diet in albino rats; histological and ultrastructural studies

Hyperlipidemia has been related to sever health outcome include cardiovascular complication, metabolic disorders and infertility. Moreover, obesity has also been linked to dangerous effects on testicular morphology, spermatogenesis and sperm malformation. Many studies using different herbal medicines exert protective and therapeutic effect on the testes, spermatogenesis and fertility in animals fed high fat diet. Objective: this study aimed to find out the protective effect of cinnamon on testes of albino rat fed high fat diet (HFD). Forty adult male albino rats were selected and equally divided into 4 groups. Group 1: animals of this group were fed standard diet. Group 2: rats were fed standard diet and cinnamon “15% weight by weight, w/w” for 8 weeks. Group 3: animals in this group were fed HFD (2% cholesterol, 15 % sucrose, 15% corn, 15% cocoa butter, starch and 4.7% cellulose) for 8 weeks. Group 4: animals in this group were fed HFD and cinnamon. At the end of 4 weeks half animals were sacrificed and the rest of animals were sacrificed at the end of 8 weeks and blood samples were collected to assay the testosterone level. As well as testes were taken and prepared for both histological and ultrastructure studies. Histological examination of testicular tissue of HFD-fed animals revealed many pathological changes include degenerated seminiferous tubules, distorted germinal layers and interstitial tissue appeared degenerated with intertubular hemorrhage. Ultrastructural observations showed severe degenerated features including both different types of spermatogonia and interstitial tissue. On the other hand, both histological and ultrastructural alterations were substantially but not completely protect in obese animals fed HFD and cinnamon for 4 weeks while advanced degree of improvement tissue appeared after 8 weeks of the same treatment. As well as, significantly increase in the level of testosterone was recorded when compared with HFD-fed animals. The present work concluded that cinnamon dietary uptake may improve testicular damage induced by HFD as it has anti-inflammatory, anti-obesity and antioxidant activities.

Protective role of eclipta alba against hyperlipidemia induced by high-fat diet in albino rats

Eclipta Alba has been used in traditional and folklore medicine to treat Hyperlipidemia and hepatic disorders. The present study was aimed to investigate the Antihyperlipidemic and hepatoprotective potentials of Eclipta Alba in high-fat diet -induced Albino rats and to determine the underlying mechanism. A total of 30 adult albino rats of Wistar strain weighing 165–215 g were utilized. Animals were treated with high-fat diet for 8 weeks followed by post-treatment of E. Alba for 1 week, 2 weeks, and 3 weeks, respectively. After 12 h of fasting on the last day of the experiment, serum blood samples were collected in EDTA vials and processed for biochemical analysis. A significant decrease in levels of total cholesterol and triglycerides was noted on animals treated with E. alba compared to high-fat diet animals. Treatment of hypercholesterolemic rats with E. Alba showed a marked decrease of serum low-density lipoprotein (LDL) and very LDL cholesterol concentrations compared to the hypercholesterolemic rats. High-fat diet feeding worsened the levels of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and alkaline phosphatase enzymes, whereas the same markers were significantly improved by supplementation with E. alba compared to the normal group. E. alba acts as an antihyperlipidemic agent in hyperlipidemic conditions and helps for better health.

Mangifera indica Solvent Fractions: A Treatment for Iron Deficiency Anaemia Induced by Diet in Albino Rats

The International Journal on Complementary & Alternative Medicine provides a global platform for discussion, perspectives and research on healing resources that encompasses all health systems, modalities, and practices and their accompanying theories and beliefs

Reducing Osteoporosis by Phytase Supplemented Diet in Albino Rats

Reducing Osteoporosis by Phytase Supplemented Diet in Albino Rats

Chemical Analysis and Toxicological Assessment of Sesamum indicum Seed Cake on Albino Rats

Sesamum indicum L. seed cake was analysed for proximate composition, mineral element content and phytochemical properties after which toxicological assessment was carried out on it. The result of the proximate composition showed that the seed cake contained 8.26±0.04% moisture, 28.96±0.12% crude protein, 9.58±0.03% ash, 13.90±0.04% crude fibre, 23.28±0.02% fat and 29.91% carbohydrate. The cake was found to be a good source of mineral elements. Calcium (1.5%) was the highest, followed by magnesium (0.4%), phosphorus (0.06%), iron (0.04%) and lead (0.02%). The qualitative phytochemical screening carried out on the seed cake revealed the presence of some secondary metabolites such as flavonoids, alkaloids, saponins, phenol, carbohydrate and steroids. This suggests its usefulness in drug manufacture. A six-week feeding trial was conducted to assess the effect of sesamum seed cake as dietary replacement of groundnut cake in the diet of albino rats. All diets were formulated to meet the entire nutrient requirement for young albino rats (Rattus norvegius). The performance of the rats fed with sesamum seed cake meal-based diet (test) was compared to rats fed a groundnut cake meal-based diet (control). There were significant differences (P 0.05) in the packed volume cell (PVC), haemoglobin (Hb), red blood cell (RBC), white blood cell (WBC), neutrophil, lymphocyte and monocyte between the rats in the test and control groups. The seed cake might be suitable for edible purposes.

Scurvy induced changes and ascorbate defense in albino rats, Rattus norvegicus

An attempt has been made to find out effectiveness of scorbutogenic diet in albino rats, Rattus norvegicus. These animals received 50 and 80 gm cakes of scorbutogenic diet for 15 and 30 days respectively. No scurvy like symptoms were observed rather boils got appeared on their hind limbs, below ear and neck region. Steroid producing glands indicated enhanced steroidogenesis as evidenced by decreased concentrations of adrenal ascorbate and cholesterol. The results suggested that scorbutogenic diet was ineffective to cause scurvy in this species.

The performance of weaned albino rats (Wister strain) fed Baobab (<i>Adansonia digitata</i>) leave-based diets

Adansonia digitata seeds were cultivated and their seedling leaves were harvested in large quantities. The seedling leaves were dried and analysed for proteins, lipids and carbohydrates using microjedahl, soxhlet and UV analytical tools respectively. This was done on weekly basis starting from 4th week of germination. The seedling leaf was found to have the highest crude protein value of 13.57% obtained at 6th week after germination. Two diets prepared from A. digitata leaf were fed parallel into albino rats with diets containing roasted full fat soyabean as control. The result reveals that A. digitata leaves can be included in the diet of albino rats at up to 20% level without depression in performance of feed intake, body weight gain and feed to gain ration (feed conversion ratio). Keywords: Rats, protein, performance, Adansonia digitata, Soya bean

Life span and causes of death of albino rats after prolonged intermittent feeding with ethylenediaminetetraacetate

The periodic addition of the sodium salt of ethylenediaminetetraacetate to the diet of albino rats, starting when the animals have reached maturity, increases the mean and maximal life span although analysis of the causes of death, revealed a higher incidence of neoplasms in these rats. The addition of the compound to the diet after the animals have reached a presenile age has no effect on the life span or morbidity of the rats.

Photosensitization of albino rats fed on lucerne-protein concentrate.

1. The photosensitizing effect of leaf-protein concentrate (LPC) prepared from lucerne (Medicago sativa) was demonstrated when it was included in the diet of albino rats at concentrations between 40 and 480 g/kg diet.2. Skin lesions of varying severity up to the sloughing of ears and tails occurred when such rats were illuminated with natural daylight through window-glass or with simulated daylight from a bank of lamps having emission maxima at 410, 437 and 660 nm and with approximately 4% of the energy of summer sunlight.3. Protein concentrates prepared from ryegrass (Lolium multiforum) and a crude chlorophyll extract of spinach (Spinacea oleracea) did not cause these effects.4. Extracts from blood plasma and livers of rats given lucerne LPC contained pheophorbide-a and two other unidentified green pigments, but no detectable phylloerythrin or chlorophyll. Extracts from the blood of rats given ryegrass LPC had no detectable pheophorbide or other chlorophyll-derived pigments.5. The lucerne LPC given to the rats contained relatively large amounts of pheophorbide-a among a variety of pigments. The ryegrass LPC and the spinach extracts had only small amounts of this pigment relative to the other chlorophyll-type pigments.6. These findings indicate that pheophorbide-a and related pigments are the agents responsible for the photosensitization of the rats. Possible explanations of their presence in lucerne LPC are discussed.

Intragastric versus dietary administration of phenacetin

Summary Phenacetin added to 1 to 2% in the diet of albino rats produced some anorexia and inhibition of growth but otherwise was less toxic than when given as a single daily intragastric administration of the same daily dose. The death rate by intragastric administration increased with increase in the volume of aqueous vehicle in which phenacetin was suspended and with the use of gum tragacanth as a suspending agent. After 5 weeks of daily administration of sublethal doses, albino rats develope resistance to the lethal effect of a large dose of phenacetin.

Renal Pigmentation Following Ingestion of Psyllium Seed

ConclusionsThe addition of a large quantity of ground psyllium seed to the diet of albino rats or dogs is followed by a darkening of the kidneys when examined grosdy. If the feeding is continued for a longer period brown pigment granules become evident microscopically in the renal tubules. Whole psyllium seed produces no renal pigmentation.