This research exhibits the design and analysis of high-quality factor ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${Q}{)}$ </tex-math></inline-formula> dielectric metamaterial sensor (DMMS) for biosensing applications. The proposed sensor consists of a silicon-based dielectric resonator along with a graphene ring, silicon dioxide (SiO <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$_{{2}}{)}$ </tex-math></inline-formula> substrate, and gold metallic layer at the bottom. A silicon-based square ring resonator (SSRR) with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\varepsilon _{\text {sr}} =11.9$ </tex-math></inline-formula> is positioned at the top of the SiO2 layer. A graphene-based circular-shaped ring (GCR) has a thickness of 0.34 nm with an inner radius of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text {g}_{\text {ri}}=8\,\,\mu \text{m}$ </tex-math></inline-formula> and an outer radius of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text {g}_{\text {ro}}$ </tex-math></inline-formula> = 10 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> is placed on the top of the SiO2 layer. The sensor provides perfect absorption at a frequency of 4.06 THz with an absorption rate of 99.993 %. The absorber performance is also verified by the circuit model using the transmission line method. Tunability and controllability are obtained for the proposed absorber by changing the chemical potential of graphene. The proposed structure exhibits a maximum sensitivity of 2.2 THz/TU with a high <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${Q}$ </tex-math></inline-formula> of 927.5. Furthermore, the absorber’s performance remains stable over the incidence angle up to 80°, providing an absorptivity greater than 85%. Moreover, the proposed sensor is insensitive to polarization. The unique features of the proposed absorber are its ultra-thin structure, simple design, tunability, polarization insensitivity, ultra-narrow absorption bandwidth (BW), high sensitivity, high figure of merit (FOM), and very high quality factor ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${Q}{)}$ </tex-math></inline-formula> , making it suitable for detection of dengue, malaria, and glucose.