Depth-Image-Based Rendering (DIBR) is one of the main fundamental techniques for generating new viewpoints in 3D video applications such as multi-viewpoint video (MVV), free viewpoint video (FVV) and virtual reality (VR). Due to the imperfections of color images, depth maps or texture restoration techniques, several types of distortions occur in synthesized views. However, most of related works evaluated the quality of DIBR-synthesized views by only detecting a specific type of distortion, such as stretching, black holes, blurring, etc., which were unable to accurately evaluate the quality of DIBR-synthesized views. In this paper, a new no-reference image quality assessment method is proposed to evaluate the quality of DIBR-synthesized images by combining multi-layer and multi-scale features of images. To be specific, the distortions introduced by different stages of virtual viewpoint synthesis are first analyzed, and then multi-layer and multi-scale features are extracted to estimate the degree of texture and structure distortions. As a result, individual quality scores associated with two types of distortions (e.g., structural distortion and texture distortion) are aggregated to an overall image quality. Experimental results on two publicly available DIBR datasets show that the method has better performance than the state-of-the-art models.Index Terms: image quality assessment, DIBR-synthesized image, distortion correction, BIQA.