Background: Renal lesions are being discovered with increasing frequency due to rapid development and advances in cross-sectional imaging studies being applied in clinical practice. Objective: The aim of the current work was to evaluate the ability of MRI with diffusion images and ADC values in assessment, characterization of renal lesions and its ability to differentiate benign from malignant lesions. Patients and Methods: This prospective study included a total of thirty patients with suspected renal lesions, referred from Urology and Internal Medicine Departments of Suez Canal authority hospital. This study was conducted between January 2019 and July 2019. Patients were examined by MRI with diffusion images and ADC values. Results: The mean apparent diffusion coefficient (ADC) value of normal renal parenchyma was higher than the mean ADC values of benign and malignant lesions. The mean ADC value of all benign lesions was higher than that of malignant lesions. However, there was overlap between ADC values of inflammatory, solid benign lesions and ADC values of malignant lesions. Conclusion: There is overlap between ADC values of inflammatory, solid benign lesions and ADC values of malignant lesions. Using of ADC value alone may lead to inaccurate assessment of renal lesions. The combination of conventional MRI and ADC value in the diagnosis of renal lesions can increase the diagnostic accuracy.