Diagnosis Of Osteomyelitis In Children Research Articles

Meta-analysis of the accuracy of the serum procalcitonin diagnostic test for osteomyelitis in children

ObjectiveThis study sought to assess the sensitivity, specificity, and predictive utility of serum procalcitonin (PCT) in the diagnosis of pediatric osteomyelitis.MethodsA systematic computer-based search was conducted for eligible literature focusing on PCT for the diagnosis of osteomyelitis in children. Records were manually screened according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Statistical analysis was performed using Review Manager software 5.3, Meta-disc software1.4, STATA 12.0, and R 3.4 software.ResultA total of 5 investigations were included. Of these, 148 children with osteomyelitis were tested for bacterial cultures in PCT. For PCT in the diagnosis of pediatric osteomyelitis, diagnostic meta-analysis revealed a pooled sensitivity and specificity of 0.58 (95% confidence interval (CI): 0.49 to 0.68) and 0.92 (95% CI: 0.90 to 0.93) respectively. The PCT had the greatest area under the curve (AUC) at 0.80 for the diagnosis of osteomyelitis in children. The Deeks’ regression test for asymmetry results indicated that there was no publication bias when evaluating publication bias (P = 0.90).ConcusionThis study provided a comprehensive review of the literature on the use of PCT in pediatric osteomyelitis diagnosis. PCT may be used as a biomarker for osteomyelitis diagnosis; however, its sensitivity was low. It still needs to be validated by a large sample study.

Acute hematogenous osteomyelitis in children: a case series

Background Chronic osteomyelitis is still a major cause of morbidity and disability in children living in developing countries. Neglect of acute osteomyelitis and its progression to chronic osteomyelitis leads to significant morbidity. This report is the first series to describe such cases in Indonesia.
 Objective To describe 12 pediatric cases of chronic osteomyelitis in order to remind clinicians about the debilitating complications of musculoskeletal infection.
 Methods This report is a case series of 12 children with chronic osteomyelitis admitted to dr. Soetomo General Hospital, Surabaya, East Java, in 2011-2017. We acquired data from medical records. The patients’ quality of life was measured using the Child Health Assessment Questionnaire Disability Index (C-HAQ-DI).
 Results The patients’ mean age was eight years and they were predominantly male. The most common infection location was the femur (7/12). Microbial cultures were positive in 9/12 of cases, predominantly with Staphylococcus aureus. Erythrocyte sedimentation rate (ESR) was elevated in 11 patients. All patients were diagnosed late, with an average delay of presentation to Orthopedics of 10.5 months. Most of patients experienced mild to moderate disability after the disease, as assessed by the C-HAQ-DI.
 Conclusion Diagnosis of osteomyelitis in children is quite difficult, given the lack of specific diagnostic tests. Delayed diagnosis and inappropriate treatment may result in long-term morbidity and disability. Clinicians should have an increased awareness of the clinical features of osteomyelitis, including unusual presentations such as calcaneal osteomyelitis.

Femoral Neck Aspiration Aids in the Diagnosis of Osteomyelitis In Children With Septic Hip.

The role of femoral aspiration (FA) in the treatment of septic arthritis of the hip is controversial. The purpose of this study was to determine if FA conducted concomitantly with irrigation and debridement (I&D) of the septic hip aids in microorganism and osteomyelitis identification and alters the treatment plan, or if the risks of the procedure outweigh its potential benefit. We also compare preoperative magnetic resonance imaging (MRI) with FA for diagnosis of osteomyelitis cooccurring with septic arthritis. Retrospective review was performed of all patients treated at a single institution between January 2003 and June 2014 for suspected septic hip arthritis. Eighty-three patients were identified with suspected or confirmed septic arthritis and 28 patients (33%) had cooccurring osteomyelitis. Demographic and clinical data were recorded for each patient. The sensitivity and specificity of FA and MRI for diagnosing osteomyelitis were determined. Among the 83 patients with confirmed or suspected septic arthritis, 31 patients (37%) had a FA performed at the time of the hip I&D, resulting in positive cultures in 17 patients. All of these patients had other positive cultures (blood and/or joint fluid) that grew the same organism. 54 patients (65%) had a preoperative MRI. The MRI was falsely negative in 10 patients, 6 of whom had a positive FA resulting in appropriate management of osteomyelitis. Missed or delayed diagnosis of osteomyelitis resulted in significant morbidity in 3 patients (avascular necrosis and femoral neck fracture, extensive lower extremity osteomyelitis, and subtrochanteric fracture with malunion). No complications associated with FA were identified. FA and MRI were found to have sensitivity/specificity for osteomyelitis of 100%/100% and 38%/95%, respectively. Although FA did not improve microorganism identification, it did aid in the diagnosis of cooccurring osteomyelitis when treating children with septic arthritis, especially in patients with false negative MRI findings for osteomyelitis. We recommend FA at the time of septic hip I&D as its benefits appear to far outweigh its risks. Level III-diagnostic study.

Methods of diagnosis of acute epiphyseal osteomyelitis in children

Summary. The article presents the analysis of different method for diagnosis of epiphyseal osteomyelitis, including radiography, ultrasonography, computed tomography, magnetic resonance tomography, and radioisotope bone scans. We address the advantages, disadvantages, and possibilities of each method from the standpoint of early diagnosis of osteomyelitis in children.
 Based upon the literature, the most effective and reliable methods for early diagnosis of epiphyseal osteomyelitis in pediatric patients are magnetic resonance and ultrasound. The present diagnostic methods involve no radiation exposure. Using an ultrasonic diagnostic method does not require complete immobility of the patient, can be used from the moment of birth, has widespread availability, and has a relative low cost to allow its use in any medical institution.

The Role of Imaging in Childhood Osteomyelitis

: Osteomyelitis in childhood can be a challenging diagnosis. Imaging plays an important role in the diagnosis of osteomyelitis in children, and the imaging findings are crucial in the treatment decision. Pediatric hematogenous osteomyelitis may have variable radiological expression, which is influenced by the age and condition of the patient, the virulence of the causative agent, the stage of the disease, or the selected imaging tool. Different imaging modalities exist for imaging of osteomyelitis which include: conventional radiography, Three-phase bone scintigraphy, ultrasound (US), computed tomography (CT) and magnetic resonance (MR) imaging. Conventional radiography is the initial step in evaluation of osseous changes. In most cases it will be the only imaging technique used in the diagnosis, as well as treatment. Ultrasonography, is a very useful modality. It allows correlating the physical exam with US findings and comparing the affected side with the opposite side. After conventional imaging MRI is the most important imaging modality for the evaluation of osteomyelitis. MRI excellent delineation of the osseous component as well as, soft tissue extension, joint effusion and complications of osteomyelitis such as abscess formation, especially in case of failure to respond to therapy. CT scan is more useful and superior to MR in detecting cortical destruction, air and sequesters. Bone scintigraphy using 99Tc methylene diphosphonate may help to confirm suspected osteomyelitis by showing increased uptake in all three phases of the dynamic perfusion.

Diagnosis of Osteomyelitis in Children: Utility of Fat-Suppressed Contrast-Enhanced MRI

The purpose of this study was to determine whether the use of fat-suppressed contrast-enhanced MRI, compared with unenhanced MRI alone, increases reader confidence in the diagnosis of osteomyelitis and its complications in children. MRI studies of 78 skeletally immature children and adolescents (median age, 3.6 years) with suspected nonspinal osteomyelitis were reviewed in consensus by two readers. Unenhanced images were evaluated first and then contrast-enhanced MR images. Images were scored for the presence or absence of osteomyelitis, abscess, septic arthritis, and physeal involvement on a 5-point scale ranging from definitely absent to definitely present. Forty-two additional studies were evaluated to test interobserver agreement. Osteomyelitis was clinically diagnosed in 40 cases (51%). There was no significant difference between the sensitivity and specificity of unenhanced MRI (p = 1.0) and those of contrast-enhanced MRI (p = 0.77) for the diagnosis of osteomyelitis. Nonetheless, there was a significant (p < 0.001) increase in confidence in the diagnosis of osteomyelitis and its complications. This increase in confidence was most pronounced for the diagnosis of abscess (46%). The addition of contrast enhancement was least useful in findings deemed definitely absent on unenhanced MR images. Although it does not increase the sensitivity or specificity of the diagnosis, use of contrast-enhanced MRI does increase reader confidence in the diagnosis of osteomyelitis and its complications in cases in which bone or soft-tissue edema is found on unenhanced images. In the clear absence of edema on unenhanced images, however, contrast enhancement is not needed.

Role of power Doppler sonography in early diagnosis of osteomyelitis in children

We describe 2 children complaining of leg pain associated with elevated C-reactive protein levels in whom power Doppler (PD) sonography suggested the diagnosis of early osteomyelitis. PD sonography detected increased blood flow that resulted in a high-intensity signal area adjacent to the symptomatic tibia surface. Antibiotic therapy led to prompt improvement. These cases suggest that PD sonography is useful in the evaluation of possible early osteomyelitis in children.

Imaging of osteomyelitis with special reference to children.

Infection of bone in children represents a diagnostic and therapeutic challenge to the pediatrician, the surgeon, the radiologist, and the pathologist. The pattern of manifestation varies and is dependent on the site of involvement, the initiating event, the infecting organism, and the acute or chronic nature of the illness. Early diagnosis allows prompt treatment, which can prevent many of the dreaded complications of this disease. Plain radiographs remain the initial imaging modality used in the diagnosis and differential diagnosis of osteomyelitis. However, with the advent of newer imaging techniques such as scintigraphy, ultrasonography, computed tomography, and magnetic resonance imaging, a higher degree of accuracy in diagnosis and definition of the extent of the disease has been achieved. The time interval between the onset of symptoms and diagnosis has also been significantly reduced. Although magnetic resonance imaging has the additional advantage of multiplanar capability, greater anatomic detail, and excellent soft tissue resolution, it is a relatively expensive technique, which somewhat limits its use. Following a brief review of the classification and pathophysiology of osteomyelitis, we have tried to elucidate the utility of various imaging modalities in the diagnosis of osteomyelitis in children, outlining their relative strengths and weaknesses. Certain entities specific to children and a brief review of differential diagnosis are also presented.

Douleurs osseuses fébriles chez l’enfant: Apport de l’IRM

Purpose To assess the value of MRI for early diagnosis of osteomyelitis in children presenting with sepsis and acute onset of musculoskeletal pain. Materials and methods MRI including fat suppressed T2W, and fat suppressed pre- and postcontrast T1W sequences was performed within 48 hours of admission in 26 children with clinical (fever and acute musculoskeletal pain) and biological (elevated WBC count and ESR in all cases, and elevated CRP in 12 patients) suspicion of acute osteomyelitis. None of the patients had sickle cell disease. Results MRI was normal in 7 children (26%). Bone marrow signal abnormality was noted in 19 cases (74%) consistent with acute osteomyelitis in 18 cases and metastatic neuroblastoma in 1 case. Conclusion MRI is useful for evaluation of children presenting with sepsis and acute musculoskeletal pain, early diagnosis of osteomyelitis and to prevent unnecessary hospital admission and work-up.

MAGNETIC RESONANCE IMAGING IN A CHILD WITH PRIMARY STERNAL OSTEOMYELITIS

Primary sternal osteomyelitis (PSO) is rare. In a 9-year-old boy with Staphylococcus aureus bacteremia, magnetic resonance imaging helped to promptly establish the diagnosis of PSO. Eleven previously reported cases are reviewed, emphasiz ing surgical drainage and antimicrobial therapy for optimal outcome. Magnetic resonance imaging may be superior to other imaging studies for the diagnosis of PSO.

Technetium bone scintigraphy in the diagnosis of osteomyelitis in children.

In a 5 1/2-year retrospective study of hospitalized children with osteomyelitis who had technetium bone scans, we found that 32 of 38 (84%) had increased radionuclide uptake, 4 (11%) had normal uptake and 2 (5%) had decreased uptake. The two patients with decreased uptake had a stormy course with extensive bone destruction and pathologic fractures in spite of prolonged courses of antibiotic therapy. Decreased uptake on bone scan in patients with clinical evidence of osteomyelitis could indicate a poor prognosis and early surgical drainage is indicated in order to decrease morbidity.

Radionuclide imaging: use in diagnosis of osteomyelitis in children

Radionuclide imaging: use in diagnosis of osteomyelitis in children

Radionuclide imaging. Use in diagnosis of osteomyelitis in children.

Forty-four children were studied for the presence of osteomyelitis by scintigraphy using Tc 99m etidronate tin complex. Evidence of osteomyelitis on radionuclide images was found in 16 of 19 patients considered to have osteomyelitis by their attending physicians. Bone scintigraphic changes were noted prior to or in the absence of roentgenographic abnormalities in 10 of 19 patients. Cases of acute hematogenous osteomyelitis, chronic osteomyelitis, and osteomyelitis caused by penetrating trauma and contiguous infection were identified. Three bone infarctions were correctly diagnosed.

Diagnosis of osteomyelitis in children by combined blood pool and bone imaging.

Differentiation of osteomyelitis from cellulitis or septic arthritis can be difficult. The radiological examination often does not have the characteristic features. Seventy of 71 children with osteomyelitis had focal areas of increased radioactivity at the site of the infection. The addition of "blood pool" images aids in the interpretation of the study as they permit evaluation of the effect of hyperemia. The 13 childrenwith cellulitis had diffuse increase in radioactivity involving both the bones and soft tissues. Bone imaging as the initial screening procedure for osteomyelitis is recommended.