Objective To evaluate the double–balloon enteroscopy(DBE) for obscure gastrointestinal bleeding(OGIB) and evaluate the health economics under the guidance of DBE for surgical treatment of obscure gastrointestinal bleeding. Methods A total of 114 patients, whose hemorrhage etiology could not be determined by conventional gastroscopy, enteroscopy and gastroenterography, underwent DBE. With pathological results as diagnostic criteria, the value of double–balloon enteroscopy for obscure gastrointestinal bleeding diagnosis was studied. Results The sensitivity, specificity and accuracy of DBE for OGIB were 85.86%, 63.63%, 81.57%, respectively. The positive likelihood ratio was 2.36 and the negative likelihood ratio was 0.22. The total days of hospitalization, hospital costs, cost of hospital drugs were lower in the DBE group than in the control group(27.2±11.8 days VS 16.4±5.3 days, 35 690.2±3 466.5 Yuan VS 19 409.3±9 253.2 Yuan, 17 805.8±2 145.5 Yuan VS 9 133.0±4 664.9 Yuan)(all P<0.05). Conclusion DBE plays an important role in diagnosis of OGIB. It has significance in clinic, health economics, and social benefits. Key words: Double–balloon enteroseopy; Obscure gastrointestinal bleeding; Etiology; Diagnosis; Health economic evaluation