A young female laboratory worker presented with chronic cumulative skin lesion over hands. The occupational exposure history supported the prolonged and frequent exposure to multiple solvents which are recognised as work irritants, improper work practice and wrong use of protective glove. The diagnosis of Irritant Contact Dermatitis (ICD) was supported by workplace dermatology risk factors, clinical features, negative skin patch test to rule out hypersensitivity reaction and fulfilment of all seven Mathias Criteria. The effective management of occupational contact dermatitis requires practices change and exposure control. The comprehensive Hand Care Programs must be individualised and incorporate several important elements namely the skin care screening and surveillance, early referral for Occupational Health assessment, effective education and training programs and provision of hand moisturising products. The support of return to work (RTW) among the affected workers is of paramount important in order to minimise the negative impacts on their quality of work as well as home life.