Diagnosis Of Hamartoma Research Articles

Outcomes of Primary Tumor Excision do not Differ from Non-Resection Methods in Pediatric Mesenchymal Hamartoma of the Liver: A Rapid Systematic Review

BackgroundTo conduct a rapid systematic review comparing the outcomes of primary tumor resection versus non-resection on patients with hepatic mesenchymal hamartoma. MethodsWe searched the Ovid MEDLINE, EMBASE, Scopus, PubMed, Web of Science, and Google Scholar databases from January 1, 2000 to March 31, 2022. Studies that described cases of hepatic mesenchymal hamartoma, including management and outcomes, were included. Results62 articles met inclusion criteria with 95 cases in total. Patients were assigned to the primary tumor resection (n = 85) or non-resection (n = 10) cohort based on the described management. Similar rates of morbidity (17% vs 20%) and mortality (6 vs 10%) were identified between cohorts. There were no differences in sex, liver lobe involvement, or tumor size among study groups. ConclusionsComplete tumor resection should remain the gold standard for hepatic mesenchymal hamartomas when an adequate liver remnant exists. Reports of non-resected tumors demonstrating spontaneous regression or stability with watchful waiting have poor long term follow-up and have inadequate evidence of a true mesenchymal hamartoma diagnosis. Level of EvidenceLevel I.

Oral hamartomas. A rare clinical case from the practice of a maxillofacial surgeon: hard palate hamartoma

Relevance. Hamartomas are common in the lungs, liver, spleen, pancreas, and kidneys. Head and neck hamartomas are rare and oral hamartomas are still rarer. The feature of hamartoma is that it consists of the same tissue elements as the affected organ; however, it is characterized by an abnormal structure. Hamartomas are most often benign tumours though there were described episodes of malignancy and development of hamartoblastomas, so the maxillofacial surgeon and the dentist should be cancer alert in this case. A small number of diagnosis cases may reflect the true rarity of the disease or may be missed, which can lead to mismanagement of the patient.Purpose. To study the literature on oral hamartomas and present a clinica l case of hard palate hamartoma.Materials and methods. We analyzed the world medical literature about oral hamartomas and hard palate hamartomas in particular and presented a clinical case of hard palate hamartoma diagnosis in a thirty-four-year-old woman. The immunohistochemical test evaluated the markers reflecting the tumour proliferation level.Results. We analyzed the world literature on oral hamartomas and presented a clinical case of the diagnosis and treatment of hard palate hamartoma identified in a thirty-four-year-old woman at an appointment with a maxillofacial surgeon. After the surgical treatment, a histological examination verified the hamartoma.Conclusion. Hard palate hamartomas are rare in the practice of the maxillofacial surgeon and dentist. Learning specific features of hamartomatous lesions is essential to understand how to plan the necessary treatment for a patient with such pathology. Immunohistochemical research methods allow for accurate histological diagnosis, which further determines the patient management strategy.

Cerebral Vascular Hamartoma In a Campeiro Bulldog

Background: Vascular hamartomas (VH) are rare or simply underdiagnosed injuries in veterinary medicine and represent a non-neoplastic developmental anomaly disorganization and proliferation of endothelial tissue. VH occur in any region of the body, however in the brain present clinical relevance related with the potential for spontaneous bleeding, adjacent tissue compression and convulsive activity. The aim of these report is to describe clinical, pathological and immunohistochemical features of a case of cerebrovascular hamartoma and highlight the diagnosis of these rare brain disorder in dogs.Case: A 10-year-old male dog, a Campeiro Bulldog breed presented convulsions episodes and died before an elective surgical procedure for eyelid nodule removal. Three red nodules were observed in the brain, one between the parietal lobe and the left occipital lobe (in the medium suprasylviam sulcus), the other in the caudal region of the corpus callosum and the third one in the cerebellar cortex. Central nervous system, eyelids and most organs and tissues samples were collected, fixed in 10% formaldehyde and processed for histopathological analysis. Histologically, in the eyelid was detected a sebaceous adenoma. The nervous system samples revealed well-differentiated different sizes vascular structures with thin-walled and blood-filled, promoting compression of the brain. Normal neuropile was detected between the vascular structures substantiating cerebral vascular hamartoma diagnosis in the dog. Immunohistochemical assay was conducted with CD31 (monoclonal mouse antibody anti-CD31, Clone JC70A, Dako Corp.) and Von Willebrand factor (monoclonal mouse antibody anti-Von Willebrand factor, Clone F8/86, Dako Corp.) using the biotin–peroxidase–streptavidin method (PolyDetector Plus DAB–HRP, Bio SB) on CNS sections to confirm the vascular origin of the lining cells in the mass. Discussion: Hamartomas are rarely reported in domestic animals and mostly are of vascular origin. VH in nervous tissues can trigger clinical signs related to hemorrhage, brain space occupation, compression and obstructive secondary hydrocephalus. In general, cerebral VH have a slow progression and usually affected animals are asymptomatic. On the other hand, cerebral vascular hamartomas may also cause clinical signs in very young animals about 15 to 16 months old. In humans, clinical presentation of VH may be related with acquired lesions such as trauma, ionizing radiation, and other central nervous system injuries. In the present case, the dog presented convulsion episode only at 10 years old during pre-chirurgical procedures. The morphological features of the vascular hamartoma we observed in the Campeiro bulldog is classified as capillary teleangiectasia composed by well differentiated capillaries lined with well differentiated endothelial cells interspaced by normal neuronal tissue. Histopathological and immunohistochemical assay are extremely important to differentiate hamartoma from other tumors, since they may be macroscopically similar. The immunolabeling of endotelial cells by anti-CD31 and anti-Von Willebrand factor antibodies in the cerebral VH, highlight the vascular origin of the masses detected. However, it is also important to perform systematic gross examination of the brain in detail to detect even the smallest injuries in asymptomatic animals avoiding underdiagnoses of cerebral VH.

Seizure outcome and prognostic factors for surgical management of hypothalamic hamartomas in children

PurposeHypothalamic hamartomas (HH) are rare benign lesions frequently associated with gelastic seizures early in life. Epilepsy can progress to multiple seizure types with cognitive impairment and behavioural disturbance, leading in some cases to epileptic encephalopathy. MethodsWe reviewed a retrospective series of 112 children treated in a single center, between 1998 and 2017. ResultsAccording to Delalande’s HH classification, type1 was found in 2 patients, type 2 in 67, type 3 in 31, and type 4 in 12 patients. Stereotactic endoscopic disconnection was performed in 92 % of the procedures. Median age at diagnosis was 40 months and 7.6 years at surgery. Median time between diagnosis and surgery was 31 months and median follow up 4.1 years. For all HH types, 77.6 % of the patients had a favourable outcome (Engel I + II outcome score) with 57.1 % seizure-free (Engel I). The best outcome was obtained in patients with type 2 HH, (68.7 % Engel I and 85.1 % Engel I + II). The overall complication rate was 8.3 %, which is in line with previous series. Patients with isolated gelastic seizures had a better outcome (Engel I + II in 90 %), as compared to those with other seizure types (p = 0.07). A short delay between hamartoma diagnosis and surgery was a statistically significant factor for a good outcome (p = 0.03). ConclusionPatients with HH and drug-resistant epilepsy should be early identified in order to propose surgical treatment without delay. Endoscopic disconnection is a safe and efficacious surgical option with good seizure outcome and immediate treatment results.

DIAGNOSTIC STRATEGIES FOR MULTIPLE PULMONARY NODULES

SESSION TITLE: Wednesday Medical Student/Resident Case Report Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: 10/23/2019 09:45 AM - 10:45 AM INTRODUCTION: Multiple pulmonary nodules are often challenging in terms of their workup. Having non-invasive diagnostic methods to exclude benign lesions such as pulmonary hamartomas is desirable and useful in avoiding risky invasive procedures. We present a case highlighting the non-invasive approach which we believe is under recognized. CASE PRESENTATION: A 49 year-old-female with an extensive smoking history was referred for known pulmonary nodules. Chest CT showed multiple ground glass opacities (GGO) within peripheral parenchyma of the lungs [Figures 1-3]. Given the patients history of smoking and the presence of GGO, malignancy was considered. CT imaging was evaluated for intranodular calcification or fat. No calcifications were observed but given the measured fat density of -124 HU a diagnosis of pulmonary hamartomas was made. Comparison with CTs from 15-years prior confirmed the stability and benign nature of the nodules. DISCUSSION: Pulmonary hamartomas are the most common benign neoplasms of the lung, representing 75% of non-malignant lung tumors. Most hamartomas are asymptomatic and are incidentally found on imaging within the peripheral parenchyma, however 10% are endobronchial. They are relatively stable with a volume doubling time over 400 days. Malignant transformation is rare thus observation is safe. However, studies have found an association with primary lung cancer. While typically solitary, pulmonary hamartomas have been observed in multiples, with one study showing an incidence of 3%. Extrapulmonary involvement, especially mucocutaneous and gastrointestinal locations, indicates Cowden disease. Characteristically, pulmonary hamartomas contain fat and/or “popcorn” calcifications, found in 60% and 5-50% of nodules respectively. Fat can be identified on CT with a Hounsfield values of -40 to -120 HU, and when found with smooth, sharply marginated nodules it provides a confident diagnosis of hamartoma. MRI is a less common imaging modality, but chemical-shift MRI shows potential in identifying intracellular lipid when CT is negative for intranodular fat. Additionally, CT texture mapping shows promise in classifying nodules via heterogeneity, something ordinarily reserved to histopathology of biopsied specimens. Lastly, PET-CT is available for characterizing intermediate to large pulmonary nodules, but increased FDG avidity of hamartomas can lead to misdiagnosis. CONCLUSIONS: Multiple pulmonary hamartomas can be diagnosed on chest CT by measuring fat density within nodules. Thin section CT is essential to avoid missing small foci of fat. When inconclusive, other imaging modalities such as chemical-shift MRI and CT texture mapping should be considered before invasive biopsy or PET-CT. Reference #1: Provenzale, James M., Rendon C. Nelson, and Emily N. Vinson, eds. Duke radiology case review: imaging, differential diagnosis, and discussion. Lippincott Williams & Wilkins; 2011. Reference #2: “Primary Lung Tumors Other than Bronchogenic Carcinoma: Benign and Malignant.” Grippi MA et al. Fishman's Pulmonary Diseases and Disorders, Fifth Edition. New York: McGraw-Hill; 2015. Reference #3: Ekinci, G. H., et al. "The frequency of lung cancer in patients with pulmonary hamartomas: An evaluation of clinical, radiological, and pathological features and follow-up data of 96 patients with pulmonary hamartomas.” Revista Portuguesa de Pneumologia (English Edition) 2017; 23(5): 280-286. DISCLOSURES: No relevant relationships by jayanth keshavamurthy, source=Web Response No relevant relationships by Matthew Potter, source=Web Response No relevant relationships by Varsha Taskar, source=Web Response No relevant relationships by Thomas Whitton, source=Web Response

Shear Wave Elastography: A New Assistant Modality in the Diagnosis of Hamartoma

Shear Wave Elastography: A New Assistant Modality in the Diagnosis of Hamartoma

Multifocal Chest Wall Hamartoma: A Rare Congenital Anomaly

Chest wall hamartoma is a very rare tumour with benign course and distinct clinical, radiological, and histopathological characteristics. The lesion develops during foetal life and is present at or shortly after birth. It should be kept in differential diagnosis of complex chest wall masses diagnosed during antenatal ultrasound. CT thorax is useful for appreciation of detailed anatomy, characterization of the congenital abnormality and for surgical planning. Histopathology is used for the confirmation. Accurate diagnosis of mesenchymal hamartoma is important since many chest wall masses in children are malignant. We report a rare case of multifocal chest wall hamartoma in an infant who presented with multiple bilateral complex chest wall masses in which characteristic radiological and histopathological features led to the diagnosis of hamartoma, which was successfully treated with surgery.

English

Introduction: Hamartoma of the breast is a rare entity, frequently underdiagnosed by pathologists. It is a benign tumour-like nodule with overgrowth of mature cells that normally occur in the affected part. Patients present at an average of 45 yrs. with a unilateral, well defined, painless mass or enlargement; incidence being 0.1% to 0.7%. The aim of our study was to investigate clinical and histopathological features of breast hamartomas. Materials and Methods: Eighteen cases of breast hamartomas operated our hospital, between Jan. 2005 to Dec. 2012 were included in this study. The clinicopathological features and follow up data were analysed in all the cases. Results: All cases in our study were female patients with age group ranged between 23-40 yrs. All patients presented with unilateral breast masses. Clinically majority of patients were suspected to have fibroadenoma with only 2 cases suspected to be cystosarcoma phyllodes. Lumpectomy was performed in all the cases. Grossly all tumors were well circumscribed, grey white, lenticular masses with some showing cystic changes, myxoid areas and nodular areas. The maximum dimension of the tumors ranged from 4 to 16 cms. Microscopically, all hamartomas demonstrated good demarcation with fibrous tissue condensation and hyalinisation. Epitheliosis, apocrine metaplasia, pseudo angiomatous stromal hyperplasia, atrophy and cystically dilated ducts were among the major microscopic features observed. No recurrence or malignant components were noted in our case series. Conclusion : The diagnosis of hamartoma is difficult as no specific diagnostic histological features are present. The presence of fibrous tissue within the lobules, or fibrous tissue and fat in the stroma, with or without pseudoangiomatous changes, should alert the pathologist to the possibility of a hamartoma. The role of FNAC and needle core biopsy is limited. Coincidental malignancy can occur in hamartomas and hence the importance of its diagnosis.

HAMARTOMA ANGIOMATOSO ÉCRINO

O hamartoma angiomatoso écrino é uma malformação benigna rara, de etiologia desconhecida, caracterizada histologicamente por numerosos capilares e estruturas glandulares écrinas. Surge mais frequentemente ao nascimento ou na infância, manifestando-se por mancha, placa ou nódulo com crescimento proporcional ao da criança. Pode apresentar hiperhidrose, hipertricose e dor. Descreve-se o caso de uma criança do sexo masculino, de 3 anos, referenciada por 3 manchas discretamente hiperpigmentadas de tonalidade castanha clara, com contornos irregulares e hipertricose, com mais de 20 cm de maior eixo cada, localizadas à área toracolombar esquerda. À fricção as lesões tornavam-se mais evidentes. Evoluíam desde os 6 meses de idade com hiperhidrose local. A biopsia confirmou o diagnóstico de hamartoma angiomatoso écrino. Face à benignidade da lesão e à fruste sintomatologia optou-se por não realizar tratamento. O hamartoma angiomatoso écrino é uma entidade rara destacando-se neste caso, as lesões de grande dimensão, segundo o nosso conhecimento, não referidas anteriormente na literatura.

Solid solitary hamartoma of the spleen

Hamartoma of the spleen is a rare, sometimes asymptomatic similar to hemangioma benign tumor of the spleen, which, owing to the new diagnostic imaging methods, is discovered with increasing frequency. It appears as solitary or multiple tumorous lesions. We present a 48-year-old woman in whom, during the investigation for Helicobacter pylori gastric infection and rectal bleeding, with ultrasonography, a mass 6.5x6.5 cm in diameter was discovered by chance within the spleen. Splenectomy was performed due to suspected lymphoma of the spleen. On histology, tumor showed to be of mixed cellular structure, with areas without white pulp, at places with marked dilatation of sinusoids and capillaries to the formation of "blood lakes" between which broad hypercellular Billroth's zones were present. Extramedullary hematopoiesis was found focally. The cells that covered vascular spaces were CD34+ and CD31+ and CD8- and CD21-. Hamartoma has to be taken into consideration always when well circumscribed hypervascular tumor within the spleen is found, particularly in children. Although the diagnosis of hamartoma may be suspected preoperatively, the exact diagnosis is established based on histological and immunohystochemistry examinations. Treatment is most often splenectomy and rarely a partial splenectomy is possible, which is recommended particularly in children.

Breast Hamartoma - An Underdiagnosed Entity

Hamartomas or fibroadenolipomas are benign breast lesions often misdiagnosed as Fibroadenomas on clinical examination and after fine needle aspiration cytology.The relevant investigation in these cases has come out to be radiological assessment, especially mammography.The following case shows how the histopathological and clinical correlation achieved the diagnosis of hamartoma and prevented its misdiagnosis as Fibroadenoma.

Retroperitoneal Hamartoma: A Rare Entity

Retroperitoneal hamartoma in adult is an extremely rare entity. Here we report a case of 23-years-old lady who presented with a large retroperitoneal mass and abdominal pain. The mass was surgically removed and the diagnosis of hamartoma was made on histological findings.

CT- and computer-based features of small hamartomas

Purpose To identify characteristic computed tomographic (CT) and computer-derived features of hamartomas manifesting as small pulmonary nodules. Methods Individuals with a diagnosis of hamartoma were identified among participants in the International Early Lung Cancer Action Program and were included if there thin section CT images that included the entire nodule. The CT findings were reviewed to determine the nodule consistency (solid, part-solid, nonsolid), nodule diameter (average of length and width), shape (round, lobulated, neither) and edge (smooth, not smooth). Computer measures of nodule compactness, sphericity, surface regularity and gradient (change in gray-scale between the nodule and the surrounding parenchyma) were determined. Volume doubling time (VDT) was also determined for those with at least two scans with similar imaging acquisitions. Results A total of 21 cases of hamartomas that had histologic or cytologic confirmation were identified. The median age was 60 and 12 (57%) were men. Average diameter was 10.7 mm (5–20.7 mm). All were solid in consistency and were described by the radiologist as having either round or lobulated shape with a smooth edge. None had pathognomonic radiologic findings for hamartoma. Computer measures demonstrated that all were compact and spherical, with a regular surface and a sharp margin between the nodule and surrounding parenchyma. Of nine on whom the VDT could be calculated, eight had VDTs longer than 450 days. Conclusion Both radiologist and computer derived features of small hamartomas suggest a consistent presentation for these lesions which may be helpful in distinguishing them from other types of nodules.

Hamartoma: Diagnostic Procedure of Unspecific Clinical Appearance in the Oral Cavity

Hamartoma is a benign tumor-like lesion composed of overgrowth of mature cells and tissues. Along with its unspecific appearance, it may occur in the oral cavity and bear resemblance to the other lesions. In this report we describes the clini-cal appearance of hamartoma as well as the diagnosis method in the case of a 37-year-old-man. The patient explained that he already has redness plaque lesion on his skin left cheek region since he was born. The lesion was sensed to grow and discomfort at the age of 22. A surgical therapy had been performed to reduce the size of lesion one year after, but the red-ness plaque still existed. Thirteen years following the operation, white lesion appeared on the inner left cheek 10 x 8.5 x 6 cm of size and extended onto lower lips within half a year. Diagnostic procedure was carried out such as biopsy, CT-scan and radiography with neuroma as an initial conclusion. New histopathological examination confirmed the diagnosis of hamartoma. It is concluded that adequate and appropriate biopsy procedure along with sufficient clinical information are needed to develop a proper diagnosis to distinguish hamartoma from other oral lesions. DOI: 10.14693/jdi.v17i3.38

Lipomatous hypopharyngeal hamartoma presenting with sudden and absolute dysphagia

To report a rare case of hamartoma of the hypopharynx. A case of hamartoma of the hypopharynx is reported here in a 51-year-old man who presented with sudden absolute dysphagia. A contrast enhanced CT scan of the patient revealed a non-infiltrative, polypoidal, lipomatous mass in the hypopharynx. This provisional diagnosis helped us in approaching the lesion conservatively by a transoral route. The lesion, originating from the left aryepiglottic fold, was excised using Eve’s tonsil snare. A histopathological diagnosis of hamartoma was made. A thorough evaluation is needed, including radiology, for assessing the complaints of dysphagia in a patient in fifth decade, to rule out mitotic pathology. In this case the preoperative radiology was helpful in establishing a preliminary diagnosis of nonmalignant etiology. Hamartoma should be considered a rare but possible differential diagnosis in such cases.

Lung Images: Primary Pulmonary Hemangiopericytoma

A 43-year-old woman presented with cough and a 6.5 9 5cm homogeneous left lung mass on a chest roentgenogram (Fig. 1). Computed tomography of the thorax revealed a 5.5 9 5.5-cm heterogeneous mass located between the upper and lower lobe bronchi of the left lung (Fig. 2). We performed thoracotomy and a 8 9 4-cm mass between the upper and lower lobes of left lung was detected. The mass was solid and noncystic. A diagnosis of hamartoma was made by frozen section. It was removed with its capsule. Severe bleeding occurred during resection. Ligation of the bleeding artery branch stopped the bleeding. She has remained asymptomatic during the 15 months of followup. On histopathologic examination, the tumor was macroscopically defined as grey-white tissue with a lobulated surface, 6.5 9 5.5 9 4.5 cm in size. Microscopically, in the stroma between the veins there was spindle cell proliferation that did not show distinctive cytologic atypicality. These spindle cells were positively stained with CD34 and C-KIT. The vein structures were CD31-positive. Vein walls were stained with actin upon which characteristic vascular structures with stag horn configuration diagnosed the mass as primary pulmonary hemangiopericytoma (Fig. 3). Hemangiopericytoma is a rare form of sarcoma that originates from the pericytes that surround the capillary membrane [1]. The age range is wide and there is an equal distribution among males and females. The symptoms are usually cough, hemoptysis, and chest pain. The preoperative diagnosis is difficult because of the lack of specific clinical symptoms and radiologic findings. However, paraneoplastic syndromes such as osteoarthropathy and hypoglycemia may appear in relation to primary pulmonary hemangiopericytoma. During surgery a frozen section will be useful in determining the existence of malignancy. The histologic findings consist of multiple mesenchymal tumors, including hemangiopericytoma. Hemangiopericytoma is surrounded by capsules or pseudocapsules and radiologic investigation of the mass reveals clear-cut borders. Also, immunohistochemical studies can be helpful for the accurate diagnosis. Malignancy is usually manifested as

Hamartoma of the Breast: An Underrecognized Disease?

Hamartomas of the breast are benign tumors composed primarily of dense, fibrous tissue with variable amounts of fat and associated ducts. A 48-year-old woman had noted a lump in her right breast for a number of years. She came to our clinics because of the recent progressive enlargement of this lump. Physical examination revealed a large, mobile, round, painless mass in the lower inner quadrant of the right breast. There were no palpable axillary lymph nodes. Mammography showed a circumscribed, 4.5 x 2.5 cm mass with a radiolucent periphery and moderately radiopaque center. On the basis of the clinical and mammographic findings, hamartoma of the breast was highly suspected. A lumpectomy was performed and histological examination of the specimen revealed overgrowth of mammary lobules and ductules, forming a well-circumscribed lesion with admixed fat tissue. Hamartoma of the breast was confirmed. With the awareness of this entity and good correlation of imaging findings, the clinical diagnosis of hamartoma of the breast should not be difficult. If careful attention is paid to the clinical information, histological underdiagnosis of hamartoma of the breast can be avoided.

Incidence and cytological features of pulmonary hamartomas indeterminate on CT scan

Pulmonary hamartomas have a characteristic heterogeneous radiological appearance. However, when composed predominantly of undifferentiated mesenchymal fibromyxoid component, their homogeneous appearance on computed tomography is indeterminate for malignancy. Rendering an accurate preoperative diagnosis in these cases can alter management. The aim of this study was to determine the incidence and accuracy of cytodiagnosis for hamartomas 'indeterminate' by imaging. We retrospectively reviewed records for hamartomas diagnosed by transthoracic fine needle aspiration (FNA) including immediate impressions and final diagnoses. Cytological features evaluated included the presence of fibromyxoid stroma, bronchioloalveolar cell hyperplasia, fibroadipose tissue, cartilage and smooth muscle. Eighteen (1.3%) hamartomas were identified from 1355 transthoracic FNAs. The immediate impression was hamartoma in 13 (72%), carcinoid in one (6%), mucinous bronchioloalveolar carcinoma in two (11%) and non-diagnostic in two (11%). The final diagnosis of hamartoma in cases diagnosed as carcinoid, mucinous bronchioloalaveolar carcinoma and non-diagnostic on immediate impression was rendered following assessment of all cytological material. Overall, FNAs are highly reliable for diagnosing hamartomas even when composed principally of undifferentiated mesenchymal fibromyxoid stroma, especially with the aid of all available preparations including Diff-Quik smears, Papanicolaou smears, ThinPreps and cell block material.

Primary vascular neoplasms unique to the spleen: Littoral cell angioma and splenic hamartoma diagnosis by fine‐needle aspiration biopsy

We report the fine-needle aspiration (FNA) biopsy diagnosis of two rare cases of primary vascular neoplasms unique to the spleen: a littoral cell angioma from a 31-yr-old Caucasian woman and a splenic hamartoma from a 46-yr-old black man. The cytologic features of splenic hamartoma and of littoral cell angioma of the spleen were described three times in cytologic literature: two were bench-top aspirates and one was FNA biopsy thought to be metastatic carcinoma. To the best of our knowledge, the current two cases were the first diagnosed by FNA biopsy. Our approach to the FNA biopsy diagnosis of these rare vascular neoplasms via compact cell block and immunohistochemistry is described. The differential diagnosis with other primary vascular splenic neoplasms is also discussed.

Hamartome de la rate (splénome) chez un enfant drépanocytaire

Hamartomas of the spleen or splenomas are uncommon benign lesions that predominantly occur in adults. We report a case of an 11-year-old girl with sickle cell anemia who had a single splenic 1.8 cm nodule incidentally found during splenectomy and histologically characterized by disorganized red pulp tissue without interspersed white pulp leading to the diagnosis of hamartoma. The association of hamartoma and hematological conditions is a very unusual condition in children.