Rationale: Florid cemento-osseous dysplasia (FCOD) is a rare, benign, multifocal fibro-osseous dysplastic process affecting the tooth-bearing areas of the jaw. Although FCOD is often symmetrically located in various regions of the jaw, cases associated with impacted teeth are very rare. FCOD most commonly affects females in the fourth and fifth decades of life, and is seen less frequently in Asian populations. Patient concerns: A 39-year-old Japanese female was referred to our department with dull pain in region 28. Intraoral examination revealed that all third molars were completely impacted. Imaging findings revealed multiple periapical sclerotic areas surrounded by radiolucent zones in regions 28, 38, and 48. Diagnosis: Histological appearance was compatible with a diagnosis of FCOD. Interventions: Under general anesthesia, we performed the extraction of the lesions with the impacted third molars. The lesions were gritty and reddish brown, continuous to the roots of 28, 38, and 48. Outcomes: The patient had no complications during the 2-year follow-up period. Lessons: Although FCOD has sex and racial ubiquity, it may occur in the opposite sex and other races. Appropriate treatment should be selected depending on the presence or absence of symptoms.