<h3>Objectives</h3> Blue nevus (BN) represents a clinicopathologically distinctive subset of benign melanocytic proliferations that may affect the oral mucosa. While diagnosis of conventional BN is usually straightforward, some of its rare variants may cause significant overlap with other entities, causing diagnostic pitfalls. Herein we present a case of hypopigmented variant of common BN and discuss the diagnostic challenges. <h3>Findings</h3> A 52 year-old male of unremarkable medical history was referred for the evaluation of a painless palatal lesion of unknown duration. The clinical examination revealed a well-circumscribed, slightly elevated lesion of normal hue with bluish halo involving the hard palate. With a provisional diagnosis of BN an excisional biopsy was decided. Histopathologically, a proliferation composed of scattered elongated, finely branching melanocytes, located deeply within the lamina propria with non-infiltrating pattern and associated with a variably desmoplastic stroma, was observed. Cytoplasmic pigmentation was detected only in a small subset of dendritic processes after serial sectioning. Minimal cytologic atypia and mild nuclear pleomorphism were also present in the absence of mitotic activity. In order to rule out malignant melanocytic tumors, especially desmoplastic melanoma, extensive immunohistochemical examination was performed. Melanocytes were strongly and diffusely positive for Melan-A, HMB-45, SOX-10, S-100, p16, and vimentin. The proliferation index Ki-67 was <5%. A final diagnosis of hypopigmented common BN was rendered. No signs of recurrence were noted during follow-up. <h3>Conclusions</h3> To this date, few cases of BN with minimal or absent pigmentation have been reported in the literature. However, this pattern is extremely rare in lesions affecting the oral mucosa. Hypopigmented BN lesions require careful evaluation to be distinguished primarily from desmoplastic melanoma. Immunohistochemistry may be helpful, especially when tumors with atypia, pleomorphism, infiltrative pattern and/or mitoses are encountered.