Diabetis Mellitus Research Articles

Ameliorative Review on Exploration of Spices in Aspects of Phytochemical Screening for their Antidiabetic Action

Diabetes is a diverse group of disorder characterized by hyperglycemia due to an deficiency in insulin production. Diabetes mellitus's chronic hyperglycemia is linked to end organ damage, dysfunction, and failure, including blood vessel, kidney, retina, and nervous system. With over 62 million cases of diabetes being identified in India, the disease is rapidly turning into a true epidemic. The majority of synthetic oral hypoglycemic medications available for the disease's treatment are costly, have significant adverse effects, and/or cannot be used while pregnant. As a result, a growing number of people worldwide are turning to traditional herbal remedies to prevent and treat diabetes. Spices having antioxidant, hypoglycemic, and hypolipidemic characteristics may be effective in the therapy of diabetes. As a result, these spices are growing in popularity due to their potential efficacy, little to nonexistent adverse effects, and synergistic effects. Spices are compounds used in food as coloring, flavoring, or preservation. They might be fresh or dried seeds, bark, roots, fruits, or even vegetables. This paper includes phytochemical screening of spices which have crucial role in the treatment of diabetis mellitus.

A Study of Prescription Pattern of Anti-Diabetic Drugs and Usage of Teneligliptin for Type II Diabetis Mellitus

A Study of Prescription Pattern of Anti-Diabetic Drugs and Usage of Teneligliptin for Type II Diabetis Mellitus

ARTICULAR CHONDROCYTES FROM DIABETIC AND NON-DIABETIC RATS EXPOSED TO NORMO- OR HYPERGLYCAEMIA RESPOND DIFFERENTIALLY TO THE COMPLEMENT SPLIT FRAGMENT ANAPHYLATOXIN C5A AND TNFA

Osteoarthritis (OA) and diabetis mellitus type 2 (DMT2) are pathogenetically linked. Complement dysregulation contributes to OA and could be involved in DMT2. The inflammatory anaphylatoxin C5a is released during complement activation. This study aims to understand the specific responses of chondrocytes isolated from diabetic and non-diabetic rats exposed to C5a and/or the proinflammatory cytokine TNFα in vitro dependent on the glucose supply. Articular chondrocytes of adult Zucker Diabetic Fatty (ZDF) rats (homozygous: fa/fa, diabetic, heterozygous: fa/+, lean controls) were exposed to 10 ng/mL TNFα and 25 ng/mL C5a alone or in combination, both, under normo- (NG, 1 g/L glucose) and hyperglycemic (HG, 4.5 g/L glucose) conditions (4 or 24 h). Chondrocyte survival, metabolic activity and gene expression of collagen type 2, suppressors of cytokine signaling (SOCS)1, −3 and anti-oxidative hemoxygenase-1 (HMOX1) were assessed. The complement regulatory protein CD46 and cell nuclei sizes were analyzed. Chondrocyte vitality remained unaffected by the treatment. Metabolic activity was impaired in chondrocytes of non-diabetic rats under HG conditions. Collagen type 2 transcription was suppressed by TNFα under HG condition in chondrocytes from nondiabetic donors and under both conditions in those of DMT2 rats (24 h)Except for DMT2 chondrocytes under HG (4 h), HMOX1 was generally induced by TNFα +/- C5a (NG, HG). C5a elevated HMOX1 only in chondrocytes of controls. The SOCS1/3 genes were increased by TNFα (NG, diabetic, non diabetic, 4 and 24 h). This could also be observed in chondrocytes of diabetic, but not of lean rats (24 h, HG). At 4 h, C5a induced SOCS1 only in non diabetic chondrocytes (NG, HG). Cytoprotective CD46 protein was suppressed by TNFα under NG condition. Nuclear volumes of chondrocyte were lower in chondrocytes from DMT2 rats compared to those from controls. The differential response suggests that chondrocytes are irreversibly compromised by DMT2.Achnowledgement: The authors are grateful for the support by the “Stiftung Edoprothetik (S 04/21)”

Efficacy and Tolerability of Gliclazide and Metformin in the management of Type-2 Diabetes Mellitus A Comparative Study

Background: Diabetes is one of the most prevalent and serious non-communicable diseases all over the world. It is the leading cause of death, disability and economic loss and thus, it is identified as a major threat to global development. So it is important to evaluate the efficacy and tolerability of drugs in the management of Type 2 DM patients Objective: The purpose of present study was to compare the efficacy and tolerability of gliclazide and metformin in the management of Type 2 DM patients. Methodology: A prospective observational study was conducted in Endocrine outpatient department of Sir Salimullah Medical College & Mitford Hospital and Shaheed Suhrawardy Medical College & Hospital, Dhaka from July 2017- June 2018. A total number of 114 diabetes mellitus patients were taken and divided into two groups. Patient age between 18- 60 years (both male and female) suffering from type 2 diabetes mellitus were included in this study. Patients having the history of Type-1 Diabetes, Hypersensitivity to any drug, pancreatitis , hepatic impairment , high ALT or serum creatinine level (>1.5) , pregnant and nursing woman were excluded from the study. Among the study population one group was given tablet gliclazide and another group was given tablet metformin. Here pre and post baseline investigations( FBG, 2HABF, HbA1c,Serum creatinine , bilirubin, ALT, body height and weight) measured on day 1, follow up at 4 weeks, 12 weeks and then compared. Results: In patients treated with gliclazide mean of pretreatment FBG 8.75±1.79 mmol/ l which was reduced to 6.75±1.19 mmol/l in 4 weeks and 6.26±0.93 mmol/l by 12 weeks. The mean base line serum glucose 2hABF was 13.85±2.52 mmol/l which was reduced to 10.35±2.04 mmol/l in 4 weeks and 9.42±1.59 mmol/l by 12 weeks. In metformin treated group the mean base line FBG was 8.52±2.26 mmol/l which was reduced to 7.01±1.76 mmol/l in 4 weeks and 6.06±0.81 mmol/l by 12 weeks. The mean base line serum glucose 2hABF was 13.23±3.40 mmol/l which was reduced to 10.57±2.19mmol/l at 4 weeks and 9.38±1.71 mmol/l by 12 weeks. Gliclazide and metformin both significantly reduced blood glucose and their efficacy are relatively similar. Adverse effects were seen more in number and intensity with gliclazide. Individual efficacy of both compounds was good but metformin was better tolerated. Conclusion: Metformin is more effective, better tolerated than gliclazide in diabetis mellitus. Sir Salimullah Med Coll J 2023; 31:13-20

Hybrid Revascularisation in Cases of Longer Arterial Occlusive Diseases of Lower Limbs in Combination with Diabetis Mellitus

Целью нашего исследования была оценка результатов баллонной дилатации поверхностных, подколенных и передних отделов артерий ниже колена без стентирования. В это исследование было включено 30 пациентов с заболеванием периферических сосудов (ЗПС). Все пациенты были мужчинами с диабетом 2-го типа. Во всех случаях выполняли дуплексное сканирование и компьютерную томографию. Клиническая фаза заболевания периферических артерий оценивалась по WIFI III. Все операции включали чрескожную транслюминальную ангиопластику (реканализацию и баллонную дилатацию) поверхностной бедренной артерии (ПБА), подколенной артерии (ПА) и передних отделов большеберцовых артерий в сочетании с профундопластикой в 27 (90%) случаях и полного протезирования короткой ПБА в 3 (10%). ИБС наблюдалась в 6 (20%) случаях. Среди них коронарное стентирование было представлено у всех. Сразу после процедуры отмечалось улучшение кровотока в стопе и/или купирование болевого синдрома. Сочетание периферической баллонной дилатации с профундопластикой или коротким аллопротезированием ПБА у пациентов со средней стадией WIFI дало достаточные достоверные результаты для спасения конечности. Մեր հետազոտության նպատակն էր գնահատել ծնկից ներքև գտնվող մակերեսային, պոպլիտեալ և առաջային զարկերակների օդապարիկային լայնացումն առանց ստենտավորման: Այս ուսումնասիրությունը ներառում էր ծայրամասային անոթային հիվանդությամբ 30 հիվանդ: Բոլոր հիվանդները տղամարդիկ էին և ունեին 2-րդ տիպի շաքարախտ: Բոլոր դեպքերում կատարվել են դուպլեքս սկանավորում և համակարգչային տոմոգրաֆիա։ Ծայրամասային զարկերակային հիվանդության կլինիկական փուլը գնահատվել է WIFI III-ի միջոցով: Բոլոր վիրահատությունները ներառում էին մակերեսային ազդրային զարկերակի (ՄԱԶ), ենթածնկային և տաբիալ զարկերակների ներմաշկային տրանսլյումինալ անգիոպլաստիկա (վերականալիզացիա և բալոն անգիոպլաստիկա) 27 (90%) դեպքերում և կարճ ՄԱԶ-ի ամբողջական փոխարինում 3 դեպքերում (10%): Սրտի իշեմիկ հիվանդություն առկա էր 6 (20%) դեպքերում: Բոլոր այդ դեպքերում կատարվել էր կորոնար զարկերակների ստենտավորում։ Միջամտությունից անմիջապես հետո նկատվել է ոտքի արյան հոսքի բարելավում և/կամ ցավի թեթևացում: WIFI-ի միջին փուլով հիվանդների մոտ ծայրամասային բալոն անգիոպլաստիկայի համակցումը պրոֆունդոպլաստիկայի կամ ՄԱԶ-ի կարճ ալոպրոթեզավորման հետ ցուցադրել է բավարար հուսալի արդյունքներ վերջույթը փրկելու համատեքստում:

Prevalence of mutations in cublin-megalin receptor genes in Diabetis Mellitus: Subset analysis of an Indian NGS (Next Generation Sequencing) study

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Analysis of the Effect of Modification of Blood Sugar Control Models in Diabetis Mellitus Patients on KGD at Puskesmas Muliorejo, Sunggal District, 2021

Background: Diabetes mellitus is a serious and chronic disease in which the pancreas does not produce insulin in sufficient quantities to regulate blood sugar in the body. (WHO, 2016).Problem : How is the effect of modification of the model of controlling blood sugar levels in patients with diabetes mellitus on KGD when.Objective: To analyze the effect of modifying the blood sugar level control model in patients with diabetes mellitus on blood sugar levels at any timeMethod: Quantitative research with quasi-experimental method pre post test control group design.Population: The population is the entire research subject. With type II DM who experienced and who did not DM as many as 638 people.Sample: The number of samples is 30 people in the intervention group and 30 people in the control group. So the total sample for both groups is 60 peopleResult: There is a significant relationship between age, history of DM, behavior, smoking, obesity and hypercholesterolemia on KGD seen from p-value <0.05.Conclusion: There is a difference between age, history of DM, behavior, smoking, obesity and hypercholesterolemia on KGD before and after the intervention.Suggestion: To respondents aged > 50 years to carry out sports activities, jogging, jogging, exercise, healthy lifestyle and diligently drinking water, control blood sugar levels and for people with diabetes do not forget to take medication regularly and control regularly.

Platinum/carbon dots nanocomposites from palm bunch hydrothermal synthesis as highly efficient peroxidase mimics for ultra-low H2O2 sensing platform through dual mode of colorimetric and fluorescent detection

Detection of hydrogen peroxide and glucose in nanomolar level is crucial for point-of-care medical diagnosis. It has been reported that human's central nervous system diseases such as Alzheimer's disease, Parkinson's disease, and even amyotrophic lateral sclerosis, are presumably caused H2O2 or reactive radical species (ROS). Sensing of H2O2 released from human biofluids, tissues, organ from metabolism disorder at ultra-low concentration assists for early identification of severe diabetis mellitus related to glucose, and heart attack, as well as stroke related to cholesterol. In this work, carbon dots (CDs) having an average diameter at 6.99 nm with highly photoluminescence performance were successfully synthesized from palm empty fruit bunch (EFB) using green and environmentally friendly process via hydrothermal condition. CDs acted well on peroxidase-like activity for H2O2 detection at room temperature, however their sensitivity on ultra-low H2O2 concentration needed to be improved. To enhance their reactivity on H2O2 nanozyme activity at room temperature, synthesis of hybrid metal nanoparticles (AgNPs and PtNPs) on CDs surface was established. The findings exhibited that CDs/PtNPs was the most suitable nanozyme achieving highly efficient peroxidase mimic for dual mode of colorimetric and fluorescent H2O2 sensing platform at very low limit of detection of 0.01 mM (10 nM) H2O2.

Reduced sRAGE Production and ADAM10 Gene Expression in Peripheral Blood Samples of Diabetic Nephropathy Patients

Introduction: Excessive signalling via the Receptor for Advanced Glycation End products (RAGE) is implicated in inflammatory renal damage in Diabetic Nephropathy (DN). RAGE signaling is modulated by its soluble form (sRAGE) that arises due to ectodomain cleavage catalysed by A Disintegrin and Metalloproteinase 10 (ADAM10). The sRAGE functions as a decoy and competes with RAGE for binding to the cognate ligand. Aim: The aim of this study was to evaluate sRAGE and ADAM10 gene levels in peripheral blood samples of Diabetic Nephropathy patients. Materials and Methods: The present observational study was conducted in the Department of General Medicine, RL Jalappa Hospital and Research Centre, Kolar, Karnataka, India, between January 2019 to April 2020. Study comprised of three groups: group 1 of 30 DN patients; group 2 of 28 Type II Diabetis Mellitus (T2DM) patients without microvascular complications and group 3 comprised of 30 healthy volunteers. Blood samples obtained from the study participants were cultured for 24 hours along with insulin treatment or a suitable control. sRAGE levels were measured in the conditioned media by Enzyme Linked Immunosorbent Assay (ELISA) technique. Expression of the ADAM10 gene was measured in the cell pellet by using the quantitative real-time Polymerase Chain Reaction (PCR) technique. Results: A total of 88 subjects were included in the study, with 30 patients in group 1 (DN, mean age 55.34±7.76 years), 28 patients in group 2 (T2DM, mean age: 55.07±7.7 years) and 30 subjects in group 3 (healthy individuals, mean age: 55±8.05 years). sRAGE levels were significantly lower in nephropathy patients when compared to healthy volunteers (p=2.5×10-9). Likewise, ADAM10 expression levels were also significantly lower in nephropathy patients when compared to healthy volunteers (p=1.3×10-4). Insulin treatment led to significantly higher sRAGE production in healthy volunteers as compared to T2DM patients (p-value 3.3×10-11). Insulin treatment leads to significant upregulation of the ADAM10 gene expression in healthy volunteers as compared to DN and T2DM. Conclusion: Abnormal RAGE signaling in DN may arise due to diminished sRAGE production as a consequence of reduced ADAM10 expression.

Ал- горитм сегментации визуальных признаков диабетической ретинопатии (ДР) и диабетического макулярного отека (ДМО) на цифровых фотографиях глазного дна

This article is devoted to the development of an algorithm for segmentation of visual signs of DR and DMO. The paper references the global statistics of patients with diabetes mellitus and their need for regular fundus screening. We propose the use of telemedicine applications to the problem of regular ophthalmological screening of patients with diabetis mellitus. The main features of DR and DME are identified with the help of artificial intelligence algorithms. A list of scientific and technical problems that needed to be solved is presented: the collection of training data, their markup and the choice of artificial neural network architectures for the tasks of feature segmentation. The process of validation of the algorithm is described and the current results are presented.

Vitiligo – Study In view of familial occurence

Vitiligo – Study In view of familial occurence

Study of dry eye in diabetes mellitus type II and it’s association with diabetic retinopathy

Dry eye disease and diabetic retinopathy are complications in diabetes mellitus. However association between diabetes mellitus type II and dry eye disease are still unclear. Objectives of this study objective is was to analyse association between dry eye disease and diabetic retinopathy in patients with type 2 diabetes mellitus.A prospective study on seventy patients of diabetis mellitus type II/patients undergone indirect ophthalmoscopy and retinal photography, and the dry eye syndrome analysis using tear break up time and Schirmer tests. Diabetic retinopathy was graded.: In this study, there was no association identified among the age, sex & duration of diabetes mellitus type II disease and diabetic retinopathy. 52.8% (n=37) patients were observed to be suffering from dry eye syndrome and it was common in older and female patients. Diabetic retniopathy observed in 67.1%(n=47) patients. Upon classification, 34.2% (n=24) belongs to non-proliferative diabetic retinopathy, 27.1% (n=19)belong to severe NPDR and 5.7% (n=4) belongs to proliferative DR. TBUP was observed as ≤10 seconds. Moderate NPDR was significantly high in diabetes mellitus type II patients with dry eye disease. Statistically significant association observed between diabetic retinopathy and dry eye disease. The dry eye disease prevalence observed as 52.8% patients. Statistically significant association observed between severity of dry eye disease with duration of diabetes mellitus disease and the degree of diabetic retinopathy. There was significant association identified between diabetic retinopathy and dry eye disease.

Prevalence and Determinants of Pre-Hypertension among Undergraduate Preclinical Medical Students in Central Malaysia

Introduction: Pre-hypertension, a classification of blood pressure ranging from 120–139 mm Hg systolic and/ or 80–89 mm Hg diastolic, has been introduced to identify those high-risk group of developing hypertension to implement early intervention to halt disease progression. This study determines the prevalence of pre-hypertension and its determinants among undergraduate preclinical medical students in Malaysia. Materials & Methods: This was a cross-sectional study conducted among 158 registered second year medical students at one research university in central Malaysia from January to April 2018. Results: The prevalence of pre-hypertension was 20.6% among undergraduate preclinical medical students. The most respondent was female (69.9%), Malay ethnic (50.6%) who had normal body mass index (67.3%), no depression (79.5%), no anxiety (60.3%), no stress (68.6%), low physical activity level (44.9%), never smoked (95.5%), and never consumed alcohol (87.8%). Some respondents had positive family history of hypertension (43.6%) and diabetis mellitus (31.4%). After adjusted for all variables, gender (AOR=14.45, 95% CI 5.58-37.43) and depression status (AOR=6.37, 95% CI 1.29-31.49) were significantly associated with pre-hypertension. Conclusion: The prevalence of pre-hypertension among preclinical medical students was lower compared to other country, predicted by gender and depression status. However, further comprehensive multicentered studies in Malaysia with larger sample size is recommended to get more precise results in identifying determinants for pre-hypertension so that early intervention could be implemented nationwide.

Modeling and Control of the Glucose‐Insulin‐Glucagon System in Type I Diabetis Mellitus

AbstractType I diabetes mellitus (DM) is a chronic disease characterized by the inability of the pancreas to produce enough insulin. This results in a high glucose concentration in the blood. External administration of insulin is required to maintain normoglycemia. The accurate amount of insulin and the right time of administration can be obtained from monitoring and practicing model‐based control. A model with insulin as a regulatory hormone has already been developed for DM. It has then been extended by considering both insulin and glucagon as regulatory hormones. The model parameters are estimated using non‐linear least‐square techniques on data from frequently sampled intravenous glucose tolerance tests (FSIGT) from the literature, thus optimizing the model parameters for type I patients. Using this model, a model‐predictive controller (MPC) has been designed to maintain normoglycemia in subjects with DM when subjected to disturbances. Finally, a comparative performance analysis between the MPC and conventional PID controller has been carried out. In conclusion, the model‐predictive controller is promising for the control of glucose concentration in subjects with type 1 diabetes mellitus when subjected to disturbances.

Alarin Level Response to an Oral Glucose Tolerance Test in Subjects with Gestational Diabetes Mellitus

Alarin has been reported to ameliorate insulin resistance in type 2 diabetis mellitus. However, until now, there is no report examined the relationship between alarin and gestational diabetes mellitus (GDM). Therefore, the purpose of this study is to examine the level of alarin in subjects with and without gestational diabetes mellitus. 30 healthy and 30 gestational diabetes mellitus subjects were recruited for this study. A 2-hour 75 g oral glucose tolerance test (OGTT) was performed at 24–28 weeks of pregnancy. GDM were diagnosed using nationally endorsed criteria (fasting [FPG], 1- or 2-hour blood glucose [at least one abnormal value]. Plasma alarin level was measured by ELISA. Plasma alarin levels were significantly higher GDM subjects than in healthy individuals (12. 3±1.4 ng/mL vs 7.8±0.8 ng/mL; p < .05).1- (18. 8±1.9 ng/mL) and 2-hour (24. 2±3.1 ng/mL) alarin levels in women with GDM were significantly increased at OGTT compared with women without GDM [1- (9.4±0.9 ng/mL); 2- (9.7±0.6 ng/mL)]. Plasma alarin positively correlated with FBG, HbA1c, HOMA-IR and insulin). The above results suggest that alarin might be associated in the pathogenesis of gestational diabetes mellitus.

Сравнение факторов риска развития посттрансплантационного сахарного диабета у пациентов с аллотрансплантацией почки

Сравнение факторов риска развития посттрансплантационного сахарного диабета у пациентов с аллотрансплантацией почки

Evaluation of relationship between dental caries, diabetes mellitus and oral microbiota in diabetics.

Background:Diabetes mellitus is a metabolic disease leading to abnormal fat, carbohydrate and protein metabolism. Reduced salivary flow rate caused by hyperglycemia is characteristic mainly for periods of poor metabolic control of diabetes, thereby facilitating the growth of aciduric bacteria and caries-lesion development. The objective of our study was to evaluate the effects of diabetes mellitus on dental caries micro-organisms responsible for caries.Materials and Methods:This study was carried out on 60 subjects consisting of 2 groups. The Group A (study group) consisted of 30 subjects with diabetes mellitus and dental caries, and the Group B (control group) consisted of 30 subjects with dental caries but no systemic disease. DFS/dfs index in all subjects was evaluated and compared. Unstimulated salivary flow was collected and levels of Streptococcus mutans were analyzed.Results:It was found that the fasting blood sugar in Group A subjects because of which there was increased streptococcus mutans count and hence high caries index as compared to that of Group B.Conclusion:From our study, we could conclude that with increased age, blood sugar levels, DMFT values, dental caries increases in diabetics than in normal (control) subjects and therefore relationship does exist between diabetis mellitus, oral microbiota and dental caries.

Assessment of hearing loss as a potential complication of diabetes mellitus

Introduction: High blood glucose levels are found to damage the vessels found in stria vascularis and adjacent nerves, this results into diminished ability to hear. To support this result, insufficient evidence of a significant relationship between diabetes and hearing impairment is there. Therefore, we aimed to assess hearing impairment in diabetic mellitus individuals as one of the potential complications. Material & Methods: The study involved 150 type 2 Diabetes Mellitus patients. Diabetes Mellitus type 2 subjects 65-89 years of age, meeting the inclusion/exclusion criteria were included in the present study. The individuals with the diabetes had been followed up for 10 years. Results: 89 patients of total 150 patients had duration of diabetes for more than 10 years. Among them mild hearing loss was found in 37 patients. Out of total 150 patients 61 patients in whom the duration of diabetes was less than 10 years, we could not find any detectable hearing loss. Duration of Diabetes mellitus and sensorineural hearing loss at 2000Hz, 4000Hz showed statistically significant correlation (Pearson coefficient r= 0.981 and r = 0.90 respectively) at 0.03 level. Discussion & Conclusion: on the basis of results we came to conclusion that progressive bilateral high frequency sensorineural hearing loss can be considered as one of complication of type 2 DM. Periodical assessment of various organs of the body, including the hearing system, should be carried out carefully and regularly, so as to provide better life condition for the diabetic patients in the future. Keywords: Complications, Diabetis Mellitus, Hearing problem, Presbycusis

The prevalence of diabetis mellitus and retinopathy among Pacific peoples residing in South Auckland, New Zealand

The prevalence of diabetis mellitus and retinopathy among Pacific peoples residing in South Auckland, New Zealand

Advances of phenylboronic acid-containing materials in drug delivery

Phenylboronic acid (PBA) and its derivatives are a kind of synthetic chemicals which can recognize diols via reacting reversibly with them in aqueous solutions. Recently, based on the reversible covalent PBA/diol complexes, strategies to construct drug delivery system for diabetes treatments and cancer therapy have made enormous progress. Diabetis mellitus have greatly increased all over the world in recent decades. With the regular use of insulin in diabetes treatment, there is a high demand of insulin self-regulated release system responding to glucose concentration in vivo . Since the apparent p K a value of PBA and its derivatives is around 8.2–8.6, which is higher than human physiological pH 7.4, efficient glucose-responsiveness of PBA-based polymer materials could not be obtained at physiological pH and glucose level. Recently, studies to construct this insulin release system based on PBA polymer materials have made enormous progress, such as reducing the p K a of the PBA group, achieving “on-off” release of insulin according to the change of glucose concentration and so on. Similar to diabetes treatments, significant efforts have recently been made to develop drug delievery system based on PBA polymer materials in cancer therapy. Traditional chemotherapy has disadvantages such as poor permeability, short resident time, and toxic side effects. Therefore, the ideal drug delivery carrier should possess tumor targeting ability to prolong the retention time and enhance the aggregation of carriers in tumors. Inaddition, carriers should release drugs and degrade in response to intracellular triggers when inside the cancer cells, in order to increase delivery efficiency and reduce toxicity. The recognition ability of boronic acid to polyol residues in cell membranes enables PBA-functionalized nanocarriers to specific target to sialic acid groups, which are overexpressed on tumor cells. The high affinity and specificity of PBA to SA could significantly improve drug accumulation and retention in tumor, and increase the cellular uptake of carriers. Moreover, the reversible covalent PBA/diol complexes provide three modes of stimuli-responsive features of PBA polymer materials. Firstly, the reversible covalent of PBA with diols depends on the pH, and the PBA-diols bond will be weak at acidic pH such as within endosomes and lysosome. So this pH-responsiveness of PBA-modified carriers could be used to release drugs and genes accurately inside tumor tissues as well as cancer cells. Secondly, one diols complex with PBA could easily be replaced by another diols having better thermodynamic stability complex with PBA. Adenosine triphosphate (ATP) with a cis -diol moiety is abundant inside cells, and the PBA-sugar complex could be exchanged by more stable PBA-ATP formation. Finally, many types of tumor tissues and cancer cells have increased levels of reactive oxygen species (ROS), and PBA ester can react with these ROS such as H2O2, thus PBA ester can be used as the oxidation-responsive trigger during the drug delievery process. Herein, the responsiveness to stimuli of PBA polymer materials has been well studied, including glucose, pH, adenosine triphosphate (ATP), and H2O2 sensitive. This paper reviews recent research on drug delivery system for diabetes treatments and cancer therapy based on PBA polymer materials, and the possible development in the future is predicated.