BACKGROUND: Quality of life (QoL) related to health is an important aspect in the treatment of diabetes mellitus (DM). AIM: This study aims to find a relationship between blood pressure and QoL of patients with DM Type 2 by controlling other variables. METHODS: This is a cross-sectional study of DM patients in Bogor City who were community-based participants with inclusion and exclusion criteria. The QoL data were collected using DM QoL modification questionnaire. Statistical analyses were performed using logistic regression. RESULTS: The result of the study conducted on 144 people with DM, more than half of the patients had hypertension (68.1%), adults aged 25–60 years (69.4%), women (79.9%), low education with <12 years of education year (62.5%), not working formally (66.0%), married (77.8%), and getting treatment (75.7%). The QoL of patients is balanced between good and poor QoL (50%). Based on the results of the bivariate test, blood pressure, education, and marital status had a significant relationship to QoL (p < 0.05). Based on multivariate test results, the OR value for blood pressure does not increase or decrease by more than 10% in the full model or partially, this indicates that the effect of pressure on QoL is relatively stable (OR = 0.293). CONCLUSION: DM patients who are not hypertensive can be a protective factor against poor QoL. The multivariate final model shows that the variable that greatly influences the QoL is education (OR = 3.63). Blood pressure, education, and married have a significant relationship to the QoL of patients with DM (p < 0.05). Age, sex, occupation, and therapy were not statistically related (p > 0.05).