AbstractAbout 90% of the Texas High Plains area depends on the water supply from the Ogallala aquifer. The decline of the Ogallala water table raises a concern for the sustainability of producing the traditional irrigated field crops due to their high water demand. Thus, diversifying cropping systems may be a solution. However, about 70% of the irrigated cropland uses center pivots that may negatively impact specialty crop quality. Thus, a 3‐year experiment was conducted to assess the potential of using mobile drip irrigation (MDI) to produce fresh watermelon compared to center pivot sprinkler irrigation using low‐elevation spray application (LESA), and surface drip irrigation with plastic mulch (DI). The study evaluated the effects of irrigation systems on crop yield, fruit quality, physiological responses, water use efficiency (WUE), and irrigation use efficiency (IUE). On average, plants under MDI had higher yields (106 Mg ha−1) than those under DI (70 Mg ha−1) and LESA (68 Mg ha−1). Plants under MDI and DI also had more fruits per plant (1.9) than those under LESA (1.4). The higher yield was associated with higher biomass and photosynthetic function. In general, fruit quality was not affected by irrigation system. In addition, plants under MDI system showed a higher WUE and IUE, and less water stress than those under LESA and DI systems. Results of this study suggest that irrigating under an MDI system is a good alternative for growers in the Texas High Plains that aim to diversify their cropping system with high‐value vegetable crops such as watermelon (Citrullus lanatus).