Aims: This study aimed to assess the causes, consequences, knowledge, attitudes, and perceptions of substance abuse among male adolescents in Dhaka North City and compare the knowledge between male adolescents attending schools and colleges who do not use drugs and substance abusers from rehabilitation centers.
 Study Design: This was a comparative cross-sectional study.
 Place and Duration of Study: The study was conducted in Dhaka North City, Bangladesh, from January to December 2023.
 Methodology: A comparative cross-sectional design was used to study substance abuse among male adolescents in Dhaka North City. Data were collected from two groups, drug addicts and non-addicts, using a pretested questionnaire. A two-stage sampling method was applied. Data analysis was performed using Microsoft Excel 365 and IBM SPSS Statistics 27, employing descriptive and inferential statistics. Statistical significance was set at a p-value of less than 0.05.
 Results: The findings revealed the strong influence of peer relationships, family dynamics, parental education and occupation, and misconceptions and attitudes toward substance abuse among male adolescents. Drug addicts reported higher frequencies of parental conflict, secrecy, and hiding information from their parents, indicating a breakdown in communication and trust within the parent-child relationship. Drug addicts also had significantly higher monthly family income and higher education levels of their parents compared to non-addicts, suggesting that higher financial resources and education may play a role in the increased risk of substance abuse. Additionally, drug addicts had a higher proportion of deceased mothers compared to non-addicts, indicating a potential influence of maternal status on substance abuse. Preventive measures, such as counselling, treatment, religious education, and engagement in productive activities, were highly endorsed by both drug addicts and non-addicts.
 Conclusion: This study contributes valuable insights into drug addiction among male adolescents in Dhaka North City. The findings underscore the importance of addressing peer influence, strengthening family dynamics, dispelling misconceptions, providing accurate knowledge, and implementing evidence-based preventive measures. By adopting a comprehensive approach, stakeholders can work towards reducing the prevalence and impact of drug addiction among adolescents.