The longer time for recording large earthquakes on a plate boundary fault, the better that understanding of large earthquake rupture behavior and seismic hazard on the fault zone. However, large earthquakes (M ≥ 7) are rarely recorded on the boundary fault with slow slipping rate, such as the Red River fault zone (RRFZ), which is an important plate boundary fault that marks the southwestern boundary of the Yangtze platform or south China block. There have been no large earthquake records on the southern segments (including the segment in Vietnam) of the RRFZ since historical earthquake records began in 886 AD, except the 1652 Midu M 7 earthquake and the 1925 Dali M 7 earthquake on the northern segment. The southern segment of the RRFZ will not have a large earthquake in the future or as a large earthquake seismogenic zone with a long period of recurrence, remains controversial, in part because of the absence of constraints from geological evidence. This controversial seriously restricts the risk assessment of future large earthquakes on the southern segment of the RRFZ. By careful interpretations of high resolution remote sensing images, in combination with a detailed field geological and geomorphic survey, we found a series of fault valleys and bedrock outcrops from Gasha toYaojie and Yuangjiang to Hekou on the southern segment of the RRFZ. Multiple trench excavation and radiocarbon dating sample analyses show that the mid valley trace in the southern segment of the RRFZ is an active fault. Geological and geomorphic evidence from Gasha to Yaojie and Yuanjiang to Hekou indicate that the mid valley trace in the southern segment of the RRFZ exhibits dip slip and dextral strike slip motion characteristics. This result is inconsistent with those of previous studies that the mid valley trace is purely strike slip. Furthermore, trenches opened on the range front trace in the southern segment of the RRFZ in Ejia are found to still be active, differing from previous studies. Thus, the seismic hazard on the southern segment of the RRFZ should be reevaluated.