Bluetooth/ANT+ heart rate monitors and smart device applications have the potential to advance heart rate monitoring in non-clinical settings. New innovative applications allow for heart rate monitoring of multiple users simultaneously; however, preliminary attempts to use a particular commercially available model in a typical university gymnasium setting revealed persistent issues with signal interruption; thus, the trustworthiness of the data was limited. PURPOSE: To reduce the prevalence of signal interruption by determining the best physical configuration of components. METHODS: A quasi-experimental repeated measures design was utilized to determine the best configuration of the system components. Cluster and ANOVA analyses determined good, better, and best configurations. The dependent variable was signal interruption and the unit of analyses was the number of signal interruptions per two-minute session. The independent variables were height (1.8m, 3.6m, and 5.4m), angle (60°, 75°, and 90°), and location (left corner, middle, right corner) of the transmitter component. University students, male and female adults ages 19-25 with no apparent health problems, were recruited to participate during undergraduate physical education teacher education lab classes. Participants were monitored while participating in physical activities during normal class sessions. Classes were conducted in a typical indoor gymnasium slightly larger than a single standard collegiate-sized basketball court. RESULTS: Inspection of the graphs and ANOVA analyses revealed that the best configuration of the system was transmitter device placement at a height of 1.8m’ F(2, 1,052) = 54.86, p < .001, partial η2 = .09, at a 60°angle F(2, 1,052) = 12.50, p < .001, partial η2 = .02, and in the left corner location F(2, 1,052) = 24.28, p < .001, partial η2 = .04. CONCLUSIONS: The height, angle, and location of the transmitter component all played a significant role in reducing the prevalence of signal interruption. It was determined that the best results were found with the lowest height and smallest angle chosen. Therefore, random placement of transmitter height, angle and location will not yield the best heart rate monitoring results.