Developmental Delay In Children Research Articles

The effect of parental age on child development at 36 months: Insights from the Japan environment and children's study

BackgroundThe impact of parent-childbearing age on child development at 36 months of age is controversial. AimsWe used data from a large cohort study with multiple imputation and mediation analyses of variables. Methods and ProceduresA total of 72,606 parent–child pairs from the Japan Environment and Children's Study were included in the study. Parents' ages were categorized into five groups. We used five domains of the Japanese translation of the Ages and Stages Questionnaire, Third Edition (J-ASQ-3). Scores below the cutoff value at 36 months were defined as developmental delays in each domain. We used three logistic analysis models. In Model 3, we analyzed maternal and paternal age using other variables and covariates. Outcomes and ResultsThe outcome was a developmental delay in the five domains of J-ASQ-3. In Model 3, ORs for the developmental delay scores regarding parental age were significantly associated with all five domains of J-ASQ-3. The mediation analysis showed a significant mediation interaction effect for mothers but localized for fathers. ConclusionAdvanced paternal and maternal ages were associated with developmental delay in children. Awareness of the risks of childbearing at an advanced age is crucial. What’s the paper addsThis manuscript used data from a large cohort study with multiple imputation and mediation analyses. With these analyses, we identified the pure effect of advanced parental age on their children’s development at 36 months.

Deep Learning-Based Architecture for Down Syndrome Assessment During Early Pregnancy Using Fetal Ultrasound Images

Down's syndrome, also known as trisomy 21, is a prevalent genetic condition characterized by intellectual disability and developmental delay in children. The current study has prioritized the development of precise screening techniques for trisomy 21 in the initial stages of pregnancy in order to facilitate prompt diagnosis. This study presents an innovative paradigm for categorizing sagittal views in obstetric ultrasound examinations, specifically identifying Nuchal Translucency, a crucial component within the fetal brain, during the 11th to 14th weeks of pregnancy. The suggested deep learning-based system effectively detects the presence of the essential cerebral structure known as Nuchal Translucency, hence aiding in the diagnosis of Down's syndrome. A dataset comprising more than 1100 pre-processed 2D sagittal-view ultrasound images was gathered to train, test, and validate the proposed convolutional neural network model. The model results were utilized to quantify neurotensin levels and assess the presence of Down's syndrome by image classification. The performance of the model was assessed by measuring its sensitivity, specificity, and area under the curve metrics. These metrics were then compared to those of human experts who had received training in prenatal and ultrasound techniques. Notably, the suggested model attained an outstanding area under the curve score of 0.97. Our study suggests the most common non-invasive method for screening pregnant women for fetal abnormalities is ultrasound, which examines the unborn organs. The application of deep learning and machine learning techniques has significantly enhanced the diagnosis. In order to detect or anticipate conditions like Down syndrome, it assesses the intercranial structures of the developing embryo during the early stages of pregnancy. Developing an improved iteration of this model could serve as the foundation for an effective automated system for diagnosing Down's syndrome in its early stages within a clinical environment.

First-trimester fetal size, accelerated growth in utero, and child neurodevelopment in a cohort study.

Early pregnancy is a critical window for neural system programming; however, the association of first-trimester fetal size with children's neurodevelopment remains to be assessed. This study aimed to explore the association between first-trimester fetal size and children's neurodevelopment and to examine whether intrauterine accelerated growth could compensate for the detrimental effects of first-trimester restricted growth on childhood neurodevelopment. The participants were from a birth cohort enrolled from March 2014 to March 2019 in Wuhan, China. A total of 2058 fetuses with crown to rump length (CRL) (a proxy of first-trimester fetal size) measurements in the first trimester and neurodevelopmental assessment at age 2 years were included. We measured the first-trimester CRL and defined three fetal growth patterns based on the growth rate of estimated fetal weight from mid to late pregnancy. The neurodevelopment was assessed using the Bayley Scales of Infant Development of China Revision at 2 years. Each unit (a Z score) increase of first-trimester CRL was associated with increased scores in mental developmental index (MDI) (adjusted beta estimate = 1.19, (95% CI: 0.42, 1.95), P = 0.03) and psychomotor developmental index (PDI) (adjusted beta estimate = 1.36, (95% CI: 0.46, 2.26), P < 0.01) at age 2 years, respectively. No significant association was observed between fetal growth rate and PDI. For children with restricted first-trimester fetal size (the lowest tertile of first-trimester CRL), those with "intrauterine accelerated growth" pattern (higher growth rates) had significantly higher MDI (adjusted beta estimate = 6.14, (95% CI: 3.80, 8.49), P < 0.001) but indistinguishable PDI compared to those with "intrauterine faltering growth" pattern (lower growth rates). Main limitations of this study included potential misclassification of gestational age due to recall bias of the last menstrual period and residual confounding. The current study suggests that restricted first-trimester fetal size is associated with mental and psychomotor developmental delay in childhood. However, in children with restricted first-trimester fetal size, intrauterine accelerated growth was associated with improved mental development but had little effect on psychomotor development. Additional studies are needed to validate the results in diverse populations.

Adaption of Follow-Up Visits for Preterm and High-Risk Children for Video Consultations.

Introduction: Structured and standardized follow-up care for preterm and high-risk infants enables an early detection of developmental deficits. The aim is to adapt the in-person follow-up to video consultation. Developmental delays can thus be identified at an early stage, independently of in-person contact. Methods: The adaptation of these follow-up to video consultation is presented descriptively, compared with the in-person consultation (similarities, differences, challenges, and limitations). Professionals's experiences with the adaption are described. Results: The experience of n = 267 video consultations for follow-up of children up to 6 years shows that an adaptation of the in-person consultation is necessary and possible. Prerequisite is a digital medium with a stable internet connection on both sides: the professional and the family, as well as a portal for video consultations with certified, encrypted data transmission. Among infants, testing is almost entirely parent guided. For older children, testing procedures have been adapted. A neurological examination is largely possible, while a general pediatric examination is omitted. A survey on professionals' (n = 7) experiences with video- and in-person consultations found that the rate of complete follow-up visits and the resources required for taking medical histories, personnel, and time remained constant for both approaches. All reported that the video consultation is generally suitable for identifying developmental delays in children up to an age of 6 years comparable with in-person consultations. One professional stated that the physical examination of children aged ≥1 year is impossible. Discussion: Video consultation is an alternative despite some limitations when an in-person consultation is impossible. Developmental delays can be identified, and therapies recommended.

Perinatal depression trajectories and child development at one year: a study in China

BackgroundThe objective of the current study was to investigate the correlation between trajectories of maternal perinatal depression (PND) spanning from early pregnancy to one year postpartum and developmental delays observed in one-year-old children.MethodsThe dataset under examination encompassed 880 women who took part in a mother-child birth study conducted in China. Latent class growth analysis (LCGA) was employed to identify patterns in Edinburgh Postnatal Depression Scale (EPDS) scores of women, spanning from early pregnancy to one year postpartum. To assess the neurodevelopment of one-year-old children, a Chinese version of the Bayley Scale of Infant Development (BSID-CR) was employed. Logistic regression was employed to explore the association between PND trajectories and developmental delays in children, with appropriate covariate adjustments.ResultsThe trajectories of maternal PND identified in this study included a minimal-stable symptom group (n = 155), low-stable symptom group (n = 411), mild-stable symptom group (n = 251), and moderate-stable symptom group (n = 63). Logistic regression analysis revealed that mothers falling into the moderate-stable symptom group exhibited a notably heightened risk of having a child with psychomotor developmental delays at the age of one year.ConclusionsThe findings drawn from a representative sample in China provide compelling empirical evidence that bolsters the association between maternal PND and the probability of psychomotor developmental delays in children. It is imperative to develop tailored intervention strategies and meticulously design mother-infant interactive intervention programs for women with PND.

Prenatal mental health and emotional experiences during the pandemic: associations with infant neurodevelopment screening results.

This study determined whether parental mental health and emotional experiences during the prenatal period were linked to infant developmental outcomes through the Ages and Stages Questionnaire (ASQ-3) at 8-10 months. Participants included 133 individuals who were living in the US and were pregnant or had given birth within 6 months prior to enrollment. Respondents were majority White with high education and income levels. Online surveys were administered from May 2020 to September 2021; follow-up surveys were administered from November 2020 to August 2022. Parent generalized anxiety symptoms were positively associated with infant communication (β = 0.34, 95% CI [0.15, 1.76], p < 0.05), while parent-fetal bonding was positively associated with infant communication (β = 0.20, 95% CI [0.05, 0.76], p < 0.05) and personal-social performance (β = 0.20, 95% CI [0.04, 0.74], p < 0.05). COVID-19-related worry was negatively associated with infant communication (β = -0.30, 95% CI [-0.75, -0.12], p < 0.05) and fine motor performance (β = -0.25, 95% CI [-0.66, -0.03], p < 0.05). Parent mental health and emotional experiences may contribute to infant developmental outcomes in high risk conditions such as a pandemic. Maternal SARS-CoV-2 infection has been evaluated in relation to child outcomes, however, parent psychosocial experiences should not be overlooked when considering pandemic risks to child development. Specific prenatal mental health and pandemic-related emotional experiences are associated with infant developmental performance, as assessed by the Ages and Stages. Questionnaire (ASQ-3) at 8 to 10 months old. Findings indicate that parental prenatal anxiety and emotional experiences from the pandemic should be assessed when evaluating child developmental delays.

Decline in Processing Speed Tells Only Half the Story: Developmental Delay in Children Living with Sickle Cell Disease.

Children with sickle cell disease (SCD) may experience cognitive difficulties, including slowed processing speed. Thus, we investigated if processing speed changes over time. From 1992-2001, 103 participants with SCD aged 3-16 years (n ≤ 8.99 = 45; n ≥ 9.00 = 58) completed cognitive assessments. MRI was available for 54 participants. Between 1992-2002, 58 participants consented to one or two further assessments. A repeated measures regression using linear mixed-effects modelling determined longitudinal changes in processing speed index (PSI), examining the interaction between age (continuous variable) and timepoint (i.e., assessment 1 or 3) and controlling for MRI infarct status (i.e., no infarct, silent infarct, or stroke). Those aged ≤8.99 and ≥9.00 at first assessment experienced PSI decline. Declines were most prominent for the processing speed coding subtest, with a significant interaction between timepoint and age, t(31) = 2.64, p = 0.01. This decline may reflect a developmental delay, likely due to disease progression, with slower improvements in processing speed. Although there have been significant improvements in SCD treatments, mostly in high-income countries, processing speed still remains a target; thus, incorporating clinical monitoring of processing speed may help identify delay and allow for early intervention.

A 9-year retrospective cohort study of the monitoring and screening of childhood developmental delay in Thailand.

Developmental delay in early childhood can have negative long-term cognitive and psychiatric sequelae, along with poor academic achievement, so early screening and surveillance are paramount. The aim of this study is to evaluate the impact of screening and surveillance on child developmental delay using the Developmental Surveillance and Promotion Manual (DSPM) and the Thai Early Developmental Assessment for Intervention (TEDA4I) for Thai children aged 0-5years old. Data were obtained from the routine developmental screening for specific disorders at ages 9, 18, 30, 42 and 60 months conducted using DSPM and TEDA4I from 2013 to 2021. Descriptive statistics were used to analyse the data, and the results are visualised graphically herein. Only 56% of the children were screened for child developmental delay using DSPM. The proportion of children screened increased from <1% in 2013 to 90% in 2021. Suspected developmental delay prevalence increased significantly from 3.91% in 2013-2015 to 10.00% in 2016-2018 and 26.48% in 2019-2021. Moreover, of the children with suspected developmental delay who received developmental stimulation within a month, only 87.9% returned for follow-up visits when they were evaluated again using TEDA4I to ascertain any abnormalities and specific areas of deficit. The overall proportion of children diagnosed with developmental delay was 1.29%. During the pandemic, the proportion of screening tests for child developmental delay at routine vaccination visits and follow-ups decreased but was still at least 80% in each region. Since 1%-3% of children have suspected developmental delay, early detection is key to treating it as soon as possible. We anticipate that our findings will raise awareness in parents and caregivers about childhood developmental delay and lead to the implementation of early intervention and follow-up at the rural level in Thailand.

Combined nutrition and psychosocial stimulation intervention for child development in rural China: the role of parental resources

Early childhood interventions played a critical role in improving child development in impoverished contexts. Combined nutrition and psychosocial stimulation interventions (CNPSI) have shown more benefits than stand-alone supplemental nutrition interventions (SNI) in many developing countries. Based on a cluster randomized controlled trial in rural northwestern China, this study tested alternative theory-driven hypotheses regarding how primary caregiver’s education and family income may moderate the CNPSI’s effects on child growth environment and developmental delay risk. The trial cluster randomized 1,566 children aged 7–33 months from 111 villages (clusters) in Huachi County, Gansu Province, into an SNI group (N = 852) and a CNPSI group (N = 714). Multilevel regression models suggested that the CNPSI group had better home growth environment (p < 0·001) and lower risk of developmental delay (p < 0·001) than the SNI group. The CNPSI’s impacts on home growth environment and development delay were weaker for parents with higher education levels. However, household income did not significantly moderate the CNPSI effect for either outcome. Future interventions need to attend to the educational disparities in the resource-poor context.

Relationship between Childhood Disability or Developmental Delay and COVID-19 Pandemic Impacts on Families across the Canadian Maritime Provinces

This study examined the relationship between having a child with a disability or developmental delay and early impacts of the COVID-19 pandemic on family environments that influenced early childhood development and health in the Maritime provinces of Canada. This was a mixed method cross-sectional survey involving 256 primary caregivers of children with disabilities or developmental delays and 1720 primary caregivers of typically developing children aged 0–8 years. A Family access to resources and social support, parenting Abilities and self-care, and home Routines and Environments change scale (FARE Change Scale) was produced from the survey to assess the early impacts of the pandemic on family environments that influenced early childhood development and health. Open-ended questions provided in-depth description of the early impacts of the pandemic on family environments. Pooled bivariate and multivariate regression coefficients revealed that having a child with a disability or developmental delay significantly decreased a caregiver’s score on the FARE Change Scale by 1.95. The open-ended questions were thematically analyzed. Caregivers of children with disabilities or developmental delays discussed positive and negative impacts of the pandemic on their family environments. Overall, the study findings indicate that the early impacts of the pandemic on family environments that influenced early childhood development and health of children with disabilities or developmental delays were mixed and context-specific. The study findings inform the development of context-specific policies and programs to adequately support families of children with disabilities or developmental delays in public health crises similar to the pandemic.

Perkembangan Anak Pra Sekolah di Tinjau dari Status Gizi

Background: The prevalence of developmental delays in children is 12-16% in America and 13-18% in Indonesia. The ability to attend school is low and the economy is limited in adulthood. A 20% income deficit in adulthood because of loss of potential development. Nutritional status is one of the factors in child development but this is still pros and cons. Objective: To analyze nutritional status with child development. Method: The design used is Cross-sectional. The Study was conducted From September - November 2019.Total Population was 200 children. The research sample was all children attending PAUD in Srijaya Village, Alang-alang Lebar District in 2019 who fulfilled the inclusion and exclusion criteria. TB and BB were measured to assess children's nutritional status and then assessed by the WHO Growth Chart. Child development using KPSP. Bivariate data analysis with Chi-Square. Results: 16.7% obese, 83.3% good nutritional status. Doubtful child development is 36.7%, and appropriate child development is 63.3%. nutritional status was not related to child development (p=0.47). The RP results show that children with good nutritional status have a 10.826x chance that their development is appropriate compared to obese children. Conclusion: Nutritional status is not related to child development. Suggestion: Parents to provide democratic parenting, stimulate and good nutrition to children. Health Workers to routine carry out early detection of the development of toddlers.

Adverse Childhood Experiences and Developmental Delay in Young US Children.

Adverse childhood experiences (ACEs) are common and have been associated with poor developmental outcomes. We aimed to investigate the relationship between early ACE exposure, subsequent diagnosis of developmental delay, and receipt of developmental delay services by young children. In addition, we aimed to assess the impact of health-promoting behaviors such as breastfeeding and daily reading on these relationships. In this cross-sectional analysis of nationally-representative data from the 2017-2018 National Survey of Children's Health, we examined the relationship between ACEs, prior breastfeeding, daily reading, and developmental delay diagnosis among 7837 children aged 3-5 years, using multivariate logistic regression to adjust for family, personal, and sociodemographic characteristics. We found a dose-dependent relationship between ACEs and developmental delay diagnosis; compared to those without ACEs, developmental delay was more common among those with either one ACE (aOR = 2.03, 95% CI 1.17-3.52) or two or more ACEs (aOR = 2.34, 95% CI 1.25-4.37). Neither breastfeeding (exclusively breastfed for 6 months vs. never breastfed aOR = 0.70, 95% CI 0.33-1.46) nor daily reading (no reading versus daily reading aOR = 1.15, CI 0.57-2.33) were associated with incidence of developmental delay among study participants. There was no significant difference in receipt of services intended to meet developmental needs between children with and without ACEs. Children with very early ACE exposure are at increased risk for diagnosis of developmental delay. Early screening for ACEs and developmental delay may mitigate the early developmental manifestations of ACE exposure in vulnerable children.

INFLUENCE OF BABY MASSAGE KIT (BABY MASSAGE, MUSIC, AROMA THERAPY) ON BABY DEVELOPMENT at BIDAN'S PRIVATE PRACTICE IN PRUMNAS DISTRICT OF REJANG LEBONG DISTRICT

Aspects of development are gross motor, fine motor, personal social, and language. child development problems such as motor delays. Developmental delays in children can be prevented by providing stimulation that can improve development in children. one form of stimulation is baby massage. This study aims to determine the effect of baby massage KIT (baby massage, music, aromaTherapy) on the development of toddlers in the independent practice of midwives in the working area of the health center prumnas rejang lebong Bengkulu.Quasi Experimental research design, with pre test and post test design with control group.The population in this study were all toddlers in the working area of Perumnas Health Center, Rejang lebong Regency, Bengkulu Province. The sample was toddlers in the work area of Perumnas Health Center, Rejang lebong Regency, Bengkulu Province. The sampling technique was purposive sampling. The number of samples in this study were 42 respondents, with the criteria of 21 respondents in each group. The data collection tool in this study used a questionnaire to determine the characteristics of the respondent's mother, development in toddlers. Data collection for development using KPSP instruments. The data analysis used was the Wilcoxon test and the man whitney test. The results showed the influence of baby massage KIT (baby massage, music, aroma therapy) on the development of toddlers with a value of P &lt;0.05. Conclusion: There is an effect of baby massage KIT (baby massage, music, aromaTherapy) on the development of toddlers. man whitney test obtained p value 0.000 &lt;0.05 this means there is a difference in influence between baby massage Kit and conventional massage counseling on development

Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

BackgroundAlthough an association between maternal nutritional intake and developmental delays in children has been demonstrated, the association of the timing of meal intake and development delays remains unclear. We examined the association between breakfast intake frequency before and during pregnancy and developmental delay in children.MethodsOf the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 7491 answered the required questions and were analyzed. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: daily, and 5–6, 3–4, and 0–2 times/week. Child developmental delays at age 2 and 3.5 years were assessed using the Ages & Stages Questionnaire, Third Edition. Logistic regression models were constructed to examine the association between breakfast intake frequency in pregnant women and developmental delays in children aged 2 and 3.5 years.ResultsThe proportion of pregnant women who had breakfast daily was 78.1% in pre- to early pregnancy, and 82.2% in early to mid-pregnancy. The proportion of children with developmental delays was 14.7% and 13.4% at age 2 and 3.5 years, respectively. Compared with the risk in children of women who had breakfast daily from pre- to early pregnancy, children of women who had breakfast 0–2 times/week had a higher risk of developmental delays at 2 years of age: odds ratio (OR) 1.30, (95% confidence interval [CI], 1.02–1.66). The risk of developmental delays at age 2 years increased in the children of women who had breakfast 0–2 times/week in early to mid- pregnancy: OR 1.75 (95% CI, 1.32–2.32). The risk of developmental delays at age 3.5 years did not increase in the children of women who had breakfast 0–2 times/week from pre- to early and early to mid-pregnancy: OR 1.06 (95% CI, 0.81–1.39 and OR 1.15 (95% CI 0.84–1.57), respectively.ConclusionFor women with a low frequency of breakfast intake from pre- to mid-pregnancy there was an association with developmental delays in their children at age 2, but not at 3.5 years.

Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions.

Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck, and lung cancer. Cisplatin is also used to treat tumors in children, such as neuroblastoma, osteosarcoma, and hepatoblastoma. However, its clinical use is limited by severe side effects, including ototoxicity, nephrotoxicity, neurotoxicity, hepatotoxicity, gastrointestinal toxicity, and retinal toxicity. Cisplatin-induced ototoxicity manifests as irreversible, bilateral, high-frequency sensorineural hearing loss in 40-60% of adults and in up to 60% of children. Hearing loss can lead to social isolation, depression, and cognitive decline in adults, and speech and language developmental delays in children. Cisplatin causes hair cell death by forming DNA adducts, mitochondrial dysfunction, oxidative stress, and inflammation, culminating in programmed cell death by apoptosis, necroptosis, pyroptosis, or ferroptosis. Contemporary medical interventions for cisplatin ototoxicity are limited to prosthetic devices, such as hearing aids, but these have significant limitations because the cochlea remains damaged. Recently, the U.S. Food and Drug Administration (FDA) approved the first therapy, sodium thiosulfate, to prevent cisplatin-induced hearing loss in pediatric patients with localized, non-metastatic solid tumors. Other pharmacological treatments for cisplatin ototoxicity are in various stages of preclinical and clinical development. This narrative review aims to highlight the molecular mechanisms involved in cisplatin-induced ototoxicity, focusing on cochlear inflammation, and shed light on potential antioxidant and anti-inflammatory therapeutic interventions to prevent or mitigate the ototoxic effects of cisplatin. We conducted a comprehensive literature search (Google Scholar, PubMed) focusing on publications in the last five years.

Associations between parental and postnatal metal mixture exposure and developmental delays in a Taiwanese longitudinal birth cohort of preschool children.

Studies have evaluated the impact of environmental exposure to neurotoxic metals on developmental delays (DDs). However, comprehensive understanding regarding the associations between parental and postnatal exposure to metal mixtures and the occurrence of DDs in offspring is limited. In this study, we assessed the relationships between parental and postnatal exposure to three metals (arsenic [As], cadmium [Cd], and lead [Pb], levels of which were measured in toenails) and suspected DDs (SDDs) in preschool children within a Taiwanese longitudinal birth cohort. In total between 2017 and 2021, 154 pairs of parents and their children under the age of 6 years were recruited, and 462 toenail samples and 154 completed questionnaires were collected. Metal concentrations in toenails were quantified using inductively coupled plasma-mass spectrometry after acid digestion of the toenails. We applied multivariable logistic regression and Bayesian kernel machine regression to evaluate the overall effect and to identify key components of the metal mixture that were associated with the SDD risk. Higher concentrations of As, Cd, and Pb were found in the toenails of the parents of children with SDDs compared with the toenails of the parents of children without SDDs. Our examination of the combined effects of exposure to the metal mixture revealed that As concentration in the father's toenail and Cd concentration in the mother's toenail were positively correlated with the risk of SDDs in their offspring. Notably, the effect of exposure to the metal mixture on the risk of SDDs was stronger in boys than in girls. Our findings suggest that parents taking measures to minimize their exposure to metals might enhance their children's developmental outcomes.

Robot-Assisted Language Education and Speech Therapy for Children with Cleft Lip and Palate

Cleft lip and palate (CLP) is a congenital anomaly that can have detrimental effects on an individual's ability to produce certain sounds, including bilabial sounds such as /m/ and alveolar sounds such as /n/, as well as sounds that require closure between the nasal and oral cavities, such as sounds ending in /-ɪŋ/. While surgical intervention can assist in correcting anatomical irregularities, consistent speech and language therapy sessions are often necessary to overcome obstacles associated with speech production. The research problem addressed in this study is the interruption of regular therapy, as evidenced by the discontinuation of services during the COVID-19 pandemic, which can lead to setbacks in progress and an increase in the risk of developmental delays in children. To explore the potential of educational robots to address this problem, this paper (i) investigates the user requirements, usability considerations, and attitudes to speech therapy robots, from the perspective of parents and carers of children with CLP, (ii) presents an experimental prototype for CLP language education and speech therapy using a humanoid robot, named Robot Lily, based on input from prospective users; and (iii) evaluates the prototype Robot Lily on a subject with CLP. The robot has been programmed to interact with the child in a naturalistic manner, using the same language and gestures employed by human speech and language therapists. The robot can respond to inquiries, practice articulation and pronunciation, aid the child with speech fluency, provide feedback, and encourage continued speech exercises. The primary interactions between a child with CLP and Robot Lily were observed and evaluated, with the robot shown to provide a unique opportunity to acquire speech and language abilities in a captivating and interactive manner. Compared to web-based applications, speech education assistant robots like Robot Lily may offer children a more appealing, engaging, and practical solution; and be remotely controlled by humans for specialized interventions at home, thereby circumventing the challenges encountered during COVID-19. These findings and methods have been used to develop an integrated model for ethical robotic speech therapy utilizing machine learning, which is expected to help meet the growing demand for speech therapy services.

Screening and determinant of suspected developmental delays among Egyptian preschool-aged children: a cross-sectional national community-based study

BackgroundEarly childhood life is critical for optimal development and is the foundation of future well-being. Genetic, sociocultural, and environmental factors are important determinants of child development.AimThe objectives were to screen for suspected developmental delays (DDs) among Egyptian preschool children, and to explore the determinants of these delays based on sociodemographic, epidemiological, maternal, and child perinatal risk factors.MethodsA national Egyptian cross-sectional developmental screening of a representative sample of preschool children (21,316 children) aged 12 to 71 months. The Revised Denver Prescreening Developmental Questionnaire (R-PDQ) followed by the Denver Developmental Screening Test, 2nd edition (DDST) was used.ResultsEach screened child manifested at least one of six developmental categories. Either typical development, gross motor delay (GM), fine motor adaptive delay (FMA), Language delay (L), Personal-social delay (PS), or multiple DDs. The prevalence of preschool children with at least one DD was 6.4%, while 4.5% had multiple DDs. Developmental language delay was the most prevalent, affecting 4.2% of children. The least affected domain was GM (1.9% of children). Boys were more likely to have DD than girls. Children in urban communities were more likely to have at least one DD than those in rural areas (OR = 1.28, 95%CI: 1.14–1.42), and children of middle social class than of low or high social class (OR = 1.49, 95%CI: 1.30–1.70 & OR = 1.40, 95%CI: 1.23–1.59 respectively). The strong perinatal predictors for at least one DD were children with a history of postnatal convulsions (OR = 2.68, 95%CI: 1.97–3.64), low birth weight (OR = 2.06, 95%CI: 1.69–2.52), or history of postnatal cyanosis (OR = 1.77, 95%CI: 1.26–2.49) and mothers had any health problem during pregnancy (OR = 1.73, 95%CI: 1.44–2.07). Higher paternal and maternal education decreased the odds of having any DD by 43% (OR = 0.57, 95% CI: 0.47–0.68) and 31% (OR = 0.69, 95%CI: 0.58–0.82) respectively.ConclusionThis study demonstrates a considerable attempt to assess the types and the prevalence of DD among preschool children in Egypt. Perinatal factors are among the most common determinants of DD in preschool children and the majority could be preventable risk factors.

Quality of childcare and delayed child development in left-behind children in China.

Inequalities in job opportunities and income prompts many Chinese parents to leave rural regions to work in urban regions. Their children are left behind in rural regions, subjected to worse quality of childcare that jeopardizes their development. This study aimed to examine the association between quality of childcare and delayed child development in under-three years children left behind in China. Cross-sectional national survey was conducted in children left behind in rural China in 2017. Exploratory and confirmatory factor analysis was used to develop a quality of childcare index. Mutlilevel analyses determined factors associated with quality of childcare and child development on a province and individual level. The largest population of at-risk children left behind were found in higher-GDP provinces. Children left behind had the lowest mean quality of childcare score. Multilevel analysis found that province level accounted for a great proportion of variance observed. While migration to urban regions for work may improve household income, a trade-off in worse quality of childcare and developmental delays exists. With improving household income often being the greatest contributing factor for parental migration, policies to reduce inequalities in job opportunities and wealth between rural and urban regions are required. Previous studies identified higher prevalence of developmental delays in children left behind in China. However, quality of childcare has not been examined. Based on WHO's Nurturing Care Framework, we developed a quality of childcare index to assess its association with child development in children left behind. Greatest proportion of children left behind at-risk of developmental delays resided in higher-GDP states, indicating a trade-off in worse quality of childcare and developmental delays. Since improving household income is the main factor for parental migration, policies to close inequalities in job opportunities and wealth between rural and urban regions are required.

Patterns of Developmental Delay in Children with Autism Spectrum Disorder: A Perspective from a Developing Country.

Patterns of Developmental Delay in Children with Autism Spectrum Disorder: A Perspective from a Developing Country.