Development Of Strategies Research Articles

Demographic transition in aging neighborhoods: a GIS-based analysis from Germany's countryside

The ongoing demographic transition within aging single-family house neighborhoods in Germany poses a significant challenge for municipalities. The scarcity of data and information related to demographic composition and location quality complicates research efforts and the development of adaptive strategies for these residential areas. This issue is particularly pronounced in rural regions where resources for capturing and analyzing demographic trends are limited. To address this gap, we propose a methodology based on geographic information systems. In this approach, municipal population registers serve as a central data source for extracting insights about the residents. We present the findings primarily in the form of maps, as they are intended to be easily comprehensible for urban planners and local government staff. Additionally, we outline the initial steps in establishing a small-scale monitoring system that incorporates demographic indicators as well as reachability estimates. A case study from northern Bavaria is used as an illustration.

'We are pulled to the four corners': Qualitative role descriptions of advanced practice children's nurses in Malawi.

This study investigated emerging roles among specialist child health nurses (CHNs) in Malawi. Advanced nursing role development is globally advocated. Nursing role descriptions provide an evidential basis for workforce planning. Rigorously developed role descriptions are scarce worldwide, especially for Africa. Advanced nursing roles were introduced in Malawi's child health system a decade ago. We followed guidance on generating nursing role descriptions to collect and analyse qualitative data from interviews and focus groups, using qualitative content analysis. We used COREQ reporting standards. More than half (41/80) of Malawi's child health nursing workforce participated. Richly descriptive accounts of roles elicited three themes: leading and developing new services and improving existing ones; holding rare knowledge which uplifts care quality; and responsibility for developing the role. These responsibilities are experienced as a privilege and a burden, often meaning CHNs are 'pulled to the four corners'. We found evidence of remarkable achievements by Malawi's CHNs but also suggestions that they are under heavy strain. Because multi-stakeholder agreement about role content is crucial to successfully implementing advanced nursing roles, we hope the approach taken by this study, and the information generated, could be useful as part of human resources for health strategy development in other lower-resourced countries globally.

Characteristics of first-time blood donors with unsatisfactory hemoglobin level and positive hepatitis B test in Binh Dinh Province

Blood transfusion is essential in the treatment of a various diseases. In order to guarantee a safe and sufficient volume of blood supply, it is crucial to select appropriate donors based on stringent eligibility criteria. The objective of this study was to furnish robust epidemiological information and identify the risk factors linked to hepatitis B virus (HBV) infection and low hemoglobin levels in first-time blood donors in Binh Dinh. Understanding the causes for donor deferrals can assist better plan and establish an efficient recruiting strategies as well as evaluate donor selection criteria. A cross-sectional study was undertaken in Binh Dinh Provincial General Hospital from November 2022 to February 2023 to examine individuals in their first-time blood donation. Data were sourced directly from voluntary blood donation registration forms. HBsAg results were assessed using rapid immunochromatographic tests and chemiluminescent immunoassays. The rate of unsatisfactory hemoglobin levels was 2.56% tested on 1,638 participants. This rate was significantly associated with female sex (18 times greater odds than males), and lower weight. The results revealed that the rate of HBV infection was 3.13% when detected by the rapid test, but increased by 0.58% when measured by chemiluminescent microparticle immunoassay. The positive hepatitis B deferral correlated with sex (p<0.05), age group (p<0.05) and occupation (p<0.05). HBV was found the leading cause of deferral in the study area and associated with males, age groups (25–35 and 36–44), officer, worker-farmer, and self-employed people. The prevalence of low hemoglobin donor deferral obtained was 2.56%. Low hemoglobin deferral is associated with female gender, lower body weight, worker-farmer, and self-employed - others. This finding underscores a significant public health concerns, highlighting the need for strategies to lower the infection rates. Understanding the factors leading to defered donation can contribute to development of proactive strategies for recruiting and retaining donors.

Development of Intelligent Control Strategy for an Anesthesia System Based on Radial Basis Function Neural Network Like PID Controller

Development of Intelligent Control Strategy for an Anesthesia System Based on Radial Basis Function Neural Network Like PID Controller

Financial Inclusion in Muslim-Majority Countries: Overcoming Economic and Social Challenges Through Islamic Lending

This study explores the impact of Islamic loans on promoting financial inclusion and addressing socio-economic issues in Muslim-majority countries. It compares Islamic loans with other financial instruments to demonstrate their contribution to creating an inclusive financial system.The research analyzes the challenges associated with using Islamic loans to enhance financial inclusiveness and mitigate economic and social challenges. The research explores the unique characteristics of Islamic loans and their impact on financial accessibility, savings, credit availability, and comprehensive banking services through a comparative descriptive methodology, including a literature review and data analysis. The study's findings reveal that Islamic finance presents opportunities for financial inclusion. However, there are several obstacles that need to be addressed, including regulatory and legal frameworks, scalability issues, global integration, public awareness, and technical accessibility. To promote the adoption of Islamic finance and advance financial inclusion, collaboration among regulatory bodies, financial institutions, legislators, and the public is crucial. Further research and the development of effective strategies are necessary to promote financial inclusion in the Islamic economy.

Epidemiological and Histopathology Study of Gastric Lesions in Ouest Africa

Gastric pathologies represent a global public health problem due to their frequency and severity. The objective of the study was to epidemiologically evaluate all gastric lesions diagnosed at the Pathological Anatomy Laboratory of Saint-Louis, Senegal over a period of 30 months. In addition to sociodemographic parameters, different histological types and molecular profiles were described. A total of 372 cases was identified, 96% were biopsies and 4% were partial gastrectomy surgical specimens. The sex ratio was 0.92 with 48% men (N=179) and 52% women (N=193). The mean age was 45.08 years. The lesions were distributed as follows: gastritis accounted for 86.02% (N=320) of which 70% were Hp gastritis (N=224) followed by gastric cancers with 10.76% (N=40) of which 95% (N=38) were adenocarcinoma (ADC). Male predominance was clear with a sex ratio of 2.1 (N=26 H/12 F) and the tubular subtype was the most common at 55.26% (N=21) for these ADCs. At the molecular level, 17.14% of cases were HER2+ cotation 3+. Other types of cancer were rare, including 1 case of GIST and 1 case of lymphoma (1 case). Polyps were rarely observed with a rate of 1.67% (N=6) and mostly hyperplastic and glandulocystic type.These epidemiological data described in our study can contribute to the development of strategies and preventive measures in the fight against these diseases in sub-Saharan Africa where studies are scarce.

Sustainable Development Strategies and Assessment for the KYCAI Artificial Island Project in Hong Kong

This paper conducts an in-depth analysis of the sustainable development strategies and assessments for the Kau Yi Chau Artificial Islands (KYCAI) project in Hong Kong. The project aims to provide about 1,000 hectares of land to meet Hong Kong's medium and long-term land demands, enhancing its competitiveness as a financial and commercial center. The study focuses on the project's environmental impact and carbon emissions, providing improvement recommendations to enhance overall sustainability. Key areas include protecting natural ecosystems and restoring biodiversity during the island's construction, optimizing the implementation of low-carbon and clean energy projects, and integrating sustainability principles throughout the project's lifecycle. The government should also assume environmental leadership by combining policy regulations with communication across various stakeholders, ensuring the project achieves sustainable economic, social, and environmental development, laying a solid foundation for Hong Kong's future growth.

Contributions in the social and environmental dimension to floriculture in the hydrangea sector under a life-cycle analysis approach

The Colombian flower industry has been growing and consolidating itself as one of the main economic activities in the country. This activity generates significant environmental and social impacts throughout its life cycle that must be resolved in order to consolidate itself as a sustainable economic activity, and for this reason the project "Environmental, economic and social life cycle assessment for hydrangea agro-industrial companies as a strategy for sustainable development in the Province of La Paz in eastern Antioquia, Colombia" is being developed for small and medium-sized producers' crops to trigger impacts and externalities in the production process. The methodology used in the project was based on the series of ISO 14040 and 14044 Life Cycle Assessment (LCA) and UNEP standards, which were evidenced in the production process of hydrangeas for export in a small farm. Some of the significant results of the research allowed identifying that the cultivation stage has grater influence on the categories of environmental impacts and social indicators evaluated, thus achieving the consolidation of relevant actions to improve the performance of the crops from a sustainability perspective.

Socio-political dynamics in clean energy transition

A rapid and effective transition to low-carbon energy production is essential to limit climate change impacts. While the scientific community has mostly focused on research and development and techno-economic aspects, quantifying the role of public acceptability and policy in shaping emission trajectories has been much more elusive. This study investigates the coupled dynamics of nonlinear socio-political acceptance and anthropogenic CO2 emissions, with implications for climate policies and clean energy investments. Our findings show that a top-down policy approach alone may not be sufficient for effective emission cuts, highlighting the need for a multi-level strategy that combines top-down and bottom-up approaches. Additionally, opinion polarization can trigger detrimental CO2 emission oscillations when governments decide to take heavy-handed policy interventions in highly polarized socio-political systems. Delayed perception of climate change damage or abrupt reactions to extreme weather events may also significantly affect emission reduction efforts, although in the opposite direction. Integrating these socio-political dynamics into climate models can enhance our understanding of the complex interplay between human and natural systems, enabling the development of more effective and resilient mitigation strategies.

Immune cell signatures and causal association with irritable bowel syndrome: A mendelian randomization study

BACKGROUND The mucosal barrier's immune-brain interactions, pivotal for neural development and function, are increasingly recognized for their potential causal and therapeutic relevance to irritable bowel syndrome (IBS). Prior studies linking immune inflammation with IBS have been inconsistent. To further elucidate this relationship, we conducted a Mendelian randomization (MR) analysis of 731 immune cell markers to dissect the influence of various immune phenotypes on IBS. Our goal was to deepen our understanding of the disrupted brain-gut axis in IBS and to identify novel therapeutic targets. AIM To leverage publicly available data to perform MR analysis on 731 immune cell markers and explore their impact on IBS. We aimed to uncover immunophenotypic associations with IBS that could inform future drug development and therapeutic strategies. METHODS We performed a comprehensive two-sample MR analysis to evaluate the causal relationship between immune cell markers and IBS. By utilizing genetic data from public databases, we examined the causal associations between 731 immune cell markers, encompassing median fluorescence intensity, relative cell abundance, absolute cell count, and morphological parameters, with IBS susceptibility. Sensitivity analyses were conducted to validate our findings and address potential heterogeneity and pleiotropy. RESULTS Bidirectional false discovery rate correction indicated no significant influence of IBS on immunophenotypes. However, our analysis revealed a causal impact of IBS on 30 out of 731 immune phenotypes (P < 0.05). Nine immune phenotypes demonstrated a protective effect against IBS [inverse variance weighting (IVW) < 0.05, odd ratio (OR) < 1], while 21 others were associated with an increased risk of IBS onset (IVW ≥ 0.05, OR ≥ 1). CONCLUSION Our findings underscore a substantial genetic correlation between immune cell phenotypes and IBS, providing valuable insights into the pathophysiology of the condition. These results pave the way for the development of more precise biomarkers and targeted therapies for IBS. Furthermore, this research enriches our comprehension of immune cell roles in IBS pathogenesis, offering a foundation for more effective, personalized treatment approaches. These advancements hold promise for improving IBS patient quality of life and reducing the disease burden on individuals and their families.

Pharmacological activation of TLR7 exerts inhibition on the replication of EV-D68 in respiratory cells.

The globally reemerging respiratory pathogen enterovirus D68 (EV-D68) is implicated in outbreaks of severe respiratory illness and associated with acute flaccid myelitis. However, there remains a lack of effective treatments for EV-D68 infection. In this work, we found that the host Toll-like receptor 7 (TLR7) proteins, which function as powerful innate immune sensors, were selectively elevated in expression in response to EV-D68 infection. Subsequently, we investigated the impact of Vesatolimod (GS-9620), a Toll-like receptor 7 agonist, on EV-D68 replication. Our findings revealed that EV-D68 infection resulted in increased mRNA levels of TLR7. Treatment with Vesatolimod significantly inhibited EV-D68 replication [half maximal effective concentration (EC50) = 0.1427 µM] without inducing significant cytotoxicity at virucidal concentrations. Although Vesatolimod exhibited limited impact on EV-D68 attachment, it suppressed RNA replication and viral protein synthesis after virus entry. Vesatolimod broadly inhibited the replication of circulating isolated strains of EV-D68. Furthermore, our findings demonstrated that treatment with Vesatolimod conferred resistance to both respiratory and neural cells against EV-D68 infection. Overall, these results present a promising strategy for drug development by pharmacologically activating TLR7 to initiate an antiviral state in EV-D68-infected cells selectively.IMPORTANCEConventional strategies for antiviral drug development primarily focus on directly targeting viral proteases or key components, as well as host proteins involved in viral replication. In this study, based on our intriguing discovery that enterovirus D68 (EV-D68) infection specifically upregulates the expression of immune sensor Toll-like receptor 7 (TLR7) protein, which is either absent or expressed at low levels in respiratory cells, we propose a potential antiviral approach utilizing TLR7 agonists to activate EV-D68-infected cells into an anti-viral defense state. Notably, our findings demonstrate that pharmacological activation of TLR7 effectively suppresses EV-D68 replication in respiratory tract cells through a TLR7/MyD88-dependent mechanism. This study not only presents a promising drug candidate and target against EV-D68 dissemination but also highlights the potential to exploit unique alterations in cellular innate immune responses induced by viral infections, selectively inducing a defensive state in infected cells while safeguarding uninfected normal cells from potential adverse effects associated with therapeutic interventions.

Design of Selective PARP-1 Inhibitors and Antitumor Studies.

Designing selective PARP-1 inhibitors has become a new strategy for anticancer drug development. By sequence comparison of PARP-1 and PARP-2, we identified a possible selective site (S site) consisting of several different amino acid residues of α-5 helix and D-loop. Targeting this S site, 140 compounds were designed, synthesized, and characterized for their anticancer activities and mechanisms. Compound I16 showed the highest PARP-1 enzyme inhibitory activity (IC50 = 12.38 ± 1.33 nM) and optimal selectivity index over PARP-2 (SI = 155.74). Oral administration of I16 (25 mg/kg) showed high inhibition rates of Hela and SK-OV-3 tumor cell xenograft models, both of which were higher than those of the oral positive drug Olaparib (50 mg/kg). In addition, I16 has an excellent safety profile, without significant toxicity at high oral doses. These findings provide a novel design strategy and chemotype for the development of safe, efficient, and highly selective PARP-1 inhibitors.

The Efficacy of SEO as a Strategic Marketing Tool for Brand Promotion and Product Advertising

This article is devoted to the study of the role of SEO optimization in the promotion of the company's brand and products on the market. The purpose of the study is to study the effectiveness of using SEO in promoting the company's brand and products on the net. The main directions and ideas of the work consist in the analysis of SEO methods, consideration of examples of successful practice in various business sectors and identification of the main factors affecting the effectiveness of SEO. The scientific and practical significance of the work is to identify the features of using SEO to promote the company's brand and products on the Internet and to establish the effectiveness of various methods of SEO in practice. The research methodology includes an analysis of the literature, consideration of the stages of the implementation of the tool and a comparative analysis of SEO methods. The main results and analysis of the work show that the use of SEO is an effective way to promote the company's brand and products on the Internet, and to achieve maximum efficiency, it is necessary to take into account the specifics of the business and the audience, as well as constantly monitor changes in search engine algorithms. The value of the conducted research lies in the development of theoretical knowledge about the effectiveness of SEO for the promotion of the company's brand and products on the Internet, as well as in the practical application of the research results in the development and implementation of SEO strategies in various business sectors.

Progress and Challenges in Polystyrene Recycling and Upcycling.

Polystyrene is a staple plastic in the packaging and insulation market. Despite its good recyclability, the willingness of PS recycling remains low, largely due to the high recycling cost and limited profitability. This review examines the research progresses, gaps, and challenges in areas that affect the recycling costs, including but not limited to logistics, packaging design, and policymaking. We critically evaluate the recent developments in upcycling strategies, and we particularly focus on tandem and hydrogen-atom transfer (HAT) upcycling strategies. We conclude that future upcycling studies should focus on not only reaction chemistry and mechanisms but also economic viability of the processes. The goal of this review is to stimulate the development of innovative recycling strategies with low recycling costs and high economic output values. We hope to stimulate the economic and technological momentum of PS recycling towards a sustainable and circular economy.

First report of Fusarium falciforme causing root rot and wilt on strawberry in Sinaloa, Mexico.

In Mexico strawberry production has great economic importance for the local and export markets as the country is the main strawberry supplier to the United States (SIAP, 2020). In 2022, strawberry plants with yellowing and wilting leaves, root rot and wilting, necrosis of vascular bundles and small fruits symptoms were observed in different commercial fields in the north-central Mexican state of Sinaloa, causing yield losses of about 10%. Typical Fusarium spp. colonies were recovered from all samples. They produced abundant white aerial mycelium with cream to orange pigment and branched septate hyphae (Fig. 1) (Leslie and Summerell, 2006). A total of 18 monosporic isolates were obtained by serial dilutions. The 18 isolates grown for 10 days on carnation leaf agar (CLA) produced hyaline microconidia with 0-2 septa, measuring 9.2 - 15.4 by 4.5 - 6.5 μm (n = 40) and hyaline macroconidia with three septa that measured 28.4 - 53.5 by 4.5 - 9 μm (n = 40). Chlamydospores were not observed. A fragment of the translation elongation factor 1-alpha (EF1-alpha) gene was amplified by polymerase chain reaction (PCR) using the primer pair EF-1/EF-2 (O'Donnell et al. 1998) from two monosporic isolates. The sequences were registered in the NCBI GenBank under accession numbers OR878541 and OR878543 (FRESIN178 and FRESIN194). BLASTn queries of NCBI GenBank identified the sequences as F. falciforme with 98% and 100% similarity to accession numbers OQ262968 and DQ246941 respectively. Fusarium ID database also identified the sequences as F. falciforme, is a member of the F. solani species complex (FSSC). Phylogenetic analysis revealed the partial EF1 sequences grouped with F. falciforme (Fig. 2). A pathogenicity test was performed on thirty strawberry plants (cv. Cabrillo) grown in sterile vermiculite. The plants were inoculated by immersing roots in 20 mL of a conidial suspension (1 × 105 conidia/mL) of isolate FRESIN194. Twelve uninoculated plants served as the control. All plants were grown for 60 days under greenhouse conditions (28 to 35°C). The assay was repeated twice. After 50 days, symptoms of root rot and wilting leaves like those observed in the field were observed. Uninoculated control plants did not develop symptoms. The fungus was reisolated from necrotic tissues of the inoculated plants and identified as F. falciforme by sequencing the EF1-alpha gene and morphological characteristics, completing Koch's postulates. Fusarium falciforme has been reported as the causal agent of root rot, stem rot, and wilt of tomato, papaya, chickpea, onion, common bean, and maize in Mexico (Díaz-Najera et al. 2021, Douriet-Angulo et al. 2021, Felix et al 2022, Tirado-Ramírez et al 2018, Vega-Gutiérrez et al. 2019a, Vega-Gutiérrez et al. 2019b). To our knowledge this is the first report of F. falciforme causing root rot and wilt on strawberry in Sinaloa, Mexico. This result provides useful information for the development and implementation of disease control strategies to mitigate damage caused by F. falciforme.

Analysis of rare mutations associated with Thalassemia and their hematological characteristics in Chenzhou region of Hunan Province

To explore the distribution and hematological characteristics of rare thalassemia-associated mutations in Chenzhou region of Hunan Province with an aim to provide a basis for genetic counseling and effective prevention. A total of 37 370 individuals enrolled from January 2015 to December 2021 were screened by routine blood test and hemoglobin electrophoresis. The genotypes were determined with high-throughput sequencing. A total of 8 455 thalassemia mutations (including 185 rare ones) were detected, which had involved 27 mutational types. Rare type α-Thalassemia --THAI and CD31 (AGG>AAG) have the typical microcytic hypochromic hematological features, whilst SEA-HPFH, CD14 (CTG>-TG), CD37 (TGG>TAG), -90(C>T), Codon 15 (G>A), IVS-I-128 (T>G), CD86 (GCC>GC-) and Chinese Gγ+(Aγδβ)0 had typical microcytic hypochromic and β-thalassemia-associated hematological features of elevated HbA2 or HbF. In addition, the -50（G>A）heterozygotes of β-thalassemia had normal or slightly decreased MCV and MCH without an increase in HbA2. Various forms of thalassemia-associated mutations have been identified in the Chenzhou region of Hunan Province. Above finding has facilitated development of preventive and control strategies for thalassemia as well as birth health programs.

Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis.

Previous evidence of host innate immunity induced by live saprophytic Leptospira in mice led us to posit that these responses might mitigate leptospirosis severity upon a subsequent challenge with a pathogenic serovar. In this study, we validated our hypothesis. This is important for development of novel strategies to control leptospirosis and for understanding the epidemiologic risk factors of this and other infectious diseases transmitted by direct contact between pathogen and host. Unexpectedly, these studies also show that there is a correlation between kidney health after L. interrogans infection (less fibrosis marker ColA1) and higher shedding of this spirochete in urine. This suggests that a status of homeostasis may be reached after kidney colonization by L. interrogans that helps the spirochete fulfill its enzootic cycle.

Modular Access to Tetrasubstituted N−H Pyrroles by Catalytic 1,3‐Dipolar Cycloaddition of Azomethine Ylides and α,β‐Ynones

AbstractThe development of efficient synthetic strategies for the preparation of tetrasubstituted N−H pyrrole derivatives, especially in an environmentally benign fashion is important yet challenging. Herein, we report a copper(II)‐catalyzed tandem reaction involving 1,3‐dipolar cycloaddition of α,β‐ynones and glycine iminoesters, followed by copper(II)‐promoted oxidative (air) dehydrogenative aromatization, allowing de novo access to tetrasubstituted N−H pyrroles in up to 81 % yield under green reaction conditions. A possible reaction pathway is tentatively proposed. Finally, fully substituted pyrroles are available by N‐alkylation, and a preliminary phase‐transfer catalytic asymmetric N‐alkylation was also studied to give an axially chiral pyrrole.

Revolutionizing travel experiences: An in-depth analysis of intelligent booking systems and behavioral patterns

This study delves into the intricacies of booking behaviors, focusing on the preference for tropical coastal cities during colder seasons, given the burgeoning need for personalized and intelligent travel recommendations in the modern tourism landscape. Traditional booking systems, with their static algorithms, have often neglected the dynamic interplay of environmental factors and user preferences, necessitating an evolution towards more sophisticated, adaptive models. To address this, the research employed advanced machine learning and artificial intelligence techniques, amalgamating data from diverse sources like major tourism websites, hotel platforms, and social media. The methodology involved meticulous data preprocessing to ensure data quality and depth, followed by the implementation of deep learning models and time series analysis, which were instrumental in deciphering complex patterns and offering predictive insights. This comprehensive approach facilitated the integration of various environmental factors such as weather conditions and temporal events, enabling the system to craft hyper-personalized recommendations that resonate with user preferences and environmental nuances. The findings were illuminating, unveiling a significant inverse relationship between temperature and bookings and highlighting the influential role of temporal events in driving bookings. The advanced predictive models showcased commendable accuracy, underscoring the transformative potential of such intelligent systems in enhancing user experiences and engagement in the tourism sector. These insights pave the way for the development of innovative strategies that can significantly elevate user satisfaction and industry growth. The study concludes that the integration of machine learning and AI in booking systems can revolutionize the tourism industry by offering unprecedented levels of personalization and adaptability, catering to the diverse and evolving needs of modern travelers.

Strategies and Models for Development of Hot Water Tourism Objects in Tombasian Village Under Kawangkoan Barat District, Minahasa Regency

Tourism development is sought to be developed in the context of economic improvement, sustainable development and technological development. Geographically, each region has different characteristics with their own uniqueness and advantages. Natural resources that are owned with all its contents, land in all its forms and the sea with all its contents. This potential can be utilized optimally through tourism. Natural resources owned with all their contents and existing potential will be utilized for development purposes. That potential can be an asset through the tourism sector. One of the attractions that attracts the attention of both domestic and foreign tourists is the hot springs in Tombasian Bawah Village. Tombasian Bawah Village is one of the villages in Kawangkoan Barat District, Minahasa Regency, where in general the people work as farmers and craftsmen on stilt houses. Furthermore, the data that has been collected is analyzed by descriptive analysis using the SWOT analysis method and breaking it down internally and externally. The stages of the research were field observations by collecting data at the physical location, conducting interviews with the government of tourist attraction locations with village programs and district governments related to the development of tourism objects, specifically hot water in the village of Tombasian Bawah and visitors to obtain data. The results of the study show that the Hot Spring Tourism Object Development Strategy is adequate which can be applied by developing tourism on holidays and other holidays. And the model is community based. The development of this hot spring tourism object can be done by diversifying tourism objects and modifying the system so that tourists can travel easily and pleasantly. The results of this research are the proceding/Sentrinov output targets and reports.