The development of virtualization technology has promoted the development of computers in education, and the reform of basic education courses has promoted profound reforms in science education. The integration of virtualization technology and science teaching is an inevitable trend in the development of information technology and science education, and it is also training the inevitable requirement of talents with scientific culture and innovation ability. This article takes undergraduates as the research object and aims at the application characteristics of local higher education institutions, combined with the purpose of higher technical personnel training, application practical ability, and innovation ability, to establish a training system for college students with innovation ability suitable for engineering application undergraduate talent training mode, and improve students’ research and innovation ability and engineering practice ability. This article proposes to organically integrate virtualization technology with undergraduate students’ engineering innovation ability training courses, explore virtual technology experimental models, cognitive models, promote student self-study and student mutual learning, where students actively participate, and strengthen student innovation and creativity training. Improve the ability of design and transform teacher education into student-centered. The results of the study show that students’ innovative ability generally accounts for 56%, and the effects of innovative activities organized by schools generally account for as high as 70%. Students are generally not very enthusiastic about innovation.