Development Of Strategies Research Articles

Recapitulating the Cancer-Immunity Cycle on a Chip.

The cancer-immunity cycle is a fundamental framework for understanding how the immune system interacts with cancer cells, balancing T cell recognition and elimination of tumors while avoiding autoimmune reactions. Despite advancements in immunotherapy, there remains a critical need to dissect each phase of the cycle, particularly the interactions among the tumor, vasculature, and immune system within the tumor microenvironment (TME). Innovative platforms such as organ-on-a-chip, organoids, and bioprinting within microphysiological systems (MPS) are increasingly utilized to enhance the understanding of these interactions. These systems meticulously replicate crucial aspects of the TME and immune responses, providing robust platforms to study cancer progression, immune evasion, and therapeutic interventions with greater physiological relevance. This review explores the latest advancements in MPS technologies for modeling various stages of the cancer-immune cycle, critically evaluating their applications and limitations in advancing the understanding of cancer-immune dynamics and guiding the development of next-generation immunotherapeutic strategies.

Digital Publik Relation KEMENSOS dalam Pemanfataan Sosial Media

In the rapidly developing digital era, social media has become a highly effective communication tool for various organizations, including government institutions. This study aims to analyze the digital public relations (PR) strategies of the Indonesian Ministry of Social Affairs (Kemensos) in utilizing social media, as well as to evaluate the effectiveness and challenges faced. This research employs a qualitative method with a case study approach. Data were collected through content analysis of Kemensos' social media, in-depth interviews with Kemensos officials and digital communication experts, and online surveys of the public to evaluate their perceptions and engagement with Kemensos' social media content. The results show that Kemensos implements various digital PR strategies to increase public awareness and participation in social programs. The published content includes information on social programs, education, and important announcements, presented in various formats such as text, images, and videos. However, Kemensos faces several challenges, such as crisis management and reputation management on social media.This study finds that Kemensos' use of social media significantly influences the public's image and trust in the institution. The level of public engagement with Kemensos' content is also quite high, indicating the effectiveness of the implemented digital communication strategies. However, there is a need to improve responsiveness and crisis management in dealing with issues that arise on social media. Based on these findings, this study provides practical recommendations for Kemensos to enhance their digital PR strategies, including improving content quality, better crisis management, and increasing public engagement. This research also contributes to the development of digital public relations strategies in other government institutions, providing insights for academics and communication practitioners.

Pengembangan Pangsa Pasar Terhadap Pelaku UMKM dalam Industri Kreatif

Micro, Small, and Medium Enterprises (MSMEs) are a crucial sector in Indonesia's economy. The lack of thorough preparation by MSME actors results in suboptimal performance. This journal aims to investigate and outline effective market share development strategies for MSME actors in the creative industry. The method used is literature review. The research results show that market analysis, branding strategies, and understanding customs procedures are key in the market share development of MSMEs.

Autocatalytic oxidation of thiophene derivatives and co-degradation of refractory contaminants in Fenton reaction

The sluggish reduction of Fe(III) to Fe(II) restricts the decontamination efficiency of Fenton reactions. New strategy development toward enhancing Fe(II) regeneration and decontamination efficiency relies primarily on the well-established inorganic Fenton chemistry, yet the involvement of organic contaminants and its potential role in the Fenton reactions have been insufficiently concerned. Here, using 2,5-thiophene carboxylic acid (TDA) as a representative sulfur-containing heterocyclic contaminant and atrazine as a coexisting contaminant, we uncovered the promoting effect of thiophene derivatives on Fenton oxidation. The degradation of TDA and coexisting refractory contaminants was highly efficient in the sluggish Fe(III)/H2O2 oxidation process with autocatalytic features. Spin trapping and chemical scavenging results underpinned the crucial contribution of hydroxyl radicals (HO•) to organic oxidation. Analysis of iron cycling combined with theoretical calculations revealed that the enhancement of TDA on Fenton oxidation originated from the rapid reduction of Fe(III) by the primary radicals generated from addition of HO• to the thiophene ring

Совершенствование стратегии по выводу из кризиса неплатежеспособных организаций

The article presents the research results aimed at strategic management of an insolvent organisation to overcome the financial and economic crisis. Nowadays enterprises in Kazakhstan often have challenges with ensuring financial stability and solvency. As a result, many organisations become uncompetitive. It can cause a business bankruptcy. The article highlights modern issues of ensuring domestic commercial organisations financial stability. The paper proposes solutions available to improve an economic efficiency mechanism for managing the financial condition of insolvent organisations. Therefore, an integrated approach to the development and implementation of strategies to recover insolvent organisations from crisis includes financial recovery, optimisation of operational processes, management reorganisation, reorientation to new markets and products, strengthening marketing activities, and improving corporate culture. Each of these strategies is aimed at stabilising the financial condition, increasing efficiency, and competitiveness. The implementation of these strategies requires all organisation departments coordinated actions and adaptation to current economic conditions.

Germanium distribution in Mississippi Valley-Type systems from sulfide deposition to oxidative weathering: A perspective from Fule Pb-Zn(-Ge) deposit, South China

Abstract Germanium (Ge) is a critical raw material for emerging high-tech and green industries, resulting in considerable recent interest in understanding its distribution and geochemical behavior in ore deposits. In this contribution, the distribution of Ge and related trace elements in the Fule Pb-Zn(-Ge) deposit, South China, is investigated to reveal the distribution of Ge in the hydrothermal ores and during sulfide weathering, using multiple microanalytical techniques, including scanning electron microscopy, electron probe microanalysis and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). In the Fule MVT deposit, sphalerite (ZnS) is the most significant Ge-carrier relative to other sulfides, though the five recognized textural types of sphalerite display progressive depletion in Ge from the first sphalerite generation to the late one. In the early stage, sphalerite with fine-grained chalcopyrite inclusions has the highest Ge concentrations, probably accounting for a significant proportion of the total Ge. We interpret that high Ge concentrations in the early sphalerite may be attributable to high Cu activity in the mineralizing fluids. During oxidative weathering, Ge was redistributed from its original host, sphalerite, to the weathering product willemite (Zn2SiO4) rather than smithsonite (ZnCO3), with high levels of Ge (up to 448 μg/g) present in the willemite. The formation of abundant willemite largely prevents the dispersion of Ge during weathering. In principle, willemite-hosted Ge should be fully recoverable, and the Zn-silicate ores may, therefore, be a potential target to meet future demand. This study provides new information on how Ge behaves from sulfide- to weathering-stage in MVT systems, which directly impacts Ge mobility and deportment changes and the development of metal-lurgical strategies for Ge recovery.

A review of CO2-injection projects in the Brazilian Pre-Salt – Storage capacity and geomechanical constraints

This review describes the main geological and geomechanical aspects of CO2-injection projects in the Brazilian Pre-Salt reservoirs, focusing on the storage potential and geomechanical aspects of CO2 injection. The Pre-Salt reservoirs in the Santos Basin offer favorable conditions for CCS due to their geological characteristics and existing infrastructure. The thick evaporite caprock, primarily composed of halite, acts as an efficient seal against CO2 migration. The CO2-injection in the Pre-Salt has been active since 2010, with significant amounts of CO2 already stored in the reservoirs. The volumetric assessment estimates the static storage capacity of the Pre-Salt reservoirs to be over 3.3 Gt of CO2, considering only the four fields currently undergoing injection. Geomechanical constraints, including the maximum injection pressure and caprock integrity, are crucial considerations for safe CCS operations. The high stress regime and the hydrostatic state of the caprock minimize the risk of fracturing during injection. Furthermore, dynamic storage capacity calculations indicate the feasibility of injecting CO2 into Pre-Salt reservoirs. This review provides insights into the current state and future prospects of CO2-injection projects in the Brazilian Pre-Salt, contributing to the development of sustainable carbon mitigation strategies in the region.

Molecular and spatial evaluation of small rodents and Didelphimorphis infected with Mycobacterium leprae in the southern Amazon, Brazil.

The high levels of recent transmission of leprosy worldwide demonstrate the necessity of epidemiologic surveillance to understand and control its dissemination. Brazil remains the second in number of cases around the world, indicating active transmission of Mycobacterium leprae (M. leprae) in the population. At this moment, there is a consensus that the bacillus is transmitted by inter-human contact, however, different serologic, molecular, and histopathological approaches indicate the existence of non-human transmission sources. The qPCR assay was used to amplify the molecular targets 16S RNAr and RLEP, in samples of liver, spleen, and ear of wild animals belonging to Didelphimorphia and Rodentia orders, in highly endemic areas of Mato Grosso, Brazil. The RLEP repetitive sequence was positive in 202 (89.0%) samples, with 96 (42.3%) of these also being positive for the 16S gene. Regarding the collection sites, it was observed that the animals were found in areas profoundly deforested, close to urban areas. Our results suggest that wild animals can play an important role in the maintenance of M. leprae in endemic regions with major anthropic action in Brazil. Therefore, integrating human, animal, and environmental health care with the One Health initiative is highly efficient for the development of effective strategies to contain and control leprosy in Brazil.

Investigating EGFR, BRAF, and RAS Mutations in Oral and Cutaneous Squamous Cell Neoplasms: A Preliminary Report on Romanian Patients

Background: Head and neck cancers, and particularly, oral cancers have a complex pathogenesis that includes genetic mutations and epigenetic alterations which interfere with cellular signaling and can trigger tumor development. The purpose of this study was to reveal whether low-frequency hotspot mutations may be detected in a study lot with histopathological evidence of squamous cell carcinoma (SCC) of the oral mucosa and skin of the head and neck. Methods: Tumor biopsies from treatment naïve patients were tested for BRAF V600, NRAS G12/G13, NRAS Q61, KRAS Q61 mutations, and EGFR exon 19 deletions (Ex19Del) using droplet digital PCR (ddPCR). The tumors were also analyzed for EGFR T790M mutations by RT-PCR, using a CE-IVD validated kit, with a limit of detection of 0.05%. Results: None of the examined cases exhibited NRAS G12/G13, NRAS Q61, KRAS Q61, BRAF V600, or EGFR T790M mutations, indicating that these alterations are rare events in SCC pathogenesis. Interestingly, among the 12 specimens tested by ddPCR for EGFR Ex19Del, an HPV-negative cSCC tumor occurring in the parotid region tested positive for this drug-sensitizing mutation, offering unexplored therapeutic perspectives to the patient from whom it was collected. Conclusions: Our study highlights the important clinical implications of detecting low-frequency hotspot mutations in tumor biopsies by ddPCR. We believe that the ddPCR-assisted analysis of these mutations in larger SCC cohorts may provide us with mechanistic insights regarding their role in SCC pathogenesis and guide the development of novel therapeutic strategies for this problematic disease.

IMPLICATIONS OF YWHAH GENE EXPRESSION IN THE EARLY DETECTION OF SEPSIS.

Sepsis, a complex and multifaceted condition, is a common occurrence with serious implications for critically ill patients in the intensive care unit (ICU). The YWHAH gene encodes the 14-3-3n protein, a member of the 14-3-3 protein family. While existing research primarily focuses on the role of 14-3-3n in conditions such as schizophrenia and various cancers, our study revealed that the expression of the YWHAH gene remained relatively stable in both infected individuals and healthy controls. Through Venn plot analysis following weighted gene correlation network analysis, we observed a potential association between elevated YWHAH expression and the transition from infection to sepsis. In a comprehensive analysis of public single-cell transcriptome databases, the expression of YWHAH was found to be distinctive in cases of sepsis and infection. These findings were corroborated through an in vitro analysis utilizing real-time polymerase chain reaction. This study represents the initial identification of variations in YWHAH gene expression between patients with infection and sepsis, potentially offering insights for the development of early detection and treatment strategies for sepsis.

Comparative assessment of dry- and humid-heat extremes in a warming climate: Frequency, intensity, and seasonal timing

Dryand humid-heat extremes are two types of heat extremes, each exhibiting unique climatological characteristics and impacts on different sectors of society. Using historical simulations and projections produced under two Shared Socioeconomic Pathways (SSP2-4.5 and SSP5-8.5) by models from the sixth phase of the Coupled Model Intercomparison Project (CMIP6), we show a comparative assessment of the future changes in dry- and humid-heat extremes over global land. Relative to 1995–2014, projections for the mid-term future (2041–2060) and long-term future (2081–2100) periods suggest that most global regions will experience an increase in frequency and intensity of both dry- and humid-heat extremes, especially the tropical regions. In these future periods, the peak occurrences of dry- and humid-heat extremes in mid- to high-latitude regions often occur within the same month. However, there will be a one- to two-month gap between the peak occurrences of dry- and humid- heat extremes in tropical regions, primarily due to monsoonal circulations that introduce variability by causing dry-heat extremes before the onset of monsoons and humid-heat extremes as the monsoons commence. This suggests the need for sector-specific adaptation strategies during different periods of the year for tropical regions. Under both future scenarios, whether considering individual exposure or land area, the average level of exposure to extreme humid-heat days is projected to increase more significantly compared to dry-heat days. The above results highlight the risks associated with the intensification of humid heat in future climate scenarios and warrant the development of effective strategies to mitigate the adverse effects.

CRISPR-CAS9-MEDIATED EX VIVO GENE EDITING FOR INHERITED HEMATOLOGICAL DISORDERS: ADVANCEMENTS, CHALLENGES, AND CLINICAL POTENTIAL

Global healthcare systems have a great challenge in the form of inherited hematological diseases, which necessitates the development of new remedial strategies. By precisely targeting inherited abnormalities, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated protein 9 (Cas9)-mediated ex vivo gene editing has surfaced as a promising approach to treat these diseases. This review offers a comprehensive examination of the advancements, challenges, and clinical eventuality of CRISPR-Cas9-intermediated ex vivo gene editing for inherited hematological diseases. With advancements in CRISPR-Cas9 technology, the eventuality to correct inheritable mutations responsible for inherited hematological diseases is within reach. However, challenges such as off-target effects, immune responses, and ethical considerations need to be addressed for the safe and effective perpetration of this technology. A promising understanding of how CRISPR-Cas9-intermediated gene editing functions in practice is handed by ongoing clinical studies, giving rise to the possibility of advanced remedial approaches and bettered patient issues. By addressing these complications in a human-readable format, this review attempts to provide greater understanding and appreciation for the eventuality of CRISPR-Cas9 technology in revolutionizing the treatment landscape for these challenging disorders and contribute to the ongoing discussion in the field and facilitate further exploration towards effective treatments for these challenging disorders.

Multidisciplinary Approach Underpins Development of Marginal Presalt Reservoir

_ This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper OTC 35273, “Sururu Central: Appraisal and Development Plan for a Marginal Presalt Reservoir,” by Thiago E.S. Azevedo, L.M. Hayashi, and Rodrigo R.S. Leal, SPE, Petrobras, et al. The paper has not been peer reviewed. Copyright 2024 Offshore Technology Conference. _ The complete paper presents a multidisciplinary view of the evolution of the concept of a development project for the central area of the Sururu reservoir and the method applied to address challenges and propose solutions. The central area presents distinct characteristics from typical Brazilian presalt fields, with low permeabilities despite high porosity. Sururu Reservoir The reservoir is in the Santos Basin 230 km offshore Rio de Janeiro at water depths ranging from 2000 to 2300 m. The wildcat in the reservoir, 1-BRSA-618-RJS (1-RJS-656), is in the central area of the field, which is the main subject of the present work. The well exhibited reasonably high average porosity while presenting low permeabilities and low productivity when compared with other presalt wells. The second well, 3-BRSA-891A-RJS (3-RJS-682A), was drilled in 2011 in an area known as Iara Horst, also in the central area of the Sururu reservoir and presenting the same challenges faced by the wildcat. The third well, 3-BRSA-1181D-RJS (3-RJS-715D), was drilled in 2013 as a high-angle multifractured well consisting of an alternative architecture. Productivity results, however, were similar to the ones obtained in the previous wells. Investments were made in acquiring and reprocessing seismic data, ultimately leading to the drilling of the fourth well, 9-BRSA-1212-RJS (9-RJS-726). This well, in the Sururu Oeste area, revealed characteristics more similar to other Brazilian presalt fields and cleared the path to the later drilling of other Sururu Oeste wells. These good results paved the way for floating production, storage, and offloading (FPSO) vessel Petrobras 68 (P-68), which has produced both the Berbigão and Sururu reservoirs since November of 2019. P-68 is a 150,000-BOPD, 6-million std m³/d gas processing “replicant” FPSO that includes 10 producers (five from Berbigão and five from Sururu) and seven injectors (four in Berbigão and three in Sururu). However, the idea of developing an alternative for producing the Sururu Central area was never abandoned. In 2020, the ninth Sururu well and the fourth well in the central area, 9-SRR-5-RJS, was drilled near some of the main Sururu Central faults, aiming to test the existence of better reservoir quality or the presence of conductive in-situ fractures. The results from the well were in line with the results from the previous three wells drilled in the area, confirming the challenging nature of Sururu Central productivity. A suitable development strategy for the area was increasingly dependent on the attainment of long-term dynamic data that could support a modeling hypothesis for this unique presalt reservoir.

Testing a rapid assessment approach for estimating ecosystem service capacity in urban green alleys

Urban green infrastructure – the network of greenspaces across cities – provides ecosystem services that are important for urban sustainability. Because of this, cities are increasingly redeveloping underused alleys into green infrastructure to improve ecosystem service capacity. But it remains unclear if these green alleys are delivering on the promise of supplying particular ecosystem services. The indicators usually used within green infrastructure to measure ecosystem services may not be suitable for green alleys because of the unique structure, vegetative features and level of community engagement of these alleys. Here we developed and tested a rapid assessment approach to evaluate ecosystem service capacity appropriate for use by community members and practitioners, using a green alley network in Montréal (Canada) as a case study. We collected data on green alley vegetation, structural form and indicators of four ecosystem services (food provision, habitat for pollinators, anthropogenic noise regulation and air temperature regulation). We modelled the relationships between vegetation, structural form, and ecosystem services, to determine if these rapidly assessed features of green alleys are appropriate indicators to evaluate ecosystem service capacity. Our results show that a rapidly assessed measure of vegetative ground cover is strongly associated with habitat for pollinators, highlighting potential for vegetative ground cover as an indicator for this service. Rapid assessments of alley vegetation were not associated with air temperature or anthropogenic noise, contrasting the findings of previous studies. Lack of relationships between the explanatory variables and the four ecosystem services suggests that further research is required to untangle these complex relationships. Our research provides a starting point for developing indicators of ecosystem service capacity that are tailored specifically to the unique structure and features of green alleys, a crucial step in testing the efficacy of this increasingly popular sustainable development strategy.

Energy Efficiency Evaluation of Green Roofs As a Passive Strategy in The Mediterranean Climate

Green roofs are comprised of living vegetation that is installed on rooftops, serving as a sustainable architectural tool that offers numerous environmental, economic, and social advantages to the community. Green roofs have emerged as a prominent sustainable development strategy and architectural element in numerous urban centres worldwide. As for the effectiveness of green roofs in terms of boosting energy conservation in the Mediterranean climate of Amman, this research focuses on a standard medium-sized office building in Jordan. The main evaluation is carried out on the feasibility of enhancing the passive sustainability and energy performance of the building by applying extensive green roof technology. To determine the energy-saving potential, an annual energy demand in the absence of a green roof is estimated by a simulation program. In this paper, the analyses were performed in the form of parametric studies for assessing the impact of variation in soil depths on energy use, indoor temperature and carbon reduction. The study also indicates that green roofs can store heat and provide insulation enough to lessen the demand for comfortable temperature regulation indoors. The findings on energy savings indicate that energy consumption had reduced annually by up to 12%. This means that large-scale green roofs have the real opportunity to become an efficient sustainable passive design strategy for increasing the energy performance of office building in Amman climatic conditions.

In silico modeling the potential clinical effect of growth factor treatment on the metabolism of human nucleus pulposus cells.

While growth factors have the potential to halt degeneration and decrease inflammation in animal models, the literature investigating the effect of dosage on human cells is lacking. Moreover, despite the completion of clinical trials using growth differentiation factor-5 (GDF-5), no results have been publicly released. The overall objective was to quantitatively assess the effect of three clinically relevant concentrations of GDF-5 (0.25, 1, and 2 mg) as a therapeutic for disc regeneration. Firstly, this work experimentally determined the effects of GDF-5 concentration on the metabolic and matrix synthesis rates of human nucleus pulposus (NP) cells. Secondly, in silico modeling was employed to predict the subsequent regenerative effect of different GDF-5 treatments (± cells). This study suggests a trend of increased matrix synthesis with 0.25 and 1 mg of GDF-5. However, 2 mg of GDF-5 significantly upregulates oxygen consumption. Despite this, in silico models highlight the potential of growth factors in promoting matrix synthesis compared to cell-only treatments, without significantly perturbing the nutrient microenvironment. This work elucidates the potential of GDF-5 on human NP cells. Although the results did not reveal statistical differences across all doses, the variability and response among donors is an interesting finding. It highlights the complexity of human response to biological treatments and reinforces the need for further human research and personalized approaches. Furthermore, this study raises a crucial question about whether these potential biologics are more regenerative in nature or better suited as prophylactic therapies for younger patient groups. Biological agents exhibit unique characteristics and features, demanding tailored development strategies and individualized assessments rather than a one-size-fits-all approach. Therefore, the journey to realizing the full potential of biological therapies is long and costly. Nonetheless, it holds the promise of revolutionizing spinal healthcare and improving the quality of life for patients suffering from discogenic back pain.

Senescent endothelial cells: a potential target for diabetic retinopathy.

Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and relevant retinal diseases. Current therapeutic strategies on DR primarily focus on antiangiogenic therapies, which particularly target vascular endothelial growth factor and its related signaling transduction. However, these therapies still have limitations due to the intricate pathogenesis of DR. Emerging studies have shown that premature senescence of endothelial cells (ECs) in a hyperglycemic environment is involved in the disease process of DR and plays multiple roles at different stages. Moreover, these surprising discoveries have driven the development of senotherapeutics and strategies targeting senescent endothelial cells (SECs), which present challenging but promising prospects in DR treatment. In this review, we focus on the inducers and mechanisms of EC senescence in the pathogenesis of DR and summarize the current research advances in the development of senotherapeutics and strategies that target SECs for DR treatment. Herein, we highlight the role played by key factors at different stages of EC senescence, which will be critical for facilitating the development of future innovative treatment strategies that target the different stages of senescence in DR.

Researching the possibilities of using digital financial instruments by future economists for sustainable development purposes

Introduction. The authors explore the problem of developing digital financial literacy as the most important characteristic feature of positive financial behavior in the context of the transition to the digital economy. The purpose of this article is to identify priorities and trends in using digital financial instruments by future economists for sustainable development purposes. Materials and Methods. The methodological basis of the study is the strategy of sustainable development, the ideological foundations of which determine the need for readiness to live and act in changing conditions, to plan socio-economic development taking into account the limitations of activities and the consequences of decisions made. The main method of the empirical part of the study is T. Saaty’s scale which was employed in order to identify global priorities in the use of digital financial instruments. A sociological survey was conducted among students of the Financial University under the Government of the Russian Federation, Omsk State University named after F.M. Dostoevsky, Omsk State Technical University, schoolchildren of specialized economics classes (Gymnasia 19, Omsk) to identify priorities and trends in the use of digital financial instruments by future economists, taking into account gender and age preferences. Results. The ideas about the level of awareness about the problem of developing digital financial literacy are systematized, explaining the relationship between digital and financial literacy from the point of view of the prospects of the socio-economic space. Global priorities of the use of digital financial instruments by respondents were identified: the general sample prefers to work with optimal combinations of 2 banking payment systems. Analysis of correlations by gender shows that male respondents are better than the sample at the range limits, and female respondents are in the middle. The interpretation of the answers characterizes the women’s choice as stable, middle options of behavior (2-3 cards), which are less risky. Men, on the contrary, consider risk as a challenge that encourages activity, and go to the border of the sample (1-4 cards). A similar trend is typical for the age groups between 17 and 20 years. This, on the one hand, is explained by the psychological peculiarities of gender, and on the other hand, by active advertising campaigns of digital sets of financial services offered by leading Russian banks. An assessment of students’ awareness of new models of the digital economy has been obtained, demonstrating a good correlation as respondents grow older, which determines the positive dynamics of digital financial literacy of future economists (1-4 year undergraduate students) in the light of current labor market trends. Conclusions. The results of the research confirm that active use of digital financial instruments determines affirmative dynamics of positive financial behavior of future economists for the purpose of sustainable socio-economic development.

Magnetic Perturbations on Cable-Connected Satellites in Equatorial Orbit: A Review of the Current State of Research

Cable-connected satellites in equatorial orbit offer enhanced capabilities for various space applications, but their stability is susceptible to magnetic perturbations from the Earth's magnetic field. This literature review examines the current state of research on the effects of geomagnetic field on the dynamics of cable-connected satellites in equatorial orbit. We synthesize findings from previous studies on the impact of magnetic field on orbital dynamics, attitude control, and communication. Our review highlights the significance of considering magnetic perturbations in the design and operation of cable-connected satellites, and identifies knowledge gaps for future research. The results of this review can inform the development of strategies to mitigate the effects of magnetic perturbations and ensure the stability of cable-connected satellites in equatorial orbit.

A Study on the Development Strategies for Metaverse Picture Books Based on the Reading Characteristics of the Alpha Generation

A Study on the Development Strategies for Metaverse Picture Books Based on the Reading Characteristics of the Alpha Generation