Development Of Self-emulsifying Drug Delivery Systems Research Articles

Preparation, optimization, and In vitro drug release study of microemulsions of posaconazole

Self-emulsifying drug delivery systems (SEDDS) are novel carriers that could be used to improve the oral bioavailability of drugs with low water solubility. This study aims to develop stable microemulsions (MEs) as SEDDS that enhance the oral bioavailability of posaconazole (PSC) (BCS Class II compound). The other objective of this study was to optimize the impact of various factors affecting the formation, physicochemical characteristics, and stability of PSC-loaded SEDDS.The MEs were formed by mixing oil, surfactants, and cosurfactants based on the water titration approach. Different formulations were made and studied to characterize each formulation. In the optimization of the ME composition, the solubility study of PSC and the triangular phase diagram with various components (i.e., oils, surfactants, and co-surfactants) were taken into consideration. After selecting the best formulations, their physicochemical properties, including average particle size, polydispersity index, zeta potential, formulation stability, and turbidity, were investigated. Finally, the formulations were used for invitro drug release study. The results of this work prove that the selection of proper combinations of components allows for reaching drug-controlled delivery formulation. Additionally, the drug's effectiveness is enhanced with the optimization and development of SEDDS so that it reduces the total dose, thereby minimizing its side effects.

Self emulsifying drug delivery system (SEDDS) for phytoconstituents: a review.

The self emulsifying drug delivery system (SEDDS) is considered to be the novel technique for the delivery of lipophillic plant actives. The self emulsifying (SE) formulation significantly enhance the solubility and bioavailability of poorly aqueous soluble phytoconstituents. The self emulsifying drug delivery system (SEDDS) can be developed for such plant actives to enhance the oral bioavailability using different excipients (lipid, surfactant, co solvent etc.) and their concentration is selected on the basis of pre formulation studies like phase equilibrium studies, solvent capacity of oil for drug and mutual miscibility of excipients. The present review focuses mainly on the development of SEDDS and effect of excipients on oral bioavailability and aqueous solubility of poorly water soluble phytoconstituents/ derived products. A recent list of patents issued for self emulsifying herbal formulation has also been included. The research data for various self emulsifying herbal formulation and patents issued were reviewed using different databases such as PubMed, Google Scholar, Google patents, Scopus and Web of Science. In a nutshell, we can say that SEDDS was established as a novel drug delivery system for herbals and with the advances in this technique, lots of patents on herbal SEDDS can be translated into the commercial products.