Development Of Research Program Research Articles

Comfort in active learning spaces – students’ perceptions and preferences

ABSTRACT Evidence suggests that Active Learning (AL) and Active Learning Spaces (ALSs) have the potential to improve student learning outcomes. In this study, the student experiences of AL and ALSs in four classes in mathematics and statistics at a Norwegian university are examined through classroom observations, surveys, and interviews. The student interviews are analysed using constant comparative method, which resulted in one main category and three sub-categories presenting what the students perceived to be significant factors that impacted their learning experiences in the ALSs and how these factors affected their motivation to engage with the subject. The main category is called Engagement and Comfort, and the three sub-categories are called Students’ Varying Preferences, Student-student Communication, and Teachers’ Communication. Students’ motivation was looked at through an Approach-Avoidance Theory lens. Crucial to the student experiences was that some students felt deeply uncomfortable in the ALSs, which prevented them from engaging and benefitting from the ALSs. This research highlights how students’ comfort in the ALSs is essential to ensure their engagement and suggests many aspects that can support students’ comfort. Future research and professional development programmes built upon the reflections here can be used to support improved educational quality.

국내 체육계 진로상담 연구 동향 분석

Objectives The purpose of this study is to analyze the existing studies related to career counseling in the Korean sports discipline and tried to understand the current situation.
 Methods For this purpose, 17 articles related to career counseling in the domestic sports discipline published in registration sites and candidate registration sites by April 2023 were analyzed by dividing them into four criteria: number of articles by period, research subjects, theme, and methods. In addition, the contents of the program structure developed in each program development research were analyzed.
 Results The main results were as follows. First, it was confirmed that the number of related studies has increased since 2016. Second, the classification of subjects by school grade revealed that the most significant number of studies targeted adults, while sort of athletes revealed that the most significant number of studies targeted non-athletes such as physical education teachers and career counselors. Third, as a result of dividing research themes into three categories: ‘career education and career counseling’, ‘career counseling program development’, and ‘career change’, it was confirmed that the number of studies increased continuously over time. Fourth, Qualitative researches were the most frequently analyzed results by methods. Fifth, an analysis of the contents of the program structure developed in each program development research showed that all programs included self-understanding and exploration of careers, and most of the program subjects were retired athletes.
 Conclusions Based on the results of this study, it was found that research related to careers in the domestic sports world is still insufficient in quantity, but it is increasing. It is expected that there will be more related studies in the future, and it is necessary to expand the research subjects and methods, such as research focusing on athletes in high school and active athletes, when career education is the most appropriate period.

Philosophy-Infused Culture-Based Learning Models In Mathematics Education

The aim of this research is to explore and leverage the synergistic relationship between the philosophy of mathematics education and culture-based learning models. It seeks to investigate how philosophical perspectives can inform and enrich the development and implementation of culture-based learning models in mathematics education. Additionally, it aims to examine how integrating philosophical underpinnings can deepen students' comprehension of mathematical concepts within diverse cultural frameworks. Reading the entire paper is essential for anyone interested in advancing the field of mathematics education with a focus on cultural integration. This research explores the intricate relationship between the philosophy of mathematics education and culture-based learning models, offering valuable insights into how philosophical perspectives can enrich teaching practices within diverse cultural contexts. Moreover, it outlines crucial future research agendas, emphasizing the need for cross-cultural studies to identify universal and context-specific approaches, as well as the importance of equipping mathematics educators with the necessary skills through professional development programs. Overall, the paper provides a comprehensive roadmap for educators, researchers, and policymakers to promote inclusive and culturally relevant mathematics education, making it a must-read for those dedicated to enhancing educational practices in a diverse world. In conclusion, the integration of cultural elements in mathematics education is a dynamic field with promising future agendas. Cross-cultural research and teacher professional development programs are essential components for advancing the inclusivity and effectiveness of mathematics education in diverse contexts. By addressing these agendas, we can foster a more equitable and culturally responsive approach to teaching and learning mathematics.

Centering PrEP: Utilizing ADAPT-ITT to inform group PrEP care for sex workers in Chicago

BackgroundSex workers, those who trade sex for monetary or nonmonetary items, experience high rates of HIV transmission but have not been adequately included in HIV prevention and Pre-Exposure Prophylaxis (PrEP) adherence program development research. Community-empowered (C.E.) approaches have been the most successful at reducing HIV transmission among sex workers. Centering Healthcare (Centering) is a C.E. model proven to improve health outcomes and reduce health disparities in other populations, such as pregnant women, people with diabetes, and sickle cell disease. However, no research exists to determine if Centering can be adapted to meet the unique HIV prevention needs of sex workers.ObjectiveWe aim to explain the process by which we collaboratively and iteratively adapted Centering to meet the HIV prevention and PrEP retention needs of sex workers.MethodsWe utilized the Assessment, Decision, Adaptation, Production, Topical Experts, Integration, Training, Testing (ADAPT-ITT) framework, a model for adapting evidence-based interventions. We applied phases one through six of the ADAPT-ITT framework (Assessment, Decision, Adaptation, Production, Topical Experts, Integration) to the design to address the distinct HIV prevention needs of sex workers in Chicago. Study outcomes corresponded to each phase of the ADAPT-ITT framework. Data used for adaptation emerged from collaborative stakeholder meetings, individual interviews (n = 36) and focus groups (n = 8) with current and former sex workers, and individual interviews with care providers (n = 8). In collaboration with our community advisory board, we used a collaborative and iterative analytical process to co-produce a culturally adapted 3-session facilitator's guide for the Centering Pre-exposure Prophylaxis (C-PrEP +) group healthcare model.ResultsThe ADAPT-ITT framework offered structure and facilitated this community-empowered innovative adaptation of Centering Healthcare. This process culminated with a facilitator's guide and associated materials ready for pilot testing.ConclusionsIn direct alignment with community empowerment, we followed the ADAPT-ITT framework, phases 1–6, to iteratively adapt Centering Healthcare to suit the stated HIV Prevention and PrEP care needs of sex workers in Chicago. The study represents the first time Centering has been adapted to suit the HIV prevention and PrEP care needs of sex workers. Addressing a gap in HIV prevention care for sex workers, Centering PrEP harnesses the power of community as it is an iteratively adapted model that can be piloted and replicated regionally, nationally, and internationally.

JAK2 Loss Arising From Tumor-Spread-Through-Air-Spaces (STAS) Promotes Tumor Progression by Suppressing CD8+ T Cells in Lung Adenocarcinoma: A Machine Learning Approach.

Tumor spread through air spaces (STAS) is a recently discovered risk factor for lung adenocarcinoma (LUAD). The aim of this study was to investigate specific genetic alterations and anticancer immune responses related to STAS. By using a machine learning algorithm and drug screening in lung cancer cell lines, we analyzed the effect of Janus kinase 2 (JAK2) on the survival of patients with LUAD and possible drug candidates. This study included 566 patients with LUAD corresponding to clinicopathological and genetic data. For analyses of LUAD, we applied gene set enrichment analysis (GSEA), in silico cytometry, pathway network analysis, in vitro drug screening, and gradient boosting machine (GBM) analysis. The patients with STAS had a shorter survival time than those without STAS (P < 0.001). We detected gene set-related downregulation of JAK2 associated with STAS using GSEA. Low JAK2 expression was related to poor prognosis and a low CD8+ T-cell fraction. In GBM, JAK2 showed improved survival prediction performance when it was added to other parameters (T stage, N stage, lymphovascular invasion, pleural invasion, tumor size). In drug screening, mirin, CCT007093, dihydroretenone, and ABT737 suppressed the growth of lung cancer cell lines with low JAK2 expression. In LUAD, low JAK2 expression linked to the presence of STAS might serve as an unfavorable prognostic factor. A relationship between JAK2 and CD8+ T cells suggests that STAS is indirectly related to the anticancer immune response. These results may contribute to the design of future experimental research and drug development programs for LUAD with STAS.

Populist Foreign Policy: Mapping the Developing Research Program on Populism in International Relations

Abstract This article reviews one of the expanding research programs in international relations (IR): the study of populist foreign policy (PFP). Recent years have witnessed a significant proliferation of IR scholars researching the nexus between the global rise of populism and their foreign policies across different countries, regions, and sub-fields. However, scientific progress at such stage of this research program demands an in-depth “mapping” of its different ontological approaches. To this end, we identify and explore five “schools” of PFP that have been consolidated in the last decade, while highlighting their accomplishments in understanding the distinctive populist elements in foreign policy and their possibilities of analyzing local and external conditions under which PFP impacts global politics. We also set the stage for future contributions on the drivers, patterns, and effects of PFP, under the assumption that the populist phenomenon and its transnational dimensions will continue to affect IR prospects for a long time to come.

Developing research programs that align with the clinical mission

Building a competitive research program within a department of surgery requires a significant commitment by the department and the institution to provide the necessary resources for faculty recruitment, retention of current faculty, and physical space/infrastructure to support research activities. We expanded the academic footprint of our department as demonstrated by the expansion of the department of surgery research funding by 13-fold over a period of 7 years, resulting in an increase in national ranking from 55th place to 10th place in the National Institutes of Health extramural funding. This required attention to multiple factors that affect the ability of faculty to establish and maintain competitive research programs. We executed a plan that established a leadership structure that coordinates resources and provides mentorship to faculty. The department invested heavily in the recruitment of new faculty, especially junior faculty, but also some mid-career and senior investigators to develop a critical mass in specific areas for competitive large grant and program project applications. The pipeline of new trainees interested in research was augmented by successful training grant applications that created a mechanism by which residents and fellows can pursue research for periods ranging from a few weeks to 2 years. Administrative infrastructure was created to assist faculty in grant submissions as well as post-award management. Finally, in partnership with institutional leadership, the department acquired the physical space necessary to support both dry-lab and wet-lab research activities. To achieve true excellence, an academic surgery department must maintain excellence in both the clinical and research areas, which, in the context of an academic medical center, are not separate goals.

P52: Gardening for others as meaningful activity for people living with dementia

Objective:Time in nature is increasingly recognised as beneficial for people living with dementia, with research often focusing on the benefits of physical activity, proximity to natural environments and social interactions. However, limited research has investigated the role of purpose while gardening for people living with dementia. Purposeful activities are often lacking in programs for people living with dementia, who are sometimes excluded and have their capabilities underestimated, especially those with younger-onset dementia. Yet, these purposeful activities may be key to supporting people living with dementia to retain a sense of self-worth and connection to their communities.This project documented participants’ experiences of purposeful activity in the form of volunteering at a farm producing food for community members in need.Methods:Individuals living with dementia participated in farming activities over several weeks to help grow food for people in need. During this time, participants completed ‘walking interviews’, discussing the tasks undertaken, their perspectives on these tasks, how these activities fitted in with their own ways of being, and how they felt spending time in nature. Walking interviews provide contextual and environmental cues that may facilitate emotional and sensory connection in a way that traditional interviews do not. Their shorter and more flexible time frame provides additional adaptability for people living with dementia.Results:Walking interviews were audio-recorded, transcribed and thematically analysed. These analyses describe participants’ experiences at the farm, related to purpose in life. These included participants’ connection to times in their lives when they provided support, assistance or service to others, and their experience of engaging with the natural environment.Conclusion:This research contributes to understanding of benefits of purpose-focused time in nature, including that it provides an opportunity for people living with dementia to connect with different points in their lives when they have held other forms of purpose. Tips on setting up such a safe, enjoyable, inclusive gardening project are provided. Additional research into meaningful engagement in natural settings is warranted for people living with dementia, especially when it involves activities with benefit to communities.This project was supported by the Australian Association of Gerontology’s Hal Kendig Research Development Program.

Diet and Chronic Disease Research in the Women’s Health Initiative

The Women’s Health Initiative (WHI) has been a major contributor to diet and chronic disease research among postmenopausal US women over its 30+ year history (1993 to present). The WHI program included full-scale randomized trials of a low-fat dietary pattern high in fruits, vegetables, and grains, and of calcium and vitamin D supplementation, each with designated primary and secondary chronic disease outcomes. The history of these trials will be briefly reviewed here, along with principal findings that included evidence for breast cancer-related benefits for each of the 2 interventions. In recent years, WHI investigators have developed an active research program in nutritional biomarker development and in the application of these biomarkers in WHI cohorts, among various other nutritional epidemiology uses of WHI observational study resources. The intake biomarker work, which primarily relies on blood and urine metabolomics profiles, lends support to the low-fat dietary pattern trial results, and supports chronic disease benefits of higher carbohydrate diets more generally, especially through the fiber component of carbohydrate.

미술교육 프로그램 개발 및 적용연구 동향 분석

Objectives This study examines the master's thesis trends of art education program planning and execution of art education majors in the department of education at graduate schools of education in Korea for 18 years from 2005 to 2022, and proposes the direction of art education program development research.&#x0D; Methods A total of 262 articles were selected by searching for art education program development studies of master's thesis in art education major in the Department of Education of the Graduate School of Education in Korea using RISS, an information provision service for academic journals. High), by region (nationwide), by development basis, by area (experience/expression/appreciation), and by teaching/learning type (general type, block type, etc.). Descriptive statistics by frequency analysis were conducted using the SPSS WIN 23.0 Program as a measurement tool.&#x0D; Results The suggestions based on the results of this study are as follows. First, detailed information such as selection of research subjects, reasons for selection, grade level, and gender, which are basic information during the program development process, needs to be faithfully described and provided as reference material for other researchers to select research subjects in the future. Second, like the above research subjects, specific and accurate information about grade, gender, region, and number of participants can also be used as basic data, so it must be indicated. Third, for the suitability of art education program development, surveys, expert group review, Delphi method, etc. should be practically carried out. do. Fourth, the program participants' evaluation activities lead to reflective reflection, and an active attitude to revise and secure the art education program according to the evaluation results is required. Finally, most of the data in this study are qualitative studies, so objective data needs to be added. It is judged to be very meaningful to support the researcher's discussion through pre-inspection and post-inspection prior to the program.&#x0D; Conclusions Based on the results of this study, it is intended to be presented as a material that can supplement the development and progress of art education programs in the Department of Education, Graduate School of Education, and Art Education Major.

Development of High Durable Pore-Filling Anion Exchange Membranes for Water Electrolysis Application

Water electrolyzer is a device that converts renewable electrical energy into environmentally friendly chemical energy, hydrogen. Water electrolysis is mainly categorized into proton exchange membrane water electrolysis (PEMWE) and anion exchange membrane water electrolysis (AEMWE). Non-precious electrocatalysts and hydrocarbon-based polymeric membranes are used for two different systems. It is advantageous for AEMWE in terms of cost. However, low current density and chemical stability for current anion exchange membrane technology (AEM) restricts early market penetration. Thus, thedevelopment of low resistance and high durable AEMs is of importance. In this study, superior ion conductivity and high durable pore-filling AEMs were developed for AEMWE. Pore-filling AMEs with different contents of crosslinking monomers were prepared by the monomers using chemically stable anion exchangeable functional groups in a porous polyethylene(PE) substrate. Properties of the AEMs were characterized through areal resistance, ionic conductivity, ion exchange capacity, water uptake, swelling ratio, mechanical strength and hydrogen crossover. In addition, AEMWE performance and durability tests were also conducted. Acknowledgments This research was supported in part by Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ016253), Rural Development Administration, Republic of Korea and by 2021 Green Convergence Professional Manpower Training Program of the Korea Environmental Industry and Technology Institute funded by the Ministry of Environment.

Achievement and Aspiration of Local Colleges and Universities on the Research Agenda of Funding Institutions: Basis for Research Capability Building

This study was conducted for a specific purpose: to assess the research culture in the local colleges and universities and to propose an enhanced research capacity-building program. There were sixteen informants of this study; four administrators and twelve faculty members in the local colleges and universities in the CAMANAVA area namely: The University of Caloocan City, City of Malabon University, Navotas Polytechnic College and Valenzuela City Polytechnic College. A Purposive sampling technique was used to identify the informants. The study made use of a qualitative research approach. The data were collected from individual interviews with the administrators and faculty members. Using open coding, six (6) themes were emerged from the interviews and analysis of the document: philosophical research perspective, impact on institution’s growth and development, motivational components in research engagement, promoting the research culture, managing challenges and impediments and enhancing research capability. The informants identified the challenges in the development of the intensified research culture in the local colleges and universities which includes the scarcity of funds, research skills and expertise, network resources, and time constraint. These can be resolved through the enhancement of research capabalities and development programs. Generally, the study concluded that the research is indeed a powerful tool in addressing institutional problems and the utmost contribution of faculty members of the local colleges and universities in the academic and curricular programs and institutional growth and development. The institutional support will address the compelling need of the local colleges and universities to improve their research capability and research output.

Traditional knowledge in Folklore Practices - A Review

Traditional knowledge, often referred to as TK, is a fundamental concept that is closely tied to the traditions and cultures of different nations across the globe. It primarily encompasses the extensive experiences and enduring practices of specific regional, indigenous, or local communities. Moreover, it includes the collective wisdom, knowledge, teachings, and accumulated experiences of these communities, typically passed down orally from one generation to the next. As it is rooted in the unique knowledge held by ordinary individuals, including ethnic communities residing in specific regions or countries, this knowledge is limited to the genetic and non-genetic resources accessible within their immediate surroundings. This article emphasizes the significance of case studies, which hold potential interest and valuable information for AYUSH doctors and researchers engaged in drug development and related research and development programs. The majority of case studies included in this publication are previously unidentified or less widely known, and may not be documented in conventional Ayurvedic literature.

In Conversation with Salima Naji

Salima Naji is a registered architect (Paris La Villette School of Architecture, Paris) with a PhD in social anthropology from the École des Hautes Études en Sciences Sociales. She is based in Morocco and has been working on projects to protect southern Morocco’s oasis heritage for the past twenty years. She has designed, restored, or built over thirty bioclimatic buildings in unfired clay and/or stone: maternity hospitals, cultural and women’s centers, eco-lodges or hostels, boarding schools, museums, etc. She established her practice in Morocco in 2004, a studio specializing in the innovative use of sustainable raw materials and biosourced technologies (earth, stone, and palm tree fiber). In addition to her professional work, she also participates in sustainable research and action programs for environmental development in collaboration with local communities. She has published extensively, both in academia and for a larger audience, in French, English, and Arabic. Naji was awarded the Young Architects Prize from the EDF Foundation (Paris, 2004), the Holcim Prize for Sustainable Development, Africa-Middle East (2011), Takrim of the Order of Architects of Morocco (2010 and 2019), and the Chevalier Arts & Lettres de la République Française (2017). She was also twice shortlisted for the Aga Khan Award for Architecture (2013 and 2022).

1688-P: Glucokinase Activator Triggers PERK-UPR Pathway in Diet-Induced Obese Mice via Inducing Hepatic Lipid Accumulation

Background: To investigate the effect of glucokinase activation on glucose and lipid metabolism in diet-induced obese mice. Methods: Mice fed with High-fat-diet (HFD) or control diet for 16 weeks were subjected to glucokinase activator (GKA) or vehicle treatment by gavage for 4 weeks. Glucose tolerance tests were performed to evaluate the glucose-lowering effect of GKA. Hepatic lipid accumulation was assessed by H&amp;E, Oil-red’O staining, and transmission electronic microscopy. The underlying mechanism and subsequent effects of glucokinase activation-induced lipid accumulation was analyzed in liver. Protein levels of related genes were analyzed in mouse livers or AML12 cells. Results: Glucokinase activation improved glucose tolerance and insulin sensitivity in obese mice. Moreover, increased liver weight and TG Content were found in GKA-treated obese mice. Significant hepatic lipid accumulation was observed by multiple assays. RNA sequencing analysis indicated the increased expression of lipogenesis genes and activated PERK-UPR pathway in the liver. Inhibition of the lipogenesis-related gene Acc reduced the lipid levels caused by GKA treatment and alleviated PERK-UPR pathway in AML12 cell line. Conclusions: Glucokinase activation improved glucose tolerance while induced hepatic lipid accumulation through increased lipogenesis, which subsequently triggered PERK-UPR signaling pathway. Disclosure N.Cai: None. L.Zeng: None. X.Chen: None. J.Liu: None. Z.Wen: None. S.Wen: None. W.Zeng: None. S.Lin: None. Y.Chen: None. G.Shi: None. Funding National Natural Science Foundation of China (81770826, 82070811); National Key R&amp;D Program of China (2017YFA0105803); Key Area R&amp;D Program of Guangdong Province (2019B020227003); Sci-Tech Research Development Program of Guangzhou City (202201020497); Natural Science Foundation of Guangdong Province (2018B030311012)

1686-P: ER Stress Aggravates Diaphragmatic Weakness through Activating PERK/JNK Signaling in Obesity Hypoventilation Syndrome

Obesity hypoventilation syndrome (OHS) is associated with reduced quality of life and increased risk of death. Diaphragmatic dysfunction has been implicated in the pathogenesis of OHS. We found that significant diaphragmatic weakness and lipid accumulation in people with obesity as well as mouse models of obesity, which was associated with activated endoplasmic reticulum (ER) stress indicated by increased PERK signaling and activation of JNK pathway. In cultured myotubes, inhibition of PERK and JNK signaling abrogated the lipids deposition and ameliorated insulin resistance, and inhibition of JNK signaling reversed the impaired elasticity of myotubes induced by lipotoxicity. Collectively, our data suggest that activation of PERK/JNK signaling is an important pathophysiological factor contributing to diaphragmatic contractile dysfunction in OHS. Disclosure X.Xiang: None. Y.Zhu: None. X.Pan: None. W.Xin: None. W.Tang: None. X.He: None. G.Shi: None. Y.Chen: None. Funding National Key R&amp;D Program of China (2017YFA0105803); National Natural Science Foundation of China (82270886, 82070811); 5010 Clinical Research Projects of Sun Yat-sen University (2015015); Science and Technology Plan Project of Guangzhou City (202007040003, 202201020497); Key Area R&amp;D Program of Guangdong Province (2019B020227003); Science and Technology Research Development Program of Guangzhou City (202007040003, 202201020497)

Timely assessment of 5-year relative survival of esophageal cancer patients in Taizhou, Zhejiang province.

Timely assessment of 5-year relative survival of esophageal cancer patients in Taizhou, Zhejiang province.

Relationship matters: a qualitative study of medical students' experiences in a learner-driven research program in South Korea

BackgroundAlthough research experience is important for medical students, it is difficult to develop research skills only through a formal curriculum. To develop research programs that address the authentic needs of students and align with the entirety of the medical school curriculum, a learner-centered approach may be more effective than an instructor-centered approach. This study investigates medical student perspectives on factors that help them develop research competency.MethodsHanyang University College of Medicine in South Korea operates the Medical Scientist Training Program (MSTP) as a supplement to its formal curriculum. Semi-structured interviews were held with 18 students (20 cases) in the program, and qualitative content analysis was performed using the software tool MAXQDA20.ResultsThe findings are discussed in relation to three domains: learner engagement, instructional design, and program development. The students were more engaged when they perceived the program as a new experience, had prior research experience, wanted to make a good impression, and felt a sense of contribution. In terms of instructional design, they positively participated in research when their supervisors respected them, set clear tasks, provided constructive feedback, and invited them into the research community. In particular, the students highly valued relationships with their professors, and these relationships served not only as a main motivating factor in their research participation but also affected their college lives and careers.ConclusionsThe longitudinal relationship between students and professors has newly emerged in the Korean context as a factor that strengthens student engagement in research and the complementary relationship between formal curriculum and MSTP was highlighted to encourage student engagement in research.

What should students be able to do? Helping students recognize professional skills in our courses

Abstract While the traditional goals of undergraduate courses are often content-based, the development of career-readiness and professional skills, such as those listed by the National Association of Colleges and Employers, are increasingly recognized as important learning outcomes. As Mammalogy courses embrace more hands-on learning activities, they provide the opportunity to embed these professional skills, which are directly relevant to many careers in science. For example, many Mammalogy courses may include projects that incorporate experimental design and data analysis that focus on quantitative literacy, in addition to technical skills including small mammal trapping and handling, or preparing voucher specimens, that focus on problem-solving and attention to detail. Here, we review the professional skills that can be developed through a Mammalogy course and evaluate evidence-based approaches to build those skills into our courses. One approach, using Course-based Undergraduate Research Experiences (CUREs), provides opportunities for both student skill development and instructor research program development. Because they invite students to participate in authentic scientific inquiry—from study design and data collection, to analysis and reporting of results—students participating in CUREs reported significant gains in their comfort with several important professional skills, including conducting field procedures, formulating and analyzing data, normalizing failure, and attempting new procedures on their own. Finally, we review the literature to demonstrate how active learning approaches inherent in CUREs can help students to build familiarity with technologies and techniques for collecting and assessing data from wild mammal populations, as well as to build important professional skills such as teamwork, leadership, problem-solving, and written and oral communication.

MP39-01 CLASSIFICATION OF INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME (IC/BPS) USING A MACHINE LEARNING BASED SYMPTOM SCORE CONSTRUCTED ON INFLAMMATORY URINE CYTOKINES AND PATIENT-REPORTED OUTCOMES IMPROVES DIAGNOSIS

You have accessJournal of UrologyCME1 Apr 2023MP39-01 CLASSIFICATION OF INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME (IC/BPS) USING A MACHINE LEARNING BASED SYMPTOM SCORE CONSTRUCTED ON INFLAMMATORY URINE CYTOKINES AND PATIENT-REPORTED OUTCOMES IMPROVES DIAGNOSIS Laura Lamb, Joseph Janicki, Nitya Abraham, Melissa Laudano, Christopher Smith, Sarah Bartolone, Elijah Ward, Kenneth Peters, Bernadette Zwaans, Michael, and Chancellor Laura LambLaura Lamb More articles by this author , Joseph JanickiJoseph Janicki More articles by this author , Nitya AbrahamNitya Abraham More articles by this author , Melissa LaudanoMelissa Laudano More articles by this author , Christopher SmithChristopher Smith More articles by this author , Sarah BartoloneSarah Bartolone More articles by this author , Elijah WardElijah Ward More articles by this author , Kenneth PetersKenneth Peters More articles by this author , Bernadette ZwaansBernadette Zwaans More articles by this author , MichaelMichael More articles by this author , and Chancellor Chancellor More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003277.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: IC/BPS is a multifactorialsyndrome of severe pelvic and genitalia pain. Diagnosis of IC/BPS currentlyutilizes patient-reported outcomes (PRO) instruments to assess symptoms, howeveroverlapping symptoms with other diseases can delay proper diagnosis and symptomrelief. The objective of this study isto develop an improved IC/BPS risk classification, using machine learningalgorithm to leverage both urine inflammatory cytokines and PROs. METHODS: A national crowdsourcing resulted in 442 clinical urine samples consisting of 153 IC patients (146 female, 7 male), and 289 asymptomatic age-matched controls (155 female, 134 male) with corresponding PRO pain and symptom scores. This included 53 patients with a bladder-centric dysfunction as defined by presence of Hunner’s lesions. An independent validation cohort was also collected. Urinary cytokine levels were determined using Luminex assay. A predictive classification model, termed the Personalized Inflammation Symptom (PIS) Score, was generated from this data into three classification: 1) normal/low IC risk; 2) moderate to high risk for IC with bladder centric dysfunction; and 3) moderate to high risk of IC without bladder centric dysfunction. RESULTS: In the training set, the PIS Score correctly classified all controls, all IC patients without Hunner’s lesions, and 98% (52/53) IC patients with Hunner’s lesions. In the independent validation set, the PIS Score correctly classified 26 of 27 (96%), 14 of 19 (73.7%) IC without Hunner’s lesions, and all IC patient’s with Hunner’s lesions. CONCLUSIONS: In one of the largest collection of urine samples of IC/BPS patients from across all 50 states of US, two key findings emerged: 1) A standardized LUMINEX laboratory urine assay based IC-Risk Score is comparable to ICSI/ICPI or pain VAS in accuracy of diagnosis; 2) PIS, using laboratory-based objective data in combination with PROs, improves the AUC and accuracy of IC/BPS diagnosis. An objective laboratory test for IC/BPS, similar to tests that have been developed to improve cancer diagnosis, may help expand access, accelerate proper diagnosis, and improve care for IC/BPS, a disease with great unmet needs.Figure 1 Source of Funding: This work was supported by the Office of the Assistant Secretary ofDefense for Health Affairs through the Technology/Therapeutic DevelopmentResearch Program under Award No. W81XWH-19-1-0288. The opinions,interpretations, conclusions, and recommendations are those of the authors andare not necessarily endorsed by the Department of Defense. © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e534 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Laura Lamb More articles by this author Joseph Janicki More articles by this author Nitya Abraham More articles by this author Melissa Laudano More articles by this author Christopher Smith More articles by this author Sarah Bartolone More articles by this author Elijah Ward More articles by this author Kenneth Peters More articles by this author Bernadette Zwaans More articles by this author Michael More articles by this author Chancellor More articles by this author Expand All Advertisement PDF downloadLoading ...