Purpose. The purpose of the article is to present the organizational and economic potential of innovative entrepreneurship in the strategic development of the regional economy. Methodology of the research. The following research methods are used to achieve such purpose: theoretical synthesis, analysis, abstract and logical - to reveal the relationship of entrepreneurship, innovation and strategic development of regions in the context of achieving sustainable development goals; interpretation and comparison - to determine the prospects for increasing the innovative activity of enterprises in the region; tabular and graphical - for a visual presentation of Ukraine's ranking of GII, the dynamics of training highly qualified scientific personnel and the cost of research and development. Findings. It has been established that dreams about the transition of Ukraine from a low-tech resource to a high-tech innovative economy are pinned on innovative entrepreneurship, which ensures qualitative structural changes in the economy in favour of knowledge-intensive types of economic activity. It is substantiated that, unfortunately, Ukraine is inferior to neighbouring states in terms of innovative indicators, taking 30th place among 39 European countries. There is a growing gap between the national economy and European countries. The main indicators of the innovative potential of the regions, which correspond to the trends, of the rating of Ukraine according to the global index of innovations are analysed. The expediency of the formation and development of entrepreneurial regional innovation systems has been determined. Originality. The substantiation of the feasibility of the development of entrepreneurial regional innovation systems, the feature of which is mobility and the ability to quickly and adequately respond to changes in external conditions of functioning, was further developed. Practical value. Proposals substantiated in the research can be used by authorities, educational institutions and business structures for the development of regional innovation systems. Key words: potential, innovation, entrepreneurship, competition, strategy, regions.
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