Development Of Pyoderma Gangrenosum Research Articles

Case report of pyoderma gangrenosum in association with orthopaedic trauma

<p>Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis characterized by painful skin ulcers. It is associated with various systemic diseases but is rarely associated with orthopedic conditions. We report a case of a pyogenic gangrenosum in a 40-year-old male, that occurred in association with a lower limb fracture. This patient suffered a laceration over the ankle which was the sutured initially and the fracture was managed conservatively. Later on the wound was complicated with the development of pyoderma gangrenosum. Failure to treat with antibiotics and local wound management lead to alternative diagnosis by dermatologist. Patient was successfully managed by dermatologist and fracture was managed conservatively. Such incidents of PG in association with orthopedic procedures, complicate treatment and cause delay in recovery, leading to poor patient outcome.</p>

Rozwój piodermii zgorzelinowej w owrzodzeniu na tle niewydolności żylnej – opis przypadku

Rozwój piodermii zgorzelinowej w owrzodzeniu na tle niewydolności żylnej – opis przypadku

Post-surgical pyoderma gangrenosum following electrosurgery and elliptical excision: A rare disease following common procedures

Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis with an estimated annual incidence of 3–10 cases per million per year. Post-surgical pyoderma gangrenosum (PSPG) refers to the development of pyoderma gangrenosum at surgical sites in the postoperative period. A 55-year-old female was admitted with two acute and enlarging painful breast ulcerations resistant to antibiotic treatment following surgical resection and electrofulguration by her dermatologist. Multiple wound cultures were negative. A skin biopsy was consistent with PG and the wounds improved after adequate oral immunosuppressive therapy. A high index of suspicion, exclusion of other differential diagnoses, and previous experience with this disease ensured an early diagnosis, prevented injury to life and unnecessary debridement, and resulted in an excellent outcome for the patient.

Familial Pyoderma Gangrenosum: About 2 cases

Pyoderma gangrenosum occurrence in a familial pattern is extremely rare. We report pyoderma gangrenosum in two Tunisian siblings with onset respectively at 28 and 26 years old. The initial lesion was a pustule that breaks down to form an ulcer with an erythematous border. Treatment with oral corticosteroids induced an excellent clinical response. This familial clustering suggests a possible genetic role in the development of pyoderma gangrenosum in some cases.

Pyoderma Gangrenosum in Two Successive Pregnancies Complicating Caesarean Wound

Pyoderma gangrenosum (PG) is a rare ulcerative cutaneous disorder with tendency to recur in the injured area. Though most of the time is associated with chronic systemic conditions, it can occur in isolation and can be a diagnostic dilemma. The aetiology is poorly understood. The diagnosis is based on clinical features and excluding other causes of skin ulcers, as it does not have characteristic histopathology or laboratory findings. Lesions can develop after surgery, after trauma or de novo. We are reporting a 32-year-old pregnant lady with two previous instances of pyoderma gangrenosum in the previous pregnancy, who in postoperative period following caesarean section developed the same condition for the third time. She responded well to local wound care, oral Prednisolone, and Dapsone and made a good recovery. Pregnancy being an immunologically altered status can play a role in development of pyoderma gangrenosum and one should always rule out its possibility when there is a delayed wound healing.

Development of pyoderma gangrenosum during therapy with infliximab

Pyoderma gangrenosum is a rare inflammatory disease of unknown etiology and a poorly understood pathogenesis. Its clinical presentation is variable and a large percentage of cases are associated with inflammatory bowel diseases. Peristomal pyoderma gangrenosum represents a variant of the diseases, occurring in patients with colostomy. Multiple cases demonstrate efficacy of infliximab and other anti-TNF-alpha drugs in treatment of pyoderma gangrenosum. A 47-year-old male with ulcerative colitis and proctocolectomy with ileal pouch reconstruction protected by ileostomy in the course of diseases received infliximab therapy together with azathioprine for his inflammatory bowel diseases. Six months after initiation of infliximab therapy the patient developed multiple pyoderma gangrenosum lesions on the trunk, abdomen, genitalia, gluteus, extremities, left preauricular region and peristomal area. After systemic corticosteroid therapy, combined with topical tacrolimus, the lesions slowly improved. Seven months later, during ongoing infliximab therapy, the patient developed a sepsis with fatal outcome. Constant trauma generated by colostomy may be a contributing factor to the development and persistence of pyoderma gangrenosum. It may be hypothesized that this patient developed pyoderma gangrenosum despite infliximab or that pyoderma gangrenosum may represent a rare adverse effect of the drug.

Development of pyoderma gangrenosum during therapy with infliximab for ulcerative colitis: A case report

Development of pyoderma gangrenosum during therapy with infliximab for ulcerative colitis: A case report

Pyoderma Gangrenosum Associated With Active Chronic Hepatitis

In two patients, active chronic hepatitis was complicated by the development of pyoderma gangrenosum. The favorable response of the pyodermatous lesions to azathioprine therapy suggests that this drug may be of value in treating this disorder in patients for whom corticosteroid therapy produces no benefit or is contraindicated because of side effects. Azathioprine, too, is a potentially toxic drug and may need to be discontinued. Possible causal relationships between pyoderma gangrenosum and active chronic hepatitis are discussed.