Development Of Nocturia Research Articles

Prevalence of nocturia in young adolescents among preclinical, clinical, and agriculture students

Background: Nocturia is defined as a complaint of micturition that wakes a person up from sleep one or more times a night. Nocturia is one of the Lower Urinary Tract Symptoms (LUTS) that can be very disturbing for patients. All age ranges can experience nocturia, although the incidence is more prevalent in the elderly. The causative factors of nocturia vary widely. Several systemic diseases, hormonal imbalances, use of certain medications, and psychological conditions can play a role in the development of nocturia. Objective: Determine prevalence and potential influencing factors of nocturia in young adolescents. Method: This cross-sectional study was conducted online on students of the Preclinical, Clinical, and Agriculture students at Universitas Brawijaya, Malang, Indonesia using Google Form adapting the International Consultation on Incontinence Questionnaire Nocturia (ICIQ-N). Results: A total of 384 respondents were obtained. The average age of respondents was 20 years. The incidence of nocturia among 384 respondents was 53%. Female respondents experienced more nocturia (67.64%) than males. Conclusion: Nocturia is a common complaint among younger age groups, and is predominantly experienced by women.

MP49-10 EFFECTS OF CONSTANT ILLUMINATION ON MOUSE VOIDING BEHAVIOR

You have accessJournal of UrologyCME1 May 2022MP49-10 EFFECTS OF CONSTANT ILLUMINATION ON MOUSE VOIDING BEHAVIOR Whitney Clearwater, Yi Wang, Marcia Urban-Maldonado, and Sylvia Suadicani Whitney ClearwaterWhitney Clearwater More articles by this author , Yi WangYi Wang More articles by this author , Marcia Urban-MaldonadoMarcia Urban-Maldonado More articles by this author , and Sylvia SuadicaniSylvia Suadicani More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002624.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Stress caused by exposure to prolonged constant illumination (CI) has been shown to result in desquamation of superficial urothelial cells and disrupt the urothelial barrier in the mouse bladder. A leaky urothelium is a recognized factor in mechanisms that can drive bladder hypersensitivity and emergence of symptoms of urgency and urinary frequency. However, little is known of the effects of this type of stressor on bladder function. The goal of this study was to determine if exposure to constant illumination stress (CIS) alters the mouse voiding behavior, and if the effects of CIS persist after stress cessation. METHODS: Female C57BL/6CrN mice (20-weeks old) were randomly assigned to control (submitted to conventional 12h/day room illumination) or CIS (96hrs of constant room illumination) groups. Voiding behavior in the animals’ active (night-time) and sleep (daytime) phases was characterized using the voided stain of paper (VSOP) method. VSOP was conducted at baseline (pre-CIS), at the day after ending the 96hrs-CIS and at 7 and 14 days after CIS cessation. Spontaneously voided urine was collected at these time points to indirectly evaluate urothelial sensory function by quantifying changes in urine ATP levels using the luciferin-luciferase assay. Data was expressed relative to pre-CIS levels and non-stressed controls, and statistical differences determined at a p<0.05 level using the Mann-Whitney test. RESULTS: Exposure to 96hrs-CIS induced a 2.5-fold increase in urinary frequency of CIS-mice (pre-CIS: 0.25±0.04 voids/hour vs 96hr-CIS: 0.40±0.06 voids/hour, n=5, p<0.03). At 7- and 14-days post-CIS, the urinary frequency of CIS-mice remained 2.7- and 2.4-fold higher than that of non-stressed controls, respectively. Remarkably, this persistent effect of CIS was observed in the animals’ sleep phase (daytime) but not in their active phase (night-time), indicating development of nocturia. Further investigation showed that voided ATP levels were markedly elevated after 96hrs-CIS and remained at 2.5-fold higher levels than controls at 14 days, indicating dysregulation of urothelial mechanosensory responses. CONCLUSIONS: Exposure to 96 hours of constant illumination causes persistent, long-lasting changes in voiding function that may be due to urothelial sensory dysfunction. The CIS model can provide a reliable and simple tool to investigate mechanisms underlying the effects of stress on urinary function. Source of Funding: DoD-CDMRP W81XWH-21-1-0465 (PI: Suadicani) © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e857 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Whitney Clearwater More articles by this author Yi Wang More articles by this author Marcia Urban-Maldonado More articles by this author Sylvia Suadicani More articles by this author Expand All Advertisement PDF DownloadLoading ...

Transition from Childhood Nocturnal Enuresis to Adult Nocturia: A Systematic Review and Meta-Analysis.

PurposeCurrent literature has suggested a relationship between nocturnal enuresis (NE) in childhood and the development of nocturia later in life as both disorders have similar underlying etiologies, comorbidities, and treatments. The objective was to synthesize the available evidence on the association between childhood NE and later presentation of nocturia.MethodsPubMed, CINAHL, Scopus, and Google Scholar were searched for peer-reviewed studies published between January 1980 and April 2021. Case–control and cohort studies that reported on childhood NE and current nocturia were included. The PRISMA protocol was followed (PROSPERO ID: CRD42021256255). A random-effects model was applied to calculate the pooled odds ratio (OR) and 95% confidence interval (CI). Risk of bias was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria and with a funnel plot.ResultsOf the 278 articles identified, 8 studies met inclusion criteria. The 6 case–control and 2 prospective cohort studies resulted in a total sample size of 26,070 participants. In a random-effect pooled analysis, childhood NE was significantly associated with the development of nocturia (OR: 1.75, 95% CI: 1.11–2.40). Significant heterogeneity (I2 = 92.7%, p < 0.01) was identified among the included studies, which was reflected in an asymmetrical funnel plot. NE and nocturia have similar underlying etiologies of hormonal abnormalities, sleep disorders, physiological disorders, and psychological disorders.ConclusionThe history of childhood NE is significantly associated with nocturia later in life. The data in this meta-analysis support this transition and identify potential similarities between the two disorders. The sparse number of articles relevant to this topic is a strong indicator of the need for more work on this transition from childhood to maturity. More studies are warranted to further explore the association between NE and nocturia.

40 SLEEP APNEA CAUSES BLADDER OXIDATIVE STRESS AND NUCTURIA IN RATS

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research (1)1 Apr 201340 SLEEP APNEA CAUSES BLADDER OXIDATIVE STRESS AND NUCTURIA IN RATS Kazem Azadzoi, Farzana Nipa, Yedan Li, and Mike Siroky Kazem AzadzoiKazem Azadzoi Boston, MA More articles by this author , Farzana NipaFarzana Nipa Boston, MA More articles by this author , Yedan LiYedan Li Boston, MA More articles by this author , and Mike SirokyMike Siroky Boston, MA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1415AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Sleep apnea (SA) is a chronic condition affecting over 18 million adults in the United States where the affected person repeatedly stops breathing during sleep causing blood oxygen levels to drop and then rapidly increase with breathing. This initiates repeating cycles of hypoxia and reoxygenation. The incidence of SA closely correlates with the prevalence of nocturia. Our goal was to assess bladder oxidative stress markers and examine micturition behavior and cystometric parameters in a rat model of SA. METHODS Male Sprague-Dawley rats were divided into treatment (SA, n=8), sham (n=8) and control (n=8) groups. The treatment group was exposed to conditions similar to SA by housing the animals in computerized servo-controlled oxycyclers that produced reductions in ambient oxygen level from 21% to 8% for 8 seconds then rebound to 21% oxygen for 20 seconds. The computer was programed to repeat this cycle every 90 seconds for 8 hours daily for 8 weeks. The sham group was housed under similar oxycycler conditions with air supply alternating slightly from 21% to 20% oxygen 8 hours daily for 8 weeks. The control group was not exposed to oxycycler and used as age-matched control. After 8 weeks, day and night time voiding behavior of animals were assessed in metabolic cages under 12:12 hours light/dark cycles conditions. After this, cystometrograms were obtained then bladder tissues were processed for biochemical assays, ELISA and transmission electron microscopy (TEM). RESULTS Animals exposure to SA conditions significantly increased micturition frequency and diminished voided volume. Cystometrograms showed a significant increase in spontaneous bladder contractions in animals exposed to SA conditions in comparison with sham and control animals. The duration and amplitude of bladder contractions were significantly greater in the SA group. ELISA of bladder samples from SA group showed oxidative tissue damage characterized by increases in protein oxidation and lipid peroxidation products, decrease in antioxidant enzymatic activity, and accumulation of the oxidative product 8-isoprostane PGF2 alpha and nitrosative product nitrotyrosine. TEM of bladder samples from SA group showed swollen mitochondria, loss of mitochondrial cristae, and diffused accumulation of connective tissue. CONCLUSIONS SA exposes the bladder to oxidative stress and may play a role in the development of nocturia. The mechanism appears to involve free radical incursion of the cellular and subcellular elements and oxidative modification of the bladder mitochondrial energy apparatus and smooth muscle contractile component. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e16 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kazem Azadzoi Boston, MA More articles by this author Farzana Nipa Boston, MA More articles by this author Yedan Li Boston, MA More articles by this author Mike Siroky Boston, MA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

1743 WHAT PREDICTS INCIDENT NOCTURIA? A POPULATION-BASED STUDY IN OLDER MEN: THE KRIMPEN STUDY

INTRODUCTION AND OBJECTIVES: Many conditions and characteristics are associated with nocturia, however, there is a paucity of data on the factors that predict the development of nocturia. We therefore determined factors predictive of incident nocturia. METHODS: We analyzed the database of a population-based cohort study among 1,688 men aged 50-78 years old, without radical prostatectomy, transurethral surgery, or bladder or prostate cancer, living in Krimpen aan den IJssel, The Netherlands. Data were obtained using frequency-volume charts (FVC), from which the nocturnal voiding frequency (NVF) was determined. Nocturia was defined as NVF ≥ 2. Conditions and characteristics were determined via medical examination and a 113-item questionnaire. Men without nocturia at baseline (BL) and no exclusion criteria met were selected. At the first follow-up round (FU-1; after 2.1 years) we determined how many men developed nocturia. Univariable analyses were done to determine the association between the BL characteristics and nocturia-status at FU-1. Variables with an association p <0.25 were selected to create a multivariable logistic regression model. After a manual backward selection procedure a final model was created with only significant associations (piu0.05). RESULTS: At BL 1597 men completed an FVC, 133 men met the exclusion criteria. 342 men were excluded because of missing sleeping-hours, and 386 men had nocturia (34.4%), resulting in a target population of 736 men. At FU-1, 341 men were excluded because they did not void during the night or within the first hour of rising, did not complete a FVC, or due to loss to follow up. Therefore, analysis could was possible in 395 men. These men did not significantly differ from the total population regarding conditions and characteristics. Median age was 59.8, the incidence-rate after 2.1 years for nocturia was 24.8%. Table 1 shows the univariable and multivariable logistic regression models. Univariably as well as in the final model only age and alcohol intake were significantly related to incident nocturia. CONCLUSIONS: Although many characteristics are associated with nocturia, only age could significantly predict incident nocturia. Alcohol intake had a protective effect. (Table presented).

116 What predicts the development of nocturia? A population-based study in older men

116 What predicts the development of nocturia? A population-based study in older men

Classification of nocturia in the adult and elderly patient: a review of clinical criteria and selected literature

Nocturia increases with age and significantly affects quality of life in both men and women. Attempts to determine the pathogenesis of nocturia have been based on frequency-volume charts, and three types of nocturia have been identified: low voided volume (previously termed low bladder capacity), nocturnal polyuria, and mixed origin. Validated clinical criteria based on frequency-volume data allow the type of nocturia to be specified using two threshold values, i.e. largest voided volume/body weight ratio <4 mL/kg for low voided volume; and nocturnal urinary output/body weight ratio >10 mL/kg for nocturnal polyuria. The utility of these thresholds was validated in a study of elderly patients with two or more nocturia episodes/night. Two other studies have improved the understanding of the epidemiology of nocturia. The first showed that in men and women, increased incidence with age was greater for nocturia than for the six other common lower urinary tract symptoms. The second study suggested that prostate changes in men (particularly bladder outlet obstruction caused by benign prostatic hyperplasia, which has been considered to be a major cause of nocturia) appear to play a relatively small role in the development of nocturia; the correlation was based on overall symptom score for seven common urological symptoms. Nocturia should thus be treated independently of other lower urinary tract symptoms, especially in men. The application of valid diagnostic criteria to differentiate the underlying cause of nocturia should help lead to more appropriate and effective management of this pervasive problem.

Development of nocturia in relation to health, age and the menopause

Objectives: To analyse the relationship between nocturia, age, the menopausal transition, parturition and hormone replacement treatment (HRT) in women. Material and methods: A questionnaire study was carried out in 3669 randomly selected women (out of 6000 invited) in the County of Jämtland, Sweden. Questions were asked about health, the occurrence of somatic diseases and symptoms, habits, health care and medication. Results: In univariate analyses age, menopausal state and HRT, but not parturition, were associated with increased nocturia. In a multiple logistic regression analysis, independent correlates for two or more nocturnal micturition episodes versus no more than one episode were: health, poor versus good 2.9 (2.1–3.8); <5 years after the menopause versus before 1.8 (1.3–2.5); 5–9 years after the menopause versus before 2.1 (1.5–3.0); ≥10 years after the menopause versus before 3.1 (2.3–4.2). Age and HRT were deleted by the logistic regression model. Conclusion: The present data indicate that menopausal state, but not age, parturition and HRT are independent correlates of nocturia in 40–64-year-old women.