Development Of New Version Research Articles

Краткосрочный прогноз смерчеопасных ситуаций для прибрежной акватории Черного моря с использованием усовершенствованного индекса WRI

The paper considers the issues of improving the quality of short-term forecasts of waterspout-risk conditions for the Black Sea coastal water. The results related to the development of new versions for calculating the regional waterspout risk index (WRI) for both the warm (WRI21) and cold (WRIW) seasons are presented. The WRI is used to identify zones of high-risk waterspout formation and subsequent localization of waterspout-risk areas of the coast. Calculations of the WRI fields are based on the output of the COSMO-Ru2 mesoscale model with a grid spacing of 2.2 km. Calculations are carried out in real time within the technology for assessing the risk of waterspouts. The skill of forecasting new WRI versions for different periods is analyzed. It is shown that the probability of waterspout detection in the warm season can reach 82% on average. At the same time, there is also a high false alarm rate (about 70%), mainly due to the excessively predicted waterspout risk in certain areas of the coast (Sochi and Tuapse). In the cold season, as expected, a significantly smaller number of waterspout-risk days is predicted as compared to the warm period. Examples of forecasts for different seasons are presented. Recommendations on the use of forecasts for preparing storm warnings are given.

On the Eight Levels theorem and applications towards Lucas-Lehmer primality test for Mersenne primes, I

Lucas-Lehmer test is the current standard algorithm used for testing the primality of Mersenne numbers, but it may have limitations in terms of its efficiency and accuracy. Developing new algorithms or improving upon existing ones could potentially improve the search for Mersenne primes and the understanding of the distribution of Mersenne primes and composites. The development of new versions of the primality test for Mersenne numbers could help to speed up the search for new Mersenne primes by improving the efficiency of the algorithm. This could potentially lead to the discovery of new Mersenne primes that were previously beyond the reach of current computational resources. The current paper proves what the author called the Eight Levels Theorem and then highlights and proves three new different versions for Lucas-Lehmer primality test for Mersenne primes and also gives a new criterion for Mersenne compositeness.

Introduction and Extraction Methods for Polyherbal Face Wash Formulation

A cleanser is a product that is used to get rid of make-up, lifeless skin cells, oil, dust, and different types of bacteria, microbes from the pores and skin of the face. This facilitates to unclog pores and prevent skin situations which includes zits. In the present work an try became made to formulate & evaluate face wash. Due to the fast improvement of urban towns inside the current many years the extent of pollution within the air has elevated exponentially, disturbing the development of new versions of private care merchandise. Face being most exposed a part of the body, comes in touch with pollutants very without difficulty making it hard to hold a healthy, brilliant and clear skin. The facial pores and skin is thinner and extra fragile in comparison to the relaxation of the frame. A cleansing product in particular formulated for face have to be used which will maintain the moisture and pH stability of skin. Activated charcoal has homes of deep cleansing and adsorbing impurities. This makes it a beneficial component for pores and skin care merchandise. Acne is one of the maximum typical pores and skin disorder affecting nearly all teens, as it's miles persistent with frequency remission and exacerbations is regularly associated with terrible psychological consequences, finished shallowness and social withdrawal. The Modern measures concerning the treatment of acne are extra or much less failure. Further it has some barriers, cost effective and plenty of side results. To triumph over from a lot of these, a very good natural technique ought to be reached. So we decided to use Luffa Cylindrica oil, Manjistha, Carrot, guava seed extract, Turmeric oil.

Comparative analysis of neurointerface technologies for the problem of their reasonable choice in human-machine information systems

The market of modern neurointerfaces, despite its active development, unfortunately, can offer users only a number of existing prototypes that have a relatively low accuracy and identification reliability of the human operator control effects. In addition, any neurointerface on the market must be individually tailored to each operator, which makes it difficult to objectify its accuracy, precision and reliability. The first step in solving the above problems is to conduct a comparative analysis of different price segments of the market of existing neurointerface technologies, as presented in this article. The market research revealed that despite the disadvantages of electroencephalography, it is one of the most accessible non-invasive methods of recording biological signals in neurointerface systems. To facilitate future research, the main advantages and disadvantages of known models and methods of signal analysis in neurointerfaces have been considered and analyzed. In particular, in the context of signal pre-processing, advantages and disadvantages of such methods as Common Average Referencing, Independent Component Analysis, Common Spatial Patterns, Surface Laplacian, Common Spatio-Spatial Patterns and Adaptive Filtering are considered. At the stage of evaluating the informative characteristics of the signal, the analysis of models and methods based on the models of adaptive parameters of autoregression, bilinear autoregression, multidimensional autoregression, fast Fourier transform, wavelet transformation, wave packet decomposition is performed. Besides, a comparative analysis of the most common methods of identification (recognition) of control effects of the human neurointerface operator, namely, the method of discriminant analysis, the method of reference vectors, nonlinear Bayesian classifiers, classifiers of nearest neighbors, artificial neural networks is carried out. The study of neurointerface technologies provides researchers with additional grounds for a sound choice of mathematical, software and hardware of neurointerface systems, as well as contributes to the development of new versions with increased accuracy, reliability and reliability.

Special-purpose computer HORN-8 for phase-type electro-holography.

Electro-holography is a promising display technology that can reconstruct a photorealistic three-dimensional (3D) movie; however, it is yet to be realized practically owing to the need for enormous calculation power. A special-purpose computer for electro-holography, namely HORN, has been studied for over 20 years as a means to solve this problem. The latest version of HORN, HORN-8, was developed using field programmable gate array (FPGA) technology. Initially, a circuit for amplitude-type electro-holography was implemented in HORN-8; however, implementation of phase-type electro-holography has remained an issue. In this paper, the development of new version of HORN-8 and its cluster system, which achieved a real-time reconstruction of a 3D movie with point clouds comprised of 32,000 points for phase-type electro-holography, was reported.

Contribution to Energy Management of the Main Standards for Environmental Management Systems: The Case of ISO 14001 and EMAS

The adoption of Energy Management Systems (EnMSs) based on international standards has gained momentum since the ISO 50001 standard was launched in 2011. Before that, the potential to improve the energy management with Environmental Management Systems (EMSs) based on ISO 14001 and EMAS was identified in the literature. However, no in-depth analysis reported in the literature has explored this claim. The need for research is now even more evident with the development of new versions of the standards for environmental management―ISO 14001:2015 and EMAS III. Since many companies that already have a certified EMSs might be uncertain whether to adopt an ISO 50001 based EnMSs, the present work aims to shed light on the contribution of ISO 14001:2015 and EMAS III to energy management. Furthermore, the work summarizes the results of an empirical exploratory study carried out in eight Spanish organizations, four with an EMS implemented and certified based on ISO 14001:2015 and four more with an EMS registered to EMAS III. The findings show that both ISO14001 and EMAS certified organizations carry out energy management practices, even though they have no formal EnMSs implemented. Implications for managers and policy makers are discussed, together with avenues for further research.

Gestión de los residuos de aparatos eléctricos y electrónicos (RAEE) en el municipio de Armenia, Quindío

This proposal is intended as an effort to acknowledge the integrated management of electrical and electronic device waste (WEEE) in the city of Armenia. The digital era has contributed to the development of the industry and society, but this boom, which is reflected on an exponential growth of ICTs (development of new versions and prototypes), has resulted in a reduction of the useful life of products, thus increasing the pressure on the final waste management system. At present, research is in phase I, which entailed conducting a survey regarding post-use among 400 people in order to characterize users. The partial findings demonstrate the need to carry out communication and dissemination initiatives among the stakeholders aiming at increasing the rate of electrical and electronic devices made available through authorized dealers who are also liable in conformance with current applicable regulations. This would lead to reducing the pressure on sanitary landfills and preventing a negative impact on the ecosystem and health of the population in Armenia. At the same time, it would also have a positive impact on the rates of utilization and valuation based on waste disposal by both specialized companies and manufacturers.

Effect of photostimulation of depolarizing opsins Chronos and ChrimsonR on macaque inferotemporal cortical response

Event Abstract Back to Event Effect of photostimulation of depolarizing opsins Chronos and ChrimsonR on macaque inferotemporal cortical response Francesco Fabbrini1*, Pascaline Vancraeyenest1, Chris Van Den Haute2, Veerle Baekelandt2 and Rufin Vogels1 1 KU Leuven, Laboratory for Neuro- and Psychophysiology, Belgium 2 KU Leuven, Research Group for Neurobiology and Gene Therapy, Belgium Optogenetics has opened new possibilities for understanding the functioning of the brain, allowing direct control of neural activity with high spatial and temporal precision. In the last years, the continuous development of new versions of genetically engineered microbial opsins and techniques for gene targeting has made it possible to manipulate with growing sensitivity the activity of specific population of neurons in a wide range of animals, including nonhuman primates. Unlike electrical microstimulation or TMS, optogenetics allows the simultaneous recording of single unit activity during stimulation with high temporal and spatial specificity. In our study, we recorded unicellular action potentials during photostimulation of neurons in the inferior temporal (IT) cortex of two awake macaques that were previously transduced with two recently developed depolarizing opsins, Chronos and ChrimsonR. To our knowledge, these opsins were not employed before in macaques. The two opsins differ in their kinetics of activation and specific wavelength sensitivity. Chronos has fast kinetics and a peak of activation tuned to the blue light. On the other hand, ChrimsonR has slower kinetics and a peak shifted to the red light. In the case of Chronos, we found that photostimulation produced a reliable increase in firing rate to short (2ms) light pulses and this with very short (=< 2ms) latency. Responses were highly transient without a late (presumably transsynaptic) component. In the case of ChrimsonR, we observed that photostimulation either enhanced or suppressed the neural activity of single neurons, the latter suggesting an indirect activation of inhibitory network components that transsynaptically inactivated the recorded neuron. These results in awake behaving monkeys demonstrate that the optogenetic tools can be used in nonhuman primates to study the mechanisms of responses in IT cortex. Acknowledgements Supported by FWO Keywords: optogenetics, monkey, Visual Cortex, Inferotemporal cortex, single-unit electrophysiology Conference: 12th National Congress of the Belgian Society for Neuroscience, Gent, Belgium, 22 May - 22 May, 2017. Presentation Type: Poster Presentation Topic: Novel Methods and Technology Development Citation: Fabbrini F, Vancraeyenest P, Van Den Haute C, Baekelandt V and Vogels R (2019). Effect of photostimulation of depolarizing opsins Chronos and ChrimsonR on macaque inferotemporal cortical response. Front. Neurosci. Conference Abstract: 12th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2017.94.00035 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Mr. Francesco Fabbrini, KU Leuven, Laboratory for Neuro- and Psychophysiology, Leuven, 3000, Belgium, francesco.fabbrini@kuleuven.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Francesco Fabbrini Pascaline Vancraeyenest Chris Van Den Haute Veerle Baekelandt Rufin Vogels Google Francesco Fabbrini Pascaline Vancraeyenest Chris Van Den Haute Veerle Baekelandt Rufin Vogels Google Scholar Francesco Fabbrini Pascaline Vancraeyenest Chris Van Den Haute Veerle Baekelandt Rufin Vogels PubMed Francesco Fabbrini Pascaline Vancraeyenest Chris Van Den Haute Veerle Baekelandt Rufin Vogels Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

A computer-aided program for helping patients with moderate Alzheimer's disease engage in verbal reminiscence.

This study assessed a simple computer-aided program for helping patients with moderate Alzheimer's disease engage in verbal reminiscence. In practice, the program was aimed at fostering the patient's verbal engagement on a number of life experiences/topics previously selected for him or her and introduced in the sessions through a friendly female, who appeared on the computer screen. The female asked the patient about the aforementioned experiences/topics, and provided him or her with positive attention, and possibly verbal guidance (i.e., prompts/encouragements). Eight patients were involved in the study, which was carried out according to non-concurrent multiple baseline designs across participants. Seven of them showed clear improvement during the intervention phase (i.e., with the program). Their mean percentages of intervals with verbal engagement/reminiscence ranged from close to zero to about 15 during the baseline and from above 50 to above 75 during the intervention. The results were discussed in relation to previous literature on reminiscence therapy, with specific emphasis on the need for (a) replication studies and (b) the development of new versions of the technology-aided program to improve its impact and reach a wider number of patients.

RDA (Resource Description and Access): Approaches to the Choice of Data Language in Bibliographic Record

The article presents the brief analysis of the provisions of RDA new international rules (Resource Description and Access), that determine the choice of language/graphic in bibliographic record. Beginning 2013, RDA rules are being implemented in the U.S. and European libraries and claim the status of International Standard. In Russia there were started preparations for the development of new version of the Russian Cataloguing rules; and in this regard, it is proposed to evaluate the possibility of use of RDA bibliographic description of text in the national practice - either in the form of authentic translation into Russian, or as an adapted methodology of the main provisions.

Studying Schizophrenia as a Neuroplastic Disorder

Brain stimulation therapies have a long history, beginning with the development of electroconvulsive (also known as electroshock) therapy in the first half of the previous century, progressing with the development of other, more refined, methods to induce electrical currents in the living brain. Those methods are used to treat various psychiatric diseases, ranging from depression and bipolar disorder to posttraumatic stress disorder and schizophrenia. Obviously, a better understanding of the mechanism of action of these treatments will allow optimization of stimulation parameters to enhance and optimize the therapeutic effects. Such understanding would also be an important milestone in development of new versions of stimulation tools, to improve and adapt existing protocols individually to each patient, and to develop objective, quantifiable measures of therapeutic outcome. An appealing possibility to explain the effects of electricity-based therapies is their ability to change the brain network activity over time; that is, to enhance or suppress global neuronal activity or specifically to encourage the creation and strengthening of existing connections.The 2 papers presented in this issue by Dr Zafiris J Daskalakis' group (see Voineskos et al1 and Rajji et al2) draw a comprehensive and consistent theory on the relation between schizophrenia, brain plasticity, and effectiveness of brain stimulation therapies. In this sense, schizophrenia is an interesting touchstone to examine the issue of brain stimulation plasticity-based treatments because it encompasses significant deficits in higher cognitive functions, including learning-related plastic changes.The first article1 is a comprehensive review demonstrating neuroplastic impairments in schizophrenia as reflected in transcranial magnetic stimulation (TMS) studies that include measurements of neural excitability and inhibition levels by various paradigms of TMS. Dr Daskalakis and colleagues' nicely introduce the concept of brain plasticity impairments in schizophrenia, and suggest that cognitive deficits accompanying this disease, especially in executive attention and working memory, are caused by reduced ability of the brain to perform adaptation of its activity in response to experience and training. Patients with schizophrenia, compared with healthy subjects, do not show adaptation of their response to motor cortex magnetic stimulation following a motor training protocol. They do not show acquisition and strengthening of association between peripheral motor stimulation and motor responses induced by TMS in a paired associative stimulation (PAS) paradigm. In these studies, patients with schizophrenia, unlike healthy subjects, show no increase or decrease in activity as a result of repetitive stimulation of the motor cortex or adjacent areas. The authors' suggest alterations in glutamate (via N-methyl-D-aspartate receptors), gammaaminobutyric acid, and dopamine neurotransmission for explaining these neuroplastic impairments as these systems had been linked with long-term plasticity processes in basic electrophysiological studies and with morbidity of schizophrenia in neuropharmacological studies.The second article, by Dr Tarek K Rajji and colleagues,2 describes current knowledge on various brain stimulation (TMS and direct electrical) approaches used in the treatment of schizophrenia. Search engines were scanned for relevant articles, and the results, concerning repetitive TMS, thetaburst stimulation, PAS, and transcranial direct current stimulation, are summarized comprehensively. …

Photomultipliers for the KM3NeT optical modules

The KM3NeT project aims to construct a multi-cubic-kilometre scale neutrino telescope in the Mediterranean Sea. The telescope's detection units, deployed in the deep sea, will be instrumented with optical modules, each housing 31 three-in. photomultiplier tubes (PMTs). Three companies are developing new types of 3in. PMTs for the KM3NeT project. The first PMT samples of type R6233mod have been delivered from Hamamatsu and tested at the Erlangen Centre for Astroparticle Physics and at Nikhef. The results of these tests are presented. Many of the parameters of the existing versions of these PMTs already meet the KM3NeT requirements and production versions will be used to build the first developmental optical modules. Hamamatsu have started the development of new versions of PMTs of current interest, with better timing parameters and a slightly larger photocathode. The first two examples of a new PMT from ET Enterprises are under tests at Nikhef. The delivery of first 82mm diameter PMTs from MELZ is also expected in October 2011. To increase photodetection efficiency in the multi-PMT optical module, PMTs will be surrounded by reflective light gathering rings (‘expansion cones’). Test results of such an assembly are also presented.

Development and testing of an automated microscopy complex

The high variability of the specimens creates problems in the formation of both a representative model of the ambient medium and stable algorithms for the automatic microscopic analysis of biomaterials. When the MECOS-C2 analyzer is being developed and maintained, the technology of reference virtual slides formed with the participation of the users and available during operation from laboratories in the service center is used to obtain a model of the ambient medium. The structure of the MECOS-C2, adjusted to use virtual slides, makes it possible to largely automate the development of new versions of the software, taking into account the data on the ambient medium. Another key principle of the development is to use robust analysis algorithms adapted to a given specimen. The combination of these principles made it possible to create the medical-class MECOS-C2 automatic analyzer suitable for analyzing blood smears in a commercial laboratory.

Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity

Despite the widespread clinical use of CD34 antibodies for the purification of human hematopoietic stem/progenitor cells, all the current anti-human CD34 monoclonal antibodies (mAbs) are murine, which have the potential to elicit human antimouse antibody (HAMA) immune response. In the present study, we developed three new mouse anti-human CD34 mAbs which, respectively, belonged to class I, class II and class III CD34 epitope antibodies. In an attempt to reduce the immunogenicity of these three murine mAbs, their chimeric antibodies, which consisted of mouse antibody variable regions fused genetically to human antibody constant regions, were constructed and characterized. The anti-CD34 chimeric antibodies were shown to possess affinity and specificity similar to that of their respective parental murine antibodies. Due to the potentially better safety profiles, these chimeric antibodies might become alternatives to mouse anti-CD34 antibodies routinely used for clinical application.

The Use of a Code‐generating System for the Derivation of the Equations for Wind Turbine Dynamics

AbstractFor many reasons the size of wind turbines on the rapidly growing wind energy market is increasing. Relations between aeroelastic properties of these new large turbines change. Modifications of turbine designs and control concepts are also influenced by growing size. All these trends require development of computer codes for design and certification. Moreover, there is a strong desire for design optimization procedures, which require fast codes. General codes, e.g. finite element codes, normally allow such modifications and improvements of existing wind turbine models. This is done relatively easy. However, the calculation times of such codes are unfavourably long, certainly for optimization use. The use of an automatic code generating system is an alternative for relevance of the two key issues, the code and the design optimization. This technique can be used for rapid generation of codes of particular wind turbine simulation models. These ideas have been followed in the development of new versions of the wind turbine simulation code VIDYN. The equations of the simulation model were derived according to the Lagrange equation and using Mathematica®, which was directed to output the results in Fortran code format. In this way the simulation code is automatically adapted to an actual turbine model, in terms of subroutines containing the equations of motion, definitions of parameters and degrees of freedom. Since the start in 1997, these methods, constituting a systematic way of working, have been used to develop specific efficient calculation codes. The experience with this technique has been very encouraging, inspiring the continued development of new versions of the simulation code as the need has arisen, and the interest for design optimization is growing. Copyright © 2003 John Wiley &amp; Sons, Ltd.

The development of ‘‘21st century’’ acoustic and orchestral instruments

The work of the Centre for New Musical Instruments (CNMI), recently established at London Guildhall University, is reported. In addition, a wide range of original slides is shown, providing an overview of international innovations relevant to the development of new versions of existing acoustic orchestral instruments, especially those offering new forms of expression to composers and performers. In view of the overwhelming majority of developments of electronic as opposed to acoustic instruments during the 20th century, the purpose of CNMI is to encourage innovations of the latter. Acoustic instruments designates not only those traditionally referred to by this term, but also those in which elements of sound generation may be electromechanical or electroacoustic, although sound diffusion is not through a loudspeaker. Three areas of innovation are discussed: (i) purely mechanical instruments; (ii) electromechanical and electroacoustic hybrids; and (iii) instruments designed for alternative tuning systems. All the orchestral families are considered. The mutually reinforcing possibilities and limitations of these elements, together with the evolving aesthetic issues of contemporary and other musics, suggests the importance of specific areas of future research and instrument making. Amongst these is the necessity of interdisciplinary perspectives and collaboration.

Guided paths through Web-based collections: Design, experiences, and adaptations

Digital libraries need to facilitate the use of digital information in a variety of settings. One approach to making information useful is to enable its application to situations unanticipated by the original author. Walden's Paths is designed to enable authors to collect, organize, and annotate information from on-line collections for presentation to their readers. Experiences with the use of Walden's Paths in high-school classrooms have identified four needs/issues: (1) better support for the gradual authoring of paths by teachers, (2) support for student authoring of paths including the ability for students to collaborate on paths, (3) more obvious distinction between content of the original source materials and that added by the path author, and (4) support for maintaining paths over an evolving set of source documents. These observed needs have driven the development of new versions of Walden's Paths. Additionally, the experiences with path authoring have led to a conceptualization of metadocuments, documents whose components include complete documents, as a general domain where issues of collaboration, intellectual property, and maintenance are decidedly different from traditional document publication.