Development Of Nanopharmaceuticals Research Articles

What lower the development of nanodrug?

Only a few nanomedicines have entered clinical application after over a decade and billions of dollars of investments in nanoscience and nanotechnology around the world. So, what lower the development of nanodrug? Recently, at our recent Editorial and Editorial Advisory Board meeting, we asked ourselves to address these questions and accelerate the development of nano pharmaceuticals. We will work with leaders in the area of drug supply to share our experiences and compare efforts around the world.

Silver Nanoparticles Induced Changes in DNA Methylation and Histone H3 Methylation in a Mouse Model of Breast Cancer.

The importance of epigenetic changes as a measurable endpoint in nanotoxicological studies is getting more and more appreciated. In the present work, we analyzed the epigenetic effects induced by citrate- and PEG-coated 20 nm silver nanoparticles (AgNPs) in a model consisting of 4T1 breast cancer tumors in mice. Animals were administered with AgNPs intragastrically (1 mg/kg b.w. daily-total dose 14 mg/kg b.w.) or intravenously (administration twice with 1 mg/kg b.w.-total dose 2 mg/kg b.w.). We observed a significant decrease in 5-methylcytosine (5-mC) level in tumors from mice treated with citrate-coated AgNPs regardless of the route of administration. For PEG-coated AgNPs, a significant decrease in DNA methylation was observed only after intravenous administration. Moreover, treatment of 4T1 tumor-bearing mice with AgNPs decreased histone H3 methylation in tumor tissue. This effect was the most pronounced for PEG-coated AgNPs administered intravenously. No changes in histone H3 Lys9 acetylation were observed. The decrease in methylation of DNA and histone H3 was accompanied by changes in expression of genes encoding chromatin-modifying enzymes (Setd4, Setdb1, Smyd3, Suv39h1, Suv420h1, Whsc1, Kdm1a, Kdm5b, Esco2, Hat1, Myst3, Hdac5, Dnmt1, Ube2b, and Usp22) and genes related to carcinogenesis (Akt1, Brca1, Brca2, Mlh1, Myb, Ccnd1, and Src). The significance of the observed changes and the mechanisms responsible for their development are unclear, and more research in this area is warranted. Nevertheless, the present work points to the epigenetic effects as an important level of interaction between nanomaterials and biological systems, which should always be taken into consideration during analysis of the biological activity of nanomaterials and development of nanopharmaceuticals.

Nanodrug Delivery Systems in Periodontics

Nanotechnology is of intense interest to researchers due to the basic fact that the properties of the material can be effectively manipulated when the size is transformed to nanoscopic. New opportunities arise out of the unique features which have been effectually utilized in the development of nano pharmaceuticals. This has revolutionized the health care system extensively by its diverse applications in modern medicine and dental science. Material science and periodontics have jointly adopted this technology to produce nanoparticles for targeted drug delivery, which find considerable significance in the management of periodontal diseases. Periodontitis is principally polymicrobial in nature, affecting the supporting structures of the tooth. In addition to the conventional mechanical debridement, adjunctive chemical therapy is, at most times, required to resolve the chronic inflammation. Hence, targeted drug delivery using nanoparticles with improved pharmacological and therapeutic properties may form better treatment strategies for managing this chronic inflammation. As nanoscale technology finds a scope in varied applications in periodontics, this current review highlights the various nanoscale drug delivery systems for managing periodontal diseases.

Stability Testing During Development of Nanopharmaceuticals

Stability Testing During Development of Nanopharmaceuticals

ChemInform Abstract: Cytokines as Biomarkers of Nanoparticle Immunotoxicity

AbstractReview: 204 refs.

Nanoradiopharmaceuticals: Development oF Labeling Process for Polymeric Nanoparticles

Nanomedicine, probably, is the future of modern medicine. Hence, there is a global effort being made in the development of nanopharmaceuticals. Among all the nano-pharmaceuticals developed so far, radiopharmaceuticals are the fewest in number of published studies. The development of nanoradiopharmaceuticals is complex but not impossible. In this work we discuss the possibility and the results of developing 4 nanoradiopharmaceuticals based on 3 different types of nanoparticles as alternative drug delivery systems. Also we present the preliminary results in animals.

Development of Nanoradiopharmaceuticals by Labeling Polymer Nanoparticles with Tc-99m

Nanomedicine is considered as the future of modern medicine. Hence, serious global efforts are being made for the development of nanopharmaceuticals. Among all the nanopharmaceuticals developed so far, radiopharmaceuticals constitute only a very small portion, as noted in the published literature. The procedures for development of nanoradiopharmaceuticals are complex. In this paper we discuss the results of a research directed at developing nanoradiopharmaceuticals based on three different types of nanopharmaceuticals as alternative drug delivery systems.

Cytokines as biomarkers of nanoparticle immunotoxicity.

Nanoscale objects, whether of biologic origin or synthetically created, are being developed into devices for a variety of bionanotechnology diagnostic and pharmaceutical applications. However, the potential immunotoxicity of these nanomaterials and mechanisms by which they may induce adverse reactions have not received sufficient attention. Nanomaterials, depending on their characteristics and compositions, can interact with the immune system in several ways and either enhance or suppress immune system function. Cytokines perform pleiotropic functions to mediate and regulate the immune response and are generally recognized as biomarkers of immunotoxicity. While the specificity and validity of certain cytokines as markers of adverse immune response has been established for chemicals, small and macromolecular drugs, research on their applicability for predicting and monitoring the immunotoxicity of engineered nanomaterials is still ongoing. The goal of this review is to provide guidelines as to important cytokines that can be utilized for evaluating the immunotoxicity of nanomaterials and to highlight the role of those cytokines in mediating adverse reactions, which is of particular importance for the clinical development of nanopharmaceuticals and other nanotechnology-based products. Importantly, the rational design of nanomaterials of low immunotoxicity will be discussed, focusing on synthetic nanodevices, with emphasis on both the nanoparticle-forming materials and the embedded cargoes.

Research and Development of Nanopharmaceuticals in China

Nanopharmacoeuticals based on nanomaterials and nanotechnology are medicinal products for drug delivery, nano drugs and nano therapies, in vivo imaging, in vitro diagnostics, biomaterials, and active implants. Nanoscience and nanotechnology in China become ever more consequential in our lives, all members of the scientific community should better inform and educate the public about the great changes this new nano era is likely to bring. Here we review some main advances on the research and development of nanomaterials, nanotechnology and nanopharmaceuticals in China. For nanopharmaceuticals, we focus on the research and application of nanotechnology in anti-cancer drugs, and biological evaluation studies of nanomaterials.

Tumor Physiology and Delivery of Nanopharmaceuticals

Over the past few decades significant advances have been made in the development of nanopharmaceuticals (including phospholipid and polymer-based therapeutics) against cancer. There is still, however, room for improvement. Today, many researchers are focusing on the development of innovative approaches to selectively deliver drugs to solid tumors, while minimizing insult to healthy tissues. Unfortunately, the majority of these efforts are confronted by physiological barriers that reduce the clinical dose required to effectively manage the disease state. In an effort to develop promising nanopharmaceutical products of the future, we review the most important problems facing drug delivery experts today. We discuss here, the physiological role of solid tumors in delivery and transport of nanopharmaceutical products. The nature of tumors in terms of their unique anatomical structure and functions is also discussed. Finally, an overview of ways to overcome physiological barrier functions and exploit tumor pathogenesis for therapeutic gain is provided.