Background/Objectives: This paper explores the theoretical perspectives on knowledge competence, use of technologies and development of SMEs in Kazakhstan in view of lack of research in this area. Methods/Statistical Analysis: Questionnaire survey was designed to study the opinions of top management of SMEs from different regions of Kazakhstan about their companies’ performance. Statistical analysis was applied to process the obtained results. Findings: The descriptive data have been collected via a questionnaire survey of SMEs directors from different regions of Kazakhstan. The results reveal good pre-conditions for further development of knowledge competence in SMEs in Kazakhstan. This study has shown the situation in the Kazakhstani SMEs in terms of knowledge development opportunities as well as the existing situation with the use of information technologies. The ability of SMEs to use the existing knowledge determines the success of companies’ strategies. Applications/Improvements: The “DAMU” role in creating the new knowledge for entrepreneurs and financial support may contribute to the development of information technologies and knowledge competence in the long term.