Development Of International Recommendations Research Articles

Ozone therapy in musculoskeletal medicine: a comprehensive review

Musculoskeletal disorders encompass a wide range of conditions that impact the bones, joints, muscles, and connective tissues within the body. Despite the ongoing debate on toxicity and administration, ozone demonstrated promise in managing several musculoskeletal disorders, modulating pain and inflammation. A literature search was conducted. The research design, methods, findings, and conclusions of the studies were then examined to evaluate the physiological effects, clinical application, controversies, and safety of the application of ozone in musculoskeletal medicine. Ozone application demonstrates considerable therapeutic applications in the management of musculoskeletal disorders, including fractures, osteoarthritis, and chronic pain syndromes. Despite these advantages, studies have raised concerns regarding its potential toxicity and emphasized the importance of adhering to stringent administration protocols to ensure safety. Additionally, heterogeneities in patient reactions and hazards from oxidizing agents were observed. Given its anti-inflammatory and analgesic qualities, ozone therapy holds potential in the management of several musculoskeletal disorders. Additional high-quality research with long follow-up is required to refine indications, efficacy and safety profile. Finally, for wider clinical acceptability and utilization, the development of international recommendations is essential.

Фізична терапія пацієнтів після кардіохірургічних втручань: аналіз опитувань фізичних терапевтів різних країн

Мета. Проаналізувати результати опитувань фізичних терапевтів різних країн щодоособливостей їх практики з кардіохірургічними пацієнтами. Методи. Аналіз та порівняннярезультатів досліджень, котрі присвячені вивченню особливостей фізичної терапії пацієнтівпісля кардіохірургічних втручань на стаціонарному етапі у формі опитувань фізичнихтерапевтів, а також аналіз обґрунтованості моделей фізичної терапії.Результати. Отримано досить великі відмінності та різноманітні підходи до передопераційногоконсультування та навчання пацієнтів елементам фізичної терапії. Частота використанняфізичної терапії для інтубованих пацієнтів також різнилася. Ключові особливості мобілізаціїпацієнтів та використання терапевтичних вправ відрізнялися у різних країнах. Кіль-кість процедур також мала широкий діапазон. Вправи з глибоким диханням були однієюз найпоширеніших технік серед респіраторної фізичної терапії. Запобіжні заходи післястернотомії та терміни їх дотримання не були однаковими. Наукова обґрунтованість практикифізичної терапії залишається сумнівною. Особистий досвід, протокол лікарні та уподобанняколег, а не результати наукових досліджень, є основою практики. Впровадження результатівнаукових досліджень у практику є складним процесом з рядом перешкод.Висновки. Подальший аналіз та розробка міжнародних рекомендацій з науковимобґрунтуванням необхідні для встановлення оптимального протоколу фізичної терапії пацієнтівпісля хірургічних втручань на серці.

COVID-19 module in SRWE system - application and use in epidemiological surveillance and reporting to international institutions.

The new SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) coronavirus causing acute respiratory disease COVID-19 (2019 coronavirus disease) detected in China in 2019 very quickly revealed its epidemic potential and was recognized as a global health problem. The situation caused by the rapidly increasing number of new cases and deaths due to COVID-19 required the rapid development of international recommendations and procedures to limit the spread of infections and ongoing monitoring of the epidemiological situation. In the field of epidemiological surveillance of COVID-19 cases, international organizations - WHO and regionally ECDC, have developed basic requirements for reporting data on newly detected cases of infection. In order to ensure the possibility of reporting new cases and activities undertaken by sanitary-epidemiological services in the country and to fulfill the obligation to report data to the European surveillance network, it was necessary to adapt the electronic system supporting epidemiological surveillance operations, for registration of suspected and confirmed cases of SARS-CoV-2 infections. This work presents the characteristics of the new COVID-19 module created as part of the central Epidemiological Case Reporting System and a preliminary evaluation of its usefulness for the purposes of combating COVID-19. CONCLUSIONS. The Epidemiological Case Reporting System is an efficient and adequate tool that can be adapted to newly emerging threats. In order to use the module to monitor the current epidemiological situation, it is necessary to integrate it with other systems collecting data about COVID-19 patients - ie. EWP and the clinical patient register.

Tracing the decision-making process for myelofibrosis: diagnosis, stratification, and management of ruxolitinib therapy in real-word practice

The management of patients with myelofibrosis (MF) has dramatically changed since the introduction of ruxolitinib as a tailored treatment strategy. However, the perceptions about the use of this drug in clinical practice remain, at times, a matter of discussion. We conducted a survey about the diagnostic evaluation, prognostic assessment, and management of ruxolitinib in real-life clinical practice in 18 Italian hematology centers. At diagnosis, most hematologists do not use genetically or molecularly inspired score systems to assess prognosis, mainly due to scarce availability of next-generation sequencing (NGS) methodology, with NGS conversely reserved only for a subset of lower-risk MF patients with the aim of possibly improving the treatment strategy. Some common points in the management of ruxolitinib were 1) clinical triggers for ruxolitinib therapy, regardless of risk category; 2) evaluation of infectious risk before the starting of the drug; and 3) schedule of monitoring during the first 12 weeks with the need, in some instances, of supportive treatment. Further development of international recommendations and insights will allow the achievement of common criteria for the management of ruxolitinib in MF, before and after treatment, and for the definition of response and failure.

NORWEGIAN-RUSSIAN COOPERATION IN NUCLEAR LEGACY REGULATION: CONTINUING EXPERIENCE AND LESSONS.

Safe management of nuclear legacies arising from past activities is a critical issue in maintaining confidence for the continuing and future use of radioactive materials. Effective and efficient regulatory supervision of nuclear legacy management is a critical part of that process. The Norwegian Radiation Protection Authority plays an active role in bilateral regulatory cooperation projects with sister authorities in the Russian Federation, as part of Norway's Plan of Action to improve radiation and nuclear safety. Based on this experience and by reference to specific legacy sites and facilities, this study provides an overview of the substantial progress made in remediation at the Site of Temporary Storage for spent fuel and radioactive waste at Andreeva Bay and presents radiation protection issues arising from the experience and lessons learned in this work. It is suggested that this experience can be useful in the further development of international recommendations, standards and guidance on remediation of nuclear legacies.