Development Of Insufficiency Research Articles

Effect of Trade Unionism on Non-Academic Staff Performance in a Public Institution

Purpose – Various challenges faced by non-academic personnel in Nigerian institutions, such as a lack of team spirit, inadequate salary, insufficient staff development programs, poor infrastructure, strike actions, insecurity, subpar health insurance, and limited career progression, prompted an examination of their effect on performance at the University of Ilorin. Aims(s) – This research aimed to investigate the influence of compensation structure, career development, and team spirit on the non-academic staff's performance. Design/methodology/approach – With a population of 1,600 and a sample size of 320, as established by Taro Yamane's sample size calculation, the study used a descriptive research approach. A questionnaire was used for data collection, and the Statistical Package for Social Sciences (SPSS) program was used for basic regression analysis. Findings – The results showed that non-academic staff performance at the public institutions were positively and significantly impacted by compensation structure, career growth, and team spirit. The study successfully determined the impact of trade unionism on non-academic employee performance, emphasizing the positive effects of a sound wage structure, strong team spirit, and career advancement. Limitations of the study – The fact that the results are context-specific represents a major limitation. Originality/value – The results suggested that the public institutions should prioritize and assess team spirit, along with enhancing non-academic personnel's remuneration packages. Furthermore, career advancement was identified as a key factor influencing non-academic staff performance, emphasizing the importance of providing opportunities for professional growth and promotion to motivate employees to excel and contribute to the institution's success.

Insufficient Muscle Development Level Associated with Serum Zinc, Manganese and Cobalt Levels in Children Aged 6 to 9 Years in Shenzhen, China.

Some trace elements have been found to be associated with muscle mass and muscle function; however, evidence in children is limited, and it remains unclear which trace elements are more relevant. We aimed to explore the association of levels of individual and combined essential trace elements and muscle development level (MDL) in young children. Muscle mass was measured by body composition analysis, and trace elements were determined by using inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression, restricted cubic spline (RCS) and weighted quantile sum regression (WQS) were used to assess the individual and joint associations between trace element levels and MDL. We enrolled 2851 children: 1595 boys (55.9%) and mean age 7.1years (range 6.8-7.3). The proportion of insufficient muscle mass in the whole body, limbs, upper and lower limbs was 1.9%, 6.5%, 44.9% and 4.6%, respectively. The odds of insufficient MDL decreased with the fourth versus first quartile of zinc (OR = 0.67, 95% CI: 0.51-0.89), manganese (OR = 0.80, 95% CI: 0.65-1.00), and cobalt (OR = 0.89, 95% CI: 0.81-0.99) and was increased with the fourth quartile of nickel (OR = 2.23, 95% CI: 1.72-2.89) and selenium (OR = 1.51, 95% CI: 1.14-1.98). The RCS yielded similar results, except for the discrepancy in high cobalt levels. The odds of insufficient MDL decreased with the combination of nine trace elements (OR = 0.84, 95% CI: 0.73-0.97), primarily zinc (weight = 0.297), manganese (weight = 0.198) and cobalt (weight = 0.173). Insufficient MDL in young children was mainly in upper limbs. Low levels of zinc, manganese, and cobalt, individually or combined, were significantly associated with risk of insufficient MDL. Further foods rich in zinc, manganese, and cobalt should be suggested to supplement in diet, and increase exercise of upper limbs to improve insufficient MDL in the young children should be needed.

Endothelial dysfunction in combination of occupational pathology of the respiratory system and atherosclerosis in coal industry workers

Introduction. The increasing prevalence of cardiovascular pathology among industrial workers determines the importance of studying not only occupational diseases, but also their combination with diseases of the circulatory system. Endothelial dysfunction is a key link in the pathogenesis of atherosclerosis. Evaluation of endothelial function indicators in occupational respiratory diseases in combination with atherosclerosis in workers of the coal mining industry is an urgent task. The study aims to consider the indicators of endothelial function in miners with occupational respiratory diseases in combination with atherosclerosis. Materials and methods. The authors have examined 88 miners with previously diagnosed occupational respiratory diseases (chronic dust bronchitis, anthracosilicosis, chronic obstructive pulmonary disease), 45 of them showed signs of atherosclerosis. There were two comparison groups without signs of atherosclerosis: 44 miners who work long-term in harmful working conditions, without lung pathology (control group) and 42 residents of Novokuznetsk who have never worked in harmful working conditions, and without lung pathology (unexposed group). Results. We found that miners with occupational respiratory diseases in combination with atherosclerosis had several forms of endothelial dysfunction: vasomotor (decreased synthesis of nitric oxide, increased endothelin-1 levels), hemostatic (increased levels of Willebrand factor), adhesive (increased levels of endothelial adhesion molecules sVCAM-1). The development of respiratory insufficiency in miners with occupational respiratory diseases increases endothelial dysfunction: miners with respiratory insufficiency have lower levels of nitric oxide (NO), higher levels of endothelin-1 and endothelial adhesion molecules sVCAM-1 than miners without respiratory insufficiency. There are correlations between indicators of endothelial function and production factors: with work experience in harmful working conditions, the level of the average concentration of coal-rock dust in the workplace and the frequency of exceeding the maximum permissible concentration of coal-rock dust. Limitations. The study is limited to a sample of workers in the main professions of coal mines who were examined at the Research Institute of Complex Hygiene Problems and Occupational Diseases, aged 40 to 54 years, with more than 15 years of experience working in underground dust conditions. Conclusion. Miners with occupational respiratory diseases in combination with atherosclerosis develop several forms of endothelial dysfunction: vasomotor, hemostatic, adhesive. The development of respiratory failure increases endothelial dysfunction. Ethics. This medical study involving a human as a subject was carried out in compliance with the Ethical principles presented in the latest version of the Helsinki Declaration, developed by the World Medical Association.

PROBLEMS OF POST-WAR DEVELOPMENT OF REGIONAL HEALTHCARE (based on materials from the administrative department of Gorky Regional Committee of the All-Union Communist Party (Bolsheviks))

The article reveals health problems in the City of Gorky and Gorky Region in the period of 1945 – early 1950s. Topicality of the study is connected, first of all, with the insufficient development of this topic in historiography. On the other hand, the secrecy of a number of archival funds and the gradual work on declassifying socially significant documents require their timely involvement in scientific circulation. The source base is the materials of the State Socio-Political Archive of Nizhny Novgorod Region and the Central Archive of Nizhny Novgorod Region. The City of Gorky and the regional centres of Gorky Region, especially Dzerzhinsk, were important industrial centres in the post-war period. Gorky was also one of the major transport hubs. The article notes that these factors directly influenced the development of regional medicine. With the outbreak of the Cold War, medical documentation became closed. The author focuses on the analysis of medical documents of the administrative department of Gorky Regional Committee of the All-Union Communist Party of Bolsheviks. Data on the state of health care in the region is just at the moment being introduced into scientific circulation. The research is based on the principles of historicism, scientific objectivity, and determinism. Methods of analysis, synthesis, comparative historicism, chronology were used. The novelty of the research lies in obtaining new knowledge about the conditions of the state, functioning and reform of the health care system of Gorky Region, as well as about the organisation of fighting social diseases, such as venereal ones and tuberculosis, in the post-war period. The author highlights the main problems of regional medicine of the period under study and the proposals of Party bodies to resolve socially significant issues.

Sunwoda's Financial Analysis Based on The Harvard Analytical Framework

In order to comply with the strategy of sustainable development, China hopes to further accelerate the rapid development of the new energy vehicle industry and supporting industries. Power battery is the core component of new energy vehicles, and the selection of sunwoda in the battery industry for financial analysis can provide a useful reference for the same type of enterprises.This paper selects sunwoda as an analysis case, applies the Harvard analytical framework to sunwoda's financial analysis, and conducts in-depth discussion and analysis of sunwoda's financial status and existing problems. The analysis found that sunwoda is currently in the growth period,adopting a growth-oriented development strategy to gradually expand the scale of the enterprise, with many projects underconstruction and rapid growth in scale. However, behind the seemingly perfect financial data, there are problems such as low profitability, intensified market competition,and insufficient future development capabilities.In view of these problems,corresponding improvement suggestions are put forward,hoping to help the development of sunwoda.

Surgical results of tetralogy of Fallot repair with pulmonary valve preservation techniques

The long-term complications arising from chronic pulmonary insufficiency after surgical correction of tetralogy of Fallot (TOF) are well documented. In our center, innovative techniques for pulmonary valve (PV) preservation have been adopted and developed for over 10 years. All patients with TOF and PV stenosis who underwent surgery at our center between January 2008 and December 2022 were included in this study. Patients were evaluated using echocardiography during follow-up, comparing those who underwent classic surgery with transannular patch (TAP) placement and those who underwent PV preservation techniques. Of the 134 patients, 99 (73.9%) were successfully treated using PV preservation techniques. At the time of surgery, the median age was 4.3 months (interquartile range [IQR] 3.4-5.9 months). The median preoperative PV z-score was -2.87 (IQR -3.61;-2.48). The median follow-up time from surgery was 6.6 years (IQR 3.5-8.4 years). During the median follow-up, the right ventricular area change fraction was 47% (IQR 43-50%) in patients treated with PV preservation and 43% (IQR 41-47%) in the TAP group (p=0.005). These data were associated with better PV function in patients treated with preservation. Specifically, insufficiency was mild in 12%, moderate in 35%, and severe in 53% of patients in the TAP group. Conversely, insufficiency was mild in 53%, moderate in 35%, and severe in 11% of patients treated with preservation (p<0.001). Annular integrity and PV function can be preserved during early TOF correction. PV preservation can prevent the long-term development of pulmonary insufficiency and right ventricular dysfunction.

ВОЗМОЖНОСТИ СОВРЕМЕННЫХ НЕИНВАЗИВНЫХ МЕТОДИК ИЗМЕРЕНИЯ ВНУТРИБРЮШНОГО ДАВЛЕНИЯ ПРИ АБДОМИНАЛЬНОМ КОМПАРТМЕНТ-СИНДРОМЕ У ПАЦИЕНТОВ В КРИТИЧЕСКОМ СОСТОЯНИИ

Intra-abdominal pressure (IAP) is rarely measured by default in intensive care patients. Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) contribute significantly to the development of multiorgan insufficiency in critically ill patients and are associated with significant morbidity and mortality. This article discusses and analyzes the causes and features of the pathophysiological mechanisms of increased intra-abdominal pressure, as well as modern aspects of the diagnosis and treatment of patients with abdominal compartment syndrome.

The study of newly-qualified teachers’ psychological well-being and personal reflection

Introduction. The article examines the peculiarities of psychological well-being and satisfaction with the profession of novice teachers in connection with personal reflection. The purpose of the study is to reveal the specifics of psychological well-being and personal reflection of teachers at the initial stage of professional development. Materials and Methods. The study follows a systematic approach and the concept of psychological well-being (K Riff). In order to achieve the purpose of the research, the authors used theoretical (analysis, comparison, generalization, systematization) and empirical (tests) methods, as well as methods of statistical information processing. To collect relevant data, the methods were presented by means of a Google form via an online resource. The research sample consisted of 162 newly-qualified teachers from Omsk and the Omsk region whose work experience ranged between 6 months and 5 years. Results. The authors of the article obtained the following results: - analyzed and summarized Russian and international research investigations on issues of psychological well-being, the level of development of reflection and novice teachers satisfaction with their profession; - the empirical results of the study are presented, which reflect the priority indicators of psychological well-being, the level and types of personal reflection, the level of satisfaction with the professional development of newly-qualified teachers; the specifics of psychological well-being and personal reflection of teachers are revealed, the types of teachers at the initial stage of professional development are described. Conclusions. The specifics of psychological well-being and personal reflection of novice teachers are determined by difficulties in managing the environment, building interaction with colleagues and self-acceptance, readiness for personal growth and autonomy, and there is also insufficient development of reflection skills, in particular, reflection on communication and real activity, which affects satisfaction with professional activities. The types of novice teachers have been identified depending on the specifics of psychological well-being, the level of development and type of personal reflection, and satisfaction with profession.

Features of labour education of students in modern social and educational environments

Introduction. The article presents the results of investigating the problem of labor education in the context of current changes in the social and educational environments. The purpose of the article is to identify the features of labor education in modern social and educational spheres from the standpoint of continuity of the tasks of its implementation at various levels of education and consistency with the tasks of general education. Materials and Methods. The theoretical research methods include sources analysis and analysis of educational programs for different levels of education. Empirical research methods used in the study include exploration of teaching experience and a questionnaire. The survey involved: 8,850 preschool teachers from 53 regions of the Russian Federation; 317,166 parents (legal representatives) of preschool-age children from 87 regions of the country; 4,913 deputy directors of comprehensive schools, representing 61 regions; 190,080 parents of school-age students, representing 88 regions. Results. The conducted research revealed: insufficient formalization of theoretical provisions; disunity of existing individual practices of labor education, their insufficient continuity at different levels of education and consistency with the tasks of general education; low activity of parents in the implementation of tasks of labor education as the child develops, vagueness of parents’ ideas about the significance and content of labor education at different levels of education. Methodological bases and conditions for the implementation of labor education in modern social and educational environments are formulated. Conclusions. The identified features of labor education at the present stage reflect the insufficient development of theoretical and methodological foundations for organizing labor education of students and actualize the need for further study of the problem, as well as the development of a model of labor education taking into account continuity at various levels of education and consistency with the priority tasks of general, secondary vocational education and model (federal) educational programs.

REVITALIZATION OF EDUCATIONAL ACTIVITIES OF FUTURE SCIENCE AND MATHEMATICS TEACHERS IN THE CONDITIONS OF DIGITALIZATION OF HIGHER EDUCATION

The article examines the possibilities for revitalization the educational activities of future teachers of natural and mathematical disciplines in the context of the digitalization of higher education. The study presents an analysis of scientific works related to the process of activating the educational activities of future teachers of natural and mathematical disciplines in the context of digitalization of higher education and the formation of competencies for their implementation. A comparison of the common features and differences between our research and others conducted in related fields has demonstrated, on one hand, the relevance of the topic and, on the other, the insufficient development of the issue. The purpose of the study is to determine effective approaches and methods for using digital technologies to enhance student activity during learning, as well as to create favorable conditions for their active participation in the educational process. The research employs the method of analyzing scientific sources was applied and experimental exercises were examined. The results indicate that the integration of digital tools, particularly energizer exercises, into the learning process significantly contributes to the development of critical thinking, creativity, and the ability to solve complex problems, which are essential for successful learning. The use of innovative approaches activates students’ cognitive processes and forms key competencies necessary for successful professional activity in a digital society. The importance of adapting education to contemporary challenges is also emphasized, particularly in light of the transition to distance learning during the pandemic and the ongoing large-scale war, which requires educators to develop new strategies and approaches to ensure the effectiveness of the educational process.

How does interregional capital misallocation affect technological innovation in China? Theoretical mechanism and empirical evidence

ABSTRACT Capital allocation plays a pivotal role in production factor inputs and technology selection within the production process, exerting a profound influence on technological innovation. Leveraging panel data encompassing 284 prefecture-level cities in China from 2001 to 2019, this paper delves into the impact and underlying mechanisms of interregional capital misallocation on technological innovation. The findings are as follows: (1) The astern coastal regions are experiencing capital overallocation, whereas inland developing areas are prone to undercapitalised. This uneven distribution uncovers a notable ‘Lucas Paradox’ within China's regional capital allocation. (2) Interregional capital misallocation hampers technological innovation. This discernible inhibitory effect persists even after a series of robustness checks. From 2001 to 2019, interregional capital misallocation resulted in an average loss of 2.35 patents per 10,000 people in China. (3) In cities with excessive capital allocation, lower administrative level, insufficient financial development, and non-innovative pilots, this inhibitory effect is more pronounced. (4) Institutional environment destruction, fiscal expenditure bias and enterprise innovation inertia are the main channels through which interregional capital misallocation hindering technological innovation.

Psycho-physiological prerequisites of the success of military-professional training of cadets of military institutions of higher education

The article examines in detail the educational process of military- professional training of future army officers, which made it possible to substantiate the structural-systemic approach to the chosen problem. The analysis of the data obtained as a result of testing the morphofunctional and motor indicators of the development of the body of the cadets of military institutions of higher education confirmed the general low physical condition of modern military personnel. Regarding physical capacity, this indicator is in the range from low to satisfactory in most cadets. The results of testing the motor readiness of future military personnel confirm the existing data on the insufficient development of endurance in young men and the insufficient development of endurance and speed in girls. The study of the psycho-emotional state of the cadets of the military institutions of higher education showed that the resistance to stress in extreme situations of the vast majority of future officers is in the range from above average to high levels. In addition, as a result of special studies, the dependence of the success of the formation of professional skills and abilities on the psychophysiological indicators of the development of the cadets' body, depending on gender and military specialization, was established. The results of the correlation analysis of the dependence of the success of the cadets' professional training on the psychophysiological indicators of their organism's development made it possible to determine the structure of the complex psychophysiological preparedness of future officers, taking into account gender and military specialization. Therefore, the differentiation of future officers by specialization and gender determines the selection of means of physical training of the appropriate orientation depending on the structure of complex psychophysiological training.

Cannabis Use during Pregnancy: An Update.

The use of cannabis during pregnancy has emerged as a mounting cause for concern due to its potential adverse consequences on both the mother and her offspring. This review will focus on the dangers associated with prenatal exposure to cannabis, particularly those related to neurodevelopment. It will also discuss the features of maternal and placental functioning that are likely to have long-term effects on the offspring's development. The most pertinent and up-to-date materials can be found through a literature search. The literature emphasizes the substantial hazards associated with prenatal exposure to cannabis. These include impairments in cognitive function and difficulties in behavior in this particular instance. Structural and functional alterations in the brain can be noticed in offspring. The use of cannabis has been associated with an increased likelihood of experiencing pregnancy-related complications, such as giving birth prematurely and having a baby with a low birth weight. Additionally, it has been connected to potential negative effects on mental and emotional well-being. Studies have shown that when a pregnant woman is exposed to cannabis, it can negatively impact the functioning of the placenta and the growth of the fetus. This might potentially contribute to the development of placental insufficiency and restricted growth in the womb. Longitudinal studies reveal that children who were exposed to cannabis in the womb experience additional long-term developmental challenges, such as decreased cognitive abilities, reduced academic performance, and behavioral issues. In order to address the problem of cannabis usage during pregnancy, it is essential to adopt a comprehensive and coordinated strategy. This method should integrate and synchronize public health policy, education, and research initiatives. By implementing these targeted strategies, it is possible to mitigate potential health and welfare concerns for both present and future generations.

The revenge as a motive for becoming and committing domestic violence

The presented research results provide a theoretical generalization of the phenomenon of revenge, its nature and qualitative characteristics. Taking into account the multifaceted nature of the phenomenon of revenge and the mutual influence of various cultural matrices, the author considered the voiced phenomenon through the prism of domestic violence.The topicality of the topic is due to insufficient scientific development of the motivational function of revenge in the formation and deployment of domestic violence. The purpose of the research involved the formation of theoretical aspects regarding revenge as a socio- legal phenomenon and as a motive for committing domestic violence. In the course of the conducted research, the state of scientific development of the problems of the phenomenon of revenge, forgiveness and domestic violence is highlighted. It has been established that revenge is based on the desire or obligation to punish the offender for an insult, injury, damage, or evil. It is emphasized that revenge is a deliberate, purposeful act, which is produced as a response (reaction) to an insult received, a violation of rights, interests, and is associated with the desire of people to satisfy the need to repay the offender for the insult caused. The author’s vision of revenge is formulated as a deliberate purposeful punishment in the sense of retribution, which is implemented both by legitimate legal institutions and informal methods, methods in an open or closed form: intentional harm for the purpose of revenge, poisoning, intentional beatings, murder, torture, intentional bodily harm and other criminal acts motivated by revenge. It is substantiated that the learned narratives, value orientations, level, degree, form of inflicted pain, evil, opportunity, ability and readiness in combination with the co-dependence of the participants of domestic violence emphasize the multi-vector nature of revenge, which, in turn, allows the researcher to come to a conclusion about the dualistic nature of the voiced phenomenon when formation and perpetration of domestic violence.The conclusions and proposals formulated in the scientific article can be used in: - the scientific research field - for further scientific research in the field of prevention and countermeasures against domestic violence; - the applicable field of law - as recommendations for improving the procedural activity of pre­trial investigation bodies; - the educational process - for the preparation of lectures on the disciplines «Criminal Law», «Criminology», «Legal Psychology», «Preventive Psychology», «Prevention, Counteraction to Domestic Violence». We see the prospect of further investigations in the legal-psychological analysis of the emotional- cognitive, behavioral (conative) components of jealousy and revenge through the prism of the socio-cultural discourse « domestic violence».

Spatial Development Strategy of the Russian Federation: Old Problems, New Solutions

The current Spatial Development Strategy of the Russian Federation for the period up to 2025 has not solved a number of tasks in this area. The level of differentiation of the socio-economic development of the subjects of the Russian Federation, their budgetary and infrastructural security remains high. Citizens have not been provided with equal access to State-guaranteed services. The current mechanisms for the allocation of productive forces and the resettlement of the population are often non-systemic in nature. In addition, the external and internal conditions for the development of the country's economy and social sphere have changed significantly by now. The Russian Federation includes 4 new regions. The concentration of population and infrastructure facilities in the largest urban agglomerations hinders the overcoming of regional imbalances. The task of ensuring the unity of the legal, economic, financial, social, cultural and educational space remains urgent. The issue of the ongoing population decline in the territories of the North, Siberia and the Far East, as well as the Arctic zone of the Russian Federation, is acute. Insufficient development of transport and energy infrastructure limits the potential of the regions, hinders the solution of tasks to increase the connectivity of the country's territory. In this regard, the task of smoothing out interregional imbalances by maximizing the full disclosure of the regions and municipalities’ own potential, and creating a comfortable living environment for citizens throughout the country is of strategic importance. This is the aim of the draft Strategy of spatial Development of the Russian Federation for the period up to 2030 with a forecast up to 2036. The article attempts to answer the question: how much is the new version of the Strategy able to solve the accumulated problems in this area?

Взаимодействие бизнеса, образования и власти в системе среднего профессионального образования в регионе

In a dynamically developing economy and changing labor market, it is important to ensure effective interaction of the secondary vocational education system with the needs of the regional economy of the Republic of Sakha (Yakutia). The article examines the key points of interaction between business, education and government. Through the analysis of normative legal acts and scientific research, the need to create educational and industrial clusters, stimulate cooperation between educational institutions and enterprises, as well as the active participation of employers in the educational process is emphasized.The article reveals that the government of the Russian Federation is taking steps to support secondary vocational education with the participation of companies, mainly large ones, for example, through the federal project ‘Professionalism’. However, there are limitations, such as insufficient development of regional regulatory legal acts, especially in terms of interaction between small and medium-sized enterprises with secondary vocational education. In conclusion, the importance of intensifying efforts to attract the business community to support and develop regional regulations, create a favorable environment for interactionbetween business, education and government is emphasized. This is the only way to ensure effective adaptation of educational programs to the needs of the labor market, the development of high-quality personnel and sustainable socio-economic development of the region.

QUALIMETRIC MODEL OF A HIGH-TECH INFORMATION AND MEASURING SYSTEM FOR THE PREPARATION AND CONDUCT OF TESTS

The issue of the report concerns the selection of information and testing equipment or a system that will be used for planning and conducting tests with minimal error and high efficiency. The complexity of consideration as a whole, when choosing the components of the information and measurement system and determining the qualitative measurement model determines the need to divide it into several stages and consider them separately. The stages of building a qualitative model of a high-tech information and measurement system for preparing and conducting tests are divided into: modeling stage; design stage; stage of implementation; interpretation stage. At the stage of determining the limitations, it should be taken into account in which division the tests are carried out, namely: by purpose; by the level of testing; by stages of product development; by testing finished products; according to the conditions and venue; by the duration of the tests; by type of action; by the result of the action; according to the characteristics of the object. The relevance of the work is the consideration of the stages of building a qualitative model of the information and measurement system in the difficult conditions of the military and political situation in Ukraine. The purpose of the work is to develop the technological aspects of qualitative modeling, as well as the stages of qualitative model examination. Additional results of the work can be – to obtain initial data (parameters); – to break down important indicators (parameters) according to their importance using an expert method; – to assess state and foreign requirements for the system for further work; – to assess and choose a direction based on the price indicator (factor) and duration of work or other indicators; – provide recommendations for making a decision regarding the construction of a qualitative model of the properties of the information and measurement system;–allow to improve (apply) the process of conducting tests of high-tech weapons and military equipment; – allow to use qualitative model databases to reduce preparation time to conducting tests of high-tech weapons and military equipment;–will allow to expand the directions for finding new features and providing recommendations in the further process of tests. The article builds a qualitative model (hereafter KM) of the formation (creation) of KM stages of the information and measurement system (hereafter IMS) at the preparatory stage of OVT tests. Stages of KM examination have been developed based on the current purpose of the tests, the required quantity and quality of recorded and measured indicators, the complexity of measurements and their analysis. Formulated KM efficiency indicators are as follows: minimal error; cost of equipment; equipment resource; others. The stages of selection of IBS components have been developed and the KM of assessment at the preparatory stage of tests has been determined. A model of quantitative quality measurement has been developed, taking into account possible errors and the provided, structural, technological aspects and stages of qualitative modeling. The most expedient tool for a systematic approach to decision-making during the construction of the IBS CM has been determined. The results of a similar review of literary sources of domestic and foreign scientists are presented. However, the insufficient development of the scientific basis for creating KM efficiency indicators is noted. The normative and real vectors of the creation of the CM are determined, which are laid down as important indicators of the effectiveness of the CM, by changing which it is possible to change the direction of the selection of the creation of the CM of the IAS.

6853 A Curious Case of MACS

Abstract Disclosure: M. Dillon: None. A. Syeda: None. V. Kantorovich: None. Introduction: Mild autonomous cortisol secretion (MACS) is characterized by biochemical evidence of mild hypercortisolemia inducing metabolic comorbidities without any obvious phenotypic stigmata of Cushing’s syndrome (CS). This case highlights the challenges faced in the diagnosis and management of MACS. Case: A 76-year-old female with past medical history of class II obesity (BMI 31.83 kg/m2), type 2 diabetes mellitus, hypertension, hyperlipidemia, osteoporosis and chronic kidney disease stage IIIb was diagnosed with MACS after an overnight 1 mg dexamethasone suppression test (DST) showed unsuppressed 8 AM cortisol of 2.4 mcg/dL (&amp;lt;1.8 mcg/dL). Dexamethasone level was appropriate at 355 ng/dL (180-550 ng/dL), ACTH was &amp;lt;5 pg/mL (6-50 pg/mL) and DHEA-S was normal. Late night salivary cortisol (LNSC) levels were elevated to 0.12 mcg/dL (&amp;lt; 0.09 mcg/dL). The 24-hour urine cortisol level was normal. Baseline 8 AM cortisol level was 17 mcg/dL and ACTH was 19 pg/mL. Abdominal CT scan showed a 1 cm left adrenal nodule of 25 HU density and a normal right adrenal with no atrophy. Phaeochromocytoma and primary hyperaldosteronism work up was negative. She started on Mifepristone 300 mg daily and titrated up to 600 mg daily. She presented to our institution one month later with 1 week of nausea, vomiting and muscle weakness. Laboratory studies revealed acute kidney injury with creatinine of 6.69 mg/dL (baseline Cr 1.5 mg/dL) and rhabdomyolysis with creatinine kinase level of 12,819 U/L (24-173 U/L) and urine myoglobin level of 888 ng/mL (0-13 ng/mL). It was evident that her catastrophic presentation was from development of adrenal insufficiency in the setting of Mifepristone glucocorticoid receptor blockade. The drug was discontinued immediately. She was treated with intravenous hydration and intermittent diuretics. Over 10 days, her clinical status gradually improved and creatinine decreased to baseline levels. Discussion: MACS is a challenging diagnosis as cortisol levels are affected by several variables including obesity, drugs, and poorly controlled diabetes. Hence, a meticulous evaluation is mandated before confirming the diagnosis. Our patient’s baseline cortisol and ACTH levels were normal, and her DST and LNSC levels were mildly elevated. Unilateral cortisol producing adenoma causes contralateral gland atrophy due to suppressed ACTH. This was not evident in our patient, thus making the diagnosis questionable. Adrenalectomy is the treatment of choice in MACS with adrenal adenoma. Off label medical management with Mifepristone, a glucocorticoid receptor antagonist, is being pursued in select cases and was trialed due to our patient's age and surgical risk. Mifepristone is approved for the treatment of hyperglycemia due to CS. The data supporting its use in MACS is sparse. Therefore, it is important to be aware of associated risks of Mifepristone when advising patients. Presentation: 6/3/2024

Пределы и формы частной автономии в соседских отношениях

The article examines the possibility of regulating neighbours’ relations by concluding private agreements between owners; the permissible limits of such regulation, as well as the legal forms in which it is possible, are assessed. It is shown that private agreements in neighbours’ relations can lead to both the establishment of a limited property right — an easement, and to the emergence of obligatory and quasi-corporate relations. The pros and cons of each of the options for organising the relationship between the parties are assessed, and problems arising due to the insufficient development of the regulation of neighbours’ relations in Russian civil law are demonstrated.

Business development management tools in the digital economy

The peculiarities of the digital environment, which contribute to the rapid growth of instability in enterprises' activities, are highlighted. The need to refine certain aspects and tools of traditional strategic planning is substantiated. The essence of digital transformation as a strategic process of business change—based on client-centric principles, systemic innovation, business model adaptation, active data usage, and competency development—is defined. The problems facing Ukrainian companies in digital transformation are highlighted, including insufficient strategy development, organizational culture misalignment with necessary changes, a shortage of digital skills, outdated technologies, lack of coordination between old and new technologies, and the high costs of implementing innovations. The approach to the digital transformation strategy is viewed as a tool for setting priorities that provides businesses with competitive advantages in rapidly changing markets through the application of digital technologies to solve new business challenges. Potential directions for ensuring the flexibility of a digital strategy are highlighted, such as developing partnerships and cooperation, utilizing big data analysis and predictive analytics for real-time decision-making, and employing flexible technologies for both implementation and strategy development. A hypothesis about the feasibility of developing a minimally viable strategy is proposed. As an additional method for increasing the flexibility of the digital transformation strategy, a modular structure for its design is proposed, based on the concept of business architecture, establishing a close connection between enterprise strategy, business model, and IT architecture. A brief overview of digital business models is provided, indicating that ecosystem-type business models, including digital platforms, are the most successful in the digital environment. The stages of digital transformation are outlined, and additional tools for their implementation are considered, such as digital maturity assessment models, a system of key indicators, and a digital transformation road map. A generalized structure of the toolkit for strategic management of business development in the digital environment is proposed, particularly aligned with the stages of digital transformation implementation.