One of the main challenges that hinder wheat cultivation is weeds through its competitiveness to obtain the essential requirements of growth as most growers claimed that no efficient method can be applied to increase the nutritional value of wheat grains. Therefore, current study aims to increase the nutritional content of wheat using different methods during the development of growth stages. A field experiment was conducted in Zulele village, Babylon province during 2020–2021 and 2021–2022 season to achieve the object above. Treatments and combinations of the experiment (manual weeds removal, herbicides, seeding rate and nano-nutrients) were arranged using randomized complete block design (R.C.B.D) with four replicates. Results showed that there were significant differences between treatments and combinations as Navigator + IQ combi and Weed free + IQ combi combinations with 180 kg.h−1 seeding rate were exceeded and gave the highest average of the percentage of carbohydrates, protein, gluten, total amino acids and tryptophan, also gave the lowest percentage of ash compare to control combination with 140 kg.h−1 seeding rate. The use of Navigator or Surage (Herbicides) or Weed free together with foliar nano-nutrients was improved the nutritional content of wheat grains.