Development Of Fast Dissolving Tablets Research Articles

Current Updates On Natural Superdisintegrants In The Development Of Fast Dissolving Tablets

CURRENT UPDATES ON NATURAL SUPERDISINTEGRANTS IN THE DEVELOPMENT OF FAST DISSOLVING TABLETS Kamde Karishma*, Kasliwal Rahul, Gholse Yogesh, Chaple Dinesh Priyadarshini J. L. College of Pharmacy, Nagpur, Maharashtra, India ABSTRACT Superdisintegrants are a rising example in the Pharmaceutical field. In the application oral separating tablets (ODTs), snappy dispersible tablets, holders, mouth-dissolving films superdisintegrants have seen as a noteworthy nearness especially for ODTs and fast dispersible tablets. Usage of customary superdisintegrants in the improvement of orally stalling tablets has different focal points, for instance, artificially lethargic, non-harmful, progressively reasonable, biodegradable and extensively available. Distinctive ordinary superdisintegrants utilized in the improvement of orally separating tablets have in like manner been discussed. Today, the whole world is continuously interested by trademark meds and excipients. These normal materials have advantage over fabricated ones since they are artificially inert, nontoxic, increasingly moderate, biodegradable and for the most part available. In this way these plans consistently accomplished a superior patient consistence in the event of Pediatric, Geriatric or Psychiatric patients experiencing Dysphagia as Dysphagia has Grown to be a disturbing concern everywhere throughout the Globe. Right now, accentuation is given on various kinds of superdisintegrants utilized in mouth dissolving tablets, their components and applications. Manufactured crumbling specialists are accessible as a profoundly prudent and less compelling when contrasted with normal breaking down operators. Thusly regular disintegrants fill in as the best choice to beat the issues of these engineered substances. Because of their various focal points over manufactured items they are broadly utilized in the pharmaceutical field as a cover, disintegrants, gums, and adhesives. Keywords: Superdisintegrants, Natural super disintegrant, fast dissolving tablet, Synthetic super disintegrant, Disintegration, Swelling Full Text Article

A REVIEW ON FAST DISSOLVING TABLET

In the present scientific scenario, the drug delivery technology has become extremely competitive and quickly evolving with ever-increasing demand. Fast dissolving tablet (FDT) is one such style of an innovative and distinctive drug delivery system. Once FDT is placed on the tongue, it disintegrates or dissolves quickly (in seconds) without chewing or water. Fast dissolving pills became well-liked because of higher patient compliance and most popular over typical capsules and tablets. Numerous FDT products entered the market in the nineteen eighties. This novel drug delivery like FDT or mouth dissolving tablet (MDT) has overcome several disadvantages like dysphagia or non-accessibility of water whereas travel. Compared with typical dosage form FDT is an alternative as well as helpful for the patient. The basic approach employed in the development of FDT is that the use of superdisintegrants like crosspovidone, croscarmellose sodium or maximizing pore structure within the formulation. This review article contains different techniques used for preparing FDT, silent features, numerous proprietary technologies, mechanism of super disintegration, and also the limitations.

ORAL DISPERSIBLE TABLETS: A REVIEW

Fast dissolving tablets (FDTs) have received ever-increasing demand during the last decade and the field has become a rapidly growing area in the pharmaceutical industry. Fast dissolving tablets (FDTs) are those solid dosage forms when put on tongue, disintegrate or dissolve instantaneously, releasing the drug, within a few seconds without the need of water. Fast dissolving tablets (FDTs) aim for designing dosage forms, convenient to be manufactured and administered, free of side effects, offering immediate release and enhanced bioavailability, to achieve better patient compliance. Fast dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. Such formulations provide an opportunity for product life extension in the many elderly persons which have difficulty in taking conventional oral dosage form (viz., solutions, suspensions, tablets, and capsules) because of hand tremors and dysphagia. The current article is focused on ideal requirements, need for development of FDTs, challenges in formulation, suitability of drug candidates, superdisintegrants employed, various technologies developed for FDTs and evaluation methods.

Dissolution rate enhancement of irbesartan and development of fast-dissolving tablets

ObjectiveThe objective of the present investigation was to enhance the solubility and dissolution rate of poorly soluble drug irbesartan by preparing it as solid dispersions and formulating it as fast-dissolving tablets (FDTs) using various excipients.BackgroundIrbesartan is poorly soluble in water, and this low aqueous solubility in addition to its poor wettability leads to poor bioavailability of the drug.Materials and methodsSolid dispersions were prepared using Soluplus, PEG 6000, and Kollidon as carriers. The dispersions were prepared using the solvent evaporation and kneading methods in a 1:1 ratio of drug and carrier. These formulations were characterized for solid state properties using X-ray powder diffraction and Fourier transform infrared spectroscopy spectral studies. Formulations were further evaluated for dissolution.ResultsThe aqueous solubility of irbesartan in solid dispersions was improved by the presence of polymer Soluplus when compared with other carriers. Solid state characterization indicated that irbesartan was present as amorphous material in the formulation with carrier. This was due to efficient entrapment of the drug in polymer matrix. Thus, the solid dispersion prepared with Soluplus would be useful for delivering poorly soluble irbesartan with enhanced solubility and dissolution rate. Furthermore, the solid dispersions that were formulated as FDTs using superdisintegrants showed faster drug release with increased dissolution rate.ConclusionFDTs containing irbesartan solid dispersions prepared using the solvent evaporation method and croscarmellose sodium as superdisintegrant showed faster disintegration and increased dissolution rate.

Utility of Mannitol and Citric Acid for Enhancing the Solubilizing and Taste Masking Properties of β-Cyclodextrin: Development of Fast-Dissolving Tablets Containing Extremely Bitter Drug

Development of Fast dissolved tablets (FDTs) in which taste is masked, and drug dissolution is improved, is a major challenge especially in case of extremely bitter drug with poor water solubility such as aceclofenac. The purpose of this study was to enhance the taste masking and solubilizing properties of β-cyclodextrin using citric acid and mannitol through preparation of acid soluble taste masked granules of aceclofenac (ASTMGA). General factorial design was applied to optimize FDTs containing ASTMGA so to have short disintegration time (<30 sec.), acceptable taste and enhanced drug dissolution in gastric fluid. Three formulation variables; the type of sugar / cellulose based diluents, X1 (Galen IQ® and Prosolv®), superdisintegrant type, X2 (Crospovidone®, Glycolys® and Ac-Di-Sol®) and superdisintegrant concentration, X3 (10 % and 20 %) were included in the design. The systems were assessed for hardness, friability, in vitro disintegration, wetting time, in vitro dissolution and in vivo oral study. The combination of Prosolv® and Crospovidone® in the formulation of FDT gave optimum disintegration time. The stability of the optimized FDT in different package materials was retained after storage at 40 ◦C/75 % RH for six months. Contrary to FDT containing conventional aceclofenac β-cyclodextrin inclusion complex, FDT containing ASTMGA showed highest dissolution rate in both simulated salivary and gastric fluids and excellent ability to mask the bitterness of drug. Our results propose that the combination of citric acid, mannitol and β-cyclodextrin could be promising to improve taste masking and solubilizing properties of β-cyclodextrin.