Development Of Dental Implants Research Articles

Design and additive manufacturing of root analogue dental implants: A comprehensive review

Dental implants are key components in treating dental diseases and correcting dental defects, and they have gained widespread utilisation in various medical operations. However, traditional screw thread implants have been associated with certain drawbacks, including issues such as poor consistency with the alveolar bone and difficulty in customisation. Root analogue implants (RAI) are considered a promising substitute; however, they are not widely applied until now as their geometry design needs more improvements. The utilisation of porous structures, such as triply periodic minimal surfaces, in dental implants can reduce the elastic modulus, increase interconnectivity, and allow for strictly controllable structural characteristics. To achieve optimal initial and long-term stability, it is essential to have a moderate geometry that promotes a proper fit between the dental implants and the natural bone. Different porous and macro-retention structures of RAIs have been investigated due to the above two demands. However, owing to their complex porosity, such structures can only be effectively manufactured using additive manufacturing techniques. Various additive manufacturing technologies have been employed for the fabrication of dental implants and have provided good surface quality and mechanical properties. In vivo tests have demonstrated that their performance is similar to that of commercial implants fabricated using subtractive manufacturing techniques. In this review, we comprehensively examine the design concepts and processes involved in the development of dental implants, along with the application of additive manufacturing methods for their fabrication, while also offering recommendations for the future advancement of dental implant designs.

THE USAGE OF THE FINITE ELEMENT ANALYSIS IN THE DESIGN OF NEW DENTAL IMPLANT SYSTEMS

Introduction. The development of new dental implants in the context of the booming domestic industry makes it possible to find alternative options in the treatment of clinically difficult situations, to select the necessary individual solution during dental implant surgery and consequently to perform the surgery in an error-free manner and achieve the desired results. The development of a dental implant is a multistep process, and the characteristics of the implant material and its biophysical characteristics must be studied in detail until the implant is integrated into the bone tissue.The aim of the study: to estimate the opportunities and prospects of applying the finite elements method by developing the new systems of dental implants according to the literature data.Materials and methods. A search was carried out in the national digital libraries e-library, CyberLeninka, as well as PubMed, Medline, Web of Science and Google Scholar using the following keywords: dental implant, finiteelement analysis, mathematical model. Sixty-nine papers were selected and analysed.Results. The finite element method is an accurate method to analyse the implant being developed, but it has certain limitations, because in the finite element mesh, the implant-bone interface is a continuous relationship. The absence of micro-movement at the implant-bone interface during loading is different from the actual clinical situation. The expected 100 % osseointegration based on 3D-modelling can’t be an ideal option and never corresponds to the reality in the clinical situation. However, the use of the finite element method makes it possible to test single loads and inclination angles, which in the clinical situation is very rare

RADIOGRAPHIC EVALUATION OF THE SUCCESS OF IMPLANT-SUPPORTED TOTAL PROSTHESES ON CONICAL EXTERNAL HEXAGON IMPLANTS AND 6-MONTH FOLLOW-UP AFTER INSTALLATION OF THE PROSTHESES.

The development of dental implants has revolutionized the rehabilitation possibilities for partially or totally edentulous patients. The long-term success of the dental implant depends on osseointegration and this is achieved by the combination of two essential stabilities: primary and secondary. Implant-supported prostheses are a great evolution for these treatments, positively interfering in the quality of life of the population, as they generate function and aesthetics for the patient. Thus, the present study aimed to radiographically evaluate complete dentures supported by an external hexagon conical implant in the anterior region of the mandible. More specifically, to evaluate the feasibility of using these implants in cortical bone of the mandible, to verify the success rate regarding the significance of peri-implant bone loss and to compare peri-implant bone loss between patients.

Application of the finite element analysis in the development of new dental implant systems. Literature review

Introduction. The development of new dental implants in the context of the booming domestic industry makes it possible to find alternative options in the treatment of clinically difficult situations, to select the necessary individual solution during dental implant surgery, and consequently, to perform the surgery in an error-free manner and achieve the desired results. The development of a dental implant is a multistep process, and the characteristics of the implant material and its biophysical characteristics must be studied in detail until the implant is integrated into the bone tissue. The aim of the study: to estimate the opportunities and prospects of applying the finite elements method by developing the new systems of dental implants according to the literature data. Material and methods. A search was carried out in the national digital libraries e-library, CyberLeninka, as well as PubMed, Medline, Web of Science and Google Scholar using the following keywords: dental implant, finite-element analysis, mathematical model. Sixty-nine papers were selected and analysed. Results. The finite element method is an accurate method to analyse the implant being developed, but it has certain limits, because in the finite element mesh, the implant-bone interface is a continuous relationship. The absence of micro-movement at the implant-bone interface during loading is different from the actual clinical situation. The expected 100 % osseointegration based on 3D-modelling can’t be an ideal option and never corresponds to the reality in the clinical situation. However, the use of the finite element method makes it possible to test single loads and inclination angles, which in the clinical situation is very rare.

Development and evaluation of osteogenesis and antibacterial properties of strontium/silver-functionalized hierarchical micro/nano-titanium implants

Promoting implant osseointegration while preventing infection is one of the major challenges in the development of dental implants. In this study, nano-needle-like structures were prepared on titanium by hot alkali treatment and then coated with uniform silver (Ag) and strontium titanate (SrTiO3) through magnetron sputtering. The results of ion release showed that the SrTiO3 outer coating reduced the release of Ag ions by 30% and 15% respectively on the 4th and 7th days, thus effectively improving the bioactivity of the Ag-modified substrates. In vitro experiments demonstrated that the Ag/SrTiO3-coated specimens (AH-Ti/Ag/Sr) had an excellent effect on the osteogenic differentiation of MC3T3-E1 cells and exhibited antibacterial function against Staphylococcus aureus and Escherichia coli (percentage of dead/total bacteria: ∼93% and ∼88%). Moreover, the in vivo results further confirmed that the Ag/SrTiO3 bilayer coating significantly promoted osteogenesis around the AH-Ti/Ag/Sr implant (the new bone volume and the number of trabeculae: 1.5 and 1.4 fold of the control group) and enhanced the bonding strength between implant and surrounding bone (about 1.9 fold of the control group). All these findings indicate that AH-Ti/Ag/Sr can substantially improve osteogenesis in complex oral microenvironment, and thus has potential applications in oral implantology.

Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement

An optimal performance of bone implants with bioceramic coatings is closely related to the surface modification technology. For the first time, we have evaluated a gas detonation deposition (GDD) approach to obtain biocompatible ceramic coatings based on bioglass (BG) and calcium phosphates on Ti-based alloys as prospective materials towards their application for the development of bone implants. For the production of the coatings, hydroxyapatite (HA), HA metal-substituted (containing Ag+, Cu2+, or Zn2+) and tricalcium phosphate (TCP) were synthesized and characterized. Pure powders and their combination with BG were used to obtain coatings on a Ti–6Al–4V alloy using the developed automatized GDD setup. The microstructure, phase and chemical composition of the produced coatings were studied using XRD, SEM-EDS and Raman spectroscopy. The produced coated materials were evaluated in vivo in Wistar rats to analyze a reparative osteogenesis over a period of 12 weeks. The results regarding the optimization of the GDD method indicate its high productivity, as confirmed by high deposition rates. The highest deposition rate was observed for the coatings obtained from the HA metal-substituted powders. The results revealed a partial transformation of a HA phase to an α-TCP phase during the deposition, with a prevalence of the HA-phase in the coatings. According to the histological evaluation, the reparative osteogenesis occurs through the perimeter of the titanium implants, whereas the regeneration level increases from the 4th to the 12th week. The highest osteointegration level was detected for the implants coated with a biocomposite consisting of BG, HA and TCP. The results of the current study demonstrate an effectiveness of the GDD method to produce biocompatible coatings on Ti-based alloys. This provides excellent prerequisites towards the application and standardization of the GDD technology to manufacture bone implants for bone fixation and defect replacement, as well as the development of dental implants.

The development and future of dental implants.

Since 1970s, a lot of effort has been devoted toward the development of dental implants. Dental implants are nowadays an indispensable part of clinical dentistry. The global dental implant market is expected to reach $13 billion in 2023. Although, the survival rate of dental implants has been reported above 90%, compromised bone conditions promote implant failure and endanger the current high success rates. The main concern is related to the aging population. Diabetes, osteoporosis, obesity and use of drugs are all medical conditions, which can hamper bone healing around dental implants. In view of this, research toward developing better methods of enhancing implant osseointegration have to be continued, especially in the presence of impaired bone condition. In this paper, the current changes and their future perspective are discussed.

Platelet Adhesion on Commercially Pure Titanium Plates in Vitro II. Immunofluorescence Visualization of PDGF-B, TGFβ1, and PPARγ Released from Activated Adherent Platelets.

Recent progress in the industrial development of dental implants has improved their surface bio-affinity, while clinical implantologists attempt to improve it through coating with various compounds, including platelet-rich plasma (PRP) in clinical settings. However, it is poorly understood how PRP acts on titanium surfaces. To validate this surface modification method and demonstrate how platelet-derived soluble biomolecules released from the activated adherent platelets act on plain, commercially pure-titanium (cp-Ti) plates, we evaluated the distribution of biomolecules by immunofluorescence. PPARγ, PDGF-B, and TGFβ1 were similarly released at immunofluorescence levels from activated adherent platelets, retained in the surrounding extra-platelet spaces for a while, and did not immediately diffuse away to distant spaces. Exogenously added CaCl2 augmented release and retention of those biomolecules along with activation and aggregation. Taken together with our previous data regarding platelet adhesion, these findings suggest that especially when treated with CaCl2, platelets immediately adhere on cp-Ti plates to release their stored biomolecules in the absence of plasma proteins and that these biomolecules do not diffuse away, but stay longer in extra-platelet spaces around the platelets by newly formed, immature fibrin fiber fragments. Consequently, these retained biomolecules are anticipated to cooperatively stabilize implants by stimulating alveolar bone regeneration and integration.

Polyether ether ketone (PEEK) and its manufacturing of customised 3D printed dentistry parts using additive manufacturing

BackgroundIdentified research articles on Polyether ether ketone (PEEK) and its application in dentistry. Further identified the direction of evolution of this material through additive manufacturing (AM) in the field of dentistry. Materials and methodsPEEK is one of the suitable thermoplastic polymers which is biocompatible for the human body. We have identified related research articles through Scopus. A bibliometric analysis helped to achieve the targeted research objective. ResultsThrough Scopus search, 46 research articles were identified by using keywords as “PEEK” “Dentistry”. Doctors and scientists are using PEEK material in medical, and other associated fields to fulfil extensive requirements of customisation. Nowadays, PEEK is also being experimented in dentistry for developing implants and associated requirements. Therefore, by using AM technologies, PEEK-based implants provide a perfect match replica in lesser time and cost. Further, this paper identifies significant challenges of using this material with AM for dentistry. In the last, the paper identifies ten important application of PEEK in AM for dentistry. ConclusionAdditive manufacturing shows a significant achievement in the design & development of dental implants, tools and devices using PEEK material. It helps in reduction of product development cycle time, cost, weight with improved quality of implants and helps fulfil various challenges faced in dentistry. This innovative technology works as concept generation and is easy to make a required modification for a product used in dentistry. Design and development of dentistry tool are done easily such as manufacturing of any implants for surgical planning and analysis whether the surgery will succeed or not. Therefore, this technology has application in the production of customised PEEK-based orthodontics, crowns, bridges, night guards and prosthodontics implants.

A review of nanostructured surfaces and materials for dental implants: surface coating, patterning and functionalization for improved performance.

The emerging field of nanostructured implants has enormous scope in the areas of medical science and dental implants. Surface nanofeatures provide significant potential solutions to medical problems by the introduction of better biomaterials, improved implant design, and surface engineering techniques such as coating, patterning, functionalization and molecular grafting at the nanoscale. This review is of an interdisciplinary nature, addressing the history and development of dental implants and the emerging area of nanotechnology in dental implants. After a brief introduction to nanotechnology in dental implants and the main classes of dental implants, an overview of different types of nanomaterials (i.e. metals, metal oxides, ceramics, polymers and hydrides) used in dental implant together with their unique properties, the influence of elemental compositions, and surface morphologies and possible applications are presented from a chemical point of view. In the core of this review, the dental implant materials, physical and chemical fabrication techniques and the role of nanotechnology in achieving ideal dental implants have been discussed. Finally, the critical parameters in dental implant design and available data on the current dental implant surfaces that use nanotopography in clinical dentistry have been discussed.

“Stop the ticking before it blows:” treatment modalities of peri-implantitis

The serendipitous discovery of osseointegration and the subsequent development of dental implants have irrefutably marked an epoch-making point of inflection in not only the basic approach of the clinicians toward treating edentulism but also in the attitudes and preferences of the patients in getting their oral rehabilitation issues resolved. This decisive shift also triggered explosive research targeting improvement in various aspects of dental implants. However, initial success in osseointegration does not necessarily translate into success in long-term function. A successfully osseointegrated implant may be afflicted with early or late complications in due course of service. Of these, peri-implantitis (PI) is considered one of the most common causes of implant failure. For the treatment of peri-implant diseases (mucositis and PI), various conservative and surgical approaches are available. Mucositis and moderate forms of PI can be contained effectively using conservative methods. These include the administration of systemic and local antibiotics alone or in conjunction with other treatment modalities such as nonsurgical therapy which consists of mechanical debridement of the affected areas, irrigation with antiseptics (such as chlorhexidine, saline, and 10% hydrogen peroxide) with or without surface decontamination, laser-supported therapy, photodynamic therapy as well as light-activated disinfection also known as photodynamic antimicrobial chemotherapy along with maintaining adequate plaque control. In cases with advanced PI, surgical therapies are more effective than conservative approaches. Open flap debridement can be done, and depending on the configuration of the defect, regenerative therapies such as guided tissue regenerative and the use of bone graft materials may be applicable for defect filling whereas resective surgery can be considered for the elimination of peri-implant lesions.

Indications for Angled Implants: A Review

The development of dental implants has led to an expansion of indications and to perfection of implantation methods and implant systems. Angulation problems due to anatomic limitations, however, still remain. In this article indications for angled implants are reviewed.

Morphological study and stress analysis of Korean Mandibular second premolar

Tooth morphology has an important role in esthetical characteristics, functional performance and physiological action. Mandibular second premolars among teeth were taken for a close investigation with a micro-CT for a nondestructive measurement. Thus, the shape of the tooth was classified into a few partitions and measured by setting the reference axis to express internal and external morphology numerically. About a thousand tomographic images were obtained for each specimen and were reconstructed to a three-dimensional form. The lengths and widths of each dental tissue were measured from the three-dimensional form. In this tooth type, the width of dentine is comparatively larger than that of enamel, and buccal tissue of the crown is thicker than lingual tissue. Hence, buccal tissue could afford to withstand against exterior impact or stimulus. Finite element models were drawn up, applied with an ordinary occlusal force and analyzed to get the stress distribution. Thus it was shown that the irregular feature of the tooth is not useful only to masticating and pronouncing as well known, but that it is also suitable for protecting inner tissue by dispersing stress and delivering proper pressure to periodontal tissue to continue a physiological action. These results could be used for development of dental implants and clinical trials.

Soft and hard tissue response to endosseous dental implants

The last two decades have seen a remarkable growth in the development of dental implants and their incorporation into the practice of dentistry. This turn of events was made possible by an improved understanding of the biological response of living tissues to implants as well as clinical trials that validated the long-term success of these implants. Despite major structural differences between teeth and implants, such as the absence of a periodontal ligament around implants, the latter appear to provide a reliable functional replacement for their natural counterparts. This review briefly summarizes the major structural differences of the interfacial region of teeth and dental implants and their supporting tissues. It focuses on our current understanding of the soft and hard tissue responses to submerged and nonsubmerged root-form dental implants. The influence of a number of factors that affect the tissue response is reviewed, including biomaterials, implant design, surgical technique, and the local microbiota. Our recently acquired ability to modulate wound healing with guided tissue regeneration and growth factors will undoubtedly play an important role in the future utilization and success rates of dental implants. © 1996 Wiley-Liss, Inc.

Soft and hard tissue response to endosseous dental implants.

The last two decades have seen a remarkable growth in the development of dental implants and their incorporation into the practice of dentistry. This turn of events was made possible by an improved understanding of biological response of living tissues to implants as well as clinical trials that validated the long-term success of these implants. Despite major structural differences between teeth and implants, such as the absence of a periodontal ligament around implants, the latter appear to provide a reliable functional replacement for their natural counterparts. This review briefly summarizes the major structural differences of the interfacial region of teeth and dental implants and their supporting tissues. It focuses on our current understanding of the soft and hard tissue responses to submerged and nonsubmerged root-form dental implants. The influence of a number of factors that affect the tissue response is reviewed, including biomaterials, implant design, surgical technique, and the local microbiota. Our recently acquired ability to modulate wound healing with guided tissue regeneration and growth factors will undoubtedly play an important role in the future utilization and success rates of dental implants.

Indications for angled implants

The development of dental implants has led to an expansion of indications and to perfection of implantation methods and implant systems. Angulation problems due to anatomic limitations, however, still remain. The indications for the use of angled Bonefit I.T.I. implants are described.