Nowadays, the calculation of masonry structures is based on studies and experiments of the past without taking into account the mechanical characteristics, which leads to overestimation or underestimation of the bearing capacity. Such an error affects the formation and development of cracks in structures. To solve this problem, it is necessary to develop a methodology for calculating brickwork, taking into account the mechanical characteristics of its components. The purpose of this work is the numerically simulation and calculation of masonry structures by the method of homogenized characteristics of material on the example of a brick partition. As the object of research, the authors selected brick partition of the building on Zhukovsky Street, 28 in Tyumen. The subject of the study is the stress-strain state of the brickwork. The study was performed based on analytical calculation and numerical simulation in PC ANSYS and PC Lira. As a result, a method of calculating brickwork using the method of homogenized material characteristics has been developed. The scope of application of the results is industrial and civil construction of buildings from masonry structures.