Development Of Convolutions Research Articles

Gliogenesis in the outer subventricular zone promotes enlargement and gyrification of the primate cerebrum

The primate cerebrum is characterized by a large expansion of cortical surface area, the formation of convolutions, and extraordinarily voluminous subcortical white matter. It was recently proposed that this expansion is primarily driven by increased production of superficial neurons in the dramatically enlarged outer subventricular zone (oSVZ). Here, we examined the development of the parietal cerebrum in macaque monkey and found that, indeed, the oSVZ initially adds neurons to the superficial layers II and III, increasing their thickness. However, as the oSVZ grows in size, its output changes to production of astrocytes and oligodendrocytes, which in primates outnumber cerebral neurons by a factor of three. After the completion of neurogenesis around embryonic day (E) 90, when the cerebrum is still lissencephalic, the oSVZ enlarges and contains Pax6+/Hopx+ outer (basal) radial glial cells producing astrocytes and oligodendrocytes until after E125. Our data indicate that oSVZ gliogenesis, rather than neurogenesis, correlates with rapid enlargement of the cerebrum and development of convolutions, which occur concomitantly with the formation of cortical connections via the underlying white matter, in addition to neuronal growth, elaboration of dendrites, and amplification of neuropil in the cortex, which are primary factors in the formation of cerebral convolutions in primates.

A Morphogenetic Model for the Development of Cortical Convolutions

The convolutions of the mammalian cortex are one of its most intriguing characteristics. Their pattern is very distinctive for different species, and there seems to be a remarkable relationship between convolutions and the architectonic and functional regionalization of the cerebral cortex. Yet the mechanisms behind the development of convolutions and their association with the cortical regionalization are poorly understood. Here we propose a morphogenetic model for the development of cortical convolutions based on the structure of the cortex as a closed surface with glial and axonal fibres pulling radially, the fundamental mechanical properties of cortex and fibres (elasticity and plasticity), and the growth of the cortical surface. The computer simulations of this model suggest that convolutions are a natural consequence of cortical growth. The model reproduces several aspects of convolutional development, such as the relationship between cortical surface and brain volume among mammals, the period of compensation in the degree of convolution observed in gyrencephalic brains and the dependence of the degree of convolution on cortical thickness. We have also studied the effect of early cortical regionalization on the development of convolutions by introducing geometric, mechanic and growth asymmetries in the model. The morphogenetic model is thus able to reproduce the gradients in the degree of convolution, the development of primary, secondary and tertiary convolution, and the overproduction of sulci observed in animals with altered afferent cortical connections.

THE CRIMINAL BRAIN NOT NECESSARILY DEGENERATE.

At the Philadelphia Academy of Natural Sciences the subject of degeneration was discussed recently by the Section on Anthropology.Dr. Charles K. Millspresented the brains of three murderers and demonstrated in them the abnormalities in the course and development of convolutions and fissures, apparently showing a reversal to the brain conformation of anthropoid apes. Two of the murderers were insane, which also was indicative in the mind structural peculiarities. Dr. M. V. Balldwelt upon the distinction between the " degenerate" and the " atavistic " brain, the former being pathologic; the latter the result of reversion to a lower type. Idiots, insane and epileptic subjects belong to the degenerate class, while, according toLombroso, born criminals are the result of a halt in evolution, or what is termed reversion. Some criminologists maintain the view that the changes are due to faulty nutrition, and as criminals are usually of