Development Of Blood Transfusion Research Articles

PERBANDINGAN HASIL PEMERIKSAAN KONTAMINASI BAKTERI PADA PRODUK TROMBOCYTE CONCENTRATE METODE KONVENSIONAL DAN APHERESIS

Platelet Concentrate (PC) is one of the blood products that is often used for transfusion. The storage temperature for TC products is in the range of 20-24OC which is the optimal temperature for bacterial growth. TC products contaminated with bacteria can cause a dangerous septic reaction. With the development of blood transfusion, apheresis methods emerged for the manufacture and aseptic collection of TC products. The apheresis method is considered safer than the conventional method which has a high chance of bacterial contamination. This study aims to compare the results of the examination of bacterial contamination in conventional TC products and apheresis methods. This study is a comparative descriptive study with a retrospective approach in the form of examining data on bacterial contamination of TC PMI Semarang City during 2019. The results of the examination of the TC apheresis method product showed that there were no TC products that were contaminated with bacteria (0.0%; 0 of 48), while in conventional method, there is 1 TC product that has bacterial contamination (0.3%; 1 out of 360). Fisher exact test on each TC product obtained p value = 1.00 (> 0.05) so that the difference that appears is not significant. Examination of bacterial contamination in conventional TC products and apheresis gave the same good results.

Переливание крови: становление

The 19th century witnessed the genesis of blood transfusion, whose history goes back several centuries. Then, after a century and a half of oblivion, an interest in blood transfusion revived again. The major contribution to the development of blood transfusion was made by the graduates of the University of Edinburgh. High among them was James Blundell, who performed the first human-to-human transfusion in 1818. His contribution is one of the first systematic studies in this field and ushered in a new era of transfusion medicine. He, along with his followers, many of whom are undeservedly forgotten, proved the danger of heterologous blood transfusions, found that venous blood was as suitable as arterial blood, developed approaches to preventing blood clotting (warming, defibrination, anticoagulants), improved transfusion techniques and equipment, and noted it was important to avoid air inside the transfusion set. The development of blood transfusion encouraged research into the intravenous injection of various liquids and gases contributing to the development of intravenous therapy. However, blood transfusion was being introduced into the medical practice slowly, as it often led to the death of patients. This was due to the imperfection of the procedure and tools and unawareness of human blood incompatibility. This review explores the key advances in the development of blood transfusion in foreign physiology and medicine in the 19th century.

The Development of Blood Transfusion in Spain during the Spanish Civil War (1936–1939): The Contribution of British Doctor, Reginald Saxton

When a failed military coup provoked civil war in Spain in July 1936, the tremendous numbers of casualties obliged the Spanish government to make a worldwide plea for medical assistance. Many thousands of people around the world rallied to the call, transforming the Republican Medical Service into a truly international effort. Some of those volunteers worked in emergency blood transfusion facilities, carrying out pioneering transfusion work in primitive and often dangerous conditions. Among the most notable of these volunteers were Canadian surgeon Norman Bethune and British doctor Reginald Saxton. Working alongside them were American, Italian and Spanish assistants, many of whom remain nameless. All played vital roles in the saving of lives and all took their lead from one man—the young Catalan haematologist, Frederic Duran Jordà, director of the Blood Transfusion Service of the Republican Army, and indisputable pioneer of Civil War blood transfusion medicine.

Cell Therapy: Past, Present, and Future

Cellular therapy started in the early twentieth century with the development of blood transfusion and later bone marrow transplantation. This review describes the historical origins and major milestones in the field of cellular therapy. We discuss ethical concerns associated with certain cell sources and how they influenced therapy strategies. A focus of this article is on the use of stem cells to understand regenerative repair after kidney injury. In addition, we give an overview over past and current kidney-related cellular therapy trials. The number of kidney-related cellular therapy trials has been growing exponentially over the last 20 years. Main applications of kidney-related cellular therapy are in renal cancer and kidney transplant tolerance. The USA and China are the countries with the highest number of cellular therapy trials. Cellular therapy, in combination with the recent advances in iPS cell generation and CRISPR-Cas 9, has a bright future. It has the potential to enable highly personalized therapy strategies to overcome problems associated with cancer therapy, transplant rejection, and organ regeneration.

Standardized management of thalassemia

Thalassemia is inherited hemolytic anemia caused by globin production disorder, clinically known as beta thalassemia and alpha thalassemia resulted from beta and alpha chain synthesis disorder. Significant anemic clinical manifestations are observed in intermediate-level and severe-level patients with the 2 types of anemia, affecting greatly the growth and life quality of children patients who need blood transfusion to stay alive. The incidence rate of thalassemia is as high as 7%-20% in South China, so the prevention and standaridized treatment of thalassemia and the management over target population draw more attention. This paper is a review on the latest development of blood transfusion, chelation therapy, health education, birth intervention for thalassemia. Key words: Thalassemia; Transfusion; Health education; Genetic intervention

Norman Béthune (1890–1939) médecin engagé et icône de la transfusion sanguine

Norman Bethune was born in 1890, in Gravenhurst (Ontario, Canada). Thereafter a strong surgical training, he implied in thoracic surgery and fight against tuberculosis. His political opinions led him to join the Republicans in the Spanish Civil War. He played an important part in the development of blood transfusion on the battlefield. Then he joined China with communist troops and therein developed surgical units and accelerated training for health personal. He died of septicemia in 1939.

The Development of Blood Transfusion: the Role of Albert Hustin and the Influence of World War I.

(2015). The Development of Blood Transfusion: the Role of Albert Hustin and the Influence of World War I. Acta Chirurgica Belgica: Vol. 115, No. 3, pp. 247-255.

Blood transfusion at the time of the First World War--practice and promise at the birth of transfusion medicine.

The centenary of the start of the First World War has stirred considerable interest in the political, social, military and human factors of the time and how they interacted to produce and sustain the material and human destruction in the 4 years of the war and beyond. Medical practice may appear distant and static and perhaps seems to have been somewhat ineffectual in the face of so much trauma and in the light of the enormous advances in medicine and surgery over the last century. However, this is an illusion of time and of course medical, surgical and psychiatric knowledge and procedures were developing rapidly at the time and the war years accelerated implementation of many important advances. Transfusion practice lay at the heart of resuscitation, and although direct transfusion from donor to recipient was still used, Geoffrey Keynes from Britain, Oswald Robertson from America and his namesake Lawrence Bruce Robertson from Canada, developed methods for indirect transfusion from donor to recipient by storing blood in bottles and also blood-banking that laid the foundation of modern transfusion medicine. This review explores the historical setting behind the development of blood transfusion up to the start of the First World War and on how they progressed during the war and afterwards. A fresh look may renew interest in how a novel medical speciality responded to the needs of war and of post-war society.

How Does the Global Economic Crisis Affect the Quality of Blood Services?

How Does the Global Economic Crisis Affect the Quality of Blood Services?

Oral abstracts

A most memorable scene in ‘‘Bram Stoker’s Dracula’’of Francis Ford Coppola sees Count Vlad II of Wallachia procl Aim: ‘‘The blood is the life!’’It is impossible to evaluate how much the Irish novelist, writer of the 1897 book the film was based upon, was influenced by the developments in blood transfusion that characterized the end of the 19th and the beginning of the 20th century, but the word ‘‘transfusion’’ figures prominently in his manuscript. Past centuries had been characterized by successful blood transfusions between animals, but success in human transfusions had been limited prior to Landsteiner’s discovery of the red blood cell (RBC) membrane ABO antigens (1901) that permitted the establishment of safe blood transfusions. The application of refrigeration and anticoagulants to blood storage in the 1910s then paved the way to blood banking. Since those early days, developments in the RBC field have been tightly associated with technologies that changed science, allowing researchers to home into the detail, and had a huge impact on the quality of life. Today, proteomics technologies can be used to tackle important but neglected aspects of transfusion medicine, such as determining changes at the peptide and protein level during storage of blood products. Studies have demonstrated that stored leucocyte-undepleted whole RBC populations release over hundred proteins compared to the few released by leucocyte-depleted blood units. The leucocyte-poor RBC predominantly released carbonic anhydrase and thioredoxin peroxidase B. The presence of oxygen, in this context, gives rise to extensive RBC surface modifications, which can be prevented by adding protease inhibitors. Proteins released during storage of leucocyte-depleted RBCs were found in form of microvesicles and nanovesicles enriched not only in integral membrane proteins, but specifically in oligomerized band 3, suggesting a preferential release of damaged cell components from otherwise functional RBCs. Flow cytometry was used in combination with proteomics to study storage of younger versus older RBCs. In leucocyte-depleted RBC stored for 42 days, phosphatidylserine exposure at the RBC membrane external surface did not increase and none of the surface markers studied decreased significantly, while the copy numbers of CD44, CD58, CD147 and glycophorin decreased and annexin release increased in RBC stored with leucocytes. A recent review summarizes the contribution of proteomics to transfusion medicine and puts forward a possible approach in form of a workflow for monitoring the quality of blood-based therapeutics by proteomics. This monitoring may be essential as more detailed analyses using state of the art mass spectrometry tools are likely to provide an even better insight into storage and environment-induced changes in the RBC that may be critical to optimize the quality of transfused RBC. Increasing our knowledge of the RBC protein make-up (low abundant proteins in particular); of their changes in health and disease and in the interplay with other blood cells/endothelial cells will also be beneficial in assessing changes in their quality, while the study of intra-species differences will be instrumental in the light of the passage from animal experimentation to clinical trials.

Proteomics, the red blood cell and transfusion medicine

Background and objectives: A most memorable scene in “Bram Stoker’s Dracula” of Francis Ford Coppola sees Count Vlad II of Wallachia proclaim: “The blood is the life It is impossible to evaluate how much the Irish novelist, writer of the 1897 book the film was based upon, was influenced by the developments in blood transfusion that characterized the end of the 19th and the beginning of the 20th century, but the word “transfusion” figures prominently in his manuscript. Past centuries had been characterized by successful blood transfusions between animals, but success in human transfusions had been limited prior to Landsteiner’s discovery of the red blood cell (RBC) membrane ABO antigens (1901) that permitted the establishment of safe blood transfusions. The application of refrigeration and anticoagulants to blood storage in the 1910s then paved the way to blood banking. Since those early days, developments in the RBC field have been tightly associated with technologies that changed science, allowing researchers to home into the detail (moving from blood to RBC and then to RBC membrane proteins) and had a huge impact on the quality of life. Today, proteomics technologies can be used to tackle important but neglected aspects of transfusion medicine, such as determining changes at the peptide and protein level during storage of blood products.Results: Studies have demonstrated that stored leucocyte‐undepleted whole RBC populations release over 100 proteins compared to the few released by leucocyte‐depleted blood units. The leucocyte‐poor RBC predominantly released carbonic anhydrase and thioredoxin peroxidase B. The presence of oxygen, in this context, gives rise to extensive RBC surface modifications, which can be prevented by adding protease inhibitors. Proteins released during storage of leucocyte‐depleted RBCs were found in form of microvesicles and nanovesicles enriched not only in integral membrane proteins, but specifically in oligomerized band 3, suggesting a preferential release of damaged cell components from otherwise functional RBCs. Flow cytometry was used in combination with proteomics to study storage of younger versus older RBCs. In leucocyte‐depleted RBC stored for 42 days, phosphatidylserine exposure at the RBC membrane external surface did not increase and none of the surface markers studied decreased significantly, while the copy numbers of CD44, CD58, CD147 and glycophorin decreased and annexin release increased in RBC stored with leucocytes. A recent review summarizes the contribution of proteomics to transfusion medicine and puts forward a possible approach in form of a workflow for monitoring the quality of blood‐based therapeutics by proteomics.Conclusions: Monitoring may be essential as more detailed analyses using state of the art mass spectrometry tools are likely to provide an even better insight into storage and environment‐induced changes in the RBC that may be critical to optimize the quality of transfused RBC. Increasing our knowledge of the RBC protein make‐up (low abundant proteins in particular); of their changes in health and disease and in the interplay with other blood cells/endothelial cells will also be beneficial in assessing changes in their quality, while the study of intra‐species differences will be instrumental in the light of the passage from animal experimentation to clinical trials.

Safety and supply of haemophilia products: worldwide perspectives.

The survival and well-being of people with haemophilia depends on the supply of safe therapeutic products. Safety and supply are entirely intertwined principles; in the absence of adequate amounts of coagulation products, safety measures may be compromised in order to enhance supply, leading to risks which may result in morbidity and mortality. As haemophilia therapy has emerged through the development of blood transfusion and plasma fractionation, the safety of the blood supply in general has had a strong effect on haemophilia care. Despite the gradual detachment of haemophilia care from blood transfusion through the use of recombinant products, the majority of the world's population with haemophilia in the developing world will be reliant on blood products for the foreseeable future. It is, therefore, important to continue efforts for a safe and sufficient blood supply worldwide. As such a blood supply develops, possibly in tandem with an independent plasma fractionation industry, the level of haemophilia care should improve with the gradual introduction of concentrates for the ultimate goal of covering all aspects of care. Constant vigilance for the threat of blood-borne pathogens should be linked to considerations of how these products are to be manufactured. This should be governed entirely by considerations of safety and pharmaceutical competence. Of equal importance is a governmental capacity to oversee the entry and maintenance of these products on the market. While it is not possible for all countries to have a regulatory authority of the same status as that of the developed countries, it is perfectly feasible to develop a set of basic principles which allow an assessment of basic product safety, quality and efficacy to be made.

The development of blood transfusion: the contributions of Norman Bethune in the Spanish Civil War (1936-1939).

Although the Spanish Civil War (1936-1939) has been the focus of many papers in many countries, there are few references concerning medicine during this war, and many of the related events and medical progress are not well known. Some of these events came to influence civilian and military medicine. Among these were advances in blood transfusion, in which the Canadian surgeon, Norman Bethune, played an important role, particularly in advocating transfusion of blood to soldiers at the front rather than at medical centres behind the lines. While much of Bethune's work, especially in Canada and China, is well known, 1-3 certain aspects of Bethune's work and his stay in Spain are worth reviewing.

Symposium ‘Future Developments in Blood Transfusion’: Organised by the Blood Transfusion Service Board, Dublin, Ireland March 24–25, 1981

Vox SanguinisVolume 41, Issue 5-6 p. 344-349 Symposium ‘Future Developments in Blood Transfusion’: Organised by the Blood Transfusion Service Board, Dublin, Ireland March 24–25, 1981 First published: November‐December 1981 https://doi.org/10.1111/j.1423-0410.1981.tb01060.xCitations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume41, Issue5-6November‐December 1981Pages 344-349 RelatedInformation

The Red Cross and new developments in blood transfusion

Although mention of blood transfusion dates back to the origin of medicine, it may be said that the genuine history of transfusion starts at the beginning of our century.Since then transfusion has passed through several decisive phases, but it is only in the past twenty years that it has made spectacular progress and has become one of the essential components of modern medicine.

A Survey of Recent Developments in Blood Transfusion

A Survey of Recent Developments in Blood Transfusion

A Survey of Recent Developments in Blood Transfusion

A Survey of Recent Developments in Blood Transfusion

CHILLS FOLLOWING TRANSFUSION OF BLOOD

Transfusion of blood, when used with proper precautions, is a comparatively safe procedure; but when used indiscriminately and without proper consideration of technic and indications, blood transfusion can be followed by most serious complications, even by death. The safety with which blood transfusion can be used in a variety of diseases is based mainly on Landsteiner's discovery of the blood groups. Landsteiner,1in 1900, demonstrated that human beings and certain animals can be classified in three different groups. A fourth group was added by Jansky2in 1907. This work of Landsteiner is the foundation underlying the modern development of blood transfusion. As compared with the preliminary testing of donor and recipient, the technic of blood transfusion, i. e., the method to be applied in a given case, is of minor importance. Any method (syringe, stopcock, paraffinized glass cylinders, sodium citrate) is applicable, provided it is possible to measure