Cultural and Creative Industries (CCIs) are widely acknowledged in academic and policy discourse as fundamental resources for local development. Nevertheless, a deeper understanding of the analysis of CCI function patterns and full potential exploitation in peripheral areas is needed in the literature on regional and local economic development. Peripheral destinations are often characterized by specific obstacles such as geographical remoteness from dominant economic centers, poor infrastructure and amenities, limited capacity for decision-making, etc. However, they can also have characteristics that can support the sustainability and development of a place, such as rich cultural heritage, traditional cultural industries, uniqueness and authenticity, and cultural identity and social cohesion. This paper provides an overview of the main characteristics of the CCIs in peripheral areas and explores synergy patterns, a significant procedure for sustainability, exchange of knowledge and practices, development of actions, promotion of innovation and local development. More specifically, the study incorporates formal networking through entrepreneurial practices and informal networking through social capital into the network theory of the cultural sector in peripheral areas of Greece. In order to identify the key traits and factors that contribute to synergies in the cultural sector, a two-stage research design has been employed. A qualitative approach based on structured interviews and relative importance index analysis to provide an assessment framework has been used. Results indicate that CCI synergy in peripheral areas depends primarily on social capital, which is extremely important in local policies rather than just entrepreneurial practices.