Development Process Research Articles

Development of emergent processes and threshold of consciousness with levels of processing

Development of emergent processes and threshold of consciousness with levels of processing

The utility of website-based quality improvement tools for health professionals: a systematic review.

As technology continues to advance, it is important to understand how website-based tools can support quality improvement. Website-based tools refer to resources such as toolkits that users can access and use autonomously through a dedicated website. This review examined how website-based tools can support healthcare professionals with quality improvement, including the optimal processes used to develop tools and the elements of an effective tool. A systematic search of seven databases was conducted to include articles published between January 2012 and January 2024. Articles were included if they were peer reviewed, written in English, based in health settings and reported the development or evaluation of a quality improvement website-based tool for professionals. A narrative synthesis was conducted using NVivo. Risk of bias was assessed using the Mixed Methods Appraisal Tool. All papers were independently screened and coded by two authors using a six-phase conceptual framework by Braun and Clarke. Eighteen studies met the inclusion criteria. Themes identified were tool development processes, quality improvement mechanisms and barriers and facilitators to tool usage. Digitalising existing quality improvement processes (n = 7), identifying gaps in practice (n = 6), and contributing to professional development (n = 3) were common quality improvement aims. Tools were associated with reported enhancement of accuracy and efficiency in clinical tasks, improvement in adherence to guidelines, facilitation of reflective practice and provision of tailored feedback for continuous quality improvement. Common features were educational resources (n = 7) and assisting the user to assess current practices against standards/recommendations (n = 6), which supported professionals in achieving better clinical outcomes, increased professional satisfaction and streamlined workflow in various settings. Studies reported facilitators to tool usage including relevance to practice, accessibility and facilitating multidisciplinary action, making these tools practical and time-efficient for healthcare. However, barriers such as being time consuming, irrelevant to practice, difficult to use and lack of organisational engagement were reported. Almost all tools were co-developed with stakeholders. The co-design approaches varied, reflecting different levels of stakeholder engagement and adoption of co-design methodologies. It is noted that the quality of included studies was low. These findings offer valuable insights for future development of quality improvement website-based tools in healthcare. Recommendations include ensuring tools are co-developed with healthcare professionals, focusing on practical usability and addressing common barriers to enhance engagement and effectiveness in improving healthcare quality. Randomised controlled trials are warranted to provide objective evidence of tool efficacy. This work was supported by the Prevention Research Support Program, funded by the New South Wales Ministry of Health, Australia. This review was registered with PROSPERO, no. CRD42023451346.

Process Development of Bersacapavir, Part 2. Early Game Route Selection: Catalytic versus Stoichiometric Haloform-Type Amidation

Process Development of Bersacapavir, Part 2. Early Game Route Selection: Catalytic versus Stoichiometric Haloform-Type Amidation

Process of language Use and Development: Case Studies in 6 Years of Age

The aim of this research is to determine the process of first language acquisition and development in 6 year old children. The method used in this research is a qualitative analysis method. The technique used in processing data and obtaining data is through observation and interviews with parents and children directly (face to face). The results of the research show that children's language development goes through several patterns, namely crying, cooing, moaning, intonation patterns, one-word speech, two-word speech, data inflections, interrogative sentences, rare/complex constructions, and mature speech.Furthermore, there are several levels of children's language, namely pre-speech, first words when names appear, word combinations and grammar. Meanwhile, there are several ways for children to acquire language, namely through acquisition and teaching. There are four factors in language acquisition, namely biology, environment, intelligence, and motivation. Parental involvement and supervision also greatly influences the complex process of children's language development.

Facilitating outstanding engineering faculty members through training from recruitment to retirement

Most of the higher engineering education institutions don't focus on continuous training of their faculty members from recruitment to retirement (R to R). Because of this, the quality of performance of untrained faculty members gradually reduces and this impacts the attributes of their graduates, sporadic contribution to knowledge capital, and poor return on the investments (ROI) in engineering education. There is a need for an integrated and dynamic model for the training and development of engineering faculty members. The objectives of this research are to assess the literature on faculty development; to identify the total needs of the engineering faculty members from recruitment to retirement (R to R); to suggest effective and efficient methods of planned faculty development; and to validate the suggested process of development through a set of engineering institutions. The action research method has been adopted to assess the global literature, and consult multinational companies, local engineering companies, and alumni on their needs. It is found that ‘Faculty Development Courses’ are required for all engineering faculty members from entry to exit to facilitate meritocracy. A critical review of the literature revealed that most of the researchers have focused their research on entry-level faculty members or some middle-level faculty members. Only a few institutes focused on the senior members. Hence, this study focused on lifelong faculty development courses from entry-level to exit level. The training needs assessment was based on the feedback from 396 entry-level faculty members who were purposefully included in this research. The outcomes are presented in seven parts: (1) Entry-level faculty development programs (FDPs), (2) Getting recognized, (3) Middle-level FDPs, (4) Student personnel administration, (5) Senior-level FDPs, (6) Advanced-level FDPs, and (7) Radical innovations. This research provides a 360-degree assessment and creates a guide both for the educational administrators and faculty members to reach excellence. Learning is a lifelong process. The suggestions were validated through a set five of institutions. and they started implementing them. The continuous process of faculty development from recruitment to retirement has been appreciated but it may take several years to institutionalize it. Limitations of this study are a smaller number of faculty members (396) and suggestions for future research have also been indicated. This gave a promising cost-effective faculty development process at every stage of faculty growth and resulted in outstanding institutes with high-performing faculty members. Further, these faculty members contributed to human and knowledge capital.

Unraveling the modulatory manner and function of circRNAs in the Asian honey bee larval guts

Circular RNAs (circRNAs) are a class of non-coding RNAs (ncRNAs) that can participate in biological processes such as gene expression, growth, and development. However, little has been explored about the function of circRNAs in the development of Apis cerana larval guts. By using our previously gained deep sequencing data from the guts of A. cerana worker larvae at 4-, 5-, and 6-day-old (Ac4, Ac5, and Ac6 groups), the expression pattern and regulatory role of circular RNAs (circRNAs) during the development process was comprehensively investigated, with a focus on differentially expressed circRNAs (DEcircRNAs) relevant to immunity pathways and developmental signaling pathways, followed by validation of the binding relationships among a key competing endogenous RNA (ceRNA) axis. Here, 224 (158) DEcircRNAs were detected in the Ac4 vs. Ac5 (Ac5 vs. Ac6) comparison group. It’s suggested that 172 (123) parental genes of DEcircRNAs were involved in 26 (20) GO terms such as developmental process and metabolic process and 138 (136) KEGG pathways like Hippo and Wnt signaling pathways. Additionally, ceRNA network analysis indicated that 21 (11) DEcircRNAs could target seven (three) DEmiRNAs, further targeting 324 (198) DEmRNAs. These DEmRNAs can be annotated to 33 (26) GO terms and 168 (200) KEGG pathways, including 12 (16) cellular and humoral immune pathways (endocytosis, lysosome, Jak-STAT, etc.) and 10 (nine) developmental signaling pathways (Hippo, mTOR, Hedgehog, etc.). Interestingly, DEcircRNAs in these two comparison groups could target the same ace-miR-6001-y, forming complex sub-networks. The results of PCR and Sanger sequencing confirmed the back-splicing sites within four randomly selected DEcircRNAs. RT-qPCR detection of these four DEcircRNAs verified the reliability of the used transcriptome data. The results of dual-luciferase reporter assay verified the binding relationships between novel_circ_001627 and ace-miR-6001-y and between ace-miR-6001-y and apterous-like. Our data demonstrated that DEcircRNAs were likely to modulate the developmental process of the A. cerana worker larval guts via regulation of parental gene transcription and ceRNA network, and novel_circ_001627/ace-miR-6001-y/apterous-like was a potential regulatory axis in the larval gut development. Findings from this work offer a basis and a candidate ceRNA axis for illustrating the circRNA-modulated mechanisms underlying the A. cerana larval guts.

Improving the non-structural preparedness of the selected hospital based on the FOCUS-PDCA1 model: action research

IntroductionWith the intensification of the country’s development process, the expansion of cities and population, and the inclusion of Iran in the accident-prone category, reducing the vulnerability of non-structures has received more attention from the organizations involved. In addition to damage to communities and infrastructure, accidents can affect hospitals and their non-organizational components. Hospitals, as the front line of providing medical services after accidents, must maintain their stability, ensure the safety of their patients and employees, and continue to operate without interruption as in normal conditions. Therefore, it is necessary to evaluate the non-structural safety and their preparedness to ensure they can perform acceptable in critical conditions.MethodsThis applied research was conducted in 2023 (September to December) using the participatory action research method in all selected hospital departments. The level of non-structural preparedness of the hospital was checked using the valid “Hospital Safety Index” questionnaire and the non-structural weaknesses of the hospital were identified. Then, in action research using the FOCUS-PDCA model, a program was implemented to improve the non-structural preparedness of different departments of hospitals in the face of accidents and disasters. The non-structural readiness level of the hospital was compared before and after the implementation of the change.ResultsBased on the evaluation conducted in the present study, the lowest level of safety was observed in the water supply system, office furniture and appliances, and fuel storage. The waste management systems, the fire protection system, and the long-distance communication systems were at a desirable performance level. Although in the evaluation before the change, the overall score of the hospital was 71.01%, and it had a desirable performance level in non-structural factors, in all the involved parts of the hospital, the sensitive, critical, and practical parts in the operation of the hospital had an average and sometimes low safety level. According to the obtained safety score, the safety level of the selected hospital before the change was 7 out of 10 (level seven of safety evaluation = medium). After the change and corrective measures, the non-structural safety assessment score was 76.93, and the hospital’s safety level was raised by one step to 8 out of 10 (8th level of safety assessment = relatively favorable).ConclusionThe present study showed that the application of Total Quality Management (TQM), primarily its application tool FOCUS-PDCA, is efficient and helpful in improving the non-structural preparedness of hospitals. Using action research in the health field in accidents and disasters can open blind knots in different dimensions of preparedness (structural, non-structural, and functional).

Geological and Hydrochemical Processes Driving Karst Development in Southeastern Riyadh, Central Saudi Arabia

This study investigates the processes leading to karst development in the southeastern part of Riyadh city extending up to Al Kharj. Numerous solution features such as sinkholes, collapsed dolines, and solution caverns are common in the area. The role of water in the development of the karst features was investigated using an integrated geological and hydrochemical approach. Geological investigations included the petrographic analysis of rock samples collected from zones of intense karstification with special emphasis on mineral dissolution. The study showed that the Sulaiy Formation is commonly fractured, brecciated, foliated, and contains numerous cavities, vugs, and openings. These features have formed by mineral dissolution by circulating groundwater, which has removed anhydrite beds from the underlying Arab–Hith sequence. Karstification likely started from the tectonically weak zones when there was more groundwater recharge. Studies show that during the early to mid-Holocene period, the climate in the Arabian Peninsula was humid, promoting groundwater recharge and subsequent mineral dissolution, though the process of karstification must have started much earlier. Hydrochemical findings reveal that mineral dissolution (halite and calcium sulfate) is the main process affecting groundwater chemistry. The Piper plot revealed two main hydrochemical facies: the (Ca2+ + Mg2+)–(Cl+ SO42−) Type (Type A) and the (Na+ + K+)–(SO42− + Cl) Type (Type B). Most of the samples belong to Type B, typical of groundwater facies affected by dissolution of halite and anhydrite mineral. The absence of the (Ca2+ + Mg2+)–(CO32− + HCO3−) type of groundwater facies indicates a lack of recent groundwater recharge and the removal of carbonate minerals from the system through precipitation, as evidenced by the saturation indices. Plots of the major ionic pairs (cations vs. anions) in groundwater indicate strong halite and gypsum/anhydrite dissolution. Of the three carbonate minerals, calcite has the highest average saturation index followed by aragonite and dolomite. This suggests significant past rock–water interaction leading to carbonate dissolution. Presently, any additional calcium or carbonate ions introduced into the water lead to calcite precipitation. The study indicates that the process of karst development may not be active today. Currently, groundwater chemistry is mainly influenced by rock–water interaction leading to gypsum/anhydrite dissolution, which has resulted in a high concentration of Na+, Ca2+, Cl− and SO42− ions in groundwater. The dissolution of gypsum and halite from the Hith Formation weakens the structural integrity of the overlying Sulaiy Formation, creating large underground cavities. These cavities increase the risk of roof collapse, leading to cover-collapse sinkholes as the roof becomes too thin to support the weight above.

Enhancing Software Developer Selection with Integrated F-AHP and F-TOPSIS Techniques

This study focuses on enhancing the selection process for software developers by integrating the Fuzzy Analytic Hierarchy Process (F-AHP) and the Fuzzy Technique for Order Preference by Similarity to Ideal Solution (F-TOPSIS). The primary objective is to address the uncertainties and ambiguities in determining evaluation criteria and weights, thereby facilitating accurate decision-making when faced with multiple criteria and alternatives. Conducted within a software development company in Bandung, Indonesia, the study involved evaluating ten potential candidates for the software developer position. The methodology employed F-AHP to assess the importance of each criterion through pairwise comparisons, and F-TOPSIS to rank the candidates based on these criteria weights. The results revealed that Candidate CK-7 exhibited the highest closeness coefficient (CCi), making them the top candidate, while CK-4 ranked the lowest. This integrated approach provided a systematic and transparent framework for decision-making, demonstrating its effectiveness in optimizing recruitment processes. The study contributes to the field by offering a robust decision-making tool that can be adapted to various industries, ensuring the selection of high-quality employees who meet necessary competencies, thereby improving overall productivity and performance.

Development and disease-specific regulation of RNA splicing in cardiovascular system

Alternative splicing is a complex gene regulatory process that distinguishes itself from canonical splicing by rearranging the introns and exons of an immature pre-mRNA transcript. This process plays a vital role in enhancing transcriptomic and proteomic diversity from the genome. Alternative splicing has emerged as a pivotal mechanism governing complex biological processes during both heart development and the development of cardiovascular diseases. Multiple alternative splicing factors are involved in a synergistic or antagonistic manner in the regulation of important genes in relevant physiological processes. Notably, circular RNAs have only recently garnered attention for their tissue-specific expression patterns and regulatory functions. This resurgence of interest has prompted a reevaluation of the topic. Here, we provide an overview of our current understanding of alternative splicing mechanisms and the regulatory roles of alternative splicing factors in cardiovascular development and pathological process of different cardiovascular diseases, including cardiomyopathy, myocardial infarction, heart failure and atherosclerosis.

Role of nuclear protein Akirin in the modulation of female reproduction in Nilaparvata lugens (Hemiptera: Delphacidae)

Introduction: Akirin as a highly conserved transcription factor, exerts a profound influence on the growth, development, immune response, and reproductive processes in animals. The brown planthopper (BPH), Nilaparvata lugens, a major pest in rice production in Asia, possesses high reproductive capacity, a critical factor contributing to reduced rice yields. The aims of this study were to demonstrate the regulatory role of Akirin in the reproduction of BPH.Methods: In this study, quantitative PCR (qPCR) was used to detect the mRNA expression of genes. RNA interference (RNAi) was used to downregulate the expression of Akirin gene, and RNA sequencing (RNA-seq) was used to screen for differentially expressed genes caused by Akirin downregulation. Hormone contents were measured with the enzyme linked immunosorbent assay (ELISA), and protein content was evaluated with the bicinchoninic acid (BCA) method.Results: Using BPH genome data, we screened for an Akirin gene (NlAkirin). An analysis of tissue-specific expressions showed that NlAkirin was expressed in all tissues tested in female BPH, but its expression level was highest in the ovary. After inhibiting the mRNA expression of NlAkirin in BPH females, the number of eggs laid, hatching rate, and number of ovarioles decreased. Transcriptome sequencing was performed, following a NlAkirin double-stranded RNA treatment. Compared with the genes of the control, which was injected with GFP double-stranded RNA, there were 438 upregulated genes and 1012 downregulated genes; the expression of vitellogenin (Vg) and vitellogenin receptor (VgR) genes as well as the mRNA expression of genes related to the target of rapamycin (TOR), juvenile hormone (JH), and insulin pathways involved in Vg synthesis was significantly downregulated. As a result of NlAkirin knockdown, the titers of JH III and Ecdysone (Ecd) were downregulated in unmated females but returned to normal levels in mated females. The ovarian protein contents in both unmated and mated females were downregulated.Discussion and conclusion: Our results suggest that NlAkirin affects female BPH reproduction by regulating the mRNA expression of genes related to the Vg, VgR, TOR, JH, and insulin signaling pathways, in addition to the titers of JH III and Ecd. The findings of this research provide novel insights into the regulatory role of Akirin in insect reproductive capacity.

Analysis of Job Promotions to Improve the Performance of Bombana Regency Civil Servants

Bombana Regency became an autonomous region based on Law Number 29 of 2003 concerning establishment in Southeast Sulawesi Province. The development of a region is highly dependent on the competence and participation of the human resources in utilizing the potential of respective areas. Therefore, the development of human resources is essential to support future development process. However, the Regional Staffing Agency (BKD) of Bombana Regency faced several challenges. The implementation of objective competency tests has not been optimal, and employees performance is hindered by inadequate Manpower Planning (workforce planning in accordance with organizational needs through identification, evaluation and needs planning). The execution of employees education and training (Diklat) has not been carried out effectively. Therefore, this study aimed to investigate the challenges to promotions affecting the performance of civil servants at the BKD of Bombana Regency and explore the efforts to address these issues. Qualitative and quantitative methods were used, in-depth interviews were conducted with key informants, and descriptive statistics were derived from processed questionnaires. Furthermore, data were collected through interviews, observation, and documentation. The results showed that subjectivity was a significant challenge that affected promotions considerations and employees performance at BKD Bombana Regency. The primary effort to address this issue and improve employees performance was the implementation of competency tests.

Guideline for reporting systematic reviews of outcome measurement instruments (OMIs): PRISMA-COSMIN for OMIs 2024

PurposeAlthough comprehensive and widespread guidelines on how to conduct systematic reviews of outcome measurement instruments (OMIs) exist, for example from the COSMIN (COnsensus-based Standards for the selection of health Measurement INstruments) initiative, key information is often missing in published reports. This article describes the development of an extension of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guideline: PRISMA-COSMIN for OMIs 2024.MethodsThe development process followed the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) guidelines and included a literature search, expert consultations, a Delphi study, a hybrid workgroup meeting, pilot testing, and an end-of-project meeting, with integrated patient/public involvement.ResultsFrom the literature and expert consultation, 49 potentially relevant reporting items were identified. Round 1 of the Delphi study was completed by 103 panelists, whereas round 2 and 3 were completed by 78 panelists. After 3 rounds, agreement (≥67%) on inclusion and wording was reached for 44 items. Eleven items without consensus for inclusion and/or wording were discussed at a workgroup meeting attended by 24 participants. Agreement was reached for the inclusion and wording of 10 items, and the deletion of 1 item. Pilot testing with 65 authors of OMI systematic reviews further improved the guideline through minor changes in wording and structure, finalized during the end-of-project meeting. The final checklist to facilitate the reporting of full systematic review reports contains 54 (sub)items addressing the review’s title, abstract, plain language summary, open science, introduction, methods, results, and discussion. Thirteen items pertaining to the title and abstract are also included in a separate abstract checklist, guiding authors in reporting for example conference abstracts.ConclusionPRISMA-COSMIN for OMIs 2024 consists of two checklists (full reports; abstracts), their corresponding explanation and elaboration documents detailing the rationale and examples for each item, and a data flow diagram. PRISMA-COSMIN for OMIs 2024 can improve the reporting of systematic reviews of OMIs, fostering their reproducibility and allowing end-users to appraise the quality of OMIs and select the most appropriate OMI for a specific application.NoteIn order to encourage its wide dissemination this article is freely accessible on the web sites of the journals: Health and Quality of Life Outcomes; Journal of Clinical Epidemiology; Journal of Patient-Reported Outcomes; Quality of Life Research.

Methods for Medical Device Design, Regulatory Compliance and Risk Management

Despite the evolution of design controls and compliance as critical elements in the medical device development process, as stipulated by both domestic and international regulations and standards, a comprehensive model describing the comprehensive approach to medical device design is needed. This gap exists because design controls and regulatory compliance have become integral to the medical device design process, mandated by regulations and standards at both national and international levels. The medical device sector prioritizes design controls and compliance with regulatory requirements in isolation. On the other hand, the integration of design controls and compliance, such as those associated with projects involving complex medical device designs, have not been considered nearly enough. This review focuses on the integration of design controls and compliance in the medical device sector. Initially, the definition of a medical device and the different phases of medical device development are introduced. Afterwards, medical device development using the basic safety and essential performance concepts outlined in the IEC 60601-1 standard is discussed. The role of risk management practices about medical devices is also elaborated upon.

Three-dimensional integrated metal-oxide transistors

AbstractThe monolithic three-dimensional vertical integration of thin-film transistor (TFT) technologies could be used to create high-density, energy-efficient and low-cost integrated circuits. However, the development of scalable processes for integrating three-dimensional TFT devices is challenging. Here, we report the monolithic three-dimensional integration of indium oxide (In2O3) TFTs on a silicon/silicon dioxide (Si/SiO2) substrate at room temperature. We use an approach that is compatible with complementary metal–oxide–semiconductor (CMOS) processes to stack ten n-channel In2O3 TFTs. Different architectures—including bottom-, top- and dual-gate TFTs—can be fabricated at different layers in the stack. Our dual-gate devices exhibit enhanced electrical performance with a maximum field-effect mobility of 15 cm2 V−1 s−1, a subthreshold swing of 0.4 V dec−1 and a current on/off ratio of 108. By monolithically integrating dual-gate In2O3 TFTs at different locations in the stack, we created unipolar invertor circuits with a signal gain of around 50 and wide noise margins. The dual-gate devices also allow fine-tuning of the invertors to achieve symmetric voltage-transfer characteristics and optimal noise margins.

Single-cell RNA sequencing uncovers cellular heterogeneity and the progression of heterotopic ossification of the elbow

Heterotopic ossification of the elbow (HOE) is a complicated pathologic process characterized by extra bone formation in the elbow. Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells into osteoblasts. The aim of this study was to explore the cellular origin and progression of HOE by single-cell RNA sequencing. We identified 13 clusters of cells in HOE and further analyzed the subclusters for 4 of the main cell types. Six subclusters of osteoblasts, nine subclusters of chondrocytes, six subclusters of fibroblasts, and five subclusters of mononuclear phagocytes (MPs) were identified and analyzed. The new findings on osterix (OSX) and SOX9 expression in osteoblast subclusters and chondrocyte subclusters indicate that HOE is mediated through endochondral ossification. Further identification of the corresponding signature gene sets of distinct subclusters indicated that subclusters of osteoblasts_3, osteoblasts_4, osteoblasts_5, and osteoblasts_6 are relatively more mature during the osteoblastic progression of HOE. The trajectory analysis of the osteoblasts demonstrated that some genes were gradually downregulated, such as CRYAB, CCL3, SFRP4, WIF1, and IGFBP3, while other critical genes were upregulated, such as VCAN, IGFBP4, FSTL1, POSTN, MDK, THBS2, and ALPL, suggesting that these factors may participate in HOE progression. Cell–cell communication networks revealed extensive molecular interactions among the 13 HOE clusters. Ligand–receptor pairs for IL6, COL24A1, COL22A1, VWF, FZD6, FGF2, and NOTCH1 were identified, suggesting that multiple signaling pathways may be involved in HOE. In conclusion, this study provided the cellular atlas for HOE. We have established a greater extent of the heterogeneity of HOE cells than previously known through transcriptomic analysis at the single-cell level. We have observed gradual patterns of signature gene expression during the differentiation and maturation progression of osteoblasts from stem cells in HOE with higher resolution. The cell heterogeneity of HOE deserves further investigation to pave the way for identification of potential targets for HOE early diagnosis and therapeutic treatment.

A Study on the Strategy of Modern Border Governance in the Qing Dynasty -- A Brief Discussion on the Governance Strategy of Zhao Erfeng during his tenure as the Resident Minister in Tibet

In the late Qing Dynasty, in order to consolidate the southwest border and resist the invasion of British colonizers. The central administrative group of the Qing Dynasty carried out a series of governance and business activities on the Xichuan border. In this series of activities, Zhao Erfeng, who was then the Minister of Border Affairs of Sichuan and Yunnan, was known as the "Zhao Butcher". He cruelly suppressed the national movement with iron and blood methods, and implemented strategies such as land reform and new policies, which greatly changed the form of border areas in Sichuan. This article aims to explore the development process of modern ethnic relations and border governance by exploring Zhao Erfeng's governance period, extracting the ruling ideas of Qing rulers towards ethnic border areas, and exploring the development process of modern ethnic relations and border governance.

Developing evidence-based clinical imaging guidelines for the diagnosis of vertically fractured teeth.

This study aimed to develop an evidence-based clinical imaging guideline for teeth suspected with vertical root fractures. An adaptation methodology based on the Korean Clinical Imaging Guidelines (K-CIG) was used in the guideline development process. After searching for guidelines using major databases such as Ovid-Medline, Elsevier-Embase, National Guideline Clearinghouse, and Guideline International Network, as well as domestic databases such as KoreaMed, KMbase, and KoMGI, two reviewers analyzed the retrieved articles. The retrieved articles were included in this review using well-established inclusion criteria. Twenty articles were identified through an online search, of which three were selected for guideline development. Based on these three guidelines, this study developed specific recommendations concerning the optimal imaging modality for diagnosing teeth suspected of vertical root fractures. Periapical radiography is the preferred method for assessing teeth with mastication-related pain and suspected vertical root fractures. However, if intraoral radiographs do not provide sufficient information about root fractures, a small FOV CBCT may be considered. However, the use of CBCT in endodontically treated teeth is significantly constrained by the presence of artificial shading.

Visual Analyses of Hot Spots and Frontiers in Zanthoxylum planispinum Research Based on CiteSpace

Zanthoxylum planispinum is a type of plant with homologous properties in medicine and food, making it well-loved in China. To explore the development of the Z. planispinum field over the past 20 years, its research hotspots and frontier trends were analyzed. This study conducted database-based visualization analyses and knowledge graph analyses using CiteSpace software with data concerning Z. planispinum published in the Chinese National Knowledge Infrastructure and Web of Science databases between 2003 and 2023. Over the last 20 years, the number of Chinese and English publications on Z. planispinum has shown increasing trends. The foci of this research were mainly germplasm resources, cultivation management, seed oil extraction technology, flavonoid extraction technology, and correlation analyses of antioxidant activities. The main research frontiers included the unified standard naming and adaptation mechanisms of Z. germplasm resources, orientation cultivation, functional component extraction, processing technology research and development, and industrial chain construction. The results provide a scientific reference for the high-quality development of the prickly ash industry.

Antibody-drug conjugates in gastric cancer: from molecular landscape to clinical strategies.

Antibody-drug conjugates (ADCs) represent a crucial component of targeted therapies in gastric cancer, potentially altering traditional treatment paradigms. Many ADCs have entered rigorous clinical trials based on biological theories and preclinical experiments. Modality trials have also been conducted in combination with monoclonal antibody therapies, chemotherapies, immunotherapies, and other treatments to enhance the efficacy of drug coordination effects. However, ADCs exhibit limitations in treating gastric cancer, including resistance triggered by their structure or other factors. Ongoing intensive researches and preclinical experiments are yielding improvements, while enhancements in drug development processes and concomitant diagnostics during the therapeutic period actively boost ADC efficacy. The optimal treatment strategy for gastric cancer patients is continually evolving. This review summarizes the clinical progress of ADCs in treating gastric cancer, analyzes the mechanisms of ADC combination therapies, discusses resistance patterns, and offers a promising outlook for future applications in ADC drug development and companion diagnostics.