Abstract Earthquake catalogs are heterogeneous, especially those developed over long time spans. Changes in seismological monitoring, which provides the records on which these catalogs are based, are common. Typically, instruments and networks become more sensitive over time, allowing for the detection and characterization of smaller earthquakes. In pursuit of improvement, new methods for routine data analysis are occasionally introduced, modifying the procedures for catalog compilation. The resulting heterogeneities may not be evident to users, but they should be unveiled and considered in any application of the catalog, especially in statistical seismology, which analyzes large earthquake data sets. The Global Centroid Moment Tensor catalog is considered the most homogeneous database of global seismicity. However, a detailed analysis of its heterogeneities has been lacking. This work reviews changes in the catalog’s development from 1976 to 2023 and reveals how these have caused improvements and heterogeneities in the resulting data. Several periods are distinguished, separated by milestones in the methods employed for moment tensor inversion and catalog compilation, as well as by the advent of global broadband monitoring in 2004. These changes are shown to have caused variations in the catalog’s completeness and in the determinations of centroid depths, scalar seismic moments, and moment tensors. The magnitude of completeness is measured here in detail, both temporally and spatially. It has decreased over the years and shows spatial variations within each period, correlated to regional differences in network monitoring and compilation biases. Moment tensor determinations have been significantly different since 2004, resulting in a different frequency distribution of rake angles and a different dependence of the double-couple component as a function of rake. This work is expected to benefit all future uses of the catalog, enabling better characterization of seismicity properties and improved building and testing of models for earthquake occurrence.