Determination Of Atenolol Research Articles

A Practical Electrochemical Sensor for Atenolol Detection Based on a Graphene Oxide Composite Film Doped with Zinc Oxide Nanoparticles

AbstractZinc oxide nanoparticles doped graphene oxide modified glassy carbon electrodes (Zn‐GO/GCE) were fabricated for easy, cheap and practical detection of atenolol (ATE). The morphological and chemical characterizations of modified electrodes were carried out with scanning electron microscopy (SEM), electron diffraction spectroscopy (EDS) and X‐Ray photoelectron spectroscopy (XPS). The amounts of the electrode modifiers and the differential pulse voltammetric parameters were optimized due to exhibited the best analytical response towards the determination of ATE. As a result, the calibration curves of ATE were obtained at Zn‐GO/GCE using DPV technique with two different linear parts: 7.8 ‐ 84 μmol L−1 and 167 μmol L−1 ‐ 639 μmol L−1. The detection limit (LOD) was also calculated as 2.50 μmol L−1. The fabricated electrode in this study is selective for ATE in the presence of some electroactive molecules. The practical, easy and cheap modified electrode was applied for the detection of ATE in atenolol medicine tablets with good recovery.

An electrochemical study of Atenolol using Patton and Reeder’s modified pencil graphite electrode as an electrochemical sensor

ABSTRACT An electrochemical sensor has been developed using Patton and Reeder’s reagent which is electropolymerised on pencil graphite electrode (PR-PGE) for the selective and sensitive determination of Atenolol (ATN). The cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectra were used to check the analytical applicability of the proposed sensor for the investigation of ATN. To achieve better electrochemical response, the parameters such as pH, scan rate and electron transfer kinetics were determined. Under optimum experimental conditions, the linear calibration curve shows concentration linear range of 0.1–1.8 µM and the limit of detection 4.9 × 10−8 M. The proposed sensor shows better selectivity towards the determination of ATN in presence of organic and inorganic interfering species. The analytical performance of the PR-PGE has been studied successfully by determining ATN present in the pharmaceutical sample.