Training with more data has always been the most stable and effective way of improving performance in the deep learning era. The Open Images dataset, the largest object detection dataset, presents significant opportunities and challenges for general and sophisticated scenarios. However, its semi-automatic collection and labeling process, designed to manage the huge data scale, leads to label-related problems, including explicit or implicit multiple labels per object and highly imbalanced label distribution. In this work, we quantitatively analyze the major problems in large-scale object detection and provide a detailed yet comprehensive demonstration of our solutions. First, we design a concurrent softmax to handle the multi-label problems in object detection and propose a soft-balance sampling method with a hybrid training scheduler to address the label imbalance. This approach yields a notable improvement of 3.34 points, achieving the best single-model performance with a mAP of 60.90% on the public object detection test set of Open Images. Then, we introduce a well-designed ensemble mechanism that substantially enhances the performance of the single model, achieving an overall mAP of 67.17%, which is 4.29 points higher than the best result from the Open Images public test 2018. Our result is published on https://www.kaggle.com/c/open-images-2019-object-detection/leaderboard.